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Journal of Neurochemistry, ISSN 0022-3042, 12/2004, Volume 91, Issue 5, pp. 1231 - 1243
The sphingomyelin‐derived messenger ceramides provoke neuronal apoptosis through caspase‐3 activation, while the neuropeptide pituitary adenylate... 
Bax | Bcl‐2 | pituitary adenylate cyclase‐activating polypeptide | mitochondrial apoptotic pathway | JNK | ERK | Bcl-2 | Pituitary adenylate cyclase-activating polypeptide | Mitochondrial apoptotic pathway | SURVIVAL | CYCLASE-ACTIVATING POLYPEPTIDE | pituitary adenylate cyclase-activating polypeptide | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | DEATH | CERAMIDE LEVELS | NEUROSCIENCES | CASPASE-3 ACTIVATION | PITUITARY | DIFFERENTIATION | ADENYLATE-CYCLASE | EXPRESSION | Intracellular Signaling Peptides and Proteins - pharmacology | Benzimidazoles | Caspase 9 | Rats, Wistar | Cytosol - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Carbocyanines | Dose-Response Relationship, Drug | Nerve Growth Factors - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA, Messenger - biosynthesis | Caspases - metabolism | Drug Interactions | MAP Kinase Kinase 4 | Time Factors | Neuropeptides - pharmacology | Neurotransmitter Agents - pharmacology | Reverse Transcriptase Polymerase Chain Reaction - methods | Caspase 3 | Neurons - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide | Animals, Newborn | Membrane Potentials - drug effects | Blotting, Western - methods | Cytochromes c - metabolism | Fluorescent Antibody Technique - methods | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mitochondria - drug effects | bcl-2-Associated X Protein | Gene Expression Regulation - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Cerebellum - cytology | Mice | Models, Neurological | Mitochondria - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Cerebellum | Enzyme Inhibitors | Cytochromes c | Neuropeptides | Cytosol | Life Sciences | Mitochondria | Toxicology | Mitogen-Activated Protein Kinase Kinases | Sphingosine | JNK Mitogen-Activated Protein Kinases | Mitogen-Activated Protein Kinases | Signal Transduction | Neurons | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Neurotransmitter Agents | Membrane Potentials | Nerve Growth Factors | Fluorescent Antibody Technique | Proto-Oncogene Proteins c-bcl-2 | Caspases | RNA, Messenger
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 07/2010, Volume 120, Issue 7, pp. 2355 - 2369
Metformin is widely used to treat hyperglycemia in individuals with type 2 diabetes. Recently the LKB1/AMP-activated protein kinase (LKB1/AMPK) pathway was... 
MEDICINE, RESEARCH & EXPERIMENTAL | RESPIRATORY-CHAIN | SKELETAL-MUSCLE | PHOSPHOENOLPYRUVATE CARBOXYKINASE | CYCLIC-AMP | ACTIVATED PROTEIN-KINASE | PHOSPHORYLATION | AICA RIBOSIDE | UPSTREAM KINASE | LKB1 | GLUCOSE-PRODUCTION | Glucose-6-Phosphatase - genetics | Hypoglycemic Agents - metabolism | Diabetes Mellitus, Type 2 - genetics | Gluconeogenesis - drug effects | Diabetes Mellitus, Type 2 - metabolism | Hepatocytes - metabolism | Metformin - metabolism | AMP-Activated Protein Kinases | Hyperglycemia - genetics | Liver - drug effects | Protein-Serine-Threonine Kinases - metabolism | Liver - metabolism | Metformin - pharmacology | Mice, Inbred C57BL | Protein-Serine-Threonine Kinases - genetics | Glucose - genetics | Glucose - pharmacology | Glucose-6-Phosphatase - metabolism | Hypoglycemic Agents - pharmacology | Mice, Knockout | Hyperglycemia - metabolism | Phosphoenolpyruvate Carboxykinase (ATP) - genetics | Up-Regulation - drug effects | Animals | Gluconeogenesis - genetics | Glucose-6-Phosphatase - biosynthesis | Phosphoenolpyruvate Carboxykinase (ATP) - metabolism | Glucose - metabolism | Mice | Protein-Serine-Threonine Kinases - pharmacology | Type 2 diabetes | Control | Usage | Genetic aspects | Research | Metformin | Gene expression | Drug therapy | Health aspects | Gluconeogenesis | Up-Regulation | Glucose-6-Phosphatase | gluconeogenesis, animal models | Liver | Protein-Serine-Threonine Kinases | Glucose | Life Sciences | Hypoglycemic Agents | Phosphoenolpyruvate Carboxykinase (ATP) | Human health and pathology | Hyperglycemia | Hepatocytes | AMPK | Endocrinology and metabolism | Diabetes Mellitus, Type 2
Journal Article
Blood, ISSN 0006-4971, 02/2015, Volume 125, Issue 9, pp. 1427 - 1434
Journal Article
Endocrine-Related Cancer, ISSN 1351-0088, 10/2014, Volume 21, Issue 5, pp. 691 - 704
Journal Article
AJP - Endocrinology and Metabolism, ISSN 0193-1849, 01/2007, Volume 292, Issue 1, pp. E7 - E15
1 Institut National de la Santé et de la Recherche Médicale, Unité 691 and Collège de France; 2 Institut National de la Santé et de la Recherche Médicale,... 
Apelin receptor | Hypothalamo-pituitary-adrenal axis | Adrenocorticotropin | Apelin | ENDOGENOUS LIGAND APELIN | PHYSIOLOGY | apelin | MESSENGER-RNA EXPRESSION | NEUROMEDIN U | apelin receptor | ANGIOTENSIN-II | HYPOTHALAMIC PARAVENTRICULAR NUCLEUS | HORMONE RELEASE | BETA-ENDORPHIN | VASOPRESSIN RECEPTOR | adrenocorticotropin | ENDOCRINOLOGY & METABOLISM | RAT-BRAIN | HUMAN APJ RECEPTOR | hypothalamo-pituitary-adrenal axis | Carrier Proteins - physiology | Receptors, G-Protein-Coupled - metabolism | Pituitary Hormones, Anterior - metabolism | Intercellular Signaling Peptides and Proteins | Rats | Rats, Inbred WKY | Male | Peptide Fragments - pharmacology | Pituitary Gland, Anterior - metabolism | Rats, Sprague-Dawley | Adrenocorticotropic Hormone - secretion | Tissue Distribution | Animals | Carrier Proteins - metabolism | Models, Biological | Apelin Receptors | Carrier Proteins - pharmacology | Corticotrophs - metabolism | Cell Membrane | Peptide Fragments | Calcium | Cricetulus | Humans | Molecular Sequence Data | Pituitary Gland, Anterior | Life Sciences | Peptide Hormones | Transfection | Base Sequence | Endocrinology and metabolism | Adrenocorticotropic Hormone | Carrier Proteins | Pituitary Hormones, Anterior | CHO Cells | Amino Acid Sequence | Cricetinae | Receptors, G-Protein-Coupled | Corticotrophs | Cyclic AMP | Human health and pathology | Forskolin | Protein Binding | Ligands | Pituitary Gland
Journal Article
Endocrinology, ISSN 0013-7227, 08/2011, Volume 152, Issue 8, pp. 3018 - 3029
Journal Article
Molecular and Cellular Biology, ISSN 0270-7306, 02/2007, Volume 27, Issue 3, pp. 1146 - 1157
Journal Article
Journal Article
The FASEB Journal, ISSN 0892-6638, 04/2014, Volume 28, Issue 4, pp. 1568 - 1581
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2012, Volume 7, Issue 7, p. e40306
Dioxins are persistent organic pollutants interfering with endocrine systems and causing reproductive and developmental disorders. The objective of our project... 
DIOXIN | SYNTHASE | IN-UTERO | NULL MUTATION | ARYL-HYDROCARBON RECEPTOR | SEMINAL-VESICLE | MULTIDISCIPLINARY SCIENCES | GROWTH-FACTORS | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN TCDD | GENE-EXPRESSION | IDENTIFICATION | Embryo, Mammalian - drug effects | Transcription, Genetic - drug effects | Testis - metabolism | Oligonucleotide Array Sequence Analysis | Pituitary Gland - metabolism | Male | Gene Expression Profiling | Promoter Regions, Genetic - genetics | Embryo, Mammalian - metabolism | Ovary - growth & development | Testis - drug effects | Liver - drug effects | Female | Ovary - drug effects | Ovary - metabolism | Animals, Newborn | Liver - metabolism | Gene Expression Regulation, Developmental - drug effects | Rats | Reproduction - genetics | Sex Characteristics | Testis - growth & development | Chemokines - genetics | Rats, Sprague-Dawley | Pregnancy | Prenatal Exposure Delayed Effects - genetics | Reproduction - drug effects | Transcription Factors - metabolism | Animals | Polychlorinated Dibenzodioxins - toxicity | Chemokines - metabolism | Software | Pituitary Gland - drug effects | Crosses, Genetic | Herbicides | DNA microarrays | Genes | Dioxin | Cytochrome P-450 | Genetic aspects | Fibroblast growth factors | Genetic transcription | Persistent organic pollutants | Transcription | Sex | Dioxins | TCDD | Gestation | Gender | Endocrine systems | Cell growth | Developmental stages | Aromatic compounds | Fertility | Gender aspects | Fibroblasts | Physiology | Localization | Pollutants | Growth factors | Age | Enzymes | Nutrition | Cytochrome P450 | Sex differences | Exposure | Inflammation | Ovaries | Metabolism | Gene expression | Intrauterine exposure | Embryos | Progeny | Offspring | Laboratory animals | Testes | Gonads | Chemokines | Life Sciences
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 2011, Volume 208, Issue 4, pp. 729 - 745
Journal Article
Molecular Pharmacology, ISSN 0026-895X, 09/2007, Volume 72, Issue 3, pp. 572 - 581
Journal Article
BMC Genomics, ISSN 1471-2164, 09/2010, Volume 11, Issue 1, pp. 530 - 530
textabstractBackground: CREB and CREM are closely related factors that regulate transcription in response to various stress, metabolic and developmental... 
TRANSCRIPTION FACTORS | SPERMATOGENESIS | RNA | COACTIVATOR TORC2 | PROMOTERS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CAMP-RESPONSE ELEMENT | GENETICS & HEREDITY | GENOME-WIDE ANALYSIS | GENE-EXPRESSION | DIFFERENTIATION | REVEALS | Testis - metabolism | Chromosomes, Mammalian - genetics | Genetic Loci - genetics | Male | MicroRNAs - metabolism | Spermatozoa - metabolism | Cyclic AMP Response Element Modulator - metabolism | RNA, Messenger - metabolism | Promoter Regions, Genetic - genetics | Haploidy | Organ Specificity - genetics | Chromatin Immunoprecipitation | Spermatids - cytology | Lysine - metabolism | Binding Sites | Cell Line | Spermatids - metabolism | Testis - cytology | RNA, Messenger - genetics | Gene Expression Regulation | Animals | Cyclic AMP Response Element-Binding Protein - metabolism | Mice | MicroRNAs - genetics | Spermatozoa - cytology | Histones - metabolism | Methylation | Physiological aspects | Genetic aspects | Germ cells | Research | Binding proteins | Genes | Proteins | Phosphorylation | Gene loci | Software | Experiments | Cancer | Apoptosis | Testis | Spermatozoa | Genomics | Genetic Loci | Life Sciences | Histones | Cyclic AMP Response Element-Binding Protein | Promoter Regions, Genetic | Biochemistry, Molecular Biology | Spermatids | Organ Specificity | Chromosomes, Mammalian | Cyclic AMP Response Element Modulator | Lysine | MicroRNAs | RNA, Messenger
Journal Article