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JAMA, ISSN 0098-7484, 06/2011, Volume 305, Issue 22, pp. 2304 - 2310
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2015, Volume 10, Issue 12, pp. e0145754 - e0145754
Background High-grade serous ovarian and endometrial cancers are the most lethal female reproductive tract malignancies worldwide. In part, failure to treat... 
CA-125 | MULTIDISCIPLINARY SCIENCES | EPITHELIAL OVARIAN-CANCER | Endometrial Neoplasms - mortality | Humans | Middle Aged | Ovarian Neoplasms - mortality | Genital Neoplasms, Female - drug therapy | DNA, Neoplasm - blood | Endometrial Neoplasms - genetics | Adult | Female | Neoplasm Recurrence, Local - blood | Ovarian Neoplasms - drug therapy | Genital Neoplasms, Female - genetics | CA-125 Antigen - blood | Ovarian Neoplasms - blood | Genital Neoplasms, Female - blood | Mutation - genetics | Breast Neoplasms - drug therapy | Biomarkers, Tumor - blood | Genital Neoplasms, Female - mortality | Exome - genetics | Breast Neoplasms - genetics | Breast Neoplasms - blood | Breast Neoplasms - mortality | Endometrial Neoplasms - drug therapy | Neoplasm Recurrence, Local - genetics | Aged | Biomarkers, Tumor - genetics | DNA, Neoplasm - genetics | Endometrial Neoplasms - blood | Physiological aspects | Prognosis | Biological markers | Genital cancer | Tumors | Plasma | Scanning | Ovarian carcinoma | Medical services | Fallopian tube | Cancer therapies | Ovarian cancer | Gene sequencing | Computed tomography | Surgery | Quality | Imaging | Bioindicators | Endometrium | Deoxyribonucleic acid--DNA | DNA probes | Gynecology | Breast cancer | Patients | Survival | Obstetrics | Medicine | Lead time | Chemotherapy | Surveillance | Womens health | Biomarkers | Diagnostic systems | Mutation | Reproductive system | Uterine cancer | Peritoneum | Cancer | Index Medicus | Deoxyribonucleic acid | DNA | Computer aided tomography
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 09/2012, Volume 104, Issue 18, pp. 1363 - 1372
Lynch syndrome is a highly penetrant cancer predisposition syndrome caused by germline mutations in DNA mismatch repair (MMR) genes. We estimated the risks of... 
SMALL-BOWEL CANCER | COLON-CANCER | REPAIR GENE MUTATION | ONCOLOGY | 2ND PRIMARY CANCERS | MICROSATELLITE INSTABILITY | MULTIPLE PRIMARY CANCERS | PROSTATE-CANCER | GERMLINE MUTATIONS | SUBSEQUENT PRIMARY CANCERS | ENDOMETRIAL CANCER | MutL Protein Homolog 1 | United States - epidemiology | Colorectal Neoplasms - genetics | Humans | Middle Aged | DNA Repair Enzymes - genetics | Male | Chromatography, High Pressure Liquid | DNA Mismatch Repair - genetics | Canada - epidemiology | Colorectal Neoplasms, Hereditary Nonpolyposis - complications | Germ-Line Mutation | Female | Registries | Mismatch Repair Endonuclease PMS2 | Nuclear Proteins - genetics | Digestive System Neoplasms - genetics | Breast Neoplasms - epidemiology | Digestive System Neoplasms - epidemiology | Risk Assessment | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Risk Factors | Kaplan-Meier Estimate | Urogenital Neoplasms - epidemiology | MutS Homolog 2 Protein - genetics | DNA-Binding Proteins - genetics | Australia - epidemiology | Breast Neoplasms - genetics | Confounding Factors (Epidemiology) | Urogenital Neoplasms - genetics | Adaptor Proteins, Signal Transducing - genetics | Heterozygote | Adenosine Triphosphatases - genetics | Aged | Colorectal Neoplasms - complications | Complications and side effects | Gene mutations | Colorectal cancer | Physiological aspects | Genetic aspects | Research | Risk factors | Risk | Genetic disorders | Genes | Deoxyribonucleic acid--DNA | Index Medicus
Journal Article
by Getz, Gad and Gabriel, Stacey B and Cibulskis, Kristian and Lander, Eric and Sivachenko, Andrey and Sougnez, Carrie and Lawrence, Mike and Kandoth, Cyriac and Dooling, David and Fulton, Robert and Fulton, Lucinda and Kalicki-Veizer, Joelle and McLellan, Michael D and O'Laughlin, Michelle and Schmidt, Heather and Wilson, Richard K and Ye, Kai and Li, Ding and Ally, Adrian and Balasundaram, Miruna and Birol, Inanc and Butterfield, Yaron S. N and Carlsen, Rebecca and Carter, Candace and Chu, Andy and Chuah, Eric and Chun, Hye-Jung E and Dhalla, Noreen and Guin, Ranabir and Hirst, Carrie and Holt, Robert A and Jones, Steven J.M and Lee, Darlene and Li, Haiyan I and Marra, Marco A and Mayo, Michael and Moore, Richard A and Mungall, Andrew J and Plettner, Patrick and Schein, Jacqueline E and Sipahimalani, Payal and Tam, Angela and Varhol, Richard J and Gordon Robertson, A and Cherniack, Andrew D and Pashtan, Itai and Saksena, Gordon and Onofrio, Robert C and Schumacher, Steven E and Tabak, Barbara and Carter, Scott L and Hernandez, Bryan and Gentry, Jeff and Salvesen, Helga B and Ardlie, Kristin and Winckler, Wendy and Beroukhim, Rameen and Meyerson, Matthew and Hadjipanayis, Angela and Lee, Semin and Mahadeshwar, Harshad S and Park, Peter and Protopopov, Alexei and Ren, Xiaojia and Seth, Sahil and Song, Xingzhi and Tang, Jiabin and Xi, Ruibin and Yang, Lixing and Dong, Zeng and Kucherlapati, Raju and Chin, Lynda and Zhang, Jianhua and Todd Auman, J and Balu, Saianand and Bodenheimer, Tom and Buda, Elizabeth and Neil Hayes, D and Hoyle, Alan P and Jefferys, Stuart R and Jones, Corbin D and Meng, Shaowu and Mieczkowski, Piotr A and Mose, Lisle E and Parker, Joel S and Perou, Charles M and Roach, Jeff and Yan, Shi and Simons, Janae V and Soloway, Mathew G and Tan, Donghui and Topal, Michael D and Waring, Scot and Wu, Junyuan and Hoadley, Katherine A and Baylin, Stephen B and Bootwalla, Moiz S and Lai, Phillip H and Triche Jr, Timothy J and Van Den Berg, David J and ... and Canc Genome Atlas Res Network and Cancer Genome Atlas Research Network and The Cancer Genome Atlas Research Network
Nature, ISSN 0028-0836, 2013, Volume 497, Issue 7447, pp. 67 - 73
Journal Article
The American Journal of Surgical Pathology, ISSN 0147-5185, 03/2017, Volume 41, Issue 3, pp. 326 - 333
Mismatch repair (MMR)-deficient endometrial carcinomas (ECs) bearing Lynch syndrome (LS)-associated germline mutations or sporadic MLH1 promoter... 
PD-L1 | mismatch repair | endometrial carcinoma | MLH1 hypermethylation | immunotherapy | Lynch syndrome | SURGERY | MICROSATELLITE INSTABILITY | INFILTRATING LYMPHOCYTES | IMMUNOSCORE | PATHOLOGY | LUNG-CANCER | PROGNOSTIC-FACTOR | IMMUNE-SYSTEM | MICROENVIRONMENT | COLORECTAL-CANCER | BLOCKADE | Immunohistochemistry | Neoplastic Syndromes, Hereditary - pathology | Prognosis | Follow-Up Studies | Endometrial Neoplasms - mortality | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Brain Neoplasms - pathology | Endometrial Neoplasms - metabolism | Gene Expression Regulation, Neoplastic | Neoplastic Syndromes, Hereditary - metabolism | Brain Neoplasms - metabolism | Neoplastic Syndromes, Hereditary - mortality | Colorectal Neoplasms, Hereditary Nonpolyposis - mortality | DNA Methylation | Endometrial Neoplasms - genetics | DNA Mismatch Repair | Biomarkers, Tumor - metabolism | Female | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Colorectal Neoplasms - metabolism | Colorectal Neoplasms - mortality | Promoter Regions, Genetic | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Brain Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - metabolism | B7-H1 Antigen - metabolism | MutL Protein Homolog 1 - genetics | Endometrial Neoplasms - pathology | Aged | Biomarkers, Tumor - genetics | Colorectal Neoplasms - pathology | Index Medicus
Journal Article
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 05/2011, Volume 8, Issue 5, pp. 302 - 306
Background. A 58-year-old woman presented with metastatic endometrioid endometrial adenocarcinoma after being previously treated with surgery and adjuvant... 
POLY(ADP-RIBOSE) POLYMERASE | INSTABILITY | THERAPEUTIC STRATEGY | ONCOLOGY | MUTANT-CELLS | BREAK REPAIR | MUTATION | INHIBITORS | TUMORS | Lung Neoplasms - drug therapy | Adenocarcinoma - pathology | Humans | Middle Aged | Neoplasm Recurrence, Local - drug therapy | Neoplasm Recurrence, Local - pathology | Brain Neoplasms - secondary | Peritoneal Neoplasms - drug therapy | Endometrial Neoplasms - genetics | Lung Neoplasms - secondary | Female | Adenocarcinoma - genetics | Liver Neoplasms - secondary | Peritoneal Neoplasms - secondary | Lung Neoplasms - genetics | PTEN Phosphohydrolase - genetics | Carcinoma, Endometrioid - genetics | PTEN Phosphohydrolase - deficiency | Liver Neoplasms - genetics | Liver Neoplasms - drug therapy | Brain Neoplasms - genetics | Treatment Outcome | Piperazines - therapeutic use | Brain Neoplasms - drug therapy | Carcinoma, Endometrioid - drug therapy | Adenocarcinoma - drug therapy | Poly(ADP-ribose) Polymerase Inhibitors | Phthalazines - therapeutic use | Peritoneal Neoplasms - genetics | Endometrial Neoplasms - drug therapy | Endometrial Neoplasms - pathology | Neoplasm Recurrence, Local - genetics | Carcinoma, Endometrioid - pathology | Case studies | Antimitotic agents | Care and treatment | Usage | Endometrial cancer | Gene mutations | Patient outcomes | Diagnosis | Antineoplastic agents | Health aspects | Risk factors | Index Medicus
Journal Article
Genes and Development, ISSN 0890-9369, 06/2006, Volume 20, Issue 12, pp. 1569 - 1574
The tumor suppressor PTEN is frequently inactivated in human cancers. A major downstream effector of PTEN is Akt, which is hyperactivated via PTEN... 
Intestinal polyps | PIN | Endometrium carcinoma | Thyroid and adrenal tumors | Cancer therapy | AKT/PKB | GENETICALLY-ENGINEERED MICE | PTEN | DEVELOPMENTAL BIOLOGY | PHOSPHOINOSITIDE 3-KINASE | CANCER | CELL BIOLOGY | cancer therapy | PATHWAY | thyroid and adrenal tumors | NEOPLASIA | RELEVANCE | intestinal polyps | MUTATION | GENETICS & HEREDITY | endometrium carcinoma | Prostatic Intraepithelial Neoplasia - pathology | Thyroid Neoplasms - enzymology | Proto-Oncogene Proteins c-akt - deficiency | Male | Intestinal Polyps - enzymology | Proto-Oncogene Proteins c-akt - genetics | Adrenal Gland Neoplasms - enzymology | Prostatic Neoplasms - genetics | Endometrial Neoplasms - genetics | Neoplasms - genetics | Female | Pseudolymphoma - genetics | Pseudolymphoma - enzymology | Adrenal Gland Neoplasms - pathology | PTEN Phosphohydrolase - genetics | Prostatic Neoplasms - pathology | Endometrial Neoplasms - enzymology | Neoplasms - enzymology | PTEN Phosphohydrolase - metabolism | Pseudolymphoma - pathology | Thyroid Neoplasms - genetics | Animals | Prostatic Intraepithelial Neoplasia - enzymology | Intestinal Polyps - pathology | Prostatic Neoplasms - enzymology | Endometrial Neoplasms - pathology | Heterozygote | Mice | Prostatic Intraepithelial Neoplasia - genetics | Neoplasms - pathology | Adrenal Gland Neoplasms - genetics | Thyroid Neoplasms - pathology | Index Medicus | Research Communication
Journal Article
Journal Article
Journal of the National Cancer Institute, ISSN 0027-8874, 06/2016, Volume 108, Issue 6, pp. djv427 - djv427
Journal Article