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Journal Article
PLoS biology, ISSN 1545-7885, 2017, Volume 15, Issue 6, p. e2001644
Antibiotic-resistant infections kill approximately 23,000 people and cost $20,000,000,000 each year in the United States alone despite the widespread use of... 
GRAM-NEGATIVE BACTERIA | ANTIMICROBIAL DRUG | ANTIBACTERIAL ACTIVITY | COMBINATION THERAPY | PLASMODIUM-FALCIPARUM | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI K-12 | BIOLOGY | NUCLEOSIDE DIPHOSPHATE KINASE | VIVO ZEBRAFISH ASSAYS | SOS RESPONSE | FLUCTUATION ANALYSIS | Trimethoprim - chemistry | Klebsiella pneumoniae - drug effects | Escherichia coli - drug effects | Embryo, Nonmammalian - drug effects | Reverse Transcriptase Inhibitors - chemistry | Anti-Infective Agents, Urinary - therapeutic use | Biological Assay | Trimethoprim - agonists | Anti-Infective Agents, Urinary - chemistry | Anti-Infective Agents, Urinary - pharmacology | Escherichia coli Infections - drug therapy | Bacterial Proteins - antagonists & inhibitors | Computational Biology | Trimethoprim - therapeutic use | Mutation Rate | Escherichia coli Infections - metabolism | Drug Synergism | Small Molecule Libraries | Klebsiella pneumoniae - growth & development | Anti-Bacterial Agents - pharmacology | Mutation | Folic Acid Antagonists - pharmacology | Folic Acid Antagonists - chemistry | Trimethoprim - pharmacology | Sulfamethizole - agonists | Embryo, Nonmammalian - metabolism | Klebsiella Infections - metabolism | Reverse Transcriptase Inhibitors - pharmacology | Zebrafish - embryology | Folic Acid Antagonists - therapeutic use | Microbial Sensitivity Tests | Anti-Bacterial Agents - therapeutic use | Sulfamethizole - chemistry | Anti-Bacterial Agents - chemistry | Drug Resistance, Multiple, Bacterial | Sulfamethizole - pharmacology | Drug Design | Escherichia coli - metabolism | Sulfamethizole - therapeutic use | Escherichia coli - growth & development | Klebsiella pneumoniae - metabolism | Reverse Transcriptase Inhibitors - therapeutic use | Drug Therapy, Combination | Klebsiella Infections - drug therapy | Bacterial Proteins - genetics | Escherichia coli Infections - microbiology | Embryo, Nonmammalian - microbiology | Klebsiella Infections - microbiology | Animals | High-Throughput Screening Assays | Bacterial Proteins - metabolism | Pattern Recognition, Automated | Prevention | Dosage and administration | Antibiotics | Drug resistance | Klebsiella | Virulence | Homeostasis | Trimethoprim | Hydroxyurea | Identification | Biosynthesis | Infections | Urinary tract | Drug development | Synergism | Folic acid | Design | Immunology | Historical account | E coli | New combinations | Antibiotic resistance | Bacteria | Libraries | Deoxyribonucleic acid--DNA | Effectiveness | Bacterial infections | Mutants | Medicine | DNA biosynthesis | Pathology | Sulfamethizole | Collection | Zidovudine | Bypasses | Methods | Deoxyribonucleic acid | DNA
Journal Article
Disease models & mechanisms, ISSN 1754-8411, 2013, Volume 6, Issue 3, pp. 841 - 854
Toll-like receptors (TLRs) are an important class of pattern recognition receptors (PRRs) that recognize microbial and danger signals. Their downstream... 
MYD88-DEFICIENT MICE | BACTERIAL-INFECTIONS | TOLL-LIKE RECEPTORS | GENE-EXPRESSION | LIPOPOLYSACCHARIDE | MODEL | PATHOLOGY | MYCOBACTERIAL INFECTION | INFLAMMATORY RESPONSE | EMBRYOS | CUTTING EDGE | CELL BIOLOGY | Transcription, Genetic - drug effects | Zebrafish - immunology | Humans | Immunity, Innate - genetics | Molecular Sequence Data | Embryo, Nonmammalian - immunology | Zebrafish - microbiology | Embryo, Nonmammalian - drug effects | Signal Transduction - immunology | Bacterial Infections - genetics | Myeloid Differentiation Factor 88 - chemistry | Bacterial Infections - immunology | Base Sequence | Flagellin - metabolism | Mycobacterium marinum - physiology | Salmonella typhimurium - drug effects | Bacterial Infections - microbiology | Mycobacterium marinum - drug effects | Amino Acid Sequence | Edwardsiella tarda - drug effects | Salmonella typhimurium - physiology | Phagocytosis - drug effects | Poly I-C - pharmacology | Disease Susceptibility | Immunity, Innate - drug effects | Zebrafish Proteins - chemistry | Embryo, Nonmammalian - pathology | Zebrafish Proteins - metabolism | Myeloid Differentiation Factor 88 - genetics | Phagocytosis - immunology | Signal Transduction - genetics | Transcriptome - genetics | Embryo, Nonmammalian - microbiology | Mutation - genetics | Zebrafish - genetics | Gene Expression Regulation - drug effects | Edwardsiella tarda - physiology | Homozygote | Animals | Signal Transduction - drug effects | Bacterial Infections - pathology | Lipopolysaccharides - pharmacology | Survival Analysis | Leukocytes - drug effects | Zebrafish Proteins - genetics | Leukocytes - metabolism | Myeloid Differentiation Factor 88 - metabolism | Resource
Journal Article
BMC genomics, ISSN 1471-2164, 2013, Volume 14, Issue 1, pp. 696 - 696
Background: MicroRNAs (miRNAs) have recently been shown to play important roles in development of the immune system and in fine-tuning of immune responses.... 
Infection | miR-146 | MicroRNA | Mycobacterium marinum | Traf6 | Innate immunity | Zebrafish | Apolipoproteins | MyD88 | Salmonella typhimurium | REGULATING IMMUNE | HOST | CANCER | I INTERFERON | POSSIBLE ROLES | EMERGING ROLE | GENE | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | INFLAMMATION | GENETICS & HEREDITY | MIR-146A | BACTERIAL-INFECTION | Zebrafish - immunology | Oligonucleotide Array Sequence Analysis | Humans | Embryo, Nonmammalian - metabolism | Immunity, Innate - genetics | MicroRNAs - metabolism | Embryo, Nonmammalian - immunology | Zebrafish - microbiology | Zebrafish - embryology | Gene Knockdown Techniques | Salmonella Infections, Animal - immunology | Apolipoproteins - genetics | Salmonella typhimurium - physiology | Zebrafish Proteins - metabolism | Apolipoproteins - metabolism | Mycobacterium - physiology | Gene Expression Regulation | Signal Transduction - genetics | Transcriptome - genetics | Embryo, Nonmammalian - microbiology | Zebrafish - genetics | Animals | Salmonella Infections, Animal - genetics | Salmonella Infections, Animal - microbiology | Inflammation - genetics | MicroRNAs - genetics | Zebrafish Proteins - genetics | Leukocytes - metabolism | RNA sequencing | Medical research | Embryonic development | Immune response | Bacterial infections | Inflammation | DNA binding proteins | Genetic transcription | DNA microarrays | Analysis | Zebra fish | Medicine, Experimental | Health aspects | Vertebrates | Rodents | MicroRNAs | Binomial distribution | Regulation | Gene expression | Embryos | Immune system
Journal Article
eLife, ISSN 2050-084X, 2012, Volume 1, Issue 1, p. e00003
We previously discovered histones bound to cytosolic lipid droplets (LDs); here we show that this forms a cellular antibacterial defense system. Sequestered on... 
LISTERIA-MONOCYTOGENES | PROTEIN | MANAGEMENT | DROSOPHILA-MELANOGASTER | BIOLOGY | ANTIMICROBIAL PEPTIDE | LIPOPOLYSACCHARIDE | HISTONE LEVELS | IDENTIFICATION | MASS-SPECTROMETRY | INNATE IMMUNITY | Drosophila melanogaster - immunology | Staphylococcus epidermidis - drug effects | Escherichia coli - drug effects | Embryo, Nonmammalian - metabolism | Liver - microbiology | Embryo, Nonmammalian - immunology | Embryo, Nonmammalian - drug effects | Drosophila melanogaster - metabolism | Liver - immunology | Bacillus subtilis - growth & development | Liver - drug effects | Teichoic Acids - pharmacology | Escherichia coli - growth & development | Lipid Droplets - metabolism | Lipid Droplets - chemistry | Histones - immunology | Histones - pharmacology | Liver - metabolism | Mice, Inbred C57BL | Listeria monocytogenes - growth & development | Embryo, Nonmammalian - microbiology | Drosophila melanogaster - microbiology | Animals | Staphylococcus epidermidis - growth & development | Lipid Droplets - immunology | Lipopolysaccharides - pharmacology | Mice | Histones - metabolism | Bacillus subtilis - drug effects | Listeria monocytogenes - drug effects | Immunoglobulins | Bacterial infections | Laboratories | Lipoteichoic acid | Antimicrobial agents | Lipids | Embryos | Lipopolysaccharides | Proteins | Antibiotics | Insects | E coli | Histones | Bacteria
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 12, p. e116052
MgtC is a virulence factor involved in intramacrophage growth that has been reported in several intracellular pathogens, including Mycobacterium tuberculosis... 
SALMONELLA-ENTERICA | ZEBRAFISH | EPITHELIAL-CELLS | YERSINIA-PESTIS | ENTERICA SEROVAR TYPHIMURIUM | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | INTRAMACROPHAGE SURVIVAL | VIRULENCE FACTOR | HOST | TUBERCULOUS GRANULOMA | Humans | Embryo, Nonmammalian - metabolism | Molecular Sequence Data | Zebrafish - microbiology | Zebrafish - embryology | Embryo, Nonmammalian - drug effects | Injections, Subcutaneous | Cell Membrane - metabolism | Mycobacterium marinum - metabolism | Mycobacterium marinum - growth & development | Cell Membrane - drug effects | Mycobacterium marinum - drug effects | Amino Acid Sequence | Cell Line | Genes, Bacterial | Phagocytosis - drug effects | Intracellular Space - drug effects | Neutrophils - drug effects | Bacterial Proteins - genetics | Embryo, Nonmammalian - microbiology | Magnesium - pharmacology | Gene Expression Regulation, Bacterial - drug effects | Sequence Alignment | Animals | Intracellular Space - microbiology | Mycobacterium marinum - genetics | Bacterial Proteins - metabolism | HeLa Cells | Mutation | Infection | Genetic engineering | Virulence (Microbiology) | Health aspects | Pathogens | Salmonella | Deprivation | Cell survival | Epithelial cells | Pathogenesis | Virulence | Transgenic | Leprosy | Zebrafish | Lipids | Infections | Leukocytes (neutrophilic) | Macrophages | Phagocytes | Tuberculosis | Internalization | Bacteria | Magnesium | Intracellular | Phagocytosis | Polymethyl methacrylate | Adaptation | Life Sciences | Microbiology and Parasitology | Innate immunity | Immunology | Bacteriology
Journal Article
Journal Article