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Journal of Molecular Biology, ISSN 0022-2836, 2002, Volume 316, Issue 3, pp. 769 - 787
Vascular endothelial growth factor (VEGF) is a potent endothelial cell-specific mediator of angiogenesis and vasculogenesis. VEGF is involved pathologically in... 
protein structure | NMR | angiogenesis | vascular endothelial growth factor | peptide antagonist | Angiogenesis | Peptide antagonist | Protein structure | Vascular endothelial growth factor | MOLECULAR-DYNAMICS | TRIPLE-RESONANCE EXPERIMENTS | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROTEIN-STRUCTURE DETERMINATION | RECEPTOR-BINDING DOMAIN | BIOACTIVE CONFORMATION | ANGSTROM RESOLUTION | DE-NOVO DESIGN | IMPROVED SENSITIVITY | INTERPROTON DISTANCE RESTRAINTS | Disulfides - metabolism | Receptors, Vascular Endothelial Growth Factor | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | Vascular Endothelial Growth Factors | Humans | Molecular Sequence Data | Receptors, Growth Factor - antagonists & inhibitors | Crystallography, X-Ray | Endothelial Growth Factors - chemistry | Proto-Oncogene Proteins - chemistry | Vascular Endothelial Growth Factor Receptor-1 | Lymphokines - genetics | Peptides - chemical synthesis | Peptides - metabolism | Alanine - genetics | Solutions | Lymphokines - antagonists & inhibitors | Protein Structure, Quaternary | Lymphokines - metabolism | Nuclear Magnetic Resonance, Biomolecular | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Binding Sites | Dimerization | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Amino Acid Sequence | Proto-Oncogene Proteins - antagonists & inhibitors | Bacteriophages - chemistry | Peptides - chemistry | Protein Structure, Secondary | Models, Molecular | Alanine - metabolism | Mutation - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Receptors, Growth Factor - chemistry | Peptides - pharmacology | Endothelial Growth Factors - antagonists & inhibitors | Lymphokines - chemistry | Endothelial Growth Factors - genetics | Hydrophobic and Hydrophilic Interactions | Receptor Protein-Tyrosine Kinases - chemistry | Receptors, Growth Factor - metabolism | Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, pp. e33418 - e33418
Switching to a glycolytic metabolism is a rapid adaptation of tumor cells to hypoxia. Although this metabolic conversion may primarily represent a rescue... 
OXYGEN | AUTOCRINE LOOP | METABOLISM | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | AEROBIC GLYCOLYSIS | GENE-EXPRESSION | GROWTH-FACTOR | HIF-1-ALPHA | CANCER | HYPOXIA-INDUCIBLE FACTOR-1 | Immunohistochemistry | RNA, Small Interfering - genetics | Enzyme-Linked Immunosorbent Assay | Endothelial Cells - metabolism | Humans | Lactic Acid - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Neoplasms - blood supply | Hypoxia-Inducible Factor 1 - metabolism | Blotting, Western | Cell Movement - physiology | Symporters - metabolism | Fibroblast Growth Factors - metabolism | Monocarboxylic Acid Transporters - metabolism | Animals | Analysis of Variance | RNA Interference | Luciferases | Polymerase Chain Reaction | Nuclear Magnetic Resonance, Biomolecular | Mice | Neovascularization, Pathologic - metabolism | Lactic Acid - pharmacology | Endothelial Cells - physiology | Physiological aspects | Fibroblast growth factors | Vascular endothelial growth factor | Tumors | Endothelium | Fibroblast growth factor | Hypoxia-inducible factor 1 | Nuclear magnetic resonance--NMR | Leukocyte migration | Activation | Angiogenesis | Rodents | Oxidation | Inhibition | Vascular endothelial growth factor receptor 2 | Hypoxia-inducible factors | Fibroblast growth factor 2 | Tumor cells | Metabolism | Endothelial cells | Microscopy | Nitric oxide | Glycolysis | Hypoxia | Lactic acid | Transporter | Cell migration | Cancer | Index Medicus | Nuclear magnetic resonance | NMR
Journal Article
Nature, ISSN 0028-0836, 05/2017, Volume 545, Issue 7653, pp. 224 - 241
Blood and lymphatic vasculatures are intimately involved in tissue oxygenation and fluid homeostasis maintenance. Assembly of these vascular networks involves... 
GENE-EXPRESSION DATA | MAINTENANCE | MULTIDISCIPLINARY SCIENCES | MOUSE | LYMPHANGIOGENESIS | ENDOTHELIAL-CELL METABOLISM | MECHANISMS | GROWTH-FACTOR | Receptor, Fibroblast Growth Factor, Type 3 - genetics | Cell Proliferation | Lymphatic Vessels - cytology | Signal Transduction | Endothelial Cells - metabolism | Mice, Inbred C57BL | Receptor, Fibroblast Growth Factor, Type 1 - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - genetics | Proto-Oncogene Proteins c-myc - metabolism | Receptor, Fibroblast Growth Factor, Type 3 - metabolism | Fibroblast Growth Factors - metabolism | Receptor, Fibroblast Growth Factor, Type 1 - deficiency | Lymphatic Vessels - metabolism | Animals | Receptor, Fibroblast Growth Factor, Type 3 - deficiency | Endothelial Cells - cytology | Glycolysis | Female | Mice | Hexokinase - metabolism | Lymphangiogenesis | Neovascularization, Physiologic | Cell Movement | Fibroblast growth factors | Metabolism | Observations | Health aspects | Cell proliferation | Fibroblast growth factor | Leukocyte migration | c-Myc protein | Homeostasis | Biology | Myc protein | Kinases | Blood | Defects | Angiogenesis | Control | Cell growth | Metabolites | Rodents | Fibroblast growth factor receptor 1 | Vascular endothelial growth factor | Growth factors | Medical research | Enzymes | Grants | Hexokinase | Endothelial cells | Endothelium | Signaling | Oxygenation | Cell migration | Fibroblast growth factor receptors | Index Medicus
Journal Article
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 10/2002, Volume 277, Issue 41, pp. 38205 - 38211
Stimulation of human colon cancer cells with insulin-like growth factor 1 (IGF-1) induces expression of the VEGF gene, encoding vascular endothelial growth... 
FACTOR 1-ALPHA HIF-1-ALPHA | CAP-BINDING PROTEIN | TRANSCRIPTIONAL ACTIVITY | ACTIVATED PROTEIN-KINASE | PROLYL HYDROXYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | IN-VIVO | TUMOR-SUPPRESSOR PROTEIN | TRANSLATION INITIATION | UP-REGULATION | HIF-ALPHA | Vascular Endothelial Growth Factor A | Endothelial Growth Factors - metabolism | MAP Kinase Signaling System - physiology | Protein-Tyrosine Kinases - metabolism | Vascular Endothelial Growth Factors | Humans | Ubiquitin - metabolism | Eukaryotic Initiation Factor-4E - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Phosphoproteins - metabolism | MAP Kinase Kinase 2 | Colonic Neoplasms - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit | Hypoxia - metabolism | Intercellular Signaling Peptides and Proteins - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Lymphokines - genetics | Lymphokines - metabolism | Repressor Proteins - metabolism | Enzyme Inhibitors - metabolism | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Gene Expression Regulation | Intercellular Signaling Peptides and Proteins - genetics | Transcription Factors - genetics | Transcription Factors - metabolism | Adaptor Proteins, Signal Transducing | Animals | Carrier Proteins - metabolism | Endothelial Growth Factors - genetics | Carcinoma - metabolism | Insulin-Like Growth Factor I - metabolism | Index Medicus
Journal Article
Journal of Cellular Physiology, ISSN 0021-9541, 09/2007, Volume 212, Issue 3, pp. 702 - 709
Adipose tissue serves as a source of adipokines and cytokines with both local and systemic actions in health and disease. In this study, we examine the... 
BREAST-CANCER | TUMOR-NECROSIS-FACTOR | IN-VITRO | PHYSIOLOGY | TEMPORAL-CHANGES | MURINE BONE-MARROW | INSULIN-RESISTANCE | HEPATOCYTE GROWTH-FACTOR | ENDOTHELIAL-CELLS | TISSUE | STROMAL CELLS | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Angiogenic Proteins - genetics | Cell Proliferation | Granulocyte-Macrophage Colony-Stimulating Factor - metabolism | Coculture Techniques | Humans | Middle Aged | Multipotent Stem Cells - metabolism | Adipose Tissue - cytology | RNA, Messenger - metabolism | Hematopoiesis - drug effects | Adipose Tissue - metabolism | Multipotent Stem Cells - drug effects | Time Factors | Inflammation Mediators - metabolism | Fibroblast Growth Factor 2 - metabolism | Adult | Female | Cell Differentiation | Interleukin-8 - metabolism | Cytokines - genetics | Interleukin-6 - metabolism | Granulocyte Colony-Stimulating Factor - metabolism | Interleukin-7 - metabolism | Adult Stem Cells - drug effects | Adult Stem Cells - cytology | Cytokines - metabolism | Paracrine Communication | Endothelial Cells - metabolism | Ascorbic Acid - analogs & derivatives | Cells, Cultured | Epidermal Growth Factor - metabolism | Interleukin-11 - metabolism | Hematopoietic Stem Cells - metabolism | Hepatocyte Growth Factor - metabolism | Adult Stem Cells - metabolism | Adipocytes - metabolism | Ascorbic Acid - pharmacology | Lipopolysaccharides - pharmacology | Adipose Tissue - drug effects | Angiogenic Proteins - metabolism | Index Medicus
Journal Article
Psychopharmacology, ISSN 0033-3158, 7/2011, Volume 216, Issue 1, pp. 75 - 84
The pharmacological actions of most antidepressants are ascribed to the modulation of serotonergic and/or noradrenergic transmission in the brain. During... 
Neurosciences | Biomedicine | Serotonin | Lactate | Antidepressants | Glycogen | Pharmacology/Toxicology | Glia | Psychiatry | Growth factors | BEHAVIORAL ACTIONS | PSYCHIATRY | ANTIDEPRESSANT TREATMENT | MAJOR DEPRESSION | SYNAPTIC PLASTICITY | NEUROSCIENCES | PREFRONTAL CORTEX | CORTICAL-NEURONS | MOOD DISORDERS | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | RAT-BRAIN | ENDOTHELIAL GROWTH-FACTOR | Animals, Newborn | Astrocytes - drug effects | Brain-Derived Neurotrophic Factor - genetics | Fluoxetine - pharmacology | Depressive Disorder, Major - metabolism | Cells, Cultured | Intercellular Signaling Peptides and Proteins - genetics | Reverse Transcriptase Polymerase Chain Reaction | Gene Expression Regulation - drug effects | Animals | Glucose - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Astrocytes - metabolism | Depressive Disorder, Major - drug therapy | Paroxetine | Brain | RNA | Fluoxetine | Depression, Mental | Glucose | Dextrose | Glucose metabolism | Imipramine | Analysis | Physiological aspects | Vascular endothelial growth factor | Health aspects | Mental depression | Psychopharmacology | Cells | Index Medicus | Astrocytes | Desipramine | Neurons | imipramine | Data processing | Depression | Serotonin uptake inhibitors | Gene expression | Neurotrophic factors | Brain-derived neurotrophic factor | paroxetine | Norepinephrine | Lactic acid | Neurotransmission
Journal Article
Journal Article
Science, ISSN 0036-8075, 11/2001, Volume 294, Issue 5548, pp. 1945 - 1948
Neurotrophins are growth factors that promote cell survival, differentiation, and cell death. They are synthesized as proforms that can be cleaved... 
Hair | Receptors | Odors | HEK293 cells | Neurons | Antibodies | Ligands | Reports | PC12 cells | Endothelial cells | Apoptosis | APOPTOSIS | COEXPRESSION | NEUROTROPHIC FACTOR | BIOSYNTHESIS | MULTIDISCIPLINARY SCIENCES | RECEPTOR | DEATH | EXPRESSION | BINDING | SMOOTH-MUSCLE CELLS | NERVE GROWTH-FACTOR | Nerve Growth Factor - secretion | Brain-Derived Neurotrophic Factor - secretion | Apoptosis - drug effects | Protein Precursors - chemistry | Humans | Protein Precursors - secretion | Neurons - cytology | Nerve Growth Factors - metabolism | Receptors, Nerve Growth Factor - metabolism | Nerve Growth Factors - pharmacology | Brain-Derived Neurotrophic Factor - pharmacology | Nerve Growth Factor - chemistry | Inhibitory Concentration 50 | Furin | Brain-Derived Neurotrophic Factor - metabolism | Subtilisins - metabolism | Cell Death - drug effects | Phosphorylation - drug effects | Neurons - drug effects | Fibrinolysin - metabolism | Cell Line | Cell Survival - drug effects | Nerve Growth Factor - metabolism | Nerve Growth Factors - secretion | Nerve Growth Factor - pharmacology | Rats | Nerve Growth Factors - chemistry | Receptor, Nerve Growth Factor | Protein Precursors - metabolism | Protein Precursors - pharmacology | Brain-Derived Neurotrophic Factor - chemistry | Animals | Receptor, trkA - metabolism | Cell Differentiation - drug effects | Mice | Protein Processing, Post-Translational | Matrix Metalloproteinases - metabolism | Growth factors | Neurotropin | Research | Brain | Nervous system | Cellular biology | Cells | matrix metalloproteinases | Index Medicus
Journal Article