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eLife, ISSN 2050-084X, 12/2018, Volume 7
Replication-dependent (RD) core histone mRNA produced during S-phase is the only known metazoan protein-coding mRNA presenting a 3'stem-loop instead of the... 
endoribonuclease | cell biology | histone pre-mRNA 3' end processing | chromosomes | metallo β-lactamase | S-phase | human | gene expression | MBL domain containing protein 1 | COMPLEX | PROTEIN | METALLO-BETA-LACTAMASE | BIOLOGY | 3'-END MATURATION | POLYADENYLATION FACTOR CPSF-73 | CELL-CYCLE | CLEAVAGE | POLY(A) | FAMILY | REVEALS | Endoribonucleases - chemistry | Endoribonucleases - genetics | Humans | Histones - biosynthesis | Substrate Specificity | Crystallography, X-Ray | S Phase Cell Cycle Checkpoints | RNA, Messenger - biosynthesis | beta-Lactamases - genetics | Cloning, Molecular | Escherichia coli - metabolism | HEK293 Cells | Protein Interaction Domains and Motifs | beta-Lactamases - metabolism | Binding Sites | Recombinant Proteins - metabolism | Amino Acid Sequence | Protein Conformation, alpha-Helical | Gene Expression | Mutagenesis, Site-Directed | Endoribonucleases - metabolism | Genetic Vectors - chemistry | RNA, Messenger - genetics | Genetic Vectors - metabolism | Models, Molecular | Recombinant Proteins - chemistry | Recombinant Proteins - genetics | Sequence Homology, Amino Acid | beta-Lactamases - chemistry | Sequence Alignment | Histones - genetics | Protein Conformation, beta-Strand | Escherichia coli - genetics | Protein Binding | HeLa Cells | Kinetics | Physiological aspects | Biosynthesis | Messenger RNA | Observations | CRISPR | Enzymes | Cloning | Cyclin-dependent kinases | mRNA | Kinases | Proteins | E coli | Polyadenylation | Cell cycle | Endonuclease | Deoxyribonucleic acid--DNA | Cancer | Index Medicus
Journal Article
American Journal of Physiology - Endocrinology And Metabolism, ISSN 0193-1849, 08/2008, Volume 295, Issue 2, pp. 393 - 400
Obesity and elevated cytokine secretion result in a chronic inflammatory state and may cause the insulin resistance observed in type 2 diabetes. Recent studies... 
Type 2 diabetes | Obesity | Insulin sensitivity | Thiazolidinediones | Fatty acid | thiazolidinediones | APOPTOSIS | OXIDATIVE STRESS | PHYSIOLOGY | ER STRESS | fatty acid | insulin sensitivity | type 2 diabetes | UNFOLDED PROTEIN RESPONSE | ADIPONECTIN | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | GENE-EXPRESSION | HEPG2 CELLS | obesity | Transcription Factor CHOP - genetics | Endoribonucleases - genetics | Humans | Middle Aged | Stress, Physiological - drug therapy | Endoplasmic Reticulum - metabolism | Heat-Shock Proteins - biosynthesis | Male | Activating Transcription Factor 6 - genetics | X-Box Binding Protein 1 | Activating Transcription Factor 6 - biosynthesis | Heat-Shock Proteins - genetics | RNA, Messenger - biosynthesis | Subcutaneous Fat - metabolism | Endoplasmic Reticulum - drug effects | Stress, Physiological - metabolism | Subcutaneous Fat - drug effects | Adult | Female | Transcription Factor CHOP - biosynthesis | Thiazolidinediones - pharmacology | Molecular Chaperones - biosynthesis | eIF-2 Kinase - genetics | Cell Line | RNA, Messenger - genetics | eIF-2 Kinase - biosynthesis | Molecular Chaperones - genetics | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Endoribonucleases - biosynthesis | Reverse Transcriptase Polymerase Chain Reaction | Regulatory Factor X Transcription Factors | Hypoglycemic Agents - pharmacology | Protein-Serine-Threonine Kinases - biosynthesis | Aged | DNA-Binding Proteins - biosynthesis | Studies | Cytokines | Rodents | Diabetes | Cells | Endocrinology | Index Medicus
Journal Article
Toxicology Letters, ISSN 0378-4274, 01/2014, Volume 224, Issue 3, pp. 341 - 348
Journal Article
Toxicology Letters, ISSN 0378-4274, 12/2009, Volume 191, Issue 2-3, pp. 203 - 210
Journal Article
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2001, Volume 98, Issue 17, pp. 9742 - 9747
Short interfering RNAs (siRNAs) are double-stranded RNAs of ≈21-25 nucleotides that have been shown to function as key intermediaries in triggering... 
Biological Sciences | Double stranded RNA | Transfection | Delta cells | RNA | Somatic cells | Cell lines | Small interfering RNA | HeLa cells | Nucleotides | Gene expression | ZEBRAFISH | MESSENGER-RNA | GERM-LINE | MULTIDISCIPLINARY SCIENCES | DROSOPHILA CELLS | POLYMERASE | DEPENDENT PROTEIN-KINASE | DEGRADATION | C-ELEGANS | INTERFERENCE | TRANSGENE | Mammals - genetics | Green Fluorescent Proteins | Phosphorylation | Gene Silencing - drug effects | Species Specificity | Vertebrates - genetics | Humans | HeLa Cells - metabolism | Chloramphenicol O-Acetyltransferase - genetics | RNA, Antisense - pharmacology | Luminescent Proteins - biosynthesis | Muscle Proteins - biosynthesis | Cell Death | RNA, Helminth - physiology | Genes, Reporter | Calmodulin-Binding Proteins - genetics | Recombinant Fusion Proteins - biosynthesis | Caenorhabditis elegans Proteins | Cells, Cultured - drug effects | Caenorhabditis elegans - metabolism | Endoribonucleases - metabolism | Caenorhabditis elegans - genetics | RNA, Antisense - chemical synthesis | RNA, Double-Stranded - physiology | Helminth Proteins - biosynthesis | Invertebrates - genetics | Helminth Proteins - genetics | HeLa Cells - drug effects | Muscle Proteins - genetics | Animals | Calmodulin-Binding Proteins - biosynthesis | Ribonuclease III | RNA, Double-Stranded - pharmacology | Luminescent Proteins - genetics | Cells, Cultured - metabolism | Mice | Chloramphenicol O-Acetyltransferase - biosynthesis | Gene Silencing - physiology | Physiological aspects | Caenorhabditis elegans | Genetic aspects | Invertebrates | Vertebrates | Genetics | Ribonucleic acid--RNA | Genes | Ribonucleic acid | siRNAs | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2010, Volume 285, Issue 45, pp. 34718 - 34728
To understand the role of microRNAs (miRNAs) in pituitary development, a group of pituitary-specific miRNAs were identified, and Dicer1 was then conditionally... 
MORPHOGENESIS | ACTIVATION | DOMAIN | INTERACT | BIOCHEMISTRY & MOLECULAR BIOLOGY | GENE-EXPRESSION | SECRETION | BETA-CATENIN | PITX2 | REPRESSORS | PROMOTER | Prolactin - biosynthesis | Thyrotropin, beta Subunit - genetics | Endoribonucleases - genetics | Homeodomain Proteins - metabolism | Lymphoid Enhancer-Binding Factor 1 - genetics | Prolactin - genetics | Pituitary Gland, Anterior - growth & development | Transcription Factor Pit-1 - genetics | Mice, Mutant Strains | Pituitary Gland, Anterior - embryology | DEAD-box RNA Helicases - metabolism | Pro-Opiomelanocortin - genetics | Cell Differentiation - physiology | Gene Expression Regulation, Developmental - physiology | Cell Line | Transcription Factor Pit-1 - biosynthesis | Endoribonucleases - metabolism | Thyrotropin, beta Subunit - biosynthesis | Mice, Transgenic | MicroRNAs - biosynthesis | Transcription Factors - genetics | Lymphoid Enhancer-Binding Factor 1 - metabolism | Homeodomain Proteins - genetics | Cell Lineage - physiology | Transcription Factors - metabolism | DEAD-box RNA Helicases - genetics | Animals | Growth Disorders - metabolism | Promoter Regions, Genetic - physiology | Luteinizing Hormone, beta Subunit - genetics | Ribonuclease III | Pro-Opiomelanocortin - biosynthesis | Mice | MicroRNAs - genetics | Growth Disorders - genetics | Luteinizing Hormone, beta Subunit - biosynthesis | Index Medicus | Gene Regulation | Wnt Signaling | Transcription Regulation | MicroRNA | Pit-1 | Antisense RNA | RNA Silencing | Pituitary Gland | Pitx2 | Lef-1
Journal Article
PLoS Pathogens, ISSN 1553-7366, 08/2013, Volume 9, Issue 8, pp. e1003544 - e1003544
During viral infection, a massive demand for viral glycoproteins can overwhelm the capacity of the protein folding and quality control machinery, leading to an... 
BAX-DEPENDENT APOPTOSIS | ER STRESS | MICROBIOLOGY | ENDOPLASMIC-RETICULUM STRESS | MUTATIONAL ANALYSIS | ACTIVATES PERK | JNK PHOSPHORYLATION | VIROLOGY | HEPATITIS-C VIRUS | MESSENGER-RNA | GENE-EXPRESSION | PARASITOLOGY | SENSOR IRE1-ALPHA | NIH 3T3 Cells | Endoribonucleases - genetics | Humans | Cytomegalovirus Infections - metabolism | Cytomegalovirus Infections - genetics | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Viral Structural Proteins - genetics | Cytomegalovirus - genetics | Membrane Proteins - genetics | Cytomegalovirus - metabolism | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Endoribonucleases - biosynthesis | Unfolded Protein Response | Regulatory Factor X Transcription Factors | Down-Regulation - genetics | Muromegalovirus - metabolism | Protein-Serine-Threonine Kinases - biosynthesis | Transcription Factors - metabolism | Membrane Proteins - biosynthesis | Animals | Mice | Muromegalovirus - genetics | Viral Structural Proteins - metabolism | Cell Line, Transformed | Physiological aspects | Host-parasite relationships | Research | Cytomegaloviruses | Protein folding | Health aspects | Index Medicus | Enzymes | Cytomegalovirus | Protein synthesis | Plasmids | Homeostasis | Sensors | Kinases | Endoplasmic reticulum | Viral infections
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 11/2013, Volume 288, Issue 46, pp. 33272 - 33282
Background: IRE1 is a kinase important for the misfolded protein response. Results: IRE1 promotes IL-4 production by stabilizing IL-4 mRNA, and IRE1-specific... 
ACTIVATION | TH2 CELLS | Signal Transduction | BIOCHEMISTRY & MOLECULAR BIOLOGY | Cytokine | STRESS-RESPONSE | IL-4 | T Cell Differentiation | UNFOLDED PROTEIN RESPONSE | ER Stress | MESSENGER-RNA | IRE1 | GENE-EXPRESSION | C-THETA | ENDOPLASMIC-RETICULUM | DIFFERENTIATION | T Cell Biology | Lymphocyte | GATA3 Transcription Factor - genetics | RNA Stability - immunology | CD8-Positive T-Lymphocytes - cytology | RNA, Messenger - immunology | Endoribonucleases - genetics | GATA3 Transcription Factor - immunology | Interleukin-13 - immunology | Th2 Cells - immunology | Interleukin-5 - biosynthesis | Interleukin-5 - genetics | Interleukin-13 - biosynthesis | Cell Differentiation - genetics | RNA, Messenger - biosynthesis | Interleukin-13 - genetics | Interleukin-4 - biosynthesis | CD8-Positive T-Lymphocytes - metabolism | Interleukin-4 - genetics | GATA3 Transcription Factor - metabolism | RNA, Messenger - genetics | Protein-Serine-Threonine Kinases - genetics | Th2 Cells - cytology | Up-Regulation - genetics | Endoribonucleases - biosynthesis | Th2 Cells - metabolism | Mice, Knockout | Interleukin-5 - immunology | Protein-Serine-Threonine Kinases - biosynthesis | Cell Differentiation - immunology | Interleukin-4 - immunology | Animals | Up-Regulation - immunology | Protein-Serine-Threonine Kinases - immunology | Mice | CD8-Positive T-Lymphocytes - immunology | Endoribonucleases - immunology | Index Medicus | Immunology
Journal Article
Journal Article
Oncology Reports, ISSN 1021-335X, 6/2015, Volume 33, Issue 6, pp. 3006 - 3014
Sorafenib is one of the preferred drugs for the treatment of advanced primary hepatocellular carcinoma (HCC). However, its side-effects and acquired resistance... 
receptor for activated C kinase 1 | unfolded protein response | chemotherapy | X-box binding protein 1 | hepatocellular carcinoma | inositol-requiring enzyme 1 | Receptor for activated C kinase 1 | Hepatocellular carcinoma | Inositol-requiring enzyme 1 | Chemotherapy | Unfolded protein response | ACTIVATION | BAY-43-9006 | ER STRESS | RECEPTOR | FATE | RAF/MEK/ERK PATHWAY | HEPATOCELLULAR-CARCINOMA | ONCOLOGY | IRE1 | PROMOTES | Niacinamide - analogs & derivatives | Endoribonucleases - genetics | Apoptosis - drug effects | Humans | GTP-Binding Proteins - genetics | X-Box Binding Protein 1 | Carcinoma, Hepatocellular - drug therapy | Carcinoma, Hepatocellular - genetics | Receptors for Activated C Kinase | Liver Neoplasms - pathology | Receptors, Cell Surface - biosynthesis | Gene Expression Regulation, Neoplastic - drug effects | Phosphorylation - drug effects | Neoplasm Proteins - genetics | Liver Neoplasms - genetics | Unfolded Protein Response - genetics | Neoplasm Proteins - biosynthesis | Liver Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - biosynthesis | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Endoribonucleases - biosynthesis | Regulatory Factor X Transcription Factors | Niacinamide - administration & dosage | Protein-Serine-Threonine Kinases - biosynthesis | Animals | Phenylurea Compounds - administration & dosage | Signal Transduction - drug effects | Carcinoma, Hepatocellular - pathology | Cell Line, Tumor | GTP-Binding Proteins - biosynthesis | DNA-Binding Proteins - biosynthesis | Receptors, Cell Surface - genetics | Enzymes | Care and treatment | Development and progression | Genetic aspects | Regulation | Hepatoma | Phosphotransferases | Health aspects | Studies | Proteins | Signal transduction | Liver cancer | Cell growth | Medical prognosis | Kinases | Cancer therapies | Tumors | Apoptosis | Index Medicus
Journal Article
Journal Article