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Blood, ISSN 0006-4971, 04/2017, Volume 129, Issue 17, pp. 2420 - 2428
The endoplasmic reticulum kinase inositol-requiring enzyme 1 (IRE1) and its downstream target X-box-binding protein 1 (XBP1) drive B-cell differentiation... 
GERMINAL CENTER FORMATION | MULTIPLE-MYELOMA | B-CELL LYMPHOMA | UNFOLDED-PROTEIN RESPONSE | TRANSCRIPTION FACTOR XBP-1 | CERVICAL-CANCER | ENDOPLASMIC-RETICULUM STRESS | BIVALENT PROMOTERS | DIFFERENTIATION | HEMATOLOGY | METHYLTRANSFERASE EZH2 | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | RNA, Messenger - immunology | Endoribonucleases - genetics | Cell Proliferation | Epigenesis, Genetic | Germinal Center - immunology | Humans | Gene Expression Regulation, Neoplastic | X-Box Binding Protein 1 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Mice, 129 Strain | Plasma Cells - pathology | Lymphoma, Large B-Cell, Diffuse - therapy | RNA, Messenger - antagonists & inhibitors | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lymphoma, Large B-Cell, Diffuse - immunology | Cell Differentiation | B-Lymphocytes - pathology | Promoter Regions, Genetic | Enhancer of Zeste Homolog 2 Protein - genetics | X-Box Binding Protein 1 - immunology | Histones - immunology | Lymphoma, Large B-Cell, Diffuse - pathology | Signal Transduction | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Germinal Center - pathology | Indazoles - pharmacology | Xenograft Model Antitumor Assays | Leupeptins - pharmacology | Animals | B-Lymphocytes - immunology | Histones - genetics | Enhancer of Zeste Homolog 2 Protein - immunology | Cell Line, Tumor | Protein-Serine-Threonine Kinases - immunology | Mice | Lymphoma, Large B-Cell, Diffuse - genetics | X-Box Binding Protein 1 - genetics | Pyridones - pharmacology | Endoribonucleases - immunology | Plasma Cells - immunology
Journal Article
Cellular Signalling, ISSN 0898-6568, 02/2014, Volume 26, Issue 2, pp. 287 - 294
Apoptosis triggered by endoplasmic reticulum (ER) stress is associated with rapid attenuation of the IRE1α and ATF6 pathways but persistent activation of the... 
UPR | Melanoma | ERK | Endoplasmic reticulum stress | CANCER-CELLS | ACTIVATION | INDUCED APOPTOSIS | GRP78 | DEATH | ENDOPLASMIC-RETICULUM STRESS | CELL BIOLOGY | UNFOLDED PROTEIN RESPONSE | INHIBITION | RESISTANCE | UP-REGULATION | Endoribonucleases - genetics | eIF-2 Kinase - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Endoribonucleases - antagonists & inhibitors | Activating Transcription Factor 6 - genetics | Mitogen-Activated Protein Kinase 1 - genetics | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Eukaryotic Initiation Factor-2 - metabolism | Protein-Serine-Threonine Kinases - metabolism | Thapsigargin - toxicity | Eukaryotic Initiation Factor-2 - antagonists & inhibitors | Melanoma - metabolism | Tunicamycin - toxicity | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Melanoma - pathology | Unfolded Protein Response | Activating Transcription Factor 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Eukaryotic Initiation Factor-2 - genetics | Cell Line, Tumor | Activating Transcription Factor 6 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Stress (Physiology) | Stresses | Deregulation | Pathways | Attenuation | Activation | Endoplasmic reticulum | Survival | Apoptosis
Journal Article
Proceedings of the National Academy of Sciences, ISSN 0027-8424, 04/2012, Volume 109, Issue 15, pp. E869 - E878
IRE1 couples endoplasmic reticulum unfolded protein load to RNA cleavage events that culminate in the sequence-specific splicing of the Xbp1 mRNA and in the... 
High-throughput screening | 8-formyl-umbelliferone | Aldehydes | Reversible covalent inhibitor | Unfolded protein response | reversible covalent inhibitor | ACTIVATION | UNFOLDED-PROTEIN RESPONSE | ER-STRESS | MULTIDISCIPLINARY SCIENCES | high-throughput screening | KINASE | IRE1-ALPHA | TRANSCRIPTION FACTOR XBP-1 | ENDOPLASMIC-RETICULUM STRESS | CELL-SURVIVAL | unfolded protein response | aldehydes | IRE1 | TRANSMEMBRANE PROTEIN | Humans | Coumarins - chemistry | Endoribonucleases - antagonists & inhibitors | RNA, Messenger - metabolism | Ribonucleases - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Ribonucleases - antagonists & inhibitors | Proteolysis - drug effects | Protein Binding - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Lysine - metabolism | Membrane Proteins - metabolism | Binding Sites | Protein-Serine-Threonine Kinases - metabolism | RNA Splicing - drug effects | Endoribonucleases - metabolism | RNA, Messenger - genetics | Regulatory Factor X Transcription Factors | Coumarins - pharmacology | Transcription Factors - metabolism | Secretory Pathway - drug effects | Animals | Membrane Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress | Schiff Bases - chemistry | Mice | Schiff Bases - metabolism | Biological Sciences | PNAS Plus
Journal Article
Cell Metabolism, ISSN 1550-4131, 10/2012, Volume 16, Issue 4, pp. 487 - 499
Journal Article
Cell, ISSN 0092-8674, 07/2014, Volume 158, Issue 3, pp. 534 - 548
Journal Article
Cellular Signalling, ISSN 0898-6568, 02/2014, Volume 26, Issue 2, pp. 332 - 342
As we previously reported, transcription factor XBP1S enhances BMP2-induced chondrocyte differentiation and acts as a positive mediator of chondrocyte... 
Cartilage | X-box binding protein 1 spliced form | Osteoarthritis | Endoplasmic reticulum stress | Apoptosis | ACTIVATION | P204 PROTEIN | ENDOPLASMIC-RETICULUM STRESS | CELL-DEATH | CELL BIOLOGY | SODIUM FERULATE | PATHWAY | NITRIC-OXIDE | DEGRADATION | CHONDROCYTE APOPTOSIS | EXPRESSION | Endoribonucleases - genetics | Interleukin-1beta - pharmacology | Apoptosis - drug effects | Humans | Middle Aged | Transcriptional Activation - drug effects | Cartilage - drug effects | Endoribonucleases - antagonists & inhibitors | Activating Transcription Factor 6 - genetics | Osteoarthritis - physiopathology | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Cell Line | Promoter Regions, Genetic | DNA-Binding Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Protein-Serine-Threonine Kinases - genetics | Osteoarthritis - metabolism | Transcription Factors - antagonists & inhibitors | Up-Regulation - genetics | Transcription Factors - genetics | Cartilage - metabolism | DNA-Binding Proteins - genetics | Cartilage - physiopathology | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Up-Regulation - drug effects | Tumor Necrosis Factor-alpha - pharmacology | Activating Transcription Factor 6 - metabolism | Protein Binding | Activating Transcription Factor 6 - antagonists & inhibitors | Aged | RNA, Small Interfering - metabolism | Bone morphogenetic proteins | Gene expression
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2014, Volume 124, Issue 6, pp. 2585 - 2598
Activation of the ER stress response is associated with malignant progression of B cell chronic lymphocytic leukemia (CLL). We developed a murine CLL model... 
SELECTIVE-INHIBITION | MULTIPLE-MYELOMA | MEDICINE, RESEARCH & EXPERIMENTAL | IN-VITRO | UNFOLDED PROTEIN RESPONSE | TCL1 | MESSENGER-RNA | TRANSGENIC MOUSE | CHRONIC LYMPHOCYTIC-LEUKEMIA | ENDOPLASMIC-RETICULUM | TARGETING BTK | Endoribonucleases - genetics | Apoptosis - drug effects | Humans | Transcription Factors - deficiency | Endoribonucleases - antagonists & inhibitors | DNA-Binding Proteins - deficiency | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Enzyme Inhibitors - chemistry | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - metabolism | Pyrazoles - pharmacology | Cell Survival - drug effects | DNA-Binding Proteins - antagonists & inhibitors | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - antagonists & inhibitors | Pyrimidines - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Mice, Knockout | Transcription Factors - metabolism | Animals | Signal Transduction - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Cell Line, Tumor | Mice | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Care and treatment | Lymphocytic leukemia | Cancer cells | Development and progression | Genetic aspects | Cellular signal transduction | Gene expression | Leukemia | Rodents | Phenols | Kinases | Stress response | Drug dosages | Immune system | Apoptosis
Journal Article
Cancer Letters, ISSN 0304-3835, 2008, Volume 274, Issue 1, pp. 40 - 46
Abstract We studied potential interactions between the endoplasmic reticulum (ER) stress response and the MEK/ERK pathway. Induction of ER stress did not... 
Hematology, Oncology and Palliative Medicine | ER stress | GRP78 | Gastric cancer | MEK/ERK | Apoptosis | PATHWAYS | TRANSCRIPTION | MITOCHONDRIA | DEATH | ENDOPLASMIC-RETICULUM STRESS | INDUCTION | CYTOCHROME-C | UNFOLDED PROTEIN RESPONSE | ONCOLOGY | MELANOMA-CELLS | EXPRESSION | Up-Regulation | Endoribonucleases - genetics | Adenocarcinoma - pathology | Molecular Chaperones - metabolism | eIF-2 Kinase - metabolism | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Stomach Neoplasms - metabolism | Stomach Neoplasms - pathology | Endoribonucleases - antagonists & inhibitors | Membrane Potential, Mitochondrial - drug effects | Activating Transcription Factor 6 - genetics | MAP Kinase Kinase 1 - genetics | Adenocarcinoma - metabolism | Caspases - metabolism | Endoplasmic Reticulum - drug effects | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Adenocarcinoma - genetics | Tumor Cells, Cultured | Protein-Serine-Threonine Kinases - metabolism | eIF-2 Kinase - genetics | Stomach Neoplasms - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Antiviral Agents - pharmacology | Endoribonucleases - metabolism | Heat-Shock Proteins - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | RNA, Small Interfering - pharmacology | Enzyme Inhibitors - pharmacology | Protein-Serine-Threonine Kinases - genetics | MAP Kinase Kinase 1 - metabolism | Blotting, Western | eIF-2 Kinase - antagonists & inhibitors | Activating Transcription Factor 6 - metabolism | Mitogen-Activated Protein Kinase 3 - metabolism | Tunicamycin - pharmacology | Thapsigargin - pharmacology | Activating Transcription Factor 6 - antagonists & inhibitors | Mitogen-Activated Protein Kinase 1 - metabolism | Kinases | Protein folding | Stress
Journal Article
Journal Article
Cellular Signalling, ISSN 0898-6568, 11/2012, Volume 24, Issue 11, pp. 2123 - 2131
Major diseases such as cardiovascular diseases, rheumatoid arthritis, diabetes, obesity and tumor growth are known to involve inflammation. Inflammatory... 
ER stress | Angiogenesis | MCPIP | Autophagy | ROS | NADPH OXIDASE | CELLS | MCP-1 | CELL BIOLOGY | CHEMOKINE RECEPTOR-2 | CARDIOVASCULAR-DISEASE | NITRIC-OXIDE | CHEMOATTRACTANT PROTEIN-1 | TRANSCRIPTION FACTOR | TUMOR-GROWTH | ENDOTHELIAL GROWTH-FACTOR | Human Umbilical Vein Endothelial Cells | Tumor Necrosis Factor-alpha - metabolism | Reactive Oxygen Species - metabolism | Humans | Endoribonucleases - antagonists & inhibitors | Autophagy - drug effects | Anti-Inflammatory Agents, Non-Steroidal - pharmacology | Taurochenodeoxycholic Acid - pharmacology | RNA Interference | Interleukin-1beta - metabolism | Acetophenones - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Chemokine CCL2 - metabolism | Membrane Proteins - metabolism | Interleukin-8 - metabolism | Chromones - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Beclin-1 | Antiviral Agents - pharmacology | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Ribonucleases | Transcription Factors - genetics | Apoptosis Regulatory Proteins - metabolism | Transcription Factors - metabolism | Membrane Proteins - antagonists & inhibitors | Apoptosis Regulatory Proteins - antagonists & inhibitors | Oxidative Stress - drug effects | Neovascularization, Physiologic | RNA, Small Interfering - metabolism | Oxidases | Oxidative stress | Rheumatoid factor | Chemical inhibitors | Proteins | Stresses | Inhibitors | Inhibition | Differentiation | Endoplasmic reticulum | Zinc | Diseases
Journal Article
Cell Death and Disease, ISSN 2041-4889, 04/2013, Volume 4, Issue 4, pp. e604 - e604
Sustained endoplasmic reticulum (ER) stress has been linked to cell death and the pathogenesis of many liver diseases, including toxic liver, cholestasis, and... 
GRP78 | ATF6 | Bile acid | MiR-199a-5p | Endoplasmic reticulum stress | SURVIVAL | APOPTOSIS | ACTIVATION | miR-199a-5p | bile acid | ER STRESS | DOWN-REGULATION | CELL-PROLIFERATION | MICRORNAS | IDENTIFICATION | endoplasmic reticulum stress | CELL BIOLOGY | HEPATOCELLULAR-CARCINOMA | LIVER | Endoribonucleases - genetics | Bile Acids and Salts - pharmacology | Humans | MicroRNAs - metabolism | Endoribonucleases - antagonists & inhibitors | Hepatocytes - metabolism | RNA, Messenger - metabolism | Activating Transcription Factor 6 - genetics | Transcription Factor AP-1 - metabolism | Heat-Shock Proteins - genetics | DEAD-box RNA Helicases - antagonists & inhibitors | HEK293 Cells | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | 3' Untranslated Regions | DEAD-box RNA Helicases - metabolism | Hepatocytes - drug effects | Protein-Serine-Threonine Kinases - metabolism | Ribonuclease III - genetics | Ribonuclease III - metabolism | Endoplasmic Reticulum Stress - drug effects | Endoribonucleases - metabolism | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Cells, Cultured | Protein-Serine-Threonine Kinases - genetics | Ribonuclease III - antagonists & inhibitors | DEAD-box RNA Helicases - genetics | Activating Transcription Factor 6 - metabolism | Animals | Thapsigargin - pharmacology | Activating Transcription Factor 6 - antagonists & inhibitors | Mice | Apoptosis | Original
Journal Article