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1. Full Text Endoplasmic reticulum stress is important for the manifestations of α-synucleinopathy in vivo
by Colla, Emanuela and Coune, Philippe and Liu, Ying and Pletnikova, Olga and Troncoso, Juan C and Iwatsubo, Takeshi and Schneider, Bernard L and Lee, Michael K
Journal of Neuroscience, ISSN 0270-6474, 03/2012, Volume 32, Issue 10, pp. 3306 - 3320
Accumulation of misfolded alpha-synuclein (alpha S) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other... 
UNFOLDED-PROTEIN RESPONSE | TARGETED OVEREXPRESSION | SIGNALING PATHWAY | ER STRESS | DISEASE-LINKED MUTATIONS | AMYOTROPHIC-LATERAL-SCLEROSIS | NIGROSTRIATAL SYSTEM | NEUROSCIENCES | PARKINSONS-DISEASE | CELL-DEATH | TRANSGENIC MICE | Parkinson Disease - pathology | Protein Unfolding | alpha-Synuclein - toxicity | Humans | Middle Aged | alpha-Synuclein - physiology | Rats | Mice, Transgenic | Molecular Chaperones - physiology | Rats, Sprague-Dawley | Animals | Cell Death - physiology | Aged, 80 and over | Cell Line, Tumor | Female | Aged | Mice | Parkinson Disease - metabolism | Endoplasmic Reticulum Stress - physiology | Molecular Chaperones - biosynthesis | Parkinson Disease - etiology | Index Medicus | ER stress | neurodegeneration | Parkinson's disease | α-synuclein
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2. Full Text Chronic enrichment of hepatic endoplasmic reticulum–mitochondria contact leads to mitochondrial dysfunction in obesity
by Arruda, Ana Paula and Pers, Benedicte M and Parlakgül, Güneş and Güney, Ekin and Inouye, Karen and Hotamisligil, Gökhan S
Nature Medicine, ISSN 1078-8956, 11/2014, Volume 20, Issue 12, pp. 1427 - 1435
Proper function of the endoplasmic reticulum (ER) and mitochondria is crucial for cellular homeostasis, and dysfunction at either site has been linked to... 
MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | MITOFUSIN 2 | FATTY LIVER-DISEASE | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | CELL BIOLOGY | SKELETAL-MUSCLE | METABOLIC DISEASE | GLUCOSE-HOMEOSTASIS | INSULIN-RESISTANCE | CALCIUM UNIPORTER | ADIPOSE-TISSUE | Microscopy, Electron, Transmission | Liver - ultrastructure | Calcium - metabolism | Vesicular Transport Proteins - metabolism | Down-Regulation | Liver - metabolism | Oxidative Stress - physiology | Endoplasmic Reticulum - metabolism | Mitochondria - metabolism | Hepatocytes - metabolism | Mitochondria - ultrastructure | Endoplasmic Reticulum - ultrastructure | Obesity - metabolism | Animals | GTP Phosphohydrolases - metabolism | Inositol 1,4,5-Trisphosphate Receptors - metabolism | Glucose - metabolism | Hepatocytes - ultrastructure | Mice | Calnexin - metabolism | Lipid Metabolism - physiology | Disease Models, Animal | Endoplasmic Reticulum Stress - physiology | Obesity | Insulin resistance | Mitochondria | Diabetes | Calcium | Endoplasmic reticulum | Index Medicus
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3. Full Text Mitochondrial – Endoplasmic Reticulum Interactions in the Trophoblast; Stress and Senescence
by Burton, G.J and Yung, H.W and Murray, A.J
Placenta, ISSN 0143-4004, 2016, Volume 52, pp. 146 - 155
Abstract Placental stress has been implicated in the pathophysiology of complications of pregnancy, including growth restriction and pre-eclampsia. Initially,... 
Internal Medicine | Obstetrics and Gynecology | Oxidative stress | Mitochondria | Endoplasmic reticulum | Unfolded protein response | ER STRESS | DEVELOPMENTAL BIOLOGY | CELLULAR SENESCENCE | OBSTETRICS & GYNECOLOGY | FETAL-GROWTH RESTRICTION | VILLOUS TROPHOBLAST | REPRODUCTIVE BIOLOGY | SIGNALING PATHWAY | PLACENTAL OXIDATIVE STRESS | UNCOUPLING PROTEIN-2 | INFLAMMATORY RESPONSE | TRANSCRIPTIONAL REGULATION | Placenta - metabolism | Pregnancy | Animals | Humans | Oxidative Stress - physiology | Cellular Senescence - physiology | Endoplasmic Reticulum - metabolism | Female | Mitochondria - metabolism | Unfolded Protein Response - physiology | Endoplasmic Reticulum Stress - physiology | Antioxidants | Tyrosine | Physiological aspects | Stem cells | Index Medicus
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4. Full Text Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
by Fumagalli, Fiorenza and Noack, Julia and Bergmann, Timothy J and Presmanes, Eduardo Cebollero and Pisoni, Giorgia Brambilla and Fasana, Elisa and Fregno, Ilaria and Galli, Carmela and Loi, Marisa and Soldà, Tatiana and D'Antuono, Rocco and Raimondi, Andrea and Jung, Martin and Melnyk, Armin and Schorr, Stefan and Schreiber, Anne and Simonelli, Luca and Varani, Luca and Wilson-Zbinden, Caroline and Zerbe, Oliver and Hofmann, Kay and Peter, Matthias and Quadroni, Manfredo and Zimmermann, Richard and Molinari, Maurizio
Nature Cell Biology, ISSN 1465-7392, 10/2016, Volume 18, Issue 11, pp. 1173 - 1184
The endoplasmic reticulum (ER) is a site of protein biogenesis in eukaryotic cells. Perturbing ER homeostasis activates stress programs collectively called the... 
AMPLIFICATION | DEGRADATION | MECHANISMS | REGULATORS | QUALITY-CONTROL | PROTEINS | SELECTIVE AUTOPHAGY | MAMMALIAN-CELLS | CANCER | CELL BIOLOGY | Animals | Molecular Chaperones - metabolism | Humans | Protein Biosynthesis - physiology | Endoplasmic Reticulum - metabolism | Homeostasis | Membrane Transport Proteins - metabolism | Protein Transport - physiology | Mice | Autophagy | Unfolded Protein Response - physiology | Endoplasmic Reticulum Stress - physiology | Index Medicus
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5. Full Text Activation of autophagy by unfolded proteins during endoplasmic reticulum stress
by Yang, Xiaochen and Srivastava, Renu and Howell, Stephen H and Bassham, Diane C
The Plant Journal, ISSN 0960-7412, 01/2016, Volume 85, Issue 1, pp. 83 - 95
Endoplasmic reticulum stress is defined as the accumulation of unfolded proteins in the endoplasmic reticulum, and is caused by conditions such as heat or... 
Arabidopsis thaliana | autophagy | vacuole | unfolded proteins | degradation | endoplasmic reticulum stress | zeolin | ER STRESS | CHEMICAL CHAPERONES | QUALITY-CONTROL | MAMMALIAN-CELLS | SECRETORY PATHWAY | PLANT SCIENCES | PROGRAMMED CELL-DEATH | SALT STRESS | PLANTS | ARABIDOPSIS | RECOMBINANT STORAGE PROTEIN | Arabidopsis - physiology | Arabidopsis - drug effects | Endoplasmic Reticulum Stress - drug effects | Protein Unfolding | Endoplasmic Reticulum - metabolism | Autophagy - physiology | Autophagy - drug effects | Arabidopsis - genetics | Taurochenodeoxycholic Acid - pharmacology | Tunicamycin - pharmacology | Phenylbutyrates - pharmacology | Vacuoles - metabolism | Dithiothreitol - pharmacology | Endoplasmic Reticulum Stress - physiology | Heat shock proteins | Enzymes | Inositol | Stress (Physiology) | Protein binding | Protein folding | Autophagy | Endoplasmic reticulum | Botany | Index Medicus
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6. Full Text STING-IRF3 pathway links endoplasmic reticulum stress with hepatocyte apoptosis in early alcoholic liver disease
by Jan Petrasek and Arvin Iracheta-Vellve and Timea Csak and Abhishek Satishchandran and Karen Kodys and Evelyn A. Kurt-Jones and Katherine A. Fitzgerald and Gyongyi Szabo
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2013, Volume 110, Issue 41, pp. 16544 - 16549
Emerging evidence suggests that innate immunity drives alcoholic liver disease (ALD) and that the interferon regulatory factor 3 (IRF3), a transcription factor... 
Phosphorylation | Hepatocytes | Ethanol | Interferons | Liver | Alcoholism | Inflammation | Mice | Dosage | Apoptosis | Stimulator of interferon genes | Interferon regulatory factor 3 | Steatohepatitis | Kupffer cells | PATHOGENESIS | steatohepatitis | ACTIVATION | IL-1 RECEPTOR ANTAGONIST | stimulator of interferon genes | MULTIDISCIPLINARY SCIENCES | ADAPTER | INJURY | ETHANOL | interferon regulatory factor 3 | MICE | Liver - metabolism | Mice, Knockout | Triglycerides - metabolism | Immunity, Innate - immunology | Regression Analysis | Signal Transduction - immunology | Animals | Liver Diseases, Alcoholic - physiopathology | Liver Diseases, Alcoholic - immunology | Interferon Regulatory Factor-3 - metabolism | Membrane Proteins - metabolism | Apoptosis - physiology | Hepatocytes - physiology | Endoplasmic Reticulum Stress - physiology | Physiological aspects | Research | Endoplasmic reticulum | Health aspects | Liver cells | Interferon | Liver diseases | Cells | Index Medicus | Biological Sciences
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7. Full Text Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains
by Romain Volmer and Kattria van der Ploeg and David Ron
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2013, Volume 110, Issue 12, pp. 4628 - 4633
Endoplasmic reticulum (ER) stress sensors use a related luminal domain to monitor the unfolded protein load and convey the signal to downstream effectors,... 
Membrane lipids | Phosphorylation | Messenger RNA | B lymphocytes | Lipids | Palmitates | Liposomes | Endoplasmic reticulum | Cells | Unfolded protein response | Lipid bilayer | Membrane fluidity | Palmitic acid | Integral membrane protein | HOMEOSTASIS | MECHANISM | PHOSPHORYLATION | ER STRESS | MACROPHAGES | MULTIDISCIPLINARY SCIENCES | TRANSLATION | palmitic acid | membrane fluidity | KINASE DOMAIN | B-CELLS | integral membrane protein | NUCLEUS | IRE1 | lipid bilayer | Protein Structure, Tertiary | Endoribonucleases - genetics | Endoplasmic Reticulum - genetics | Endoribonucleases - metabolism | Membrane Lipids - genetics | eIF-2 Kinase - metabolism | Humans | Protein-Serine-Threonine Kinases - genetics | Cercopithecus aethiops | Endoplasmic Reticulum - metabolism | Animals | HEK293 Cells | Membrane Lipids - metabolism | Signal Transduction - physiology | COS Cells | Unfolded Protein Response - physiology | Intracellular Membranes - metabolism | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum Stress - physiology | eIF-2 Kinase - genetics | Physiological aspects | Lipid membranes | Research | Protein folding | Homeostasis | Obesity | Membranes | Diabetes | Biosensors | Index Medicus | Biological Sciences
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8. Full Text Endoplasmic reticulum stress induces hepatic steatosis via increased expression of the hepatic very low‐density lipoprotein receptor
by Jo, Hyunsun and Choe, Sung Sik and Shin, Kyung Cheul and Jang, Hagoon and Lee, Jae Ho and Seong, Je Kyung and Back, Sung Hoon and Kim, Jae Bum
Hepatology, ISSN 0270-9139, 04/2013, Volume 57, Issue 4, pp. 1366 - 1377
Recent evidence suggests that obese animals exhibit increased endoplasmic reticulum (ER) stress in the liver and adipose tissue. Although ER stress is closely... 
ACTIVATION | UNFOLDED PROTEIN RESPONSE | METABOLISM | ER STRESS | INSULIN-RESISTANCE | GENE-EXPRESSION | SECRETION | KNOCKOUT MICE | GASTROENTEROLOGY & HEPATOLOGY | VLDL RECEPTOR | APOLIPOPROTEIN-E | Receptors, LDL - genetics | Fatty Liver - metabolism | Apolipoproteins E - deficiency | Fatty Liver - physiopathology | Liver - metabolism | Apolipoproteins E - metabolism | Mice, Knockout | Triglycerides - metabolism | Animals | Activating Transcription Factor 4 - metabolism | Apolipoproteins E - genetics | Up-Regulation - physiology | Lipoproteins - metabolism | Receptors, LDL - deficiency | Mice | Receptors, LDL - physiology | Disease Models, Animal | Endoplasmic Reticulum Stress - physiology | Proteins | Lipoproteins | Diet | Rodents | Hepatology | Kinases | Cholesterol | Index Medicus
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9. Full Text Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes
by Zhong, Yimin and Li, Jingming and Chen, Yanming and Wang, Joshua J and Ratan, Rajiv and Zhang, Sarah X
Diabetes, ISSN 0012-1797, 02/2012, Volume 61, Issue 2, pp. 492 - 504
Inflammation plays an important role in diabetes-induced retinal vascular leakage. The purpose of this study is to examine the role of endoplasmic reticulum... 
OXYGEN-INDUCED RETINOPATHY | ER STRESS | JNK | ENDOCRINOLOGY & METABOLISM | RAT MODELS | RETINAL BARRIER BREAKDOWN | TRANSCRIPTION FACTOR | EXPRESSION | TERMINAL KINASE | ENDOTHELIAL GROWTH-FACTOR | VASCULAR LEAKAGE | Vascular Endothelial Growth Factor A - biosynthesis | Diabetic Retinopathy - immunology | Streptozocin | Mice, Inbred C57BL | Cells, Cultured | Rats | Retina - immunology | Vascular Endothelial Growth Factor A - genetics | Diabetes Mellitus, Experimental - immunology | Hyperglycemia - metabolism | Animals | Intercellular Adhesion Molecule-1 - biosynthesis | Intercellular Adhesion Molecule-1 - genetics | Inflammation Mediators - metabolism | JNK Mitogen-Activated Protein Kinases - physiology | Mice | Active Transport, Cell Nucleus | Activating Transcription Factor 4 - physiology | Cytokines - biosynthesis | Endoplasmic Reticulum Stress - physiology | Physiological aspects | Inflammation | Research | Diabetes | Mediators | Endoplasmic reticulum | Index Medicus | Abridged Index Medicus | Complications
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10. Full Text Involvement of oxidative stress-induced DNA damage, endoplasmic reticulum stress, and autophagy deficits in the decline of β-cell mass in Japanese type 2 diabetic patients
by Mizukami, Hiroki and Takahashi, Kazunori and Inaba, Wataru and Tsuboi, Kentaro and Osonoi, Sho and Yoshida, Taro and Yagihashi, Soroku
Diabetes Care, ISSN 0149-5992, 2014, Volume 37, Issue 7, pp. 1966 - 1974
OBJECTIVE Deficits of beta-cells characterize the islet pathology in type 2 diabetes. It is yet to be clear how the beta-cell loss develops in type 2 diabetes.... 
INDIVIDUALS | APOPTOSIS | GOTO-KAKIZAKI RATS | EUROPEAN SUBJECTS | PROTEIN | GLUCOTOXICITY | ISLET ENDOCRINE-CELLS | ENDOCRINOLOGY & METABOLISM | HUMANS | SENSITIVITY | MECHANISMS | Humans | Japan | Middle Aged | Oxidative Stress - physiology | Pancreas - pathology | Male | Autophagy - physiology | Asian Continental Ancestry Group | Insulin-Secreting Cells - metabolism | Diabetes Mellitus, Type 2 - physiopathology | DNA Damage - physiology | Autopsy | Female | Aged | Endoplasmic Reticulum Stress - physiology | Type 2 diabetes | Oxidative stress | Complications and side effects | Influence | DNA damage | Risk factors | Index Medicus
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11. Full Text IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress
by Lerner, Alana G and Upton, John-Paul and Praveen, P.V.K and Ghosh, Rajarshi and Nakagawa, Yoshimi and Igbaria, Aeid and Shen, Sarah and Nguyen, Vinh and Backes, Bradley J and Heiman, Myriam and Heintz, Nathaniel and Greengard, Paul and Hui, Simon and Tang, Qizhi and Trusina, Ala and Oakes, Scott A and Papa, Feroz R
Cell Metabolism, ISSN 1550-4131, 08/2012, Volume 16, Issue 2, pp. 250 - 264
When unfolded proteins accumulate to irremediably high levels within the endoplasmic reticulum (ER), intracellular signaling pathways called the unfolded... 
TRANSCRIPTION FACTORS | CARBOHYDRATE RESPONSE ELEMENT | UNFOLDED PROTEIN | MESSENGER-RNA | GLUCOSE | BETA-CELLS | IRE1 | ENDOCRINOLOGY & METABOLISM | TXNIP | ENDOPLASMIC-RETICULUM | EXPRESSION | CELL BIOLOGY | Cell Line | Inflammasomes - metabolism | Endoribonucleases - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Mice, Inbred C57BL | DNA Primers - genetics | Blotting, Western | Animals | Carrier Proteins - metabolism | Flow Cytometry | Interleukin-1beta - metabolism | Thioredoxins - metabolism | Mice | Apoptosis - physiology | Real-Time Polymerase Chain Reaction | Unfolded Protein Response - physiology | Protein-Serine-Threonine Kinases - metabolism | Endoplasmic Reticulum Stress - physiology | Index Medicus
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