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1. Full Text Reprogramming in vivo produces teratomas and iPS cells with totipotency features
by Abad, María and Mosteiro, Lluc and Pantoja, Cristina and Cañamero, Marta and Rayon, Teresa and Ors, Inmaculada and Graña, Osvaldo and Megías, Diego and Domínguez, Orlando and Martínez, Dolores and Manzanares, Miguel and Ortega, Sagrario and Serrano, Manuel
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7471, pp. 340 - 345
Reprogramming of adult cells to generate induced pluripotent stem cells (iPS cells) has opened new therapeutic opportunities; however, little is known about... 
TRANSCRIPTION FACTORS | GENE | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | MOUSE | DIRECT CONVERSION | NEURONS | GENERATION | DIFFERENTIATION | EXPRESSION | FIBROBLASTS | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Pancreas - cytology | Blood Cells - metabolism | Cell Dedifferentiation | Male | Gene Expression Profiling | SOXB1 Transcription Factors - metabolism | Teratoma - metabolism | Embryoid Bodies - metabolism | Octamer Transcription Factor-3 - genetics | Blood Cells - cytology | Embryoid Bodies - cytology | SOXB1 Transcription Factors - genetics | Kruppel-Like Transcription Factors - metabolism | Female | Trophoblasts - cytology | Induced Pluripotent Stem Cells - cytology | Totipotent Stem Cells - cytology | Totipotent Stem Cells - metabolism | Cellular Reprogramming - genetics | Induced Pluripotent Stem Cells - metabolism | Cell Separation | Mice, Inbred C57BL | Cells, Cultured | Kidney - cytology | Transcriptome - genetics | Organ Specificity | Proto-Oncogene Proteins c-myc - metabolism | Ectoderm - cytology | Teratoma - pathology | Animals | Octamer Transcription Factor-3 - metabolism | Stomach - cytology | Teratoma - genetics | Fibroblasts - cytology | Mice | Proto-Oncogene Proteins c-myc - genetics | Kruppel-Like Transcription Factors - genetics | Intestines - cytology | Physiological aspects | Cell research | Nuclear reprogramming | Research | Embryonic stem cells | Regenerative medicine | Transplants & implants | Bone marrow | Rodents | Index Medicus
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2. Full Text Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells
by Wagers, Amy J and Eminli, Sarah and Evans, Todd and Liu, Susanna and Kulalert, Warakorn and Li, Yushan and Apostolou, Effie and Tan, Kah Yong and Natesan, Sridaran and Melnick, Ari and Polo, Jose M and Shioda, Toshi and Hochedlinger, Konrad and Stadtfeld, Matthias and Figueroa, Maria Eugenia
Nature Biotechnology, ISSN 1087-0156, 08/2010, Volume 28, Issue 8, pp. 848 - 855
Induced pluripotent stem cells (iPSCs) have been derived from various somatic cell populations through ectopic expression of defined factors. It remains... 
SKELETAL-MUSCLE | DEFINED FACTORS | DNA METHYLATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | EPIGENETIC MEMORY | DISEASE | GENE-EXPRESSION | GENERATION | PATIENT | HUMAN SOMATIC-CELLS | REPROGRAMMING FACTORS | B-Lymphocytes - cytology | Epigenomics | Cells, Cultured | Gene Expression Profiling | Hematopoietic Stem Cells - metabolism | Stem Cells - cytology | Muscle, Skeletal - cytology | Embryoid Bodies - metabolism | Cell Lineage | Animals | Embryoid Bodies - cytology | Hematopoietic Stem Cells - cytology | Transcription, Genetic | Cell Differentiation | Fibroblasts - cytology | Mice | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Biotechnology | Molecular biology | Gene expression | Rodents | Stem cells | Index Medicus
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3. Full Text A universal system for highly efficient cardiac differentiation of human induced pluripotent stem cells that eliminates interline variability
by Burridge, Paul W and Thompson, Susan and Millrod, Michal A and Weinberg, Seth and Yuan, Xuan and Peters, Ann and Mahairaki, Vasiliki and Koliatsos, Vassilis E and Tung, Leslie and Zambidis, Elias T
PLoS ONE, ISSN 1932-6203, 2011, Volume 6, Issue 4, pp. e18293 - e18293
Background: The production of cardiomyocytes from human induced pluripotent stem cells (hiPSC) holds great promise for patient-specific cardiotoxicity drug... 
DEFINED MEDIUM | MESODERM | MULTIDISCIPLINARY SCIENCES | ENDODERM | CARDIOMYOCYTE DIFFERENTIATION | INDUCTION | LINES | FUNCTIONAL-PROPERTIES | Body Patterning - drug effects | Oxygen - pharmacology | Antigens, CD34 - metabolism | Polyvinyl Alcohol - pharmacology | Humans | Fibroblast Growth Factor 2 - pharmacology | Mesoderm - drug effects | Mesoderm - cytology | Cell Culture Techniques - methods | Embryoid Bodies - metabolism | Embryoid Bodies - cytology | Adult | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Cell Line | Insulin - pharmacology | Induced Pluripotent Stem Cells - drug effects | Myocytes, Cardiac - cytology | Transgenes - genetics | Fetal Blood - cytology | Cell Adhesion - drug effects | Bone Morphogenetic Protein 4 - pharmacology | Genetic Vectors - genetics | Embryoid Bodies - drug effects | Animals | Myocytes, Cardiac - drug effects | Cell Differentiation - drug effects | Fibroblasts - drug effects | Culture Media - pharmacology | Myocytes, Cardiac - metabolism | Cell Proliferation - drug effects | Fibroblasts - cytology | Mice | Electrophysiological Phenomena - drug effects | Physiological aspects | Bone morphogenetic proteins | Fibroblast growth factors | Embryonic stem cells | Analysis | Drugs | Neonates | Neuropathology | Variability | Embryo cells | Alcohol | Drug development | Blood | Contraction | Regeneration (physiology) | Engineering | Cord blood | Efficiency | Calcium-binding protein | Fibroblasts | Long QT syndrome | Modelling | Polyvinyl alcohol | Heart diseases | Biomedical engineering | Fibroblast growth factor 2 | CD34 antigen | Bone morphogenetic protein 4 | Anemia | Cardiomyocytes | Insulin | Embryos | Coronary artery disease | Medicine | Regeneration | Troponin | Troponin I | Plasmids | Stem cells | Epigenetics | Mutation | Differentiation | Pluripotency | Index Medicus
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4. Full Text Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells
by Mae, Shin-Ichi and Shono, Akemi and Shiota, Fumihiko and Yasuno, Tetsuhiko and Kajiwara, Masatoshi and Gotoda-Nishimura, Nanaka and Arai, Sayaka and Sato-Otubo, Aiko and Toyoda, Taro and Takahashi, Kazutoshi and Nakayama, Naoki and Cowan, Chad A and Aoi, Takashi and Ogawa, Seishi and McMahon, Andrew P and Yamanaka, Shinya and Osafune, Kenji
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1367 - 1367
A method for stimulating the differentiation of human pluripotent stem cells into kidney lineages remains to be developed. Most cells in kidney are derived... 
LONG-TERM | MAINTENANCE | POPULATION | MULTIDISCIPLINARY SCIENCES | MOUSE EMBRYOS | HUMAN FIBROBLASTS | GENERATION | DIFFERENTIATION | KIDNEY | ESTABLISHMENT | LINES | Cell Line | Gene Dosage - genetics | Gene Targeting | Green Fluorescent Proteins - metabolism | Embryonic Stem Cells - cytology | Kidney - embryology | Mesoderm - embryology | Humans | Genetic Loci - genetics | Kidney - cytology | Mesoderm - cytology | Gene Knock-In Techniques | Kidney - metabolism | Animals | Embryoid Bodies - cytology | Flow Cytometry | Time Factors | Gene Expression Regulation, Developmental | Polymorphism, Single Nucleotide - genetics | Cell Differentiation | Mice | Induced Pluripotent Stem Cells - cytology | Protein-Serine-Threonine Kinases - metabolism | Induced Pluripotent Stem Cells - metabolism | Index Medicus
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5. Full Text Dynamic regulation of 5-hydroxymethylcytosine in mouse ES cells and during differentiation
by Ficz, Gabriella and Branco, Miguel R and Seisenberger, Stefanie and Santos, Fátima and Krueger, Felix and Hore, Timothy A and Marques, C. Joana and Andrews, Simon and Reik, Wolf
Nature, ISSN 0028-0836, 05/2011, Volume 473, Issue 7347, pp. 398 - 404
Methylation at the 59 position of cytosine in DNA has important roles in genome function and is dynamically reprogrammed during early embryonic and germ cell... 
HUMAN GENOME | DNA METHYLATION | 5-METHYLCYTOSINE | RNA-SEQ | CONVERSION | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | SELF-RENEWAL | WIDE | SPECIFICATION | PLURIPOTENT | Cytosine - analogs & derivatives | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | 5-Methylcytosine - analogs & derivatives | Genome - genetics | Promoter Regions, Genetic - genetics | DNA-Binding Proteins - deficiency | Embryoid Bodies - metabolism | Cell Differentiation - genetics | DNA Methylation | Embryoid Bodies - cytology | Cytosine - metabolism | Gene Expression Regulation, Developmental | Antibodies - immunology | Transcription, Genetic | Euchromatin - genetics | Cytosine - analysis | Cell Lineage - genetics | Cytosine - immunology | Cell Line | Reproducibility of Results | Pluripotent Stem Cells - cytology | Down-Regulation | Gene Silencing | Exons - genetics | Proto-Oncogene Proteins - deficiency | Sequence Analysis, DNA | Euchromatin - metabolism | Pluripotent Stem Cells - metabolism | Animals | CpG Islands - genetics | Mice | Physiological aspects | Cytosine | Genetic aspects | Research | Cell differentiation | Embryonic stem cells | Gene expression | DNA methylation | Genomes | Binding sites | Index Medicus
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6. Full Text Modeling Hippocampal Neurogenesis Using Human Pluripotent Stem Cells
by Yu, Diana Xuan and Di Giorgio, Francesco Paolo and Yao, Jun and Marchetto, Maria Carolina and Brennand, Kristen and Wright, Rebecca and Mei, Arianna and Mchenry, Lauren and Lisuk, David and Grasmick, Jaeson Michael and Silberman, Pedro and Silberman, Giovanna and Jappelli, Roberto and Gage, Fred H
Stem Cell Reports, ISSN 2213-6711, 03/2014, Volume 2, Issue 3, pp. 295 - 310
The availability of human pluripotent stem cells (hPSCs) offers the opportunity to generate lineage-specific cells to investigate mechanisms of human diseases... 
IMMATURE DENTATE GYRUS | DIRECTED DIFFERENTIATION | DOPAMINE NEURONS | FUNCTIONAL MATURATION | CORTEX | TRANSCRIPTIONAL CONTROL | SCHIZOPHRENIA | PROX1 | GRANULE CELLS | INTERNEURONS | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Pyramidal Cells - metabolism | Schizophrenia - metabolism | Homeodomain Proteins - metabolism | Humans | Neurons - cytology | Neural Stem Cells - cytology | Neurogenesis | Action Potentials | Embryoid Bodies - metabolism | Embryoid Bodies - cytology | Schizophrenia - physiopathology | Cell Differentiation | Neurons - metabolism | Genes, Reporter | Pyramidal Cells - cytology | Gene Expression | Tumor Suppressor Proteins - metabolism | Dentate Gyrus - metabolism | Pluripotent Stem Cells - cytology | Neurotransmitter Agents - biosynthesis | Hippocampus - cytology | Hippocampus - metabolism | Dentate Gyrus - cytology | Nerve Net | Electrophysiological Phenomena | Neural Stem Cells - metabolism | Index Medicus
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7. Full Text MacroH2A histone variants act as a barrier upon reprogramming towards pluripotency
by Gaspar-Maia, Alexandre and Qadeer, Zulekha A and Hasson, Dan and Ratnakumar, Kajan and Adrian Leu, N and Leroy, Gary and Liu, Shichong and Costanzi, Carl and Valle-Garcia, David and Schaniel, Christoph and Lemischka, Ihor and Garcia, Benjamin and Pehrson, John R and Bernstein, Emily
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, pp. 1565 - 1565
The chromatin template imposes an epigenetic barrier during the process of somatic cell reprogramming. Using fibroblasts derived from macroH2A double knockout... 
OPEN CHROMATIN | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | SELF-RENEWAL | CORE HISTONE | GENERATION | DIFFERENTIATION | INACTIVE X-CHROMOSOME | EXPRESSION | DELETION | MAMMALS | Chromatin - metabolism | Humans | Genome - genetics | Male | Embryoid Bodies - metabolism | Embryoid Bodies - cytology | Protein Processing, Post-Translational - drug effects | HEK293 Cells | Epigenesis, Genetic - drug effects | Dermis - cytology | Induced Pluripotent Stem Cells - cytology | Fibroblasts - metabolism | Induced Pluripotent Stem Cells - metabolism | Tretinoin - pharmacology | Pluripotent Stem Cells - cytology | Rats | Mice, Knockout | Cellular Reprogramming - drug effects | Pluripotent Stem Cells - metabolism | Histone Demethylases - metabolism | Animals | Cell Differentiation - drug effects | Models, Biological | Fibroblasts - drug effects | Pluripotent Stem Cells - drug effects | Fibroblasts - cytology | Mice | Histones - metabolism | Index Medicus
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8. Full Text Polycomb Regulates Mesoderm Cell Fate-Specification in Embryonic Stem Cells through Activation and Repression Mechanisms
by Morey, Lluis and Santanach, Alexandra and Blanco, Enrique and Aloia, Luigi and Nora, Elphège P and Bruneau, Benoit G and Di Croce, Luciano
Cell Stem Cell, ISSN 1934-5909, 09/2015, Volume 17, Issue 3, pp. 300 - 315
Polycomb complexes (PRC1 and PRC2) are essential regulators of epigenetic gene silencing in embryonic and adult stem cells. Emerging evidence suggests that the... 
COMPLEX | PCGF HOMOLOGS | MOUSE | GENE-EXPRESSION | SELF-RENEWAL | H2A UBIQUITYLATION | DIFFERENTIATION | BMI1 | CPG ISLANDS | GROUP PROTEIN | CELL & TISSUE ENGINEERING | CELL BIOLOGY | Myocytes, Cardiac - cytology | Signal Transduction | Polycomb Repressive Complex 1 - metabolism | Gene Expression Regulation | Mouse Embryonic Stem Cells - cytology | Mesoderm - cytology | Polycomb-Group Proteins - metabolism | Mouse Embryonic Stem Cells - metabolism | Myocardium - cytology | Polycomb Repressive Complex 1 - deficiency | Cell Lineage | Bone Morphogenetic Proteins - metabolism | Animals | Embryoid Bodies - cytology | Cartilage - cytology | Protein Binding | Transcription, Genetic | Cell Differentiation | Mice | Protein Stability | Genome | Index Medicus | Regulació genètica | Diferenciació cel·lular
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9. Full Text Principles of early human development and germ cell program from conserved model systems
by Kobayashi, Toshihiro and Zhang, Haixin and Tang, Walfred W.C and Irie, Naoko and Withey, Sarah and Klisch, Doris and Sybirna, Anastasiya and Dietmann, Sabine and Contreras, David A and Webb, Robert and Allegrucci, Cinzia and Alberio, Ramiro and Surani, M. Azim
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7658, pp. 416 - 420
Human primordial germ cells (hPGCs), the precursors of sperm and eggs, originate during weeks 2-3 of early post-implantation development(1). Using in vitro... 
PLURIPOTENT STEM-CELLS | IN-VITRO | MULTIDISCIPLINARY SCIENCES | MOUSE | DEFINITIVE ENDODERM | DYNAMICS | MICE | DIFFERENTIATION | SPECIFICATION | INDUCTION | FATE | Macaca fascicularis - embryology | Epigenesis, Genetic | Humans | Male | Bone Morphogenetic Proteins - metabolism | Embryoid Bodies - cytology | Female | Models, Animal | Cell Differentiation | Germ Cells - cytology | Germ Cells - metabolism | Germ Layers - cytology | Wnt Signaling Pathway | Gastrulation | Pluripotent Stem Cells - cytology | Repressor Proteins - genetics | Primitive Streak - cytology | Gene Dosage | Embryonic Development | Cell Lineage | Animals | Models, Biological | Swine - embryology | In Vitro Techniques | SOXF Transcription Factors - genetics | Positive Regulatory Domain I-Binding Factor 1 | Biological research | Models | Germ cells | Research | Human growth | Biology, Experimental | Surgical implants | Animal models | Transcription factors | Divergence | Wnt protein | Dosage | Eggs | Cell fate | DNA methylation | Bone morphogenetic proteins | Deoxyribonucleic acid--DNA | Gene dosage | Streak | Cytokines | Computer simulation | Implantation | Embryos | Signaling | Stem cells | Epigenetics | Disks | In vitro methods and tests | Combinatorial analysis | Pluripotency | Index Medicus
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10. Full Text Ribosome Profiling of Mouse Embryonic Stem Cells Reveals the Complexity and Dynamics of Mammalian Proteomes
by Ingolia, Nicholas T and Lareau, Liana F and Weissman, Jonathan S
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 4, pp. 789 - 802
The ability to sequence genomes has far outstripped approaches for deciphering the information they encode. Here we present a suite of techniques, based on... 
TRANSCRIPTION FACTORS | MESSENGER-RNA TRANSLATION | OPEN READING FRAMES | PROTEIN TRANSLATION | NONCODING RNAS | HUMAN ERM | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSLATION INITIATION MECHANISM | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | MOLECULAR-CLONING | CELL BIOLOGY | Embryonic Stem Cells - metabolism | Protein Biosynthesis | RNA - analysis | Artificial Intelligence | Open Reading Frames | Ribosomes - chemistry | Peptide Chain Initiation, Translational | Embryoid Bodies - metabolism | Sequence Analysis, RNA - methods | Algorithms | Animals | Embryoid Bodies - cytology | Harringtonines - pharmacology | Ribosomes - drug effects | Mice | Kinetics | Genomics - methods | High-Throughput Nucleotide Sequencing - methods | Proteins | Messenger RNA | Codon | Analysis | Genomics | Protein biosynthesis | Data mining | Embryonic stem cells | RNA | Genetic translation | Learning algorithms | Translation elongation | Embryo cells | Ribosomes | Stem cells | Translation initiation | Genomes | Open reading frames | Codons | Differentiation | Gene mapping | Index Medicus
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