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1. Full Text Autoimmune post–herpes simplex encephalitis of adults and teenagers
by Armangue, Thaís and Moris, Germán and Cantarín-Extremera, Verónica and Conde, Carlos Enrique and Rostasy, Kevin and Erro, Maria Elena and Portilla-Cuenca, Juan Carlos and Turón-Viñas, Eulàlia and Málaga, Ignacio and Muñoz-Cabello, Beatriz and Torres-Torres, Carmen and Llufriu, Sara and González-Gutiérrez-Solana, Luis and González, Guillermo and Casado-Naranjo, Ignacio and Rosenfeld, Myrna and Graus, Francesc and Dalmau, Josep and Spanish Prospective Multicentric S and Spanish Prospective Multicentric Study of Autoimmunity in Herpes Simplex Encephalitis
Neurology, ISSN 0028-3878, 11/2015, Volume 85, Issue 20, pp. 1736 - 1743
OBJECTIVE:To report 14 patients with immune-mediated relapsing symptoms post–herpes simplex encephalitis (HSE) and to compare the clinical and immunologic... 
ANTIBODIES | RELAPSE | VIRUS ENCEPHALITIS | DOPAMINE-2 RECEPTOR | CASE SERIES | MECHANISMS | D-ASPARTATE RECEPTOR | CLINICAL NEUROLOGY | CHILDREN | Single-Blind Method | Encephalitis, Herpes Simplex - immunology | Prospective Studies | Herpes Simplex - diagnosis | Humans | Middle Aged | Male | Herpes Simplex - drug therapy | Herpes Simplex - immunology | Young Adult | Immunotherapy - trends | Adolescent | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - drug therapy | Adult | Female | Aged | Index Medicus | Abridged Index Medicus | 132 | 199 | 235 | 137 | 227
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2. Full Text Herpes Simplex Encephalitis as a Potential Cause of Anti–N-Methyl-d-Aspartate Receptor Antibody Encephalitis: Report of 2 Cases
by DeSena, Allen and Graves, Donna and Warnack, Worthy and Greenberg, Benjamin M
JAMA Neurology, ISSN 2168-6149, 03/2014, Volume 71, Issue 3, pp. 344 - 346
IMPORTANCE Encephalitis mediated by anti–N-methyl-d-aspartate (NMDA) receptor antibodies and herpes simplex (HS) encephalitis are seemingly separate causes of... 
NMDAR ENCEPHALITIS | CLINICAL NEUROLOGY | CHILDREN | Comorbidity | Humans | Infant | Male | Simplexvirus - pathogenicity | Treatment Outcome | Encephalitis, Herpes Simplex - epidemiology | Anti-N-Methyl-D-Aspartate Receptor Encephalitis - epidemiology | Autoantibodies - biosynthesis | Anti-N-Methyl-D-Aspartate Receptor Encephalitis - therapy | Anti-N-Methyl-D-Aspartate Receptor Encephalitis - diagnosis | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - drug therapy | Adult | Receptors, N-Methyl-D-Aspartate - immunology | Index Medicus | Abridged Index Medicus
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3. Full Text TLR3 deficiency in herpes simplex encephalitis: High allelic heterogeneity and recurrence risk
by Lim, Hye Kyung and Seppänen, Mikko and Hautala, Timo and Ciancanelli, Michael J and Itan, Yuval and Lafaille, Fabien G and Dell, William and Lorenzo, Lazaro and Byun, Minji and Pauwels, Elodie and Rönnelid, Ylva and Cai, Xin and Boucherit, Soraya and Jouanguy, Emmanuelle and Paetau, Anders and Lebon, Pierre and Rozenberg, Flore and Tardieu, Marc and Abel, Laurent and Yildiran, Alisan and Vergison, Anne and Roivainen, Reina and Etzioni, Amos and Tienari, Pentti J and Casanova, Jean-Laurent and Zhang, Shen-Ying
Neurology, ISSN 0028-3878, 11/2014, Volume 83, Issue 21, pp. 1888 - 1897
OBJECTIVE:To determine the proportion of children with herpes simplex encephalitis (HSE) displaying TLR3 deficiency, the extent of TLR3 allelic heterogeneity,... 
TOLL-LIKE RECEPTOR-3 | IMMUNITY | RESPONSES | RELAPSE | DOUBLE-STRANDED-RNA | DEFECTS | VIRUS | PROTEIN | ECTODOMAIN | HUMANS | CLINICAL NEUROLOGY | Recurrence | Gene Frequency - genetics | Humans | Risk Factors | Cells, Cultured | Child, Preschool | Infant | Male | Mutation - genetics | Pedigree | Toll-Like Receptor 3 - deficiency | Adolescent | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - genetics | Female | Toll-Like Receptor 3 - genetics | Child | Index Medicus | Abridged Index Medicus
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4. Full Text Relapse in herpes simplex virus encephalitis: Itʼs not just about the virus
by Bale, James F and Du Pasquier, Renaud
Neurology, ISSN 0028-3878, 11/2015, Volume 85, Issue 20, pp. 1730 - 1731
Herpes simplex virus type 1 (HSV) causes approximately 10% of encephalitis cases among humans worldwide, corresponding to an incidence of 1 per 500,000... 
ACYCLOVIR | CLINICAL NEUROLOGY | Encephalitis, Herpes Simplex - immunology | Herpes Simplex - diagnosis | Humans | Encephalitis, Herpes Simplex - diagnosis | Female | Male | Herpes Simplex - immunology | Index Medicus | Abridged Index Medicus
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5. Full Text Herpes simplex virus encephalitis: Clinical manifestations, diagnosis and outcome in 106 adult patients
by Sili, Uluhan and Kaya, Abdurrahman and Mert, Ali and HSV Encephalitis Study Grp and HSV Encephalitis Study Group
Journal of Clinical Virology, ISSN 1386-6532, 2014, Volume 60, Issue 2, pp. 112 - 118
Abstract Background Herpes simplex virus (HSV) is one of the most common causes of sporadic encephalitis worldwide. Objective We aimed to determine clinical... 
Infectious Disease | Allergy and Immunology | prognostic factors | Herpes simplex virus | viral encephalitis | Prognostic factors | Viral encephalitis | ACYCLOVIR THERAPY | MULTICENTER | MANAGEMENT | VIROLOGY | prognostic factorsa | GUIDELINES | VIDARABINE | Brain - diagnostic imaging | Acyclovir - therapeutic use | Humans | Middle Aged | Male | Young Adult | Polymerase Chain Reaction | Aged, 80 and over | Encephalitis, Herpes Simplex - diagnosis | Adult | Female | Interviews as Topic | Retrospective Studies | Antiviral Agents - therapeutic use | Cerebrospinal Fluid - virology | Treatment Outcome | Encephalitis, Herpes Simplex - pathology | DNA, Viral - cerebrospinal fluid | Radiography | Magnetic Resonance Imaging | Simplexvirus - isolation & purification | Adolescent | Brain - pathology | Encephalitis, Herpes Simplex - drug therapy | Aged | Virus diseases | Herpes simplex | Encephalitis | Medical colleges | Patient outcomes | Index Medicus
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6. Full Text Screening cerebrospinal fluid prior to herpes simplex virus PCR testing might miss cases of herpes simplex encephalitis
by Galen, Benjamin T
Journal of Clinical Microbiology, ISSN 0095-1137, 10/2017, Volume 55, Issue 10, pp. 3142 - 3143
Encephalitis | Herpes simplex virus | herpes simplex virus | encephalitis | MICROBIOLOGY | Encephalitis, Herpes Simplex - cerebrospinal fluid | Herpes Simplex - diagnosis | Humans | Simplexvirus - genetics | False Negative Reactions | Cerebrospinal Fluid - virology | Cerebrospinal Fluid - cytology | Cerebrospinal Fluid - chemistry | Herpes Simplex - cerebrospinal fluid | Diagnostic Tests, Routine - methods | Simplexvirus - isolation & purification | Polymerase Chain Reaction | Encephalitis, Herpes Simplex - diagnosis | Leukocyte Count | Index Medicus | Letter to the Editor
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7. Full Text Plasma and Cerebrospinal Fluid Herpes Simplex Virus Levels at Diagnosis and Outcome of Neonatal Infection
by Melvin, Ann J., MD, MPH and Mohan, Kathleen M., ARNP and Schiffer, Joshua T., MD, MPH and Drolette, Linda M., BS and Magaret, Amalia, PhD and Corey, Lawrence, MD and Wald, Anna, MD, MPH
Journal of Pediatrics, The, ISSN 0022-3476, 2015, Volume 166, Issue 4, pp. 827 - 833
Objective To evaluate the utility of quantitative herpes simplex virus (HSV) polymerase chain reaction (PCR) levels for prognosis and management of neonatal... 
Pediatrics | ACYCLOVIR | VIREMIA | POLYMERASE-CHAIN-REACTION | MANAGEMENT | ASSAY | CLINICAL PRESENTATION | ENCEPHALITIS | PEDIATRICS | HSV DNA | TYPE-1 | LESIONS | Severity of Illness Index | Follow-Up Studies | Herpes Simplex - diagnosis | Humans | Simplexvirus - genetics | Cerebrospinal Fluid - virology | DNA, Viral - analysis | Infant | Male | Disease Progression | Herpes Simplex - cerebrospinal fluid | Simplexvirus - isolation & purification | Herpes Simplex - blood | Polymerase Chain Reaction | Pregnancy Complications, Infectious - blood | Female | Retrospective Studies | Pregnancy Complications, Infectious - cerebrospinal fluid | Infant, Newborn | Pregnancy Complications, Infectious - diagnosis | Infants (Newborn) | Herpes simplex | Herpes simplex virus | Index Medicus | Abridged Index Medicus
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8. Full Text Use of clinical and neuroimaging characteristics to distinguish temporal lobe herpes simplex encephalitis from its mimics
by Chow, Felicia C and Glaser, Carol A and Sheriff, Heather and Xia, Dongxiang and Messenger, Sharon and Whitley, Richard and Venkatesan, Arun
Clinical Infectious Diseases, ISSN 1058-4838, 05/2015, Volume 60, Issue 9, pp. 1377 - 1383
Background. We describe the spectrum of etiologies associated with temporal lobe (TL) encephalitis and identify clinical and radiologic features that... 
Herpes simplex | Encephalitis | Temporal lobe | Brain infection | Magnetic resonance imaging | DIFFUSION-WEIGHTED MRI | brain infection | DIAGNOSIS | POPULATION | INFECTIOUS DISEASES | temporal lobe | magnetic resonance imaging | MULTICENTER | ETIOLOGIES | ABNORMALITIES | INVOLVEMENT | MICROBIOLOGY | IMMUNOLOGY | NEUROSYPHILIS | herpes simplex | CHILDREN | encephalitis | EXPERIENCE | Neuroimaging | Multivariate Analysis | Diagnosis, Differential | Encephalitis - diagnosis | Encephalitis - virology | Temporal Lobe - virology | Humans | Middle Aged | Male | California | Models, Statistical | Tuberculosis - diagnosis | Magnetic Resonance Imaging | Time Factors | Adolescent | Encephalitis, Herpes Simplex - diagnosis | Adult | Female | Aged | Retrospective Studies | Encephalitis - etiology | Encephalitis, Varicella Zoster - diagnosis | Complications and side effects | Usage | Herpesvirus diseases | Herpes | Research | Causes and theories of causation | Risk factors | Diseases | Pathology | Medical imaging | Nuclear magnetic resonance--NMR | Herpes viruses | Medical diagnosis | Viral infections | Index Medicus | and Commentaries
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9. Full Text Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised
by Tan, Ik L and McArthur, Justin C and Venkatesan, Arun and Nath, Avindra
Neurology, ISSN 0028-3878, 11/2012, Volume 79, Issue 21, pp. 2125 - 2132
Objective: To characterize clinical features, neuroimaging, and outcomes of herpes simplex encephalitis (HSE) in immunocompromised individuals. Methods: We... 
ACQUIRED-IMMUNODEFICIENCY-SYNDROME | VIRUS ENCEPHALITIS | MULTICENTER | POLYMERASE-CHAIN-REACTION | THERAPY | MULTIPLE-SCLEROSIS | 1 INFECTION | EXPERIENCE | CLINICAL PRESENTATIONS | DEFICIENCY | CLINICAL NEUROLOGY | Immunocompromised Host - immunology | Encephalitis, Herpes Simplex - immunology | Acyclovir - therapeutic use | Humans | Middle Aged | Male | Treatment Outcome | Prodromal Symptoms | Case-Control Studies | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - drug therapy | Adult | Female | Aged | Retrospective Studies | Cohort Studies | Index Medicus | Abridged Index Medicus | 137 | 142
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10. Full Text Herpes Simplex Encephalitis during Treatment with Tumor Necrosis Factor–α Inhibitors
by Russell D. Bradford and April C. Pettit and Patty W. Wright and Mark J. Mulligan and Larry W. Moreland and David A. McLain and John W. Gnann and Karen C. Bloch
Clinical Infectious Diseases, ISSN 1058-4838, 9/2009, Volume 49, Issue 6, pp. 924 - 927
We report 3 cases of herpes simplex virus encephalitis in patients receiving tumor necrosis factor–alpha (TNF-α) inhibitors for rheumatologic disorders.... 
Polymerase chain reaction | Encephalitis | Simplexvirus | Infectious diseases | Human herpesvirus 1 | Infections | Dosage | Herpes simplex encephalitis | Necrosis | Tumors | BRIEF REPORTS | RHEUMATOID-ARTHRITIS | DIAGNOSIS | INFECTIOUS DISEASES | VIRUS ENCEPHALITIS | INFECTIONS | POLYMERASE-CHAIN-REACTION | MANAGEMENT | THERAPY | RISK | MICROBIOLOGY | IMMUNOLOGY | CEREBROSPINAL-FLUID | Herpesvirus 2, Human - isolation & purification | Rheumatic Diseases - drug therapy | Antiviral Agents - therapeutic use | Humans | Middle Aged | Risk Factors | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Treatment Outcome | Encephalitis, Herpes Simplex - etiology | Antibodies, Monoclonal, Humanized | Magnetic Resonance Imaging | Infliximab | Rheumatic Diseases - complications | Antirheumatic Agents - adverse effects | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - drug therapy | Adult | Female | Adalimumab | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Antirheumatic Agents - therapeutic use | Herpesvirus 1, Human - isolation & purification | Index Medicus
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11. Full Text CXCL11 production in cerebrospinal fluid distinguishes herpes simplex meningitis from herpes simplex encephalitis
by Lind, Liza and Studahl, Marie and Persson Berg, Linn and Eriksson, Kristina and Institutionen för biomedicin, avdelningen för infektionssjukdomar and Göteborgs universitet and Gothenburg University and Sahlgrenska Academy and Institute of Biomedicine, Department of Infectious Medicine and Sahlgrenska akademin and Institutionen för medicin, avdelningen för reumatologi och inflammationsforskning and Institute of Medicine, Department of Rheumatology and Inflammation Research
Journal of Neuroinflammation, ISSN 1742-2094, 07/2017, Volume 14, Issue 1, pp. 134 - 134
Background: The closely related herpes simplex viruses 1 and 2 can cause inflammations of the central nervous system (CNS), where type 1 most often manifest as... 
Chemokine | Herpes simplex | Encephalitis | Meningitis | Cytokine | LEUKOCYTE RECRUITMENT | CXCR3 LIGANDS | VIRUS TYPE-2 INFECTION | IMMUNOLOGY | NEUROSCIENCES | VIRAL-INFECTIONS | IMMUNE SURVEILLANCE | ASEPTIC-MENINGITIS | CENTRAL-NERVOUS-SYSTEM | CHEMOKINE RECEPTORS | T-CELLS | MOLECULAR-MECHANISMS | Herpesvirus 2, Human - isolation & purification | Encephalitis, Herpes Simplex - cerebrospinal fluid | Meningitis, Viral - diagnosis | Humans | Middle Aged | Male | Meningitis, Viral - cerebrospinal fluid | Young Adult | Chemokine CXCL11 - cerebrospinal fluid | Chemokine CCL8 - cerebrospinal fluid | Aged, 80 and over | Encephalitis, Herpes Simplex - diagnosis | Adult | Female | Aged | Biomarkers - cerebrospinal fluid | Herpesvirus 1, Human - isolation & purification | Cytokines | Central nervous system | Causes of | Inflammation | Research | Health aspects | Index Medicus | molecular-mechanisms | chemokine receptors | viral-infections | t-cells | Immunologi inom det medicinska området | leukocyte recruitment | cxcr3 ligands | virus type-2 infection | aseptic-meningitis | Immunology in the medical area | central-nervous-system | immune surveillance
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12. Full Text Herpes simplex and varicella zoster CNS infections: clinical presentations, treatments and outcomes
by Kaewpoowat, Quanhathai and Salazar, Lucrecia and Aguilera, Elizabeth and Wootton, Susan H and Hasbun, Rodrigo
Infection, ISSN 0300-8126, 06/2016, Volume 44, Issue 3, pp. 337 - 345
To describe the clinical manifestations, cerebrospinal fluid (CSF) characteristics, imaging studies and prognostic factors of adverse clinical outcomes (ACO)... 
Varicella zoster virus | Clinical outcome | Encephalitis | Meningitis | Herpes simplex virus | DIAGNOSIS | VALACYCLOVIR | INFECTIOUS DISEASES | GUIDELINES | ADULTS | MENINGOENCEPHALITIS | CEREBROSPINAL-FLUID | VIRUS TYPE-2 MENINGITIS | CENTRAL-NERVOUS-SYSTEM | ASPARTATE RECEPTOR ANTIBODIES | Meningitis, Viral - diagnosis | Meningitis, Viral - virology | Humans | Middle Aged | Male | Treatment Outcome | Encephalitis, Herpes Simplex - epidemiology | Meningitis, Viral - epidemiology | Herpesvirus 3, Human | Young Adult | Simplexvirus | Encephalitis, Herpes Simplex - virology | Adolescent | Aged, 80 and over | Encephalitis, Herpes Simplex - diagnosis | Adult | Female | Aged | Retrospective Studies | Polymerase chain reaction | Complications and side effects | Care and treatment | Usage | Physiological aspects | Research | Index Medicus
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13. Full Text Herpes simplex encephalitis
by Kennedy, P.G.E and Chaudhuri, A
Journal of Neurology Neurosurgery and Psychiatry, ISSN 0022-3050, 2002, Volume 73, Issue 3, pp. 237 - 238
  Herpes simplex virus (HSV) is a human herpesvirus that causes HSV encephalitis (HSE), which is the commonest fatal sporadic encephalitis in humans. 1, 2... 
SURGERY | NERVOUS-SYSTEM | DIAGNOSIS | VIRUS | PSYCHIATRY | VIDARABINE | CEREBROSPINAL-FLUID | CLINICAL NEUROLOGY | ACYCLOVIR | DNA | DISEASE | POLYMERASE CHAIN-REACTION | BRAIN | Acyclovir - therapeutic use | Drug Administration Schedule | Trigeminal Ganglion - pathology | Antiviral Agents - therapeutic use | Temporal Lobe - virology | Humans | Olfactory Pathways - virology | Cerebrospinal Fluid - virology | Antigens, Viral - immunology | Magnetic Resonance Imaging | Encephalitis, Herpes Simplex - virology | Biopsy | Polymerase Chain Reaction | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - drug therapy | Ganciclovir - therapeutic use | Adult | Encephalitis, Herpes Simplex - mortality | Herpesvirus 1, Human - immunology | Trigeminal Ganglion - virology | Temporal Lobe - pathology | Child | Olfactory Pathways - pathology | Herpesvirus 1, Human - isolation & purification | Coma | Encephalitis | Enzymes | Medical imaging | Nuclear magnetic resonance--NMR | Mortality | Human immunodeficiency virus--HIV | Herpes viruses | Infections | Genomes | Patients | Viral infections | Index Medicus
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14. Full Text Outcome of and Prognostic Factors for Herpes Simplex Encephalitis in Adult Patients: Results of a Multicenter Study
by Franck Raschilas and Michel Wolff and Frédérique Delatour and Cendrine Chaffaut and Thomas De Broucker and Sylvie Chevret and Pierre Lebon and Philippe Canton and Flore Rozenberg and French Herpes Simplex Encephalitis and French Herpes Simplex Encephalitis Study Group
Clinical Infectious Diseases, ISSN 1058-4838, 8/2002, Volume 35, Issue 3, pp. 254 - 260
Management of herpes simplex encephalitis (HSE) has been considerably improved by the availability of acyclovir therapy and rapid polymerase chain reaction... 
Polymerase chain reaction | Health outcomes | Simplexvirus | Nervous system diseases | Prognosis | Major Articles | Antivirals | Hospital admissions | Disabilities | Glasgow coma scale | Herpes simplex encephalitis | DIAGNOSIS | INFECTIOUS DISEASES | VIRUS ENCEPHALITIS | REACTION ASSAY | VIDARABINE | MICROBIOLOGY | IMMUNOLOGY | CEREBROSPINAL-FLUID | ACYCLOVIR | POLYMERASE-CHAIN-REACTION | AMPLIFICATION | ACUTE PHYSIOLOGY | DISEASE | Multivariate Analysis | Brain - diagnostic imaging | Acyclovir - therapeutic use | Antiviral Agents - therapeutic use | Encephalitis, Herpes Simplex - diagnostic imaging | Humans | Middle Aged | Brain - virology | Male | Treatment Outcome | Radiography | Multicenter Studies as Topic | Encephalitis, Herpes Simplex - physiopathology | Adolescent | Aged, 80 and over | Encephalitis, Herpes Simplex - diagnosis | Encephalitis, Herpes Simplex - drug therapy | Adult | Female | Aged | Retrospective Studies | Herpes simplex | Physiological aspects | Reports | Encephalitis, Viral | Virus research | Index Medicus
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15. Full Text Impact of a rapid herpes simplex virus PCR assay on duration of acyclovir therapy
by Van, Tam T and Mongkolrattanothai, Kanokporn and Arevalo, Melissa and Lustestica, Maryann and Bard, Jennifer Dien
Journal of Clinical Microbiology, ISSN 0095-1137, 05/2017, Volume 55, Issue 5, pp. 1557 - 1565
Herpes simplex virus (HSV) infections of the central nervous system (CNS) are associated with significant morbidity and mortality rates in children. This study... 
Rapid diagnosis | Encephalitis | Toxicity | Meningitis | HSV | Acyclovir | Herpes simplex virus | toxicity | DIAGNOSIS | INFECTIONS | rapid diagnosis | MOLECULAR PANEL | meningitis | MICROBIOLOGY | CEREBROSPINAL-FLUID | CULTURE | herpes simplex virus | POLYMERASE-CHAIN-REACTION | encephalitis | NEONATAL-PERIOD | acyclovir | OUTCOMES | Acyclovir - therapeutic use | Herpes Simplex - diagnosis | Humans | Real-Time Polymerase Chain Reaction - methods | Child, Preschool | Infant | Male | Meningitis - virology | Herpes Simplex - drug therapy | Young Adult | Meningitis - drug therapy | Meningitis - diagnosis | Encephalitis, Herpes Simplex - diagnosis | Adult | Female | Retrospective Studies | Child | Central Nervous System - virology | Infant, Newborn | Antiviral Agents - therapeutic use | Cerebrospinal Fluid - virology | Encephalitis, Herpes Simplex - virology | Adolescent | Encephalitis, Herpes Simplex - drug therapy | Herpesvirus 1, Human - genetics | Index Medicus | Virology
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