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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 136 - 139
Journal Article
Cell Death and Differentiation, ISSN 1350-9047, 12/2015, Volume 22, Issue 12, pp. 1946 - 1956
Polo-like kinase 1 (PLK1) is frequently overexpressed in cancer, which correlates with poor prognosis. Therefore, we investigated PLK1 as therapeutic target... 
INDUCED APOPTOSIS | PHOSPHORYLATION | BI 6727 | MCL-1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | RHABDOMYOSARCOMA | MITOTIC ARREST | KINASE INHIBITOR | NEUROBLASTOMA-CELLS | ENDONUCLEASE-G | CANCER-THERAPY | CELL BIOLOGY | Reactive Oxygen Species - metabolism | Apoptosis - drug effects | Humans | Rhabdomyosarcoma - metabolism | Myeloid Cell Leukemia Sequence 1 Protein - metabolism | bcl-2 Homologous Antagonist-Killer Protein - genetics | Rhabdomyosarcoma - pathology | Transplantation, Heterologous | bcl-2 Homologous Antagonist-Killer Protein - metabolism | Pteridines - toxicity | Cell Cycle Proteins - antagonists & inhibitors | Proto-Oncogene Proteins c-bcl-2 - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Tumor Cells, Cultured | Tubulin Modulators - toxicity | Protein-Serine-Threonine Kinases - metabolism | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | bcl-2 Homologous Antagonist-Killer Protein - antagonists & inhibitors | Cell Cycle Proteins - metabolism | Mitochondria - metabolism | Mitochondria - drug effects | Myeloid Cell Leukemia Sequence 1 Protein - genetics | Drug Synergism | Animals | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Protein Kinase Inhibitors - toxicity | Mice | Index Medicus | Original Paper
Journal Article
Experimental Cell Research, ISSN 0014-4827, 10/2012, Volume 318, Issue 16, pp. 1973 - 1986
Chromatin remodeling complex SWI/SNF plays important roles in many cellular processes including transcription, proliferation, differentiation and DNA repair.... 
Brm | Brg1 | Cisplatin | Chromatin remodeling | STRAND BREAK REPAIR | DNA-DAMAGE | CANCER-CELL-LINES | NECK-CANCER | CHEMOTHERAPY | NUCLEOTIDE EXCISION-REPAIR | P53 | CELL BIOLOGY | LUNG-CANCER | ONCOLOGY | SWI-SNF COMPLEX | Chromatin - metabolism | RNA, Small Interfering - genetics | Endonucleases - genetics | Humans | Chromatin Assembly and Disassembly - genetics | Endonucleases - metabolism | Chromatin Assembly and Disassembly - drug effects | Head and Neck Neoplasms - metabolism | Protein Subunits - metabolism | Gene Knockdown Techniques | Chromosomal Proteins, Non-Histone - antagonists & inhibitors | DNA-Binding Proteins - metabolism | Antineoplastic Agents - pharmacology | Gene Expression Regulation, Neoplastic - drug effects | Nuclear Proteins - genetics | Chromatin - drug effects | DNA Helicases - genetics | Protein Subunits - genetics | DNA-Binding Proteins - antagonists & inhibitors | Chromosomal Proteins, Non-Histone - metabolism | Carcinoma, Non-Small-Cell Lung - genetics | Endonucleases - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Head and Neck Neoplasms - drug therapy | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Signal Transduction - genetics | Cisplatin - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Chromosomal Proteins, Non-Histone - genetics | Transcription Factors - metabolism | DNA Helicases - metabolism | Signal Transduction - drug effects | DNA Repair | Nuclear Proteins - antagonists & inhibitors | Cell Line, Tumor | Head and Neck Neoplasms - genetics | DNA Adducts - genetics | Protein Subunits - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - drug therapy | DNA Helicases - antagonists & inhibitors | Chromatin - genetics | Enzymes | Chromatin | Squamous cell carcinoma | DNA damage | Lung cancer | Genetic transcription | Lung cancer, Non-small cell | Antineoplastic agents | Antimitotic agents | DNA | Physiological aspects | Universities and colleges | Enzyme-linked immunosorbent assay | Cytotoxicity | Cellular biology | Platinum | Cancer | BRG1 protein | Head | Transcription | DNA repair | ERCC1 protein | XPC protein | DNA adducts | Kinetics | Neck | Differentiation | Apoptosis | Catalytic subunits | APOPTOSIS | HEAD | CHROMATIN | LUNGS | TRANSCRIPTION | SENSITIVITY | TOXICITY | 60 APPLIED LIFE SCIENCES | DNA ADDUCTS | STRAND BREAKS | NUCLEOTIDES | EXCISION REPAIR | ENZYMES | CARCINOMAS | ENZYME IMMUNOASSAY | NECK
Journal Article
Nature Reviews Clinical Oncology, ISSN 1759-4774, 2014, Volume 11, Issue 5, pp. 282 - 298
Journal Article
The New England Journal of Medicine, ISSN 0028-4793, 01/2010, Volume 362, Issue 3, pp. 197 - 205
Journal Article
DNA Repair, ISSN 1568-7864, 07/2016, Volume 43, pp. 38 - 47
DNA topoisomerase 2 (Top2) poisons, including common anticancer drugs etoposide and doxorubicin kill cancer cells by stabilizing covalent Top2-tyrosyl-DNA... 
High throughput screening | Enzyme assay | TDP2 | NSC111041 | Molecular probe | Inhibitor | DNA repair | GLYCOSYLASE | TOPOISOMERASE-II | CANCER | DAMAGE | REPAIR | DISCRIMINATION | ANTICANCER THERAPY | GENETICS & HEREDITY | TOXICOLOGY | INHIBITORS | APURINIC/APYRIMIDINIC ENDONUCLEASE | BINDING | DNA, Neoplasm - metabolism | Epithelial Cells - drug effects | Humans | Gene Expression Regulation, Neoplastic | DNA Breaks, Double-Stranded | DNA Adducts - metabolism | DNA-Binding Proteins - metabolism | Topoisomerase Inhibitors - pharmacology | Poly-ADP-Ribose Binding Proteins | DNA Adducts - antagonists & inhibitors | Antigens, Neoplasm - metabolism | Nuclear Proteins - genetics | Aminoquinolines - pharmacology | Antigens, Neoplasm - genetics | DNA Topoisomerases, Type II - metabolism | DNA Repair - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Etoposide - pharmacology | Phosphodiesterase Inhibitors - pharmacology | Epithelial Cells - pathology | Nuclear Proteins - metabolism | Transcription Factors - antagonists & inhibitors | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Drug Synergism | Transcription Factors - metabolism | High-Throughput Screening Assays | Histones - genetics | Nuclear Proteins - antagonists & inhibitors | Epithelial Cells - enzymology | Cell Line, Tumor | Protein Binding | DNA Topoisomerases, Type II - genetics | DNA, Neoplasm - antagonists & inhibitors | DNA, Neoplasm - genetics | Histones - metabolism | Genetic research | Etoposide | Molecular biology | DNA | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2011, Volume 471, Issue 7336, pp. 74 - 79
Protein acetylation is mediated by histone acetyltransferases (HATs) and deacetylases (HDACs), which influence chromatin dynamics, protein turnover and the DNA... 
YEAST | REPAIR | ACTIVATION | ACETYLATION | MULTIDISCIPLINARY SCIENCES | VALPROIC ACID | CHECKPOINT | HOMOLOGOUS RECOMBINATION | END RESECTION | HISTONE DEACETYLASE INHIBITORS | SACCHAROMYCES-CEREVISIAE | Autophagy-Related Proteins | Protein Kinases - genetics | Microtubule-Associated Proteins - metabolism | Saccharomyces cerevisiae - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Endonucleases - metabolism | Valproic Acid - pharmacology | Autophagy - drug effects | DNA Breaks, Double-Stranded - drug effects | Protein Processing, Post-Translational - drug effects | Histone Acetyltransferases - metabolism | Endodeoxyribonucleases - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Aminopeptidases - metabolism | Chromosomal Instability | Protein-Serine-Threonine Kinases - metabolism | DNA Repair - drug effects | Histone Deacetylases - genetics | Saccharomyces cerevisiae Proteins - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Histone Deacetylases - metabolism | Saccharomyces cerevisiae Proteins - genetics | Endonucleases - chemistry | Saccharomyces cerevisiae - cytology | Autophagy-Related Protein 8 Family | Acetylation - drug effects | Signal Transduction - drug effects | Exodeoxyribonucleases - metabolism | Saccharomyces cerevisiae Proteins - metabolism | Saccharomyces cerevisiae - enzymology | Histone Deacetylase Inhibitors - pharmacology | Saccharomyces cerevisiae Proteins - chemistry | Proteins | Physiological aspects | Causes of | Enzymes | Genetic aspects | DNA damage | Phosphorylation | Yeast | Kinases | DNA repair | Autophagy | Experiments | Recruitment | Cell cycle | Genetics | Influence | Apoptosis
Journal Article
Journal Article
Nature Communications, ISSN 2041-1723, 12/2017, Volume 8, Issue 1, pp. 1470 - 16
Journal Article
PLoS ONE, ISSN 1932-6203, 06/2016, Volume 11, Issue 6, p. e0157520
RNA interference (RNAi) is being developed as a potential tool for insect pest management. Increased understanding of the RNAi pathway in target insect pests... 
DOUBLE-STRANDED-RNA | MULTIDISCIPLINARY SCIENCES | ARGONAUTE | INSECTS | DICER-2 | DISTINCT ROLES | GENOME | Coleoptera - genetics | Pest Control, Biological | RNA, Small Interfering - genetics | Vacuolar Proton-Translocating ATPases - genetics | Coleoptera - metabolism | Transcriptome | Argonaute Proteins - antagonists & inhibitors | Coleoptera - growth & development | Vacuolar Proton-Translocating ATPases - metabolism | Gene Knockdown Techniques | RNA Interference | Larva - growth & development | Plants, Genetically Modified | Larva - genetics | RNA, Double-Stranded - metabolism | Insect Proteins - metabolism | Zea mays - genetics | Argonaute Proteins - metabolism | Argonaute Proteins - genetics | Ribonuclease III - genetics | Ribonuclease III - metabolism | Plant Immunity - genetics | Larva - metabolism | Insect Proteins - genetics | Zea mays - parasitology | Ribonuclease III - antagonists & inhibitors | Insect Proteins - antagonists & inhibitors | Vacuolar Proton-Translocating ATPases - antagonists & inhibitors | Animals | Zea mays - immunology | RNA, Double-Stranded - genetics | RNA, Small Interfering - metabolism | RNA-mediated interference | Genes | Mortality | Double-stranded RNA | Interference | Pest control | Corn | siRNA | RNA-induced silencing complex | Pests | Argonaute 2 protein | Gene expression | Transgenic plants | Proteins | Beetles | Developmental stages | Ribonucleic acids | Insects | Plant tissues | Efficiency | Adults | Catalysis | Endonuclease | Laccase
Journal Article