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1. Full Text Concurrent endometrial carcinoma in women with a biopsy diagnosis of atypical endometrial hyperplasia: A gynecologic oncology group study
by Trimble, Cornelia L and Kauderer, James and Zaino, Richard and Silverberg, Steven and Lim, Peter C and Burke II, James J and Alberts, David and Curtin, John and Mackey, Denise
Cancer, ISSN 0008-543X, 02/2006, Volume 106, Issue 4, pp. 812 - 819
BACKGROUND. Adenocarcinoma of the endometrium is the most common gynecologic malignancy in the United States, accounting for approximately 36,000 diagnoses of... 
Consensus diagnosis | Endometrial hyperplasia | Hysterectomy | Atypia | Biopsy | Endometrioid adenocarcinoma | CRITERIA | atypia | UTERUS | endometrioid adenocarcinoma | hysterectomy | CANCER | REPRODUCIBILITY | LESIONS | ONCOLOGY | endometrial hyperplasia | WELL-DIFFERENTIATED CARCINOMA | biopsy | consensus diagnosis | Adenocarcinoma - pathology | Prevalence | Prospective Studies | Endometrial Hyperplasia - diagnosis | Adenocarcinoma - etiology | Humans | Middle Aged | Risk Factors | Endometrial Neoplasms - etiology | Endometrial Hyperplasia - pathology | Endometrial Neoplasms - epidemiology | Endometrial Hyperplasia - complications | Patient Care Planning | Endometrial Hyperplasia - surgery | Aged, 80 and over | Adult | Endometrial Neoplasms - pathology | Female | Hospitals, Community - statistics & numerical data | Aged | Adenocarcinoma - epidemiology | Endometrial cancer | Patient outcomes | Analysis | Diagnosis | Risk factors | Endometrium | Index Medicus | Abridged Index Medicus
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2. Full Text Treatment of Low-Risk Endometrial Cancer and Complex Atypical Hyperplasia With the Levonorgestrel-Releasing Intrauterine Device
by Pal, Navdeep and Broaddus, Russell R and Urbauer, Diana L and Balakrishnan, Nyla and Milbourne, Andrea and Schmeler, Kathleen M and Meyer, Larissa A and Soliman, Pamela T and Lu, Karen H and Ramirez, Pedro T and Ramondetta, Lois and Bodurka, Diane C and Westin, Shannon N
Obstetrics & Gynecology, ISSN 0029-7844, 01/2018, Volume 131, Issue 1, pp. 109 - 116
OBJECTIVE:To assess efficacy of the levonorgestrel-releasing intrauterine device (LNG-IUD) for treatment of complex atypical hyperplasia or low-grade... 
SYSTEM | THERAPY | GYNECOLOGIC-ONCOLOGY-GROUP | PROGESTERONE | ORAL MEDROXYPROGESTERONE ACETATE | ADENOCARCINOMA | FERTILITY-SPARING-MANAGEMENT | YOUNG-WOMEN | CARCINOMA | SOCIETY | OBSTETRICS & GYNECOLOGY | Immunohistochemistry | Risk Assessment | Humans | Middle Aged | Endometrial Hyperplasia - pathology | Cancer Care Facilities | Disease Progression | Intrauterine Devices, Medicated | Precancerous Conditions - drug therapy | Young Adult | Endometrial Hyperplasia - drug therapy | Levonorgestrel - administration & dosage | Neoplasm Invasiveness - pathology | Texas | Adult | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Female | Precancerous Conditions - pathology | Retrospective Studies | Biopsy, Needle | Neoplasm Staging | Cohort Studies | Index Medicus | Abridged Index Medicus
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3. Full Text Absolute Risk of Endometrial Carcinoma During 20-Year Follow-Up Among Women With Endometrial Hyperplasia
by James V. Lacey, Jr and Mark E. Sherman and Brenda B. Rush and Brigitte M. Ronnett and Olga B. Ioffe and Máire A. Duggan and Andrew G. Glass and Douglas A. Richesson and Nilanjan Chatterjee and Bryan Langholz
Journal of Clinical Oncology, ISSN 0732-183X, 02/2010, Volume 28, Issue 5, pp. 788 - 792
Purpose The severity of endometrial hyperplasia (EH)-simple (SH), complex (CH), or atypical (AH)-influences clinical management, but valid estimates of... 
DIAGNOSIS | CLASSIFICATION | MANAGEMENT | NESTED CASE-CONTROL | ONCOLOGY | ADENOCARCINOMA | Precancerous Conditions - epidemiology | Follow-Up Studies | Humans | Middle Aged | Endometrial Hyperplasia - pathology | Case-Control Studies | Time Factors | Carcinoma - epidemiology | Female | Precancerous Conditions - pathology | Registries | Carcinoma - pathology | Endometrial Hyperplasia - therapy | Oregon - epidemiology | Endometrial Hyperplasia - epidemiology | Severity of Illness Index | Precancerous Conditions - therapy | Risk Assessment | Risk Factors | Kaplan-Meier Estimate | Endometrial Neoplasms - epidemiology | Disease Progression | Biopsy | Endometrial Neoplasms - pathology | Aged | Health Maintenance Organizations | Index Medicus | Gync8 | Original Reports
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4. Full Text Routine histologic features in complex atypical hyperplasia can predict the presence of endometrial carcinoma: a clinicopathological study of 222 cases
by Zhang, Cunxian and Wang, Edmond Y and Liu, Fang and Sung, C. James and Quddus, M. Ruhul and Ou, Joyce and Lomme, Michele and Lawrence, W. Dwayne
Human Pathology, ISSN 0046-8177, 10/2018, Volume 80, pp. 40 - 46
There is a wide range of finding endometrial adenocarcinoma (ADCA) in the uterus after a diagnosis of complex atypical hyperplasia (CAH), likely due to a poor... 
Predict | Clinicopathologic study | Endometrial carcinoma | Routine histologic features | Complex atypical hyperplasia | LONG-TERM | DIAGNOSIS | RISK | CURETTAGE | PATHOLOGY | CANCER | ADENOCARCINOMA IN-SITU | WOMEN | Adenocarcinoma - pathology | Uterine Neoplasms - pathology | Humans | Middle Aged | Male | Endometrial Hyperplasia - pathology | Hyperplasia - pathology | Adult | Endometrial Neoplasms - pathology | Female | Precancerous Conditions - pathology | Aged | Endometrium - pathology | Carcinoma | Endometrial cancer | Hyperplasia | Cancer | Human subjects | Hysterectomy | Patients | Age | Index Medicus
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5. Full Text Histologic alterations in endometrial hyperplasia and well-differentiated carcinoma treated with progestins
by Wheeler, Darren T and Bristow, Robert E and Kurman, Robert J
American Journal of Surgical Pathology, ISSN 0147-5185, 07/2007, Volume 31, Issue 7, pp. 988 - 998
The treatment of complex atypical hyperplasia (CAH) and well-differentiated endometrioid carcinoma (WDC) by progestin therapy has been shown to be a safe... 
Classification of endometrial hyperplasia | Endometrial hyperplasia | Endometrioid carcinoma | Endometrial carcinoma | Progestins | Progestin therapy | SURGERY | progestins | PROGESTERONE | ADENOCARCINOMA | endometrial carcinoma | PATHOLOGY | WOMEN 40 YEARS | CANCER | YOUNGER | LESIONS | THERAPY | endometrial hyperplasia | progestin therapy | endometrioid carcinoma | classification of endometrial hyperplasia | AGE | Progestins - therapeutic use | Humans | Middle Aged | Endometrium - drug effects | Endometrial Hyperplasia - pathology | Carcinoma, Endometrioid - drug therapy | Disease Progression | Endometrial Hyperplasia - drug therapy | Adult | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Female | Retrospective Studies | Cell Nucleus - drug effects | Endometrium - pathology | Carcinoma, Endometrioid - pathology | Index Medicus
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6. Full Text Reproducibility of the diagnosis of atypical endometrial hyperplasia: A gynecologic oncology group study
by Zaino, Richard J and Kauderer, James and Trimble, Cornelia Liu and Silverberg, Steven G and Curtin, John P and Lim, Peter C and Gallup, Donald G and Mackey, Denise
Cancer, ISSN 0008-543X, 02/2006, Volume 106, Issue 4, pp. 804 - 811
Most gynecologists determine therapy based on current International Society of Gynecologic Pathologists (ISGP)/World Health Organization classification of... 
Reproducibility | Hyperplasia | Endometrium | Reproducibility of Results | Prognosis | Prospective Studies | Endometrial Hyperplasia - diagnosis | Gynecology - standards | Humans | Middle Aged | Endometrial Hyperplasia - pathology | Endometrial Hyperplasia - classification | Pathology - standards | Aged, 80 and over | Adult | Female | Aged | Referral and Consultation | Observer Variation | Endometrial hyperplasia | Diagnosis | Research | Histology, Pathological | Index Medicus | Abridged Index Medicus
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7. Full Text β-catenin mediates glandular formation and dysregulation of β-catenin induces hyperplasia formation in the murine uterus
by Jeong, J.-W and Lee, H.S and Franco, H.L and Broaddus, R.R and Taketo, M.M and Tsai, S.Y and Lydon, J.P and DeMayo, F.J
Oncogene, ISSN 0950-9232, 01/2009, Volume 28, Issue 1, pp. 31 - 40
Endometrioid adenocarcinoma is the most frequent form of endometrial cancer, usually developing in pre- and perimenopausal women. beta-catenin abnormalities... 
β-catenin | Uterus | Hyperplasia | Estrogen | beta-catenin | estrogen | ENDOMETRIAL CARCINOMAS | CYCLIN D1 | MICROSATELLITE INSTABILITY | BIOCHEMISTRY & MOLECULAR BIOLOGY | LEUKEMIA INHIBITORY FACTOR | E-CADHERIN | CELL BIOLOGY | NUCLEAR-LOCALIZATION | uterus | ONCOLOGY | GENETICS & HEREDITY | hyperplasia | MOUSE UTERUS | TRANSCRIPTIONAL TARGET | FEMALE REPRODUCTIVE-TRACT | COLON-CARCINOMA | Cell Proliferation | Endometrium - growth & development | Endometrial Hyperplasia - genetics | Endometrial Hyperplasia - pathology | Infertility, Female - genetics | beta Catenin - genetics | Cell Differentiation - genetics | Animals | Cell Transformation, Neoplastic - genetics | Mice, Mutant Strains | Female | Mice | beta Catenin - physiology | Cell Transformation, Neoplastic - pathology | Endometrium - pathology | Disease Models, Animal | Index Medicus
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8. Full Text Expression of miRNAs and PTEN in endometrial specimens ranging from histologically normal to hyperplasia and endometrial adenocarcinoma
by Lee, Heejeong and Choi, Hyun Joo and Kang, Chang Suk and Lee, Hee Jin and Lee, Weon Sun and Park, Chul Soo
Modern Pathology, ISSN 0893-3952, 11/2012, Volume 25, Issue 11, pp. 1508 - 1515
We investigated the relationship between frequently deregulated microRNAs (miRNAs) and enodometrial pathology in an attempt to find the most dependable miRNA... 
PTEN | endometrial hyperplasia and carcinoma | microRNA | OVARIAN-CANCER | PATHOLOGY | SIGNATURE | PROFILE | MICRORNA EXPRESSION | CARCINOMA | BIOPSIES | PROGRESSION | CLINICOPATHOLOGICAL FEATURES | EPIGENETIC ALTERATIONS | IMMUNOHISTOCHEMISTRY | Immunohistochemistry | Predictive Value of Tests | Adenocarcinoma - pathology | Endometrium - enzymology | Endometrial Hyperplasia - enzymology | Humans | Middle Aged | PTEN Phosphohydrolase - analysis | Endometrial Hyperplasia - pathology | Formaldehyde | Paraffin Embedding | Endometrial Neoplasms - genetics | Fixatives | Cell Transformation, Neoplastic - genetics | MicroRNAs - analysis | Sensitivity and Specificity | Adult | Female | Precancerous Conditions - pathology | Adenocarcinoma - genetics | Tissue Fixation | Real-Time Polymerase Chain Reaction | Precancerous Conditions - enzymology | Endometrial Neoplasms - enzymology | Biomarkers, Tumor - analysis | Adenocarcinoma - enzymology | Endometrial Hyperplasia - genetics | Gene Expression Profiling - methods | Chi-Square Distribution | Reverse Transcriptase Polymerase Chain Reaction | Cell Transformation, Neoplastic - metabolism | Precancerous Conditions - genetics | Disease Progression | Endometrial Neoplasms - pathology | Aged | Cell Transformation, Neoplastic - pathology | Endometrium - pathology | Index Medicus
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9. Full Text Endometrial hyperplasia-related inflammation: its role in the development and progression of endometrial hyperplasia
by Kubyshkin, A V and Aliev, L L and Fomochkina, I I and Kovalenko, Ye P and Litvinova, S V and Filonenko, T G and Lomakin, N V and Kubyshkin, V A and Karapetian, O V
Inflammation Research, ISSN 1023-3830, 10/2016, Volume 65, Issue 10, pp. 785 - 794
Endometrial hyperplasia (EH) is one of the most common gynecologic diseases in the world. Different statistical categories implicate an imbalance of estrogens... 
Allergology | Neurology | Biomedicine | Immunology | Nonspecific proteases | Cytokines | Dermatology | Rheumatology | Endometrial hyperplasia | Inflammation | Pharmacology/Toxicology | Carcinogenesis | DIAGNOSIS | IMMUNOLOGY | CANCER | BETA | CELL BIOLOGY | WOMEN | ESTROGEN | CARCINOMA | EXPRESSION | Tumor Necrosis Factor-alpha - metabolism | Estradiol - metabolism | Inflammation - pathology | Receptors, Estrogen - metabolism | Leukocyte Common Antigens - metabolism | Humans | Middle Aged | Endometrial Hyperplasia - pathology | Disease Progression | Receptors, Progesterone - metabolism | Prolactin - metabolism | Inflammation - metabolism | Endometrial Hyperplasia - metabolism | Interleukin-1beta - metabolism | Progesterone - metabolism | Adult | Female | Endometrium - pathology | Interleukin-6 - metabolism | Endometrium - metabolism | Peptide Hydrolases - metabolism | Development and progression | Proteases | Hyperplasia | Index Medicus
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10. Full Text Adipose-Derived VEGF–mTOR Signaling Promotes Endometrial Hyperplasia and Cancer: Implications for Obese Women
by Sahoo, Subhransu S and Lombard, Janine M and Ius, Yvette and O'Sullivan, Rachel and Wood, Lisa G and Nahar, Pravin and Jaaback, Kenneth and Tanwar, Pradeep S
Molecular Cancer Research, ISSN 1541-7786, 02/2018, Volume 16, Issue 2, pp. 309 - 321
Obesity is responsible for increased morbidity and mortality in endometrial cancer. Despite the positive correlation of body mass index (BMI) or obesity in... 
TARGET | INVASION | ADIPOCYTES | ONCOLOGY | PATHWAY | TISSUE | OVERWEIGHT | DISEASE | PREVENTION | CARCINOMA | ENDOTHELIAL GROWTH-FACTOR | CELL BIOLOGY | Up-Regulation | Cell Proliferation | TOR Serine-Threonine Kinases - metabolism | Humans | Endometrial Neoplasms - metabolism | Adipose Tissue - cytology | Culture Media, Conditioned - pharmacology | Endometrial Hyperplasia - pathology | Vascular Endothelial Growth Factor A - metabolism | Adipose Tissue - metabolism | Endometrial Hyperplasia - metabolism | Female | Disease Models, Animal | Cytokines - metabolism | Signal Transduction | Cells, Cultured | Tumor Burden | Obesity - metabolism | Obesity - pathology | Animals | Cell Line, Tumor | Endometrial Neoplasms - pathology | Mice | 3T3 Cells | Cell Movement | TOR protein | Cell proliferation | Adipose tissue | Endometrial cancer | Pathogenesis | Downstream effects | Xenotransplantation | Hyperplasia | Body weight | AKT protein | Adipocytes | Carcinogenesis | Body mass index | Signal transduction | Carcinogens | Xenografts | Conditioning | Vascular endothelial growth factor | Endometrium | Obesity | Cell survival | Cytokines | Patients | Morbidity | 1-Phosphatidylinositol 3-kinase | Signaling | Body mass | Body size | Cell migration | Cancer | Index Medicus
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11. Full Text Complex Atypical Endometrial Hyperplasia: The Risk of Unrecognized Adenocarcinoma and Value of Preoperative Dilation and Curettage
by Suh-Burgmann, Elizabeth and Hung, Yun-Yi and Armstrong, Mary Anne
Obstetrics & Gynecology, ISSN 0029-7844, 09/2009, Volume 114, Issue 3, pp. 523 - 529
OBJECTIVE:To evaluate whether preoperative dilation and curettage (D&C) lowers the risk of unexpected cancer at hysterectomy. METHODS:Women with complex... 
DIAGNOSIS | GYNECOLOGIC-ONCOLOGY-GROUP | BIOPSY INSTRUMENTS | PIPELLE | CURETTAGE | CARCINOMA | CANCER | REPRODUCIBILITY | ACCURACY | OBSTETRICS & GYNECOLOGY | Predictive Value of Tests | Adenocarcinoma - pathology | Age Factors | Humans | Middle Aged | Risk Factors | Endometrial Hyperplasia - pathology | Hysterectomy | Endometrial Hyperplasia - surgery | Endometrial Neoplasms - surgery | Aged, 80 and over | Adult | Endometrial Neoplasms - pathology | Female | Aged | Dilatation and Curettage | Retrospective Studies | Adenocarcinoma - surgery | Cohort Studies | Index Medicus | Abridged Index Medicus
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12. Full Text Thickened endometrium in asymptomatic postmenopausal women - determining an optimum threshold for prediction of atypical hyperplasia and cancer
by Ghoubara, Ahmed and Emovon, Emmanuel and Sundar, Sudha and Ewies, Ayman
Journal of Obstetrics and Gynaecology, ISSN 0144-3615, 11/2018, Volume 38, Issue 8, pp. 1146 - 1149
There is a lack of consensus about the significance and the management of an incidental finding of endometrial thickness (ET) > 4 mm on transvaginal ultrasound... 
postmenopausal bleeding | endometrial polyp | Endometrial cancer | endometrial hyperplasia | endometrial thickness | PATHOLOGIES | MALIGNANCY | ULTRASOUND | THICKNESS | OBSTETRICS & GYNECOLOGY | Endometrial Hyperplasia - epidemiology | Polyps - diagnosis | Prevalence | Endometrial Hyperplasia - diagnosis | Polyps - epidemiology | Humans | Middle Aged | Asymptomatic Diseases - epidemiology | Polyps - pathology | Endometrial Hyperplasia - pathology | Endometrial Neoplasms - epidemiology | Endometrial Neoplasms - diagnosis | Aged, 80 and over | Postmenopause | Endometrial Neoplasms - pathology | Female | Aged | United Kingdom - epidemiology | Index Medicus
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13. Full Text The utility of sentinel lymph node mapping in the management of endometrial atypical hyperplasia
by Touhami, Omar and Grégoire, Jean and Renaud, Marie-Claude and Sebastianelli, Alexandra and Grondin, Katherine and Plante, Marie
Gynecologic Oncology, ISSN 0090-8258, 03/2018, Volume 148, Issue 3, pp. 485 - 490
To determine the risk of endometrial cancer (EC) and lymph node involvement in patients with a preoperative diagnosis of “AH-only” versus “AH - cannot rule out... 
Endometrial atypical hyperplasia | Endometrial carcinoma | Sentinel lymph node mapping | INDOCYANINE GREEN | DIAGNOSIS | GYNECOLOGIC-ONCOLOGY-GROUP | ADENOCARCINOMA | ALGORITHM | RISK | CANCER | ACCURACY | OBSTETRICS & GYNECOLOGY | GRADE 1 | ONCOLOGY | CARCINOMA | Lymph Node Excision | Predictive Value of Tests | Humans | Middle Aged | Carcinoma, Endometrioid - complications | Endometrial Hyperplasia - pathology | Carcinoma, Endometrioid - diagnosis | Endometrial Hyperplasia - blood | Pelvis | Neoplasm Grading | Sensitivity and Specificity | Endometrial Hyperplasia - surgery | Endometrial Neoplasms - complications | Aged, 80 and over | Adult | Female | Membrane Proteins - blood | Carcinoma, Endometrioid - blood | CA-125 Antigen - blood | Myometrium - pathology | Neoplasm Invasiveness | Sentinel Lymph Node Biopsy - methods | Lymphatic Metastasis | Endometrial Neoplasms - diagnosis | Endometrial Hyperplasia - complications | Endometrial Neoplasms - pathology | Aged | Neoplasm Staging | Endometrial Neoplasms - blood | Carcinoma, Endometrioid - pathology | Index Medicus
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14. Full Text Measuring the biological effect of presurgical metformin treatment in endometrial cancer
by Sivalingam, V.N and Kitson, S and McVey, R and Roberts, C and Pemberton, P and Gilmour, K and Ali, S and Renehan, A.G and Kitchener, H.C and Crosbie, E.J
British Journal of Cancer, ISSN 0007-0920, 02/2016, Volume 114, Issue 3, pp. 281 - 289
Background: Preclinical studies in endometrial cancer (EC) show that metformin reduces cellular proliferation by PI3K-AKT-mTOR inhibition. We tested the... 
endometrial cancer | Ki-67 | metformin | presurgical window study | PI3K-AKT-mTOR phosphoproteins | atypical endometrial hyperplasia | SURVIVAL | MARKERS | RISK | PROLIFERATION | P53 | THERAPY | ONCOLOGY | INSULIN-RESISTANCE | BODY-MASS INDEX | EXPRESSION | CARCINOMA | Immunohistochemistry | Phosphorylation | Metformin - therapeutic use | TOR Serine-Threonine Kinases - metabolism | Humans | Middle Aged | Endometrial Neoplasms - metabolism | Endometrial Hyperplasia - pathology | Phosphatidylinositol 3-Kinases - metabolism | Carcinoma, Endometrioid - metabolism | Endometrial Hyperplasia - metabolism | Neoplasm Grading | Ki-67 Antigen | Aged, 80 and over | Female | Neoadjuvant Therapy | Proto-Oncogene Proteins c-akt - metabolism | C-Peptide - metabolism | Hypoglycemic Agents - therapeutic use | Enzyme-Linked Immunosorbent Assay | Myometrium - pathology | Neoplasm Invasiveness | Insulin Resistance | Treatment Outcome | Hysterectomy | Carcinoma, Endometrioid - drug therapy | Preoperative Care | Endometrial Hyperplasia - drug therapy | Insulin - metabolism | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Aged | Blood Glucose - metabolism | Carcinoma, Endometrioid - pathology | Index Medicus | Translational Therapeutics
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