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Circulation, ISSN 0009-7322, 01/2014, Volume 129, Issue 2, pp. 234 - 243
Journal Article
Leukemia, ISSN 0887-6924, 03/2007, Volume 21, Issue 3, pp. 524 - 528
Single-agent bortezomib, a potent, selective and reversible inhibitor of the 26S proteasome, has demonstrated clinical efficacy in relapsed and refractory... 
MULTIPLE-MYELOMA | SURVIVAL | cytarabine | APOPTOSIS | KAPPA-B ACTIVATION | combination treatment | CYCLOPHOSPHAMIDE | PHASE-II | TRIAL | IN-VITRO | ONCOLOGY | mantle cell lymphoma | NON-HODGKINS-LYMPHOMA | bortezomib | HEMATOLOGY | HEMATOLOGIC MALIGNANCIES | Hodgkin's lymphoma | Recurrence | Cyclophosphamide - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Cytarabine - pharmacology | Mitoxantrone - administration & dosage | Apoptosis - drug effects | Cytarabine - therapeutic use | Humans | Middle Aged | Pyrazines - administration & dosage | Lymphoma, Mantle-Cell - pathology | Salvage Therapy | Drug Resistance, Neoplasm | Male | Cell Line, Tumor - drug effects | Pyrazines - therapeutic use | Boronic Acids - therapeutic use | Yttrium Radioisotopes - administration & dosage | Protease Inhibitors - pharmacology | Proteasome Endopeptidase Complex - drug effects | Protease Inhibitors - administration & dosage | Vincristine - administration & dosage | Female | Boronic Acids - administration & dosage | Protease Inhibitors - therapeutic use | Yttrium Radioisotopes - therapeutic use | Doxorubicin - administration & dosage | Prednisone - administration & dosage | Antibodies, Monoclonal, Murine-Derived | Bortezomib | Drug Administration Schedule | Lymphoma, Mantle-Cell - radiotherapy | Radioimmunotherapy | Lymphoma, Mantle-Cell - drug therapy | Combined Modality Therapy | Vidarabine - analogs & derivatives | Remission Induction | Cytarabine - administration & dosage | Drug Synergism | Antibodies, Monoclonal - administration & dosage | Antineoplastic Combined Chemotherapy Protocols - therapeutic use | Aged | Vidarabine - administration & dosage | Pyrazines - pharmacology | Boronic Acids - pharmacology | Cytarabine | Dosage and administration | Non-Hodgkin's lymphomas | Diagnosis | Research | Drug therapy
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 02/2007, Volume 100, Issue 3, pp. 802 - 809
Generation and deposition of the amyloid β (Aβ) peptide following proteolytic processing of the amyloid precursor protein (APP) by BACE‐1 and γ‐secretase is... 
secretase | p‐glycoprotein | TASTPM | amyloid precursor protein | Alzheimer's disease | β‐site amyloid precursor protein cleaving enzyme 1 | β-site amyloid precursor protein cleaving enzyme 1 | p-glycoprotein | Amyloid precursor protein | Secretase | SITE | ASPARTYL PROTEASE | ALZHEIMERS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | NEUROSCIENCES | beta-site amyloid precursor protein cleaving enzyme 1 | SECRETASE ACTIVITY | PURIFICATION | MICE | BRAIN | STRUCTURE-BASED DESIGN | Thiazines - therapeutic use | Amyloid beta-Protein Precursor - chemistry | Humans | ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism | Male | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Enzyme Inhibitors - chemical synthesis | Brain - metabolism | Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Thiazines - pharmacology | Disease Models, Animal | Alzheimer Disease - physiopathology | Administration, Oral | Aspartic Acid Endopeptidases - antagonists & inhibitors | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Enzyme Inhibitors - pharmacology | Alzheimer Disease - drug therapy | Mice, Transgenic | Treatment Outcome | Down-Regulation - drug effects | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Brain - drug effects | Down-Regulation - physiology | Amyloid Precursor Protein Secretases - metabolism | Animals | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Cell Line, Tumor | Mice | Amyloid Precursor Protein Secretases - antagonists & inhibitors
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1646, pp. 217 - 225
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2003, Volume 278, Issue 50, pp. 50259 - 50272
Journal Article
Journal Article
Journal Article
Journal Article
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 59, Issue 25, pp. 2344 - 2353
Objectives The primary objective of this study was to evaluate the low-density lipoprotein cholesterol (LDL-C)–lowering efficacy of 5 SAR236553/REGN727... 
Cardiovascular | Internal Medicine | statin | low-density lipoprotein cholesterol | safety | apolipoprotein-B | PCSK9 | SAR236553/REGN727 | hypercholesterolemia | CUTANEOUS VASCULITIS | CARDIAC & CARDIOVASCULAR SYSTEMS | METAANALYSIS | CHOLESTEROL | CARDIOVASCULAR OUTCOMES | LOW-DENSITY-LIPOPROTEIN | PREVENTION | REDUCTION | DISEASE | 14 RANDOMIZED-TRIALS | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Proprotein Convertases - antagonists & inhibitors | Humans | Middle Aged | Antibodies, Monoclonal - adverse effects | Antibodies, Monoclonal - therapeutic use | Male | Hypercholesterolemia - drug therapy | Time Factors | Pyrroles - administration & dosage | Heptanoic Acids - administration & dosage | Adult | Cholesterol, LDL - blood | Female | Hypercholesterolemia - blood | Double-Blind Method | Proprotein Convertases - metabolism | Treatment Outcome | Anticholesteremic Agents - adverse effects | Drug Synergism | Atorvastatin Calcium | Anticholesteremic Agents - therapeutic use | Antibodies, Monoclonal - administration & dosage | Anticholesteremic Agents - administration & dosage | Aged | Serine Endopeptidases - metabolism | Proprotein Convertase 9 | Care and treatment | Serine | Low density lipoproteins | Antibodies | Thrombin | Lipoprotein A | Cholesterol | Cardiovascular agents | Antilipemic agents | Viral antibodies | Complications and side effects | Hypercholesterolemia | Proteases | Monoclonal antibodies | Universities and colleges | Laboratories | Lipids | Triglycerides | Lipoproteins | Pain | Influenza | Patient safety | Population | Mutation | Clinical medicine | Diabetes | Statins
Journal Article
Journal Article
Molecular Neurobiology, ISSN 0893-7648, 10/2017, Volume 54, Issue 8, pp. 6507 - 6522
Alzheimer’s disease (AD) is associated with reduced insulin level and impairment of insulin receptor (IR) signaling in the brain, which correlates to amyloid... 
Neurology | post synaptic neurotoxicity | Neurosciences | Glial activation | Biomedicine | Neurobiology | Insulin receptor dysfunction | Amyloidogenic protein expression | Intranasal insulin | Cell Biology | OXIDATIVE STRESS | ALZHEIMERS-DISEASE | IMPROVES MEMORY | FACTOR-KAPPA-B | DEPENDENT PATHWAY | KINASE-B | BLOOD-BRAIN-BARRIER | NEUROSCIENCES | A-BETA | CENTRAL-NERVOUS-SYSTEM | DEGRADING ENZYME | Microglia - metabolism | Streptozocin | Memory Disorders - metabolism | Male | NF-kappa B - metabolism | Hippocampus - drug effects | Insulin Receptor Substrate Proteins - metabolism | Cerebral Cortex - metabolism | Inflammation - metabolism | Hypoglycemic Agents - administration & dosage | Inflammation - drug therapy | Amyloid beta-Peptides - metabolism | Cerebral Cortex - drug effects | Phosphorylation - drug effects | Proto-Oncogene Proteins c-akt - metabolism | Hypoglycemic Agents - therapeutic use | Astrocytes - drug effects | Peptide Fragments - metabolism | Cytokines - metabolism | Microglia - drug effects | Rats | Insulin - administration & dosage | Down-Regulation - drug effects | Glycogen Synthase Kinase 3 - metabolism | Administration, Intranasal | Glycogen Synthase Kinase 3 beta - metabolism | Hippocampus - metabolism | Amyloid Precursor Protein Secretases - metabolism | Animals | Memory Disorders - drug therapy | Spatial Memory - drug effects | Signal Transduction - drug effects | Aspartic Acid Endopeptidases - metabolism | Receptor, Insulin - metabolism | Insulin - therapeutic use | Astrocytes - metabolism | Proteins | Medical research | Memory | Medicine, Experimental | Amyloidosis | Alzheimer's disease | Insulin | Amyloidogenesis | Neuroprotection | Brain | Cerebral cortex | Mental disorders | Medical services | Impairment | Activation | Neuronal-glial interactions | Inflammatory diseases | Neurotoxicity | Cell activation | Rodents | Amyloid | Drug therapy | Translocation | b-Site APP cleaving enzyme 1 | Neurodegenerative diseases | Neurons | Glial fibrillary acidic protein | Cortex | Caspase | Inflammation | Hypoglycemia | Pathology | Tumor necrosis factor | Interleukin 10 | Cyclooxygenase-2 | b-Site APP cleaving enzyme | Alzheimers disease | Index Medicus
Journal Article