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Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2015, Volume 112, Issue 40, pp. 12516 - 12521
Human pluripotent stem cell-based in vitro models that reflect human physiology have the potential to reduce the number of drug failures in clinical trials and... 
Organoid | Toxicology | Differentiation | Tissue engineering | Machine learning | toxicology | tissue engineering | DEVELOPMENTAL NEUROTOXICITY | differentiation | MULTIDISCIPLINARY SCIENCES | INVOLVEMENT | CLASSIFICATION | NEURODEGENERATION | machine learning | CANCER | organoid | IN-VITRO | MICROGLIA | GENE-EXPRESSION | SYSTEMS | BRAIN | Embryonic Stem Cells - metabolism | Microglia - metabolism | Embryonic Stem Cells - cytology | Humans | Brain - growth & development | Support Vector Machine | Neural Stem Cells - cytology | Xenobiotics - pharmacology | Brain - metabolism | Neurogenesis - genetics | Mesenchymal Stromal Cells - cytology | Xenobiotics - classification | Gene Expression Regulation, Developmental | Cell Differentiation | Neurogenesis - drug effects | Culture Media, Serum-Free - pharmacology | Gene Ontology | Polyethylene Glycols - pharmacology | Microglia - cytology | Mesenchymal Stromal Cells - drug effects | Brain - cytology | Pluripotent Stem Cells - cytology | Tissue Engineering - methods | Microglia - drug effects | Endothelial Cells - metabolism | Cells, Cultured | Neural Stem Cells - drug effects | Mesenchymal Stromal Cells - metabolism | Cell Communication - genetics | Macrophages - cytology | Pluripotent Stem Cells - metabolism | Macrophages - metabolism | Embryonic Stem Cells - drug effects | Endothelial Cells - cytology | Models, Biological | Pluripotent Stem Cells - drug effects | Cell Communication - drug effects | Macrophages - drug effects | Hydrogels - pharmacology | Neural Stem Cells - metabolism | Endothelial Cells - drug effects | Neurotoxicity | Stem cells | Gene expression | Biological assays | Bioinformatics | Artificial intelligence | Index Medicus | Biological Sciences
Journal Article
Cell Reports, ISSN 2211-1247, 06/2012, Volume 1, Issue 6, pp. 703 - 714
To model human neural-cell-fate specification and to provide cells for regenerative therapies, we have developed a method to generate human neural progenitors... 
HUMAN ES | IN-VITRO | VENTRAL MESENCEPHALON | FLOOR PLATE | MIDBRAIN DOPAMINE NEURONS | SUBSTANTIA-NIGRA | RAT MODEL | LINES | PARKINSONS-DISEASE | IPS CELLS | CELL BIOLOGY | Body Patterning - drug effects | Organ Specificity - drug effects | Embryonic Stem Cells - metabolism | Embryonic Stem Cells - cytology | Humans | Cell Survival - genetics | Motor Activity - drug effects | Neurons - cytology | Neural Stem Cells - cytology | Cell Culture Techniques - methods | Cell Lineage - drug effects | Neural Tube - drug effects | Cell Differentiation - genetics | Organ Specificity - genetics | Dopamine - secretion | Dopaminergic Neurons - metabolism | Telencephalon - drug effects | Dopaminergic Neurons - drug effects | Neural Stem Cells - transplantation | Neurons - metabolism | Neurons - drug effects | Cell Lineage - genetics | Cell Survival - drug effects | Telencephalon - metabolism | Telencephalon - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Neural Stem Cells - drug effects | Rats | Glycogen Synthase Kinase 3 - metabolism | Aging - pathology | Gene Expression Regulation - drug effects | Phenotype | Animals | Wnt Signaling Pathway - drug effects | Embryonic Stem Cells - drug effects | Wnt Signaling Pathway - genetics | Cell Differentiation - drug effects | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Neural Tube - embryology | Body Patterning - genetics | Neural Stem Cells - metabolism | Electrophysiological Phenomena - drug effects | Index Medicus | Biological Sciences | Biologi | Naturvetenskap | Cellbiologi | Natural Sciences | Cell Biology
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7332, pp. 105 - 110
Studies in embryonic development have guided successful efforts to direct the differentiation of human embryonic and induced pluripotent stem cells (PSCs) into... 
VIVO | NEUROGENIN-3 | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | ENDODERM | DEFINED CONDITIONS | GENERATION | SPECIFICATION | FATE | EFFICIENT DIFFERENTIATION | ENDOCRINE-CELLS | Body Patterning - drug effects | Intestines - drug effects | Wnt Proteins - pharmacology | Embryonic Stem Cells - cytology | Humans | Endoderm - embryology | Intestines - embryology | Organogenesis - drug effects | Intestines - anatomy & histology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Time Factors | Endoderm - cytology | Fibroblast Growth Factor 4 - pharmacology | Cell Culture Techniques | Culture Media - chemistry | Induced Pluripotent Stem Cells - cytology | Basic Helix-Loop-Helix Transcription Factors - genetics | Induced Pluripotent Stem Cells - drug effects | Cells, Cultured | Nerve Tissue Proteins - genetics | Nerve Tissue Proteins - metabolism | Microvilli - drug effects | Activins - pharmacology | Embryonic Stem Cells - drug effects | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Endoderm - drug effects | Culture Media - pharmacology | Morphogenesis - drug effects | Wnt3 Protein | Wnt3A Protein | Intestines - cytology | Physiological aspects | Intestines | Genetic aspects | Health aspects | Endoderm | Stem cells | Proteins | Studies | Index Medicus | posterior endoderm | intestine | FGF | transplantation | colon | drug transport | Wnt | progenitor cell
Journal Article
Nature, ISSN 0028-0836, 05/2008, Volume 453, Issue 7194, pp. 519 - 523
In the three decades since pluripotent mouse embryonic stem (ES) cells were first described they have been derived and maintained by using various empirical... 
MAINTENANCE | ACTIVATION | COMMITMENT | MECHANISM | TERATOCARCINOMA | MULTIDISCIPLINARY SCIENCES | PLURIPOTENCY | MOUSE ES CELLS | DIFFERENTIATION | EXPRESSION | PROTEIN-KINASE INHIBITORS | Embryonic Stem Cells - metabolism | Diphenylamine - pharmacology | Embryonic Stem Cells - cytology | Diphenylamine - analogs & derivatives | STAT3 Transcription Factor - deficiency | Benzamides - pharmacology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Survival - drug effects | Pluripotent Stem Cells - cytology | Glycogen Synthase Kinase 3 - antagonists & inhibitors | Cells, Cultured | Pyrimidines - pharmacology | Glycogen Synthase Kinase 3 - metabolism | Regeneration - physiology | Pluripotent Stem Cells - metabolism | Regeneration - drug effects | Animals | MAP Kinase Signaling System - drug effects | Embryonic Stem Cells - drug effects | Mitogen-Activated Protein Kinases - antagonists & inhibitors | Cell Differentiation - drug effects | Pluripotent Stem Cells - drug effects | Cell Proliferation - drug effects | Mice | Pyridines - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Morphogenesis | Cytokines | Influence | Regeneration (Biology) | Research | Genetic transcription | Embryonic stem cells | Properties | Protein kinases | Proteins | Signal transduction | Cyclin-dependent kinases | Stem cells | Cell cycle | Kinases | Apoptosis | Index Medicus
Journal Article
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 10/2012, Volume 111, Issue 9, pp. 1125 - 1136
Journal Article