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Nature Medicine, ISSN 1078-8956, 04/2011, Volume 17, Issue 4, pp. 495 - 499
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76495 - e76495
Multiple sclerosis (MS) is a chronic autoimmune neuroinflammatory disease found mostly in young adults in the western world. Oxidative stress induced neuronal... 
IN-VITRO | INHIBITION | ACID | INDUCED APOPTOSIS | MULTIDISCIPLINARY SCIENCES | TAU | CENTRAL-NERVOUS-SYSTEM | BLOOD-BRAIN-BARRIER | EXPRESSION | SCLEROSIS PATIENTS | CELL-DEATH | Reactive Oxygen Species - metabolism | Triterpenes - pharmacology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Demyelinating Diseases - metabolism | Glial Fibrillary Acidic Protein | Th1 Cells - metabolism | CD11b Antigen - genetics | Inflammation - metabolism | Th17 Cells - drug effects | Th17 Cells - metabolism | Inflammation - drug therapy | Apoptosis Regulatory Proteins - genetics | Female | Encephalomyelitis, Autoimmune, Experimental - genetics | Nuclear Receptor Subfamily 1, Group F, Member 3 - genetics | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Cell Line | Th1 Cells - drug effects | Drugs, Chinese Herbal | Cytokines - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | RNA, Messenger - genetics | Multiple Sclerosis - genetics | Antioxidants - pharmacology | Forkhead Transcription Factors - genetics | Nerve Tissue Proteins - genetics | T-Box Domain Proteins - genetics | Disease Progression | Apoptosis Regulatory Proteins - metabolism | Gene Expression Regulation - drug effects | Nerve Tissue Proteins - metabolism | Animals | Nitric Oxide Synthase Type II - genetics | Mice | CD11b Antigen - metabolism | Oxidative Stress - drug effects | Multiple Sclerosis - drug therapy | Nitric Oxide Synthase Type II - metabolism | Saponins - pharmacology | Antioxidants | Oxidative stress | Nervous system diseases | Multiple sclerosis | Cytokines | Encephalomyelitis | T cells | Tumor proteins | Neurophysiology | Cell culture | Phosphorylation | Hydrogen peroxide | Bax protein | Bcl-2 protein | Laboratories | Pathogenesis | p53 Protein | Differentiation (biology) | Central nervous system | Lymphocytes T | Chinese medicine | Blood-brain barrier | Neurodegeneration | Rodents | Modulation | Cell cycle | Inhibition | Stresses | Free radicals | Young adults | Inflammation | Gene expression | Cell differentiation | Experimental allergic encephalomyelitis | Nitric-oxide synthase | Molecular chains | Microglia | Tau protein | Nitric oxide | γ-Interferon | Adults | Infiltration | Apoptosis | Index Medicus
Journal Article
Journal Article
Nature, ISSN 0028-0836, 06/2015, Volume 522, Issue 7555, pp. 216 - 220
Multiple sclerosis involves an aberrant autoimmune response and progressive failure of remyelination in the central nervous system. Prevention of neural... 
MYELIN BASIC-PROTEIN | TRANSCRIPTS | GLUCOCORTICOIDS | MULTIPLE-SCLEROSIS | LYSOLECITHIN | RNA-SEQ | MULTIDISCIPLINARY SCIENCES | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION | OLIGODENDROCYTE PROGENITOR CELLS | Oligodendroglia - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Cerebellum - drug effects | Myelin Sheath - drug effects | Male | Receptors, Glucocorticoid - metabolism | Demyelinating Diseases - metabolism | MAP Kinase Signaling System | Myelin Sheath - metabolism | Oligodendroglia - drug effects | Female | Oligodendroglia - cytology | Demyelinating Diseases - pathology | Demyelinating Diseases - drug therapy | Disease Models, Animal | Multiple Sclerosis - metabolism | Germ Layers - drug effects | Germ Layers - pathology | Encephalomyelitis, Autoimmune, Experimental - pathology | Lysophosphatidylcholines | Pluripotent Stem Cells - cytology | Germ Layers - metabolism | Tissue Culture Techniques | Cerebellum - metabolism | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Cerebellum - pathology | Pluripotent Stem Cells - metabolism | Phenotype | Regeneration - drug effects | Animals | Cell Differentiation - drug effects | Miconazole - pharmacology | Pluripotent Stem Cells - drug effects | Multiple Sclerosis - pathology | Mice | Clobetasol - pharmacology | Mitogen-Activated Protein Kinases - metabolism | Multiple Sclerosis - drug therapy | Medical research | Myelination | Multiple sclerosis | Stem cells | Physiological aspects | Medicine, Experimental | Research | Drugs | Proteins | Blood-brain barrier | Laboratories | Rodents | Clinical trials | FDA approval | Gene expression | Index Medicus
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 2/2013, Volume 110, Issue 9, pp. 3543 - 3548
Journal Article
Nature, ISSN 0028-0836, 2013, Volume 502, Issue 7471, pp. 327 - 332
Progressive phases of multiple sclerosis are associated with inhibited differentiation of the progenitor cell population that generates the mature... 
OLIGODENDROCYTE DIFFERENTIATION | PROGENITOR CELLS | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | MUSCARINIC RECEPTOR SUBTYPES | THYROID-HORMONE | MYELIN REPAIR | MULTIDISCIPLINARY SCIENCES | EMBRYONIC STEM-CELLS | SPINAL-CORD | CENTRAL-NERVOUS-SYSTEM | PRECURSOR CELLS | Cuprizone - therapeutic use | Oligodendroglia - metabolism | Optic Nerve - cytology | Recurrence | Antiparkinson Agents - pharmacology | Coculture Techniques | Myelin Sheath - drug effects | Receptor, Muscarinic M1 - antagonists & inhibitors | Stem Cells - cytology | Myelin Proteolipid Protein - pharmacology | Myelin Sheath - metabolism | Antiparkinson Agents - therapeutic use | Oligodendroglia - drug effects | Cuprizone - pharmacology | Encephalomyelitis, Autoimmune, Experimental - chemically induced | Propylene Glycols - therapeutic use | Immune System - immunology | Female | Oligodendroglia - cytology | Benztropine - therapeutic use | Propylene Glycols - pharmacology | Encephalomyelitis, Autoimmune, Experimental - pathology | Myelin Sheath - pathology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Receptor, Muscarinic M3 - metabolism | Fingolimod Hydrochloride | Rats | Receptor, Muscarinic M3 - antagonists & inhibitors | Oligodendroglia - pathology | Sphingosine - pharmacology | Regeneration - drug effects | Sphingosine - analogs & derivatives | Animals | Cell Differentiation - drug effects | Models, Biological | Immune System - drug effects | Multiple Sclerosis - pathology | Stem Cells - drug effects | Sphingosine - therapeutic use | Mice | Benztropine - pharmacology | Receptor, Muscarinic M1 - metabolism | Multiple Sclerosis - drug therapy | Benztropine | Multiple sclerosis | Myelination | Physiological aspects | Oligodendroglia | Dosage and administration | Drug therapy | Cell differentiation | Cell culture | Dopamine | Drug dosages | Rodents | Cell cycle | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 2014, Volume 124, Issue 5, pp. 2188 - 2192
Journal Article
Brain Research Bulletin, ISSN 0361-9230, 2017, Volume 134, pp. 1 - 9
Journal Article
Circulation Research, ISSN 0009-7330, 04/2012, Volume 110, Issue 9, pp. 1202 - 1210
RATIONALE:Multiple sclerosis (MS) and its mouse model, experimental autoimmune encephalomyelitis (EAE), are inflammatory disorders of the central nervous... 
Experimental autoimmune encephalomyelitis | Autoimmune disease | Vascular inflammation | Platelets | PROGENITOR CELLS | CARDIAC & CARDIOVASCULAR SYSTEMS | autoimmune disease | platelets | LEUKOCYTE INTEGRIN MAC-1 | VESSEL WALL | IN-VITRO | experimental autoimmune encephalomyelitis | GLYCOPROTEIN IB-ALPHA | MULTIPLE-SCLEROSIS | P-SELECTIN | vascular inflammation | PERIPHERAL VASCULAR DISEASE | CENTRAL-NERVOUS-SYSTEM | INFLAMMATORY CELL RECRUITMENT | HEMATOLOGY | T-CELLS | Platelet Adhesiveness | Blood Platelets - immunology | Central Nervous System - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Central Nervous System - immunology | Leukocytes - immunology | Membrane Glycoproteins - antagonists & inhibitors | Platelet Glycoprotein GPIb-IX Complex - metabolism | Time Factors | Platelet Glycoprotein GPIIb-IIIa Complex - metabolism | Inflammation Mediators - metabolism | Platelet Aggregation Inhibitors - pharmacology | Female | Blood Platelets - drug effects | Anti-Inflammatory Agents - pharmacology | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Cells, Cultured | Encephalomyelitis, Autoimmune, Experimental - blood | Membrane Glycoproteins - blood | Platelet Glycoprotein GPIIb-IIIa Complex - antagonists & inhibitors | Animals | Blood Platelets - metabolism | Central Nervous System - drug effects | Platelet Glycoprotein GPIb-IX Complex - antagonists & inhibitors | Leukocytes - drug effects | Mice | Index Medicus | Animal models | Multiple sclerosis | Leukocyte migration | Microscopy | Central nervous system | Glycoproteins | Inflammation | Experimental allergic encephalomyelitis | Inflammatory diseases | EAE | inflammation
Journal Article
Nature Medicine, ISSN 1078-8956, 2010, Volume 16, Issue 4, pp. 406 - 412
Journal Article
Nature Medicine, ISSN 1078-8956, 2015, Volume 21, Issue 3, pp. 248 - 257
Journal Article