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Cell, ISSN 0092-8674, 04/2011, Volume 145, Issue 1, pp. 54 - 66
Journal Article
Scientific Reports, ISSN 2045-2322, 2013, Volume 3, Issue 1, pp. 1077 - 1077
Our studies in HUVECs show that ox-LDL induced autophagy and damaged mtDNA leading to TLR9 expression. LOX-1 antibody or the ROS inhibitor apocynin attenuated... 
HEART | APOPTOSIS | ATHEROGENESIS | ARTERY ENDOTHELIAL-CELLS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DEGRADATION | OXIDIZED-LDL | LOX-1 | Human Umbilical Vein Endothelial Cells | Leukocyte Common Antigens - metabolism | Reactive Oxygen Species - metabolism | Microtubule-Associated Proteins - metabolism | Humans | Toll-Like Receptor 9 - genetics | Autophagy - drug effects | Antigens, CD - metabolism | Inflammation - metabolism | RNA Interference | Diet, High-Fat | Endodeoxyribonucleases - metabolism | Receptors, LDL - deficiency | Beclin-1 | DNA Damage - drug effects | Receptors, LDL - genetics | Atherosclerosis - pathology | Endodeoxyribonucleases - antagonists & inhibitors | Scavenger Receptors, Class E - genetics | DNA, Mitochondrial - metabolism | Cells, Cultured | Lipoproteins, LDL - pharmacology | Receptors, LDL - metabolism | Atherosclerosis - metabolism | Apoptosis Regulatory Proteins - metabolism | Mice, Knockout | Scavenger Receptors, Class E - metabolism | Endodeoxyribonucleases - genetics | Animals | Antigens, Differentiation, Myelomonocytic - metabolism | Mice | Oxidative Stress - drug effects | Scavenger Receptors, Class E - deficiency | Toll-Like Receptor 9 - metabolism | RNA, Small Interfering - metabolism | Lipoproteins (low density) | Deoxyribonuclease | Oxidative stress | Reactive oxygen species | High cholesterol diet | DNA damage | siRNA | Mitochondrial DNA | Inflammation | LOX-1 protein | Autophagy | TLR9 protein | Cholesterol | CD45 antigen | Clonal deletion | Arteriosclerosis | Rodents | Atherosclerosis | Toll-like receptors | Lipoprotein (low density) receptors | Phagocytosis | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 05/2013, Volume 50, Issue 4, pp. 589 - 600
Replication protein A (RPA) is an essential eukaryotic single-stranded DNA binding protein with a central role in DNA metabolism. RPA directly participates in... 
POLYMERASE-DELTA | DAMAGE CHECKPOINT | BIOCHEMISTRY & MOLECULAR BIOLOGY | YEAST RAD52 PROTEIN | REPLICATION-PROTEIN-A | DOUBLE-STRAND BREAKS | HOMOLOGOUS RECOMBINATION | CHECKPOINT ACTIVATION | PRESYNAPTIC COMPLEX-FORMATION | SACCHAROMYCES-CEREVISIAE | MEIOTIC RECOMBINATION | CELL BIOLOGY | DNA, Fungal - genetics | RecQ Helicases - metabolism | Saccharomyces cerevisiae - genetics | RecQ Helicases - genetics | DNA, Fungal - chemistry | DNA Breaks, Double-Stranded | DNA-Directed DNA Polymerase - genetics | DNA, Single-Stranded - genetics | Saccharomyces cerevisiae - metabolism | Replication Protein A - genetics | Endodeoxyribonucleases - metabolism | Exodeoxyribonucleases - genetics | Nucleic Acid Conformation | DNA Helicases - genetics | Rad51 Recombinase - metabolism | Rad51 Recombinase - genetics | DNA, Single-Stranded - metabolism | Replication Protein A - metabolism | Saccharomyces cerevisiae Proteins - genetics | Blotting, Western | DNA, Single-Stranded - chemistry | DNA Helicases - metabolism | Endodeoxyribonucleases - genetics | DNA Repair | DNA, Fungal - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Luminescent Proteins - genetics | Models, Genetic | DNA-Directed DNA Polymerase - metabolism | Mutation | Microscopy, Fluorescence | Luminescent Proteins - metabolism | Physiological aspects | DNA synthesis | Surgery | Genomics | DNA | Protein binding | Index Medicus
Journal Article
Molecular Cell, ISSN 1097-2765, 09/2017, Volume 67, Issue 5, pp. 867 - 881.e7
Journal Article
EMBO reports, ISSN 1469-221X, 08/2018, Volume 19, Issue 8, pp. e46182 - n/a
Toll‐like receptors (TLRs) are important sensors that recognize pathogen‐associated molecular patterns. Generally, TLR9 is known to recognize bacterial or... 
TLR9 | immune response | mitochondrial DNA | dendritic cell | dengue virus | RECOGNITION | INFLAMMATORY RESPONSES | BIOCHEMISTRY & MOLECULAR BIOLOGY | MITOCHONDRIAL-DNA | SUPPRESSION | EVASION | CELL BIOLOGY | INNATE IMMUNITY | Phosphorylation | Inflammasomes - metabolism | Reactive Oxygen Species - metabolism | Humans | Dendritic Cells - pathology | RNA, Messenger - metabolism | Dengue - pathology | Gene Knockdown Techniques | DNA-Binding Proteins - metabolism | Extracellular Space - metabolism | DNA, Mitochondrial - genetics | Mitochondrial Proteins - metabolism | Endodeoxyribonucleases - metabolism | RNA, Viral - metabolism | Interferons - genetics | Dendritic Cells - virology | Dendritic Cells - metabolism | Oxidation-Reduction | Signal Transduction | RNA, Messenger - genetics | Mitochondria - metabolism | Dengue - virology | Mice, Knockout | Transcription Factors - metabolism | Animals | Dengue - metabolism | Interferons - metabolism | Cytosol - metabolism | Dengue Virus - physiology | Toll-Like Receptor 9 - metabolism | RNA, Small Interfering - metabolism | Reactive oxygen species | Mitochondrial permeability transition pore | Viral diseases | Membrane permeability | Viruses | Infections | Activation | Mitochondrial DNA | Cytosol | Proteins | Mitochondria | Receptors | Rodents | Cyclic GMP | Bone marrow | Toll-like receptors | Deoxyribonucleic acid--DNA | Vector-borne diseases | RNA viruses | Immune response | Dendritic cells | AMP | Dengue | Permeability | Ribonucleic acid--RNA | TLR9 protein | Immune systems | Signaling | Mice | Pores | Interferon | Dendritic structure | Index Medicus | Microbiology, Virology & Host Pathogen Interaction
Journal Article
Aging, ISSN 1945-4589, 01/2009, Volume 1, Issue 1, pp. 109 - 121
Journal Article
Nature, ISSN 0028-0836, 05/2012, Volume 484, Issue 7397, pp. 251 - 255
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 12/2018, Volume 115, Issue 51, pp. E11961 - E11969
The Mre11-Rad50-Xrs2(NBS1) complex plays important roles in the DNA damage response by activating the Tel1(ATM) kinase and catalyzing 5'-3' resection at DNA... 
DNA damage checkpoint | Mre11 | Rad9 | Sae2 | DNA repair | MULTIDISCIPLINARY SCIENCES | BUDDING YEAST SAE2 | MRE11-RAD50-XRS2 COMPLEX | HISTONE H2A PHOSPHORYLATION | DAMAGE RESPONSE | REPAIR | EXO1 | HOMOLOGOUS RECOMBINATION | PROMOTES RESECTION | FUNCTIONAL MRX | MRE11 NUCLEASE | Cell Cycle - genetics | Endonucleases - genetics | DNA, Fungal - genetics | RecQ Helicases - metabolism | DNA Repair - physiology | RecQ Helicases - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Endonucleases - metabolism | DNA Breaks, Double-Stranded | Checkpoint Kinase 2 - metabolism | DNA-Binding Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Endodeoxyribonucleases - metabolism | Cell Cycle Proteins - genetics | Exodeoxyribonucleases - genetics | Protein-Serine-Threonine Kinases - metabolism | Cell Cycle Proteins - metabolism | Signal Transduction - genetics | DNA - metabolism | Saccharomyces cerevisiae Proteins - genetics | DNA Helicases | Endodeoxyribonucleases - genetics | Mutagens | DNA, Fungal - metabolism | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | DNA Damage | Cellular signal transduction | Genetic aspects | Health aspects | DNA damage | Binding | Chromatin | Phenotypes | Mre11 nuclease | Cells | Substrates | Accumulation | Mutants | Genotype & phenotype | Rad9 protein | MRE11 protein | Nuclease | Mutation | Endonuclease | Deoxyribonucleic acid--DNA | Index Medicus | Biological Sciences | PNAS Plus
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2012, Volume 46, Issue 1, pp. 43 - 53
Journal Article