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PLoS ONE, ISSN 1932-6203, 2012, Volume 7, Issue 9, p. e44789
Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of inflammation in human neurological disorders. In the present study we... 
INTERLEUKIN-1 | CORTICAL DYSPLASIA | ACTIVATION | MALFORMATIONS | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTOR | DISEASE | EPILEPSY | NF-KAPPA-B | EXPRESSION | RAT MODEL | Brain Diseases - metabolism | Interleukin-1 Receptor-Associated Kinases - metabolism | Interleukin-1beta - pharmacology | Humans | Astrocytes - pathology | Brain Diseases - genetics | Epilepsy - metabolism | Male | MicroRNAs - metabolism | NF-kappa B - metabolism | Brain Diseases - immunology | Ganglioglioma - pathology | Inflammation Mediators - metabolism | Epilepsy - genetics | Female | Toll-Like Receptors - metabolism | Malformations of Cortical Development - immunology | Malformations of Cortical Development - pathology | Interleukin-6 - metabolism | Astrocytes - drug effects | Malformations of Cortical Development, Group I | Immunity, Innate - drug effects | Malformations of Cortical Development - metabolism | Malformations of Cortical Development - genetics | Receptors, Interleukin-1 - metabolism | Gene Expression Regulation - drug effects | Pregnancy | Ganglioglioma - genetics | Brain Diseases - pathology | Signal Transduction - drug effects | Cyclooxygenase 2 - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Cell Line, Tumor | MicroRNAs - genetics | Ganglioglioma - metabolism | Epilepsy - pathology | Astrocytes - metabolism | Astrocytes - secretion | Medical research | Nervous system diseases | Immune response | MicroRNA | Cytokines | Epilepsy | Medicine, Experimental | Inflammation | Research | Enzyme-linked immunosorbent assay | Neurosciences | Downstream effects | Disorders | Inflammatory response | Nervous system | Kinases | Interleukin 6 | Transfection | Modulation | Lesions | Immune system | IRAK protein | Encephalitis | Immunomodulation | Astrocytes | MiRNA | Cultures | Tumor necrosis factor-α | Gene expression | Ribonucleic acid--RNA | Neurological diseases | Pathology | Signaling | Brain research | MicroRNAs | Cyclooxygenase-2 | RNA | Ribonucleic acid
Journal Article
Journal Article
Neuropathology and Applied Neurobiology, ISSN 0305-1846, 06/2009, Volume 35, Issue 3, pp. 306 - 328
Journal Article
Journal of Cerebral Blood Flow & Metabolism, ISSN 0271-678X, 05/2008, Volume 28, Issue 5, pp. 927 - 938
The nuclear protein high-mobility group box 1 (HMGB-1) promotes inflammation in sepsis, but little is known about its role in brain ischemia-induced... 
MCAO | Brain ischemia | Neuroinflammation | NeuN | HMGB-1 | brain ischemia | FOCAL CEREBRAL-ISCHEMIA | NEUROSCIENCES | INTERLEUKIN-1-BETA CONVERTING-ENZYME | TUMOR-NECROSIS-FACTOR | MICROGLIAL-MACROPHAGE SYNTHESIS | neuroinflammation | CHROMATIN PROTEIN HMGB1 | ENDOTHELIAL-CELLS | ENDOCRINOLOGY & METABOLISM | TOLL-LIKE RECEPTORS | MOBILITY GROUP BOX-1 | END-PRODUCTS RAGE | HEMATOLOGY | NF-KAPPA-B | Tumor Necrosis Factor-alpha - metabolism | Toll-Like Receptor 2 - genetics | Brain Ischemia - metabolism | Culture Media, Conditioned - pharmacology | Male | HMGB1 Protein - immunology | Brain Ischemia - immunology | Infarction, Middle Cerebral Artery - immunology | Infarction, Middle Cerebral Artery - metabolism | RNA, Messenger - metabolism | Extracellular Space - metabolism | Astrocytes - immunology | Encephalitis - metabolism | HMGB1 Protein - metabolism | Neurons - metabolism | Neurons - drug effects | Receptor for Advanced Glycation End Products | Glutamic Acid - pharmacology | Endothelial Cells - metabolism | Mice, Inbred C57BL | Cells, Cultured | Neurons - immunology | Toll-Like Receptor 4 - genetics | Encephalitis - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Extracellular Space - immunology | Antibodies - pharmacology | Endothelial Cells - immunology | Animals | Endothelial Cells - cytology | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Astrocytes - metabolism
Journal Article
American Journal of Pathology, The, ISSN 0002-9440, 2013, Volume 183, Issue 5, pp. 1548 - 1558
Journal Article
Brain, Behavior, and Immunity, ISSN 0889-1591, 2014, Volume 44, pp. 221 - 234
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 11/2006, Volume 99, Issue 4, pp. 1263 - 1272
It is well established that inflammatory changes contribute to brain ageing, and an increased concentration of proinflammatory cytokine, interleukin‐1β... 
interleukin‐1β | interferon‐γ | long‐term potentiation | age | interleukin‐18 | microglial activation | Interleukin-18 | Interferon-γ | Interleukin-1β | Long-term potentiation | Age | Microglial activation | NITRIC-OXIDE SYNTHASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | DOWN-REGULATION | NEUROSCIENCES | PROTEIN-KINASES | CELL-DEATH | IN-VITRO | interleukin-1 beta | interleukin-18 | MOUSE MODEL | AGING HUMAN BRAIN | CENTRAL-NERVOUS-SYSTEM | RAT HIPPOCAMPUS | interferon-gamma | long-term potentiation | Memory Disorders - physiopathology | Microglia - metabolism | Interleukin-18 - immunology | Interleukin-1alpha - immunology | Rats, Wistar | Minocycline - pharmacology | Memory Disorders - metabolism | Interleukin-1alpha - metabolism | Male | Gliosis - physiopathology | Interferon-gamma - metabolism | Dentate Gyrus - physiopathology | CD40 Antigens - metabolism | Encephalitis - physiopathology | Microglia - immunology | Long-Term Potentiation - drug effects | Encephalitis - metabolism | Long-Term Potentiation - physiology | Gliosis - immunology | B7-2 Antigen - immunology | Cytokines - immunology | Biomarkers - metabolism | Dentate Gyrus - metabolism | Cytokines - metabolism | Microglia - drug effects | Anti-Inflammatory Agents - pharmacology | Intercellular Adhesion Molecule-1 - immunology | Gliosis - metabolism | Rats | Encephalitis - immunology | Memory Disorders - immunology | B7-2 Antigen - metabolism | Hippocampus - metabolism | Intercellular Adhesion Molecule-1 - metabolism | Animals | Aging - physiology | Interferon-gamma - immunology | Hippocampus - physiopathology | CD40 Antigens - immunology | Interleukin-18 - metabolism | Brain | Neurology | Cytokines | Long term | Rodents
Journal Article
Neurobiology of Disease, ISSN 0969-9961, 2009, Volume 37, Issue 3, pp. 596 - 603
Abstract Bipolar disorder (BD) is a progressive psychiatric disorder characterized by recurrent changes of mood and is associated with cognitive decline. There... 
Neurology | Caspase | Synaptophysin | Drebrin | Bipolar disorder | BDNF | Apoptosis | CYTOSOLIC PHOSPHOLIPASE A | ALZHEIMERS-DISEASE | ARACHIDONIC-ACID CASCADE | BINDING PROTEIN | NEUROSCIENCES | POSITRON-EMISSION-TOMOGRAPHY | RAT FRONTAL-CORTEX | GENE-EXPRESSION | MOOD STABILIZERS | LITHIUM | ADMINISTRATION INCREASES | Bipolar Disorder - metabolism | Arachidonic Acid - metabolism | Humans | Middle Aged | Prefrontal Cortex - physiopathology | Bipolar Disorder - physiopathology | Male | RNA, Messenger - metabolism | Brain - metabolism | Synaptophysin - genetics | Encephalitis - physiopathology | Synapses - metabolism | Encephalitis - metabolism | Up-Regulation - physiology | Atrophy - genetics | Aged, 80 and over | Apoptosis Regulatory Proteins - genetics | Adult | Female | Neuropeptides - genetics | Synaptophysin - metabolism | Biomarkers - metabolism | Atrophy - physiopathology | Encephalitis - genetics | Brain - physiopathology | Biomarkers - analysis | Neuropeptides - metabolism | Bipolar Disorder - genetics | Nerve Tissue Proteins - genetics | Disease Progression | Apoptosis Regulatory Proteins - metabolism | Down-Regulation - physiology | Nerve Tissue Proteins - metabolism | Prefrontal Cortex - metabolism | Aged | Apoptosis - physiology | Atrophy - metabolism | Unsaturated fatty acids | Messenger RNA | Lymphomas | Peptide hormones | Arachidonic acid | Growth factors
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2011, Volume 286, Issue 9, pp. 7214 - 7226
The Ca2+-binding protein of the EF-hand type, S100B, is abundantly expressed in and secreted by astrocytes, and release of S100B from damaged astrocytes occurs... 
CYTOPLASMIC DOMAIN | IN-VITRO | ACTIVATION | NEURITE OUTGROWTH | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | NITRIC-OXIDE | RECEPTOR | GROWTH-FACTOR | RHO-GTPASES | GLYCATION END-PRODUCTS | Microglia - metabolism | Chemokine CCL3 - immunology | Nerve Growth Factors - metabolism | S100 Proteins - immunology | Cell Movement - immunology | S100 Proteins - genetics | Chemokine CXCL12 - genetics | Microglia - immunology | Chemokine CCL3 - genetics | Calcium-Binding Proteins - immunology | Cattle | Encephalitis - metabolism | Chemokine CCL3 - metabolism | Chemokine CCL5 - metabolism | Receptors, Immunologic - immunology | Receptor for Advanced Glycation End Products | Chemokine CXCL12 - immunology | Chemokines - immunology | Calcium-Binding Proteins - metabolism | Microglia - cytology | Recombinant Proteins - metabolism | Cell Line | S100 Calcium Binding Protein beta Subunit | Mice, Inbred C57BL | Rats | Encephalitis - immunology | S100 Proteins - metabolism | Nerve Growth Factors - immunology | Recombinant Proteins - genetics | Chemokines - genetics | Animals | Carrier Proteins - metabolism | Chemokine CXCL12 - metabolism | Recombinant Proteins - immunology | Up-Regulation - immunology | Nerve Growth Factors - genetics | Chemokine CCL5 - genetics | Cytoskeleton - metabolism | Chemokines - metabolism | Mice | Receptors, Immunologic - genetics | Chemokine CCL5 - immunology | Receptors, Immunologic - metabolism | Calcium-Binding Proteins - genetics | Index Medicus | Immunology | Defensins | Signal Transduction | Neurodegeneration | Migration | Calcium-binding Proteins | Innate Immunity | RAGE | S100B | Chemokines | Microglia
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 24, pp. 8285 - 8295
Toll-like receptors play an important role in the innate immune response, although emerging evidence indicates their role in brain injury and... 
ETHANOL TREATMENT | ALZHEIMERS-DISEASE | IN-VIVO | TOLL-LIKE RECEPTORS | INJURY | NEURODEGENERATION | ENHANCES INFLAMMATORY MEDIATORS | ASTROGLIAL CELLS | ASTROCYTES | NEUROSCIENCES | CELL-DEATH | Tumor Necrosis Factor-alpha - metabolism | Rats, Wistar | Lymphocyte Antigen 96 - metabolism | Tumor Necrosis Factor-alpha - genetics | Caspase 3 - metabolism | Ethanol - administration & dosage | Green Fluorescent Proteins - genetics | Brain Injuries - metabolism | Interleukin-1beta - genetics | Lipopolysaccharides - adverse effects | Lipopolysaccharide Receptors - metabolism | Lymphocyte Antigen 96 - genetics | Ethanol - blood | Time Factors | Toll-Like Receptor 4 - deficiency | Cyclooxygenase 2 - genetics | Interleukin-1beta - metabolism | Encephalitis - metabolism | Statistics, Nonparametric | Brain Injuries - blood | Female | Disease Models, Animal | Calcium-Binding Proteins - metabolism | Astrocytes - drug effects | Mice, Inbred C57BL | RNA, Messenger - genetics | RNA, Small Interfering - pharmacology | Brain Injuries - chemically induced | Encephalitis - pathology | Rats | Mice, Knockout | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Toll-Like Receptor 4 - physiology | Animals | Microfilament Proteins | Central Nervous System Depressants - administration & dosage | Cyclooxygenase 2 - metabolism | Mice | Encephalitis - chemically induced | Central Nervous System Depressants - blood | Brain Injuries - pathology | Encephalitis - blood | Astrocytes - metabolism | Calcium-Binding Proteins - genetics
Journal Article