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Oncotarget, ISSN 1949-2553, 2015, Volume 6, Issue 19, pp. 16832 - 16847
Pancreatic ductal adenocarcinoma (PDAC) is expected to become the second leading cause of cancer death by 2030. Current therapeutic options are limited,... 
Glycolysis | Hypoxia | Metformin | Glutamine | Warburg effect | Animals | Pancreatic Neoplasms - metabolism | Humans | Pancreatic Neoplasms - pathology | Carcinoma, Pancreatic Ductal - metabolism | Carcinoma, Pancreatic Ductal - pathology | Disease Progression
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 9/2011, Volume 108, Issue 38, pp. 16062 - 16067
Journal Article
Genes and Development, ISSN 0890-9369, 08/2011, Volume 25, Issue 16, pp. 1680 - 1685
Journal Article
Nature, ISSN 0028-0836, 04/2010, Volume 464, Issue 7292, pp. 1149 - 1154
Journal Article
Diabetes, ISSN 0012-1797, 11/2011, Volume 60, Issue 11, pp. 2872 - 2882
OBJECTIVE-To evaluate whether healthy or diabetic adult mice can tolerate an extreme loss of pancreatic a-cells and how this sudden massive depletion affects... 
INSULIN | HYPERGLUCAGONEMIA | ENDOCRINE PANCREAS | GLUCOSE-HOMEOSTASIS | ENDOCRINOLOGY & METABOLISM | RECEPTOR GENE | SECRETION | DIFFERENTIATION | HYPERPLASIA | ISLET CELLS | EXPRESSION | Insulin-Secreting Cells - secretion | Apoptosis - drug effects | Cell Count | Glucagon - genetics | Male | Diphtheria Toxin - toxicity | Insulin - blood | Glucagon - blood | Diabetes Mellitus, Experimental - blood | Hypoglycemia - prevention & control | Intercellular Signaling Peptides and Proteins - metabolism | Glucagon-Secreting Cells - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Glucagon-Secreting Cells - metabolism | Diabetes Mellitus, Experimental - chemically induced | Diabetes Mellitus, Experimental - metabolism | Glucagon-Secreting Cells - secretion | Hyperglycemia - prevention & control | Promoter Regions, Genetic | Signal Transduction | Glucagon-Secreting Cells - pathology | Intercellular Signaling Peptides and Proteins - genetics | Pancreas - drug effects | Pancreas - pathology | Receptors, Glucagon - metabolism | Mice, Transgenic | Pancreas - metabolism | Heparin-binding EGF-like Growth Factor | Insulin - metabolism | Animals | Insulin-Secreting Cells - drug effects | Tamoxifen - pharmacology | Diabetes Mellitus, Experimental - pathology | Glucagon - metabolism | Mice | Streptozocin - toxicity | Insulin-Secreting Cells - pathology | Selective Estrogen Receptor Modulators - pharmacology | Islet Studies
Journal Article
Development (Cambridge), ISSN 0950-1991, 06/2013, Volume 140, Issue 12, pp. 2472 - 2483
Insulin-secreting pancreatic beta-cells are essential regulators of mammalian metabolism. The absence of functional beta-cells leads to hyperglycemia and... 
Cell | Mammalian metabolism | Diabetes mellitus | PANCREAS DEVELOPMENT | DEFINED FACTORS | TYPE-1 DIABETES-MELLITUS | MOUSE PANCREAS | SMALL-MOLECULE | DEVELOPMENTAL BIOLOGY | PLURIPOTENT STEM-CELLS | ISLET TRANSPLANTATION | ENDOCRINE PANCREAS | beta-cell | INSULIN-RESISTANCE | IN-VIVO | β cell | Primers
Journal Article
PLoS Genetics, ISSN 1553-7390, 01/2013, Volume 9, Issue 1, p. e1003274
Journal Article
EMBO Journal, ISSN 0261-4189, 2013, Volume 32, Issue 20, pp. 2708 - 2721
Journal Article