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1. Full Text The Distribution of Macrophages with a M1 or M2 Phenotype in Relation to Prognosis and the Molecular Characteristics of Colorectal Cancer
by Edin, Sofia and Wikberg, Maria L and Dahlin, Anna M and Rutegård, Jörgen and Öberg, Åke and Oldenborg, Per-Arne and Palmqvist, Richard and Medicinska fakulteten and Institutionen för integrativ medicinsk biologi (IMB) and Institutionen för medicinsk biovetenskap and Institutionen för strålningsvetenskaper and Umeå universitet and Patologi and Kirurgi and Histologi med cellbiologi and Institutionen för kirurgisk och perioperativ vetenskap
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47045
High macrophage infiltration has been correlated to improved survival in colorectal cancer (CRC). Tumor associated macrophages (TAMs) play complex roles in... 
CELL LUNG-CANCER | ISLAND METHYLATOR PHENOTYPE | COLON-CANCER | HUMAN PROSTATE-CANCER | MICROSATELLITE INSTABILITY | MULTIDISCIPLINARY SCIENCES | REGULATORY T-CELLS | TUMOR-ASSOCIATED MACROPHAGES | INFILTRATING MACROPHAGES | PATIENT SURVIVAL | ENDOMETRIAL CANCER | Immunohistochemistry | Antigens, CD - immunology | Microsatellite Instability | Prognosis | Rectum - pathology | Colorectal Neoplasms - genetics | Humans | Receptors, Cell Surface - analysis | Colon - immunology | Colorectal Neoplasms - diagnosis | Antigens, CD - analysis | Nitric Oxide Synthase Type II - analysis | DNA Methylation | Nitric Oxide Synthase Type II - immunology | Antigens, Differentiation, Myelomonocytic - immunology | Macrophages - immunology | Macrophages - pathology | Colon - pathology | Rectum - metabolism | Rectum - immunology | Receptors, Cell Surface - immunology | Colon - metabolism | Macrophages - metabolism | Phenotype | Colorectal Neoplasms - immunology | Antigens, Differentiation, Myelomonocytic - analysis | CpG Islands | Colorectal Neoplasms - pathology | Genetic aspects | Research | Macrophages | Analysis | Colorectal cancer | Correlation | Colorectal carcinoma | Microsatellite instability | Cancer therapies | Subgroups | Metastases | Ethics | Genotype & phenotype | Angiogenesis | Surgery | Tumorigenesis | Growth factors | CpG islands | Cell survival | Microsatellites | Stability | Invasiveness | Patients | Survival | Nitric-oxide synthase | Studies | CD163 antigen | Pathology | Screening | Nitric oxide | Medical prognosis | Infiltration | Health risk assessment | Tumors | Cancer | Medical and Health Sciences | Medicin och hälsovetenskap
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2. Full Text Immune microenvironment in microsatellite-instable endometrial cancers: Hereditary or sporadic origin matters
by Pakish, Janelle B and Zhang, Qian and Chen, Zhongyuan and Liang, Han and Chisholm, Gary B and Yuan, Ying and Mok, Samuel C and Broaddus, Russell R and Lu, Karen H and Yates, Melinda S
Clinical Cancer Research, ISSN 1078-0432, 08/2017, Volume 23, Issue 15, pp. 4473 - 4481
Purpose: Recent studies show that colorectal tumors with high microsatellite instability (MSI-H) have increased immunogenicity and response to immunotherapy... 
ISLAND METHYLATOR PHENOTYPE | TUMOR-INFILTRATING LYMPHOCYTES | INSTABILITY | ONCOLOGY | COLORECTAL-CANCER | LYNCH SYNDROME | MUTATIONS | EXPRESSION | Microsatellite Instability | CD8-Positive T-Lymphocytes - pathology | Colorectal Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - pathology | Humans | Middle Aged | Colorectal Neoplasms, Hereditary Nonpolyposis - immunology | Endometrial Neoplasms - diagnosis | Colorectal Neoplasms - diagnosis | Microsatellite Repeats - genetics | Tumor Microenvironment - immunology | Endometrial Neoplasms - immunology | Colorectal Neoplasms - immunology | Tumor Microenvironment - genetics | Endometrial Neoplasms - genetics | Colorectal Neoplasms, Hereditary Nonpolyposis - diagnosis | Immunotherapy | Endometrial Neoplasms - pathology | Female | Aged | CD8-Positive T-Lymphocytes - immunology | Colorectal Neoplasms - pathology | Multiplexing | Populations | Endometrial cancer | CD8 antigen | Clinical trials | Fluorescence | Microsatellite instability | Macrophages | Metastases | Granzyme B | Compartments | Endometrium | Immune system | Medical research | Immune response | Microsatellites | Stability | Stroma | Immunogenicity | Lymphocytes B | Experimental design | PD-L1 protein | Infiltration | Hormone replacement therapy | Health risk assessment | Tumors | Cancer | microsatellite instability | immune microenvironment | Uterine cancer | hereditary cancers | Lynch syndrome
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3. Full Text Ovarian Cancer-associated Ascites Demonstrates Altered Immune Environment: Implications for Antitumor Immunity
by ROBERT L. GIUNTOLI II and TONYA J. WEBB and ALESSIA ZOSO and OPHELIA ROGERS and TERESA P. DIAZ-MONTES and ROBERT E. BRISTOW and MATHIAS OELKE
Anticancer Research, ISSN 0250-7005, 08/2009, Volume 29, Issue 8, pp. 2875 - 2884
Background: To identify immunosuppressive elements present in ovarian cancer associated ascites. Patients and Methods: Ascites and plasma were obtained from... 
Cell mediated immunity | Cytokines | Ascites | Chemokines | Ovarian cancer | DENDRITIC CELLS | PANCREATIC-CANCER | PERIPHERAL-BLOOD | chemokines | CYTOTOXIC T-LYMPHOCYTES | TUMOR-INFILTRATING LYMPHOCYTES | ascites | ADOPTIVE TRANSFER | ONCOLOGY | IN-VIVO | cytokines | cell mediated immunity | ANTIGEN-PRESENTING CELLS | PROGNOSTIC-SIGNIFICANCE | ENDOTHELIAL GROWTH-FACTOR | CD8-Positive T-Lymphocytes - pathology | Prognosis | Humans | Middle Aged | Cystadenocarcinoma, Serous - metabolism | Endometrial Neoplasms - metabolism | Ovarian Neoplasms - pathology | CD4-Positive T-Lymphocytes - pathology | Adenocarcinoma, Clear Cell - immunology | T-Lymphocytes, Regulatory - immunology | CD4-Positive T-Lymphocytes - immunology | Antigen-Presenting Cells - pathology | Endometrial Neoplasms - immunology | Flow Cytometry | Fallopian Tube Neoplasms - immunology | Aged, 80 and over | Ascites - immunology | CD8-Positive T-Lymphocytes - metabolism | Adult | Female | Ovarian Neoplasms - metabolism | Cystadenocarcinoma, Serous - immunology | Peritoneal Neoplasms - immunology | Peritoneal Neoplasms - pathology | Cystadenocarcinoma, Serous - secondary | Antigen-Presenting Cells - metabolism | Cytokines - metabolism | Adenocarcinoma, Clear Cell - metabolism | CD4-Positive T-Lymphocytes - metabolism | Fallopian Tube Neoplasms - pathology | Survival Rate | Chromium - metabolism | Antigen-Presenting Cells - immunology | Endometrial Neoplasms - secondary | Adenocarcinoma, Clear Cell - secondary | Ascites - metabolism | Peritoneal Neoplasms - metabolism | Aged | Fallopian Tube Neoplasms - metabolism | CD8-Positive T-Lymphocytes - immunology | Ascites - pathology | Ovarian Neoplasms - immunology
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4. Full Text Assessing Tumor-Infiltrating Lymphocytes in Solid Tumors: A Practical Review for Pathologists and Proposal for a Standardized Method from the International Immuno-Oncology Biomarkers Working Group: Part 2: TILs in Melanoma, Gastrointestinal Tract Carcinomas, Non-Small Cell Lung Carcinoma and Mesothelioma, Endometrial and Ovarian Carcinomas, Squamous Cell Carcinoma of the Head and Neck, Genitourinary Carcinomas, and Primary Brain Tumors
by Hendry, Shona and Salgado, Roberto and Gevaert, Thomas and Russell, Prudence A and John, Tom and Thapa, Bibhusal and Christie, Michael and van de Vijver, Koen and Estrada, M V and Gonzalez-Ericsson, Paula I and Sanders, Melinda and Solomon, Benjamin and Solinas, Cinzia and Van den Eynden, Gert G G M and Allory, Yves and Preusser, Matthias and Hainfellner, Johannes and Pruneri, Giancarlo and Vingiani, Andrea and Demaria, Sandra and Symmans, Fraser and Nuciforo, Paolo and Comerma, Laura and Thompson, E A and Lakhani, Sunil and Kim, Seong-Rim and Schnitt, Stuart and Colpaert, Cecile and Sotiriou, Christos and Scherer, Stefan J and Ignatiadis, Michail and Badve, Sunil and Pierce, Robert H and Viale, Giuseppe and Sirtaine, Nicolas and Penault-Llorca, Frederique and Sugie, Tomohagu and Fineberg, Susan and Paik, Soonmyung and Srinivasan, Ashok and Richardson, Andrea and Wang, Yihong and Chmielik, Ewa and Brock, Jane and Johnson, Douglas B and Balko, Justin and Wienert, Stephan and Bossuyt, Veerle and Michiels, Stefan and Ternes, Nils and Burchardi, Nicole and Luen, Stephen J and Savas, Peter and Klauschen, Frederick and Watson, Peter H and Nelson, Brad H and Criscitiello, Carmen and O'Toole, Sandra and Larsimont, Denis and de Wind, Roland and Curigliano, Giuseppe and André, Fabrice and Lacroix-Triki, Magali and van de Vijver, Mark and Rojo, Federico and Floris, Giuseppe and Bedri, Shahinaz and Sparano, Joseph and Rimm, David and Nielsen, Torsten and Kos, Zuzana and Hewitt, Stephen and Singh, Baljit and Farshid, Gelareh and Loibl, Sibylle and Allison, Kimberly H and Tung, Nadine and Adams, Sylvia and Willard-Gallo, Karen and Horlings, Hugo M and Gandhi, Leena and Moreira, Andre and Hirsch, Fred and Dieci, Maria V and Urbanowicz, Maria and Brcic, Iva and Korski, Konstanty and Gaire, Fabien and Koeppen, Hartmut and Lo, Amy and Giltnane, Jennifer and Rebelatto, Marlon C and Steele, Keith E and Zha, Jiping and Emancipator, Kenneth and Juco, Jonathan W and Denkert, Carsten and Reis-Filho, Jorge and Loi, Sherene and Fox, Stephen B
Advances in anatomic pathology, ISSN 1072-4109, 11/2017, Volume 24, Issue 6, pp. 311 - 335
Assessment of the immune response to tumors is growing in importance as the prognostic implications of this response are increasingly recognized, and as... 
Immunohistochemistry | Mesothelioma - immunology | Predictive Value of Tests | Mesothelioma - pathology | Carcinoma, Squamous Cell - pathology | Humans | Brain Neoplasms - pathology | Ovarian Neoplasms - pathology | Lung Neoplasms - pathology | Pathology - standards | Gastrointestinal Neoplasms - pathology | Endometrial Neoplasms - immunology | Squamous Cell Carcinoma of Head and Neck | Brain Neoplasms - immunology | Female | Carcinoma, Non-Small-Cell Lung - pathology | Skin Neoplasms - pathology | Skin Neoplasms - immunology | Biomarkers, Tumor - analysis | Urogenital Neoplasms - pathology | Melanoma - pathology | Carcinoma, Squamous Cell - immunology | Head and Neck Neoplasms - pathology | Urogenital Neoplasms - immunology | Carcinoma, Non-Small-Cell Lung - immunology | Gastrointestinal Neoplasms - immunology | Head and Neck Neoplasms - immunology | Lung Neoplasms - immunology | Phenotype | Lymphocytes, Tumor-Infiltrating - pathology | Biopsy | Melanoma - immunology | Endometrial Neoplasms - pathology | Pathology - methods | Lymphocytes, Tumor-Infiltrating - immunology | Ovarian Neoplasms - immunology | Biomarkers | Pathology | Lymphocytes | Immunotherapy | tumor-infiltrating | Cancer
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5. Full Text Toxoplasma gondii infection in cancer patients: Prevalence, risk factors, genotypes and association with clinical diagnosis
by Cong, Wei and Liu, Guo-Hua and Meng, Qing-Feng and Dong, Wei and Qin, Si-Yuan and Zhang, Fu-Kai and Zhang, Xiang-Yan and Wang, Xiang-Yang and Qian, Ai-Dong and Zhu, Xing-Quan
Cancer Letters, ISSN 0304-3835, 2015, Volume 359, Issue 2, pp. 307 - 313
Highlights • The prevalence of anti- T. gonii IgG in cancer patients (35.56%) was significantly higher than that in controls (17.44%). • Lung cancer patients... 
Hematology, Oncology and Palliative Medicine | Genotype | Cancer patients | Toxoplasma gondii | Prevalence | Risk factors | ANTIBODIES | STRAINS | OOCYSTS | GENETIC-CHARACTERIZATION | CLONAL LINEAGES | ONCOLOGY | COMPRISE | PREGNANT-WOMEN | Toxoplasma - immunology | Humans | Middle Aged | Uterine Cervical Neoplasms - epidemiology | Genes, Protozoan | Male | Seroepidemiologic Studies | Case-Control Studies | Toxoplasmosis - parasitology | Toxoplasmosis - epidemiology | Antibodies, Protozoan - blood | Endometrial Neoplasms - immunology | Brain Neoplasms - immunology | Adult | Female | Risk Factors | Uterine Cervical Neoplasms - immunology | China - epidemiology | Endometrial Neoplasms - epidemiology | Lung Neoplasms - immunology | Lung Neoplasms - epidemiology | Toxoplasma - genetics | Aged | Immunocompromised Host | Brain Neoplasms - epidemiology | Genetic aspects | Health aspects | Cervical cancer | Prevalence studies (Epidemiology) | Polymerase chain reaction | Confidence intervals | Protozoa | Drinking water | Cysts | Mortality | Infections | Multivariate analysis | Cancer
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6. Full Text Immunotherapy in ovarian, endometrial and cervical cancer: State of the art and future perspectives
by Ventriglia, Jole and Paciolla, Immacolata and Pisano, Carmela and Cecere, Sabrina Chiara and Di Napoli, Marilena and Tambaro, Rosa and Califano, Daniela and Losito, Simona and Scognamiglio, Giosuè and Setola, Sergio Venanzio and Arenare, Laura and Pignata, Sandro and Della Pepa, Chiara
Cancer Treatment Reviews, ISSN 0305-7372, 09/2017, Volume 59, pp. 109 - 116
The tumors of the female genital tract represent a leading cause of morbidity and mortality among women worldwide. Substantial progresses have been made in... 
PD1/PD-L1 | Endometrial cancer | Immunotherapy | Cervical cancer | Ovarian cancer | NEOANTIGEN LOAD | HUMAN-PAPILLOMAVIRUS | T-CELL | HPV E7 | TUMOR-INFILTRATING LYMPHOCYTES | METASTATIC MELANOMA | INHIBITION | ANTI-PD-1 ANTIBODY | ONCOLOGY | PROGNOSTIC-SIGNIFICANCE | NIVOLUMAB | Immunotherapy - methods | Antibodies, Monoclonal, Humanized - therapeutic use | Prognosis | Risk Assessment | Endometrial Neoplasms - mortality | Humans | Middle Aged | Uterine Cervical Neoplasms - immunology | Uterine Cervical Neoplasms - drug therapy | Uterine Cervical Neoplasms - pathology | Ovarian Neoplasms - mortality | Disease-Free Survival | Endometrial Neoplasms - immunology | Survival Analysis | Endometrial Neoplasms - therapy | Adult | Endometrial Neoplasms - pathology | Female | Aged | Ovarian Neoplasms - drug therapy | Uterine Cervical Neoplasms - mortality | Ovarian Neoplasms - immunology | Medical colleges | Chemotherapy | Vaccination | Diagnosis | Health aspects | Papillomavirus infections | Cancer
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7. Full Text Predominant infiltration of macrophages and CD8+ T Cells in cancer nests is a significant predictor of survival in stage IV nonsmall cell lung cancer
by Kawai, Osamu and Ishii, Genichiro and Kubota, Kaoru and Murata, Yukinori and Naito, Yoichi and Mizuno, Tetsuya and Aokage, Keiju and Saijo, Nagahiro and Nishiwaki, Yutaka and Gemma, Akihiko and Kudoh, Syoji and Ochiai, Atsushi
Cancer, ISSN 0008-543X, 09/2008, Volume 113, Issue 6, pp. 1387 - 1395
BACKGROUND. The purpose of this study was to investigate whether tumor‐infiltrating immune cells in biopsy specimens can be used to predict the clinical... 
mast cell | macrophage | CD8+ T cell | stage IV | nonsmall cell lung cancer | Nonsmall cell lung cancer | Mast cell | Stage IV | CD8 | T cell | Macrophage | ANGIOGENESIS | CD8(+) T cell | MAST-CELLS | ENDOMETRIAL CANCER | BREAST-CANCER | CYTO-TOXICITY | ONCOLOGY | TUMOR-ASSOCIATED MACROPHAGES | PROGNOSTIC-SIGNIFICANCE | CARCINOMA | PROGRESSION | LYMPHOCYTES | Lung Neoplasms - drug therapy | CD8-Positive T-Lymphocytes - pathology | Prognosis | Lung Neoplasms - mortality | Stromal Cells - pathology | Humans | Middle Aged | Lung Neoplasms - pathology | Male | Antigens, CD - metabolism | Lymphocyte Activation - immunology | Carcinoma, Squamous Cell - mortality | Adult | Female | Macrophages - immunology | Carcinoma, Non-Small-Cell Lung - pathology | Mast Cells - immunology | Macrophages - pathology | Adenocarcinoma - immunology | Stromal Cells - immunology | Survival Rate | Adenocarcinoma - drug therapy | Carcinoma, Non-Small-Cell Lung - mortality | Carcinoma, Squamous Cell - immunology | Adenocarcinoma - secondary | Carcinoma, Non-Small-Cell Lung - immunology | Lung Neoplasms - immunology | Carcinoma, Squamous Cell - drug therapy | Lymphocytes, Tumor-Infiltrating - pathology | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Antigens, Differentiation, Myelomonocytic - metabolism | Mast Cells - pathology | Carcinoma, Squamous Cell - secondary | Aged | Carcinoma, Non-Small-Cell Lung - drug therapy | CD8-Positive T-Lymphocytes - immunology | Neoplasm Staging | Adenocarcinoma - mortality | Lymphocytes, Tumor-Infiltrating - immunology | Patient outcomes | CD8 lymphocytes | Physiological aspects | Research | Macrophages | Lung cancer, Non-small cell | Biological markers
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8. Full Text SYD985, a novel duocarmycin-based her2-targeting antibody–drug conjugate, shows antitumor activity in uterine and ovarian carcinosarcoma with HER2/Neu expression
by Menderes, Gulden and Bonazzoli, Elena and Bellone, Stefania and Black, Jonathan and Predolini, Federica and Pettinella, Francesca and Masserdotti, Alice and Zammataro, Luca and Altwerger, Gary and Buza, Natalia and Hui, Pei and Wong, Serena and Litkouhi, Babak and Ratner, Elena and Silasi, Dan-Arin and Azodi, Masoud and Schwartz, Peter E and Santin, Alessandro D
Clinical Cancer Research, ISSN 1078-0432, 10/2017, Volume 23, Issue 19, pp. 5836 - 5845
Purpose: Carcinosarcomas (CS) are highly aggressive gynecologic malignancies containing both carcinomatous and sarcomatous elements with heterogeneous HER2/neu... 
EPITHELIAL-MESENCHYMAL TRANSITION | TRASTUZUMAB PLUS DOCETAXEL | PHASE-II TRIAL | GYNECOLOGIC-ONCOLOGY-GROUP | ONCOLOGY | GASTRIC-CANCER | SEROUS CARCINOMA | METASTATIC BREAST-CANCER | ENDOMETRIAL CARCINOSARCOMA | PRECLINICAL PROFILE | MONOCLONAL-ANTIBODY | Receptor, ErbB-2 - genetics | Uterine Neoplasms - pathology | Humans | Ovarian Neoplasms - pathology | Antibody-Dependent Cell Cytotoxicity - immunology | Pyrrolidinones - immunology | Immunoconjugates - administration & dosage | Indoles - administration & dosage | Carcinosarcoma - immunology | Immunoconjugates - immunology | Ovarian Neoplasms - genetics | Pyrrolidinones - administration & dosage | Female | Receptor, ErbB-2 - antagonists & inhibitors | Receptor, ErbB-2 - immunology | Gene Expression Regulation, Neoplastic - drug effects | Ovarian Neoplasms - drug therapy | Carcinosarcoma - pathology | Uterine Neoplasms - genetics | Maytansine - analogs & derivatives | Indoles - immunology | Trastuzumab - administration & dosage | Xenograft Model Antitumor Assays | Maytansine - administration & dosage | Animals | Uterine Neoplasms - drug therapy | Cell Line, Tumor | Carcinosarcoma - drug therapy | Carcinosarcoma - genetics | Cell Proliferation - drug effects | Mice | Trastuzumab - immunology | Maytansine - immunology | Uterine Neoplasms - immunology | Ovarian Neoplasms - immunology | Biotechnology | Animal models | Toxicity | Tumor cells | Effector cells | Cytotoxicity | Gene expression | ErbB-2 protein | Anticancer properties | Gene amplification | Chemotherapy | Uterus | Experimental design | Cell lines | Xenografts | Antitumor activity | Biocompatibility | In vivo methods and tests | Viability | Trastuzumab | Cancer | SYD985 | T-DM1 | HER2 | Uterine Carcinosarcoma | Ovarian Carcinosarcoma
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9. Full Text POLE Proofreading Mutations Elicit an Antitumor Immune Response in Endometrial Cancer
by van Gool, Inge C and Eggink, Florine A and Freeman-Mills, Luke and Stelloo, Ellen and Marchi, Emanuele and de Bruyn, Marco and Palles, Claire and Nout, Remi A and de Kroon, Cor D and Osse, Elisabeth M and Klenerman, Paul and Creutzberg, Carien L and Tomlinson, Ian P. M and Smit, Vincent T. H. B. M and Nijman, Hans W and Bosse, Tjalling and Church, David N
Clinical Cancer Research, ISSN 1078-0432, 07/2015, Volume 21, Issue 14, pp. 3347 - 3355
Purpose: Recent studies have shown that 7% to 12% of endometrial cancers are ultramutated due to somatic mutation in the proofreading exonuclease domain of the... 
SURVIVAL | RECTAL-CANCER | ONCOLOGY | EXONUCLEASE DOMAIN MUTATIONS | MICROSATELLITE INSTABILITY | COLORECTAL-CANCER | RANDOMIZED-TRIAL | DNA-POLYMERASE EPSILON | CARCINOMA | EXOME ANALYSIS REVEALS | T-CELLS | Immunohistochemistry | Humans | DNA Polymerase II - immunology | Poly-ADP-Ribose Binding Proteins | Endometrial Neoplasms - immunology | Endometrial Neoplasms - genetics | DNA Mutational Analysis | Fluorescent Antibody Technique | Polymerase Chain Reaction | Female | Mutation | DNA Polymerase II - genetics | Cohort Studies | Lymphocytes, Tumor-Infiltrating - immunology
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10. Full Text Mismatch Repair Deficiency and Response to Immune Checkpoint Blockade
by Lee, Valerie and Murphy, Adrian and Le, Dung T and Diaz, Luis A
The Oncologist, ISSN 1083-7159, 10/2016, Volume 21, Issue 10, pp. 1200 - 1211
More than 1.6 million new cases of cancer will be diagnosed in the U.S. in 2016, resulting in more than 500,000 deaths. Although chemotherapy has been the... 
Microsatellite instability | Colorectal neoplasms | Colonic neoplasms | Immunotherapy | DNA mismatch repair | Hereditary nonpolyposis | ADJUVANT CHEMOTHERAPY | LYNCH-SYNDROME | ENDOMETRIAL CANCER | COLON-CANCER | BREAST-CANCER | COLORECTAL-CANCER PATIENTS | ONCOLOGY | GASTRIC-CANCER | PROTEIN EXPRESSION | PROSTATE-CANCER | LEVEL MICROSATELLITE INSTABILITY | Microsatellite Instability | Neoplasms - genetics | Neoplasms - immunology | DNA Mismatch Repair | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Neoplasms - drug therapy | Gastrointestinal Cancer
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11. Full Text Immunotherapy holds the key to cancer treatment and prevention in Constitutional Mismatch Repair Deficiency (CMMRD) syndrome
by Westdorp, Harm and Kolders, Sigrid and Hoogerbrugge, Nicoline and de Vries, I. Jolanda M and Jongmans, Marjolijn C.J and Schreibelt, Gerty
Cancer Letters, ISSN 0304-3835, 2017, Volume 403, pp. 159 - 164
Abstract Monoallelic germline mutations in one of the DNA mismatch repair (MMR) genes cause Lynch syndrome, with a high lifetime risks of colorectal and... 
Hematology, Oncology and Palliative Medicine | Neoantigens | Prevention | Constitutional mismatch repair deficiency syndrome | CMMRD | Cancer immunotherapy | IMMUNE-RESPONSE | LYNCH-SYNDROME | MICROSATELLITE | DENDRITIC CELL VACCINATION | PD-1 BLOCKADE | EUROPEAN CONSORTIUM CARE | HEREDITARY | ONCOLOGY | COLORECTAL-CANCER | MSH6 MUTATIONS | NIVOLUMAB | Immunotherapy - methods | Neoplastic Syndromes, Hereditary - immunology | Colorectal Neoplasms - genetics | Humans | DNA Repair Enzymes - genetics | DNA Mismatch Repair - genetics | Neoplastic Syndromes, Hereditary - mortality | Cancer Vaccines - therapeutic use | Colorectal Neoplasms - therapy | Brain Neoplasms - immunology | Neoplastic Syndromes, Hereditary - genetics | Brain Neoplasms - mortality | Colorectal Neoplasms - mortality | Antibodies - therapeutic use | Antigens, Neoplasm - genetics | Genetic Predisposition to Disease | Antigens, Neoplasm - immunology | Brain Neoplasms - genetics | Cancer Vaccines - adverse effects | Antibodies - adverse effects | DNA Mismatch Repair - immunology | Immunotherapy - adverse effects | Immunotherapy - mortality | Phenotype | Animals | Colorectal Neoplasms - immunology | Brain Neoplasms - therapy | Neoplastic Syndromes, Hereditary - therapy | Mutation | DNA Repair Enzymes - immunology | Care and treatment | Immune response | Endometrial cancer | Brain tumors | Vaccination | Mortality | Colorectal cancer | Development and progression | T cells | Gene mutations | Gastrointestinal diseases | Tumor antigens | Drug therapy | Cancer | Brain | Brain cancer | Genes | Medical services | Vaccines | Cancer therapies | DNA repair | Risk factors | Intestine | Immunotherapy | Mismatch repair | Children | Repair | Age | Endometrium | Deoxyribonucleic acid--DNA | Immune system | Hematology | Health risks | Patients | Disease prevention | Inhibitors | Immune checkpoint | Health risk assessment | Tumors
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