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Cell reports (Cambridge), ISSN 2211-1247, 2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors and neurons from human embryonic stem... 
HUMAN ES | IN-VITRO | VENTRAL MESENCEPHALON | FLOOR PLATE | MIDBRAIN DOPAMINE NEURONS | SUBSTANTIA-NIGRA | RAT MODEL | LINES | PARKINSONS-DISEASE | IPS CELLS | CELL BIOLOGY | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences | Cell Biology
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and offer a cost-effective approach... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | HUMAN NEOCORTEX | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | HUMAN BRAIN | MULTIDISCIPLINARY SCIENCES | CLASSIFICATION | FATTY-ACIDS | machine learning | CANCER | organoid | IN-VITRO | HUMAN CEREBRAL-CORTEX | MICROGLIA | GENE-EXPRESSION | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Biological Sciences
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 6, p. e39885
Journal Article
Bioimpacts, ISSN 2228-5660, 12/2018, Volume 8, Issue Suppl 1, pp. S1 - S129
Journal Article
Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2016, Volume 113, Issue 3, pp. E291 - E299
Protein transduction domains (PTDs) are powerful nongenetic tools that allow intracellular delivery of conjugated cargoes to modify cell behavior... 
Human embryonic stem cells | Transduction | Cell-penetrating peptides | Differentiation | Heparin-binding domain | differentiation | transduction | MULTIDISCIPLINARY SCIENCES | MECHANISMS | HEPARIN | MAMMALIAN-CELLS | IPS CELLS | PLURIPOTENT STEM-CELLS | cell-penetrating peptides | heparin-binding domain | MACROPINOCYTOSIS | GROWTH-FACTOR | PROTEINS | human embryonic stem cells | NIH 3T3 Cells | Homeodomain Proteins - metabolism | Human Embryonic Stem Cells - cytology | Humans | Mouse Embryonic Stem Cells - cytology | Mouse Embryonic Stem Cells - drug effects | Mouse Embryonic Stem Cells - metabolism | Drug Delivery Systems | Nanoparticles | Human Embryonic Stem Cells - drug effects | Integrases - metabolism | Cell Membrane - metabolism | Cell Membrane - drug effects | Cell-Penetrating Peptides - chemistry | Induced Pluripotent Stem Cells - metabolism | Protein Structure, Tertiary | Detergents - pharmacology | Human Embryonic Stem Cells - metabolism | Nanog Homeobox Protein | Induced Pluripotent Stem Cells - drug effects | Glycosaminoglycans - metabolism | Endocytosis - drug effects | Solubility | MyoD Protein - metabolism | Nucleic Acids - metabolism | Trypsin - metabolism | Amino Acid Motifs | Animals | Muscle Development - drug effects | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Mice | Genome | Cell-Penetrating Peptides - metabolism | Physiological aspects | Physiological research | Cellular signal transduction | Glycosaminoglycans | Research | Biological Sciences | PNAS Plus
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2010, Volume 470, Issue 7332, pp. 105 - 109
Studies in embryonic development have guided successful efforts to direct the differentiation of human embryonic and induced pluripotent stem cells (PSCs... 
NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | LIVER | ENDODERM | GENERATION | SPECIFICATION | FATE | CULTURE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2008, Volume 453, Issue 7194, pp. 519 - 523
In the three decades since pluripotent mouse embryonic stem (ES) cells were first described they have been derived and maintained by using various empirical... 
SURVIVAL | MAINTENANCE | ACTIVATION | TERATOCARCINOMA | MECHANISM | GENE | MULTIDISCIPLINARY SCIENCES | RECEPTOR | PLURIPOTENCY | DIFFERENTIATION | EXPRESSION | Embryonic Stem Cells - metabolism | Diphenylamine - pharmacology | Embryonic Stem Cells - cytology | Diphenylamine - analogs & derivatives | STAT3 Transcription Factor - deficiency | Benzamides - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Survival - drug effects | Pluripotent Stem Cells - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Pyrimidines - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Regeneration - physiology | Pluripotent Stem Cells - metabolism | Regeneration - drug effects | Animals | MAP Kinase Signaling System - drug effects | Embryonic Stem Cells - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Differentiation - drug effects | Pluripotent Stem Cells - drug effects | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Morphogenesis | Cytokines | Influence | Regeneration (Biology) | Research | Genetic transcription | Embryonic stem cells | Properties | Protein kinases | Proteins | Signal transduction | Cyclin-dependent kinases | Stem cells | Cell cycle | Kinases | Apoptosis
Journal Article
PloS one, ISSN 1932-6203, 2012, Volume 7, Issue 1, p. e29597
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological disease... 
HUMAN ES | INHIBITION | FGF | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION CAPACITY | PRECURSORS | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Neuroglia - cytology | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pluripotent Stem Cells - cytology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Neuroglia - metabolism | Cell Proliferation - drug effects | Neuroepithelial Cells - metabolism | Epidermal Growth Factor - pharmacology | Neural Stem Cells - metabolism | Cluster Analysis | Medical research | Nervous system diseases | Epidermal growth factor | Neurons | Medicine, Experimental | Fibroblast growth factors | Comparative analysis | Embryonic stem cells | Neurophysiology | Neurosciences | Laboratories | Neurobiology | Embryo cells | Radial glial cells | Nervous system | Biochemistry | Neurodevelopmental disorders | Neuronal-glial interactions | Genotype & phenotype | Fibroblasts | Physiology | Growth factors | Fibroblast growth factor 2 | Fetuses | Embryos | Brain research | Stem cells | Comparative studies | Hindbrain | Bayesian analysis | Pluripotency
Journal Article