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Aging Cell, ISSN 1474-9718, 08/2015, Volume 14, Issue 4, pp. 644 - 658
The healthspan of mice is enhanced by killing senescent cells using a transgenic suicide gene. Achieving the same using small molecules would have a tremendous... 
dasatinib | plasminogen‐activated inhibitor | dependence receptors | quercetin | ephrins | 3K delta | p21 | Dasatinib | Dependence receptors | Ephrins | Plasminogen-activated inhibitor | Quercetin | PI3K delta | P21 | ENDOTHELIAL DYSFUNCTION | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | EXPRESSION PROFILES | plasminogen-activated inhibitor | CELLULAR SENESCENCE | CANCER-THERAPY | CELL BIOLOGY | GERIATRICS & GERONTOLOGY | LUNG-CANCER | SET ENRICHMENT ANALYSIS | GENE-EXPRESSION | IONIZING-RADIATION | TUMOR-GROWTH | Carotid Arteries - drug effects | Endonucleases - genetics | Plasminogen Activator Inhibitor 2 - genetics | Transcriptome | Gene Expression Profiling | Adipocytes - drug effects | Aging - genetics | Osteoporosis - metabolism | Ephrins - metabolism | Plasminogen Activator Inhibitor 2 - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Osteoporosis - genetics | Intervertebral Disc - pathology | Fibroblasts - metabolism | Endothelial Cells - metabolism | Intervertebral Disc - chemistry | Fibroblasts - pathology | Mesenchymal Stem Cells - pathology | Mice, Knockout | Dasatinib - pharmacology | Osteoporosis - pathology | Ephrins - genetics | Fibroblasts - drug effects | Mice | Endothelial Cells - pathology | bcl-X Protein - metabolism | Aging - metabolism | Aging - drug effects | bcl-X Protein - genetics | Cellular Senescence - drug effects | Phosphatidylinositol 3-Kinases - metabolism | Endonucleases - metabolism | DNA-Binding Proteins - metabolism | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Mesenchymal Stem Cells - drug effects | Mesenchymal Stem Cells - metabolism | Heart - physiopathology | Cellular Senescence - genetics | Osteoporosis - prevention & control | DNA-Binding Proteins - genetics | Adipocytes - pathology | Aging - pathology | Phosphatidylinositol 3-Kinases - genetics | Animals | Quercetin - pharmacology | Adipocytes - metabolism | Heart - drug effects | Carotid Arteries - pathology | Intervertebral Disc - drug effects | Drug Combinations | Endothelial Cells - drug effects | Index Medicus | Original
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 09/2011, Volume 194, Issue 5, pp. 705 - 720
DNA double-strand break (DSB) resection, which results in RPA-bound single-stranded DNA (ssDNA), is activated in S phase by Cdk2. RPA-ssDNA activates the... 
CYCLE CHECKPOINT CONTROL | DAMAGE RESPONSE | MRE11-RAD50-NBS1 COMPLEX | HOMOLOGOUS RECOMBINATION | RPA PHOSPHORYLATION | CELL-FREE-EXTRACTS | SACCHAROMYCES-CEREVISIAE | REPLICATION STRESS | DNA-END-RESECTION | WERNER-SYNDROME PROTEIN | CELL BIOLOGY | Protein Kinases - metabolism | Chromatin - metabolism | Meiosis - physiology | Nuclear Envelope - physiology | Antigens, Nuclear - metabolism | RecQ Helicases - metabolism | Humans | Werner Syndrome Helicase | DNA Repair - physiology | Endonucleases - metabolism | DNA Breaks, Double-Stranded | CDC2 Protein Kinase - metabolism | DNA-Binding Proteins - metabolism | MRE11 Homologue Protein | Cell Nucleus - metabolism | Protein Binding - drug effects | Phosphorylation - drug effects | Protein-Serine-Threonine Kinases - metabolism | Rad51 Recombinase - metabolism | Cyclin-Dependent Kinase 2 - metabolism | Tumor Suppressor Proteins - metabolism | CDC2 Protein Kinase - antagonists & inhibitors | DNA, Single-Stranded - metabolism | Xenopus laevis | Cell Cycle Proteins - metabolism | Replication Protein A - metabolism | Ataxia Telangiectasia Mutated Proteins | Xenopus Proteins - antagonists & inhibitors | Cell Division - physiology | DNA Helicases - metabolism | Animals | Cell-Free System | Ku Autoantigen | Mitosis - physiology | Cyclin-Dependent Kinase 2 - antagonists & inhibitors | S Phase - physiology | Checkpoint Kinase 1 | Xenopus Proteins - metabolism | Ovum | Protein Kinase Inhibitors - pharmacology | HeLa Cells | Histones - metabolism | Protein Binding - physiology | Vertebrates | Phosphorylation | DNA repair | Deoxyribonucleic acid--DNA | Cells | Index Medicus
Journal Article
Nucleic Acids Research, ISSN 0305-1048, 09/2017, Volume 45, Issue 17, pp. 9901 - 9916
Journal Article
Archives of Pathology and Laboratory Medicine, ISSN 0003-9985, 2014, Volume 138, Issue 8, pp. 1015 - 1026
Context.-Distinction of medullary carcinoma of the large intestine from other cytokeratin (CK) 7(-)/CK20(-) carcinomas can be challenging when working on a... 
MEDICINE, RESEARCH & EXPERIMENTAL | MARKER | MICROSATELLITE INSTABILITY | COLON | PATHOLOGY | CYTOKERATIN-20 | GASTROINTESTINAL ADENOCARCINOMAS | COLORECTAL CARCINOMAS | IMMUNOHISTOCHEMICAL SURVEY | GENE-EXPRESSION | FACTOR CDX2 | DIFFERENTIATION | MEDICAL LABORATORY TECHNOLOGY | Immunohistochemistry | MutL Protein Homolog 1 | Cadherins - metabolism | Tissue Array Analysis | Cecal Neoplasms - pathology | Humans | Middle Aged | Carcinoma, Medullary - diagnosis | Colonic Neoplasms - diagnosis | Carcinoma, Medullary - metabolism | Male | Neoplasm Proteins - metabolism | Colonic Neoplasms - metabolism | Cecal Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Cecum - metabolism | Sensitivity and Specificity | DNA Repair Enzymes - metabolism | Aged, 80 and over | Female | Mismatch Repair Endonuclease PMS2 | Biomarkers - metabolism | Colon - pathology | Matrix Attachment Region Binding Proteins - metabolism | Down-Regulation | Adenosine Triphosphatases - metabolism | Cecal Neoplasms - diagnosis | Carcinoma, Medullary - pathology | Nuclear Proteins - metabolism | Tumor Burden | Colon - metabolism | Cecum - pathology | Transcription Factors - metabolism | Colonic Neoplasms - pathology | Aged | Adaptor Proteins, Signal Transducing - metabolism | Keratin | Carcinoma | Diagnosis | Colorectal cancer | Mucins | Cancer | Index Medicus | Abridged Index Medicus
Journal Article
Cell Metabolism, ISSN 1550-4131, 09/2013, Volume 18, Issue 3, pp. 403 - 415
Journal Article
Cell, ISSN 0092-8674, 09/2016, Volume 167, Issue 1, pp. 233 - 247.e17
Journal Article
Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7571, pp. 136 - 139
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 10/2009, Volume 4, Issue 10, pp. 1212 - 1220
The use of biomarkers to evaluate the presence of a target or to select a specific therapy is increasingly advocated. The correlation of biomarker expression... 
Biomarker | Primary tumor | ERCC1 | Non-small cell lung cancer | Corresponding metastasis | SURVIVAL | FACTOR-RECEPTOR GENE | PROTEIN | EGF-R | TUMORS | SURGICAL SPECIMENS | REPAIR | ONCOLOGY | RESPIRATORY SYSTEM | KI-67 EXPRESSION | CARCINOMA | BIOPSIES | Adenocarcinoma - pathology | Prognosis | Adenocarcinoma, Bronchiolo-Alveolar - pathology | Carcinoma, Large Cell - pathology | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Lung Neoplasms - metabolism | Middle Aged | Bone Neoplasms - secondary | Lung Neoplasms - pathology | Male | Vascular Endothelial Growth Factor A - metabolism | Endonucleases - metabolism | Brain Neoplasms - metabolism | Immunoenzyme Techniques | Bone Neoplasms - metabolism | DNA-Binding Proteins - metabolism | Brain Neoplasms - secondary | Receptor, Epidermal Growth Factor - metabolism | Adenocarcinoma - metabolism | Receptors, Vascular Endothelial Growth Factor - metabolism | Aged, 80 and over | Biomarkers, Tumor - metabolism | Adrenal Gland Neoplasms - secondary | Adult | Female | Carcinoma, Non-Small-Cell Lung - pathology | Carcinoma, Large Cell - metabolism | Carcinoma, Non-Small-Cell Lung - metabolism | Survival Rate | Adenocarcinoma, Bronchiolo-Alveolar - metabolism | Adrenal Gland Neoplasms - metabolism | Aged | Neoplasm Staging | Index Medicus
Journal Article
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