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Biotechnology and Bioengineering, ISSN 0006-3592, 07/2016, Volume 113, Issue 7, pp. 1403 - 1412
ABSTRACT In the developing heart, a specific subset of endocardium undergoes an endothelial‐to‐mesenchymal transformation (EndMT) thus forming nascent valve... 
endothelial‐to‐mesenchymal transformation | microarray | high‐throughput | heart valve | High-throughput | Endothelial-to-mesenchymal transformation | Heart valve | Microarray | AORTIC-STENOSIS | IDENTIFICATION | HEART-VALVE DEVELOPMENT | endothelial-to-mesenchymal transformation | PLURIPOTENT STEM-CELLS | IN-VITRO | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | REGURGITATION | high-throughput | DISEASE | GROWTH | DIFFERENTIATION | MICROENVIRONMENTS | Intercellular Signaling Peptides and Proteins - analysis | Endothelial Cells - metabolism | Extracellular Matrix Proteins - genetics | Intercellular Signaling Peptides and Proteins - genetics | Mesenchymal Stromal Cells - metabolism | Rats | Tissue Array Analysis - methods | Extracellular Matrix Proteins - analysis | Intercellular Signaling Peptides and Proteins - metabolism | Mesenchymal Stromal Cells - cytology | Animals | Cell Transdifferentiation - physiology | Endothelial Cells - cytology | Swine | Heart Valves - cytology | Extracellular Matrix Proteins - metabolism | High-Throughput Screening Assays - methods | Fibronectins | Collagen | Stem cells | Vascular endothelial growth factor | Growth factors | Investigations | Endothelium | Heart | Bioengineering | Cellular biology | Proteins | Cellular | Electrochemical machining | Attachment | Transformations | Adults | Fibronectin | Combinatorial analysis
Journal Article
Journal Article
Circulation Research: Journal of the American Heart Association, ISSN 0009-7330, 04/2004, Volume 94, Issue 7, pp. 910 - 917
ABSTRACT—Various studies have identified a critical role for Notch signaling in cardiovascular development. In this and other systems, Notch receptors and... 
Endocardial cushion | Endothelial-to-mesenchymal transformation | Jagged1 | Notch | CARDIAC & CARDIOVASCULAR SYSTEMS | MOUSE | CUSHION TISSUE | endocardial cushion | VASCULAR ENDOTHELIUM | DEVELOPING MAMMALIAN HEART | HUMAN JAGGED1 | MICE LACKING | endothelial-to-mesenchymal transformation | IN-VITRO | ALAGILLE-SYNDROME | EMBRYONIC STEM-CELLS | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | Endothelium, Vascular - cytology | Protein Biosynthesis | Cadherins - metabolism | Humans | Recombinant Fusion Proteins - physiology | Mesoderm - cytology | Proto-Oncogene Proteins - biosynthesis | Actins - genetics | Receptors, Notch | Gene Expression Regulation, Developmental | Platelet Endothelial Cell Adhesion Molecule-1 - metabolism | Serrate-Jagged Proteins | Cell Differentiation | Receptors, Cell Surface - biosynthesis | Receptors, Cell Surface - physiology | Endocardium - cytology | Fetal Heart - metabolism | Jagged-1 Protein | Cell Line | Proteins - physiology | Actins - biosynthesis | Calcium-Binding Proteins | Transduction, Genetic | Proto-Oncogene Proteins c-sis | Intercellular Signaling Peptides and Proteins | Proto-Oncogene Proteins - genetics | Fetal Heart - ultrastructure | Platelet-Derived Growth Factor - pharmacology | Muscle, Smooth, Vascular - cytology | Membrane Proteins | Proteins - genetics | Phenotype | Animals | Endothelium, Vascular - metabolism | Proto-Oncogene Proteins - physiology | Sheep | Signal Transduction - physiology | Mice | Transcription Factors | Receptor, Notch1 | Heart Septum - embryology | Receptor, Notch4 | Antigens, CD | Receptors, Cell Surface - genetics
Journal Article
DEVELOPMENTAL BIOLOGY, ISSN 0012-1606, 11/2011, Volume 359, Issue 2, pp. 209 - 221
Cardiac valves originate from endocardial cushions (EC) formed by endothelial-to-mesenchymal transformation (EMT) during embryogenesis. The zinc-finger... 
Endocardial cushion | CELLS | COLLAGEN | E-CADHERIN EXPRESSION | DEVELOPMENTAL BIOLOGY | Snail | Heart valve | SLUG | HEART-VALVE DEVELOPMENT | INVASION | Endothelial-to-mesenchymal transformation | GENE | REPRESSION | MMP15 | EXTRACELLULAR-MATRIX | TRANSITIONS
Journal Article
Developmental Biology, ISSN 0012-1606, 11/2011, Volume 359, Issue 2, pp. 209 - 221
Journal Article
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, ISSN 1079-5642, 03/2019, Volume 39, Issue 3, pp. 467 - 481
Objective Calcific aortic valve (AV) disease, characterized by AV sclerosis and calcification, is a major cause of death in the aging population; however,... 
microRNAs | aortic valve | TARGETING HYPOXIA | BLADDER-CANCER | MATRIX | endothelial cells | STENOSIS | aortic valve stenosis | ADHESION MOLECULES | endothelial-to-mesenchymal transition | MESENCHYMAL TRANSFORMATION | SHEAR | inflammation | ubiquitination | EARLY LESION | DISEASE | CONJUGATING ENZYME E2C | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY
Journal Article
Cardiovascular Research, ISSN 0008-6363, 2015, Volume 105, Issue 3, pp. 279 - 291
Methylation of CpG island promoters is a prototypical epigenetic mechanism to stably control gene expression. The aim of this study was to elucidate the... 
Endothelial to mesenchymal transition | Rasal1 | Cardiac fibrosis | Hydroxymethylation | Methylation | Tet3 | TRANSFORMATION | CARDIAC & CARDIOVASCULAR SYSTEMS | HYPERMETHYLATION | PROTEIN | MECHANISM | MESENCHYMAL TRANSITION | FIBROBLAST ACTIVATION | CONTRIBUTES | EXPRESSION | PROGRESSION | Dioxygenases - metabolism | Epigenesis, Genetic | Humans | Heart Failure - physiopathology | ras Proteins - metabolism | Cardiomyopathies - prevention & control | GTPase-Activating Proteins - metabolism | Case-Control Studies | DNA-Binding Proteins - metabolism | Heart Failure - prevention & control | Cardiomyopathies - genetics | Cardiomyopathies - physiopathology | DNA Methylation | Transfection | RNA Interference | Time Factors | Epithelial-Mesenchymal Transition | Transcription, Genetic | Disease Models, Animal | Proto-Oncogene Proteins - metabolism | Cell Line | Promoter Regions, Genetic | Signal Transduction | Endothelial Cells - metabolism | Gene Expression Regulation | Cardiomyopathies - pathology | Heart Failure - genetics | Heart Failure - metabolism | Heart Failure - pathology | Disease Progression | Carrier Proteins - genetics | Myocytes, Cardiac - pathology | Animals | Carrier Proteins - metabolism | Myocytes, Cardiac - drug effects | Cardiomyopathies - metabolism | Fibrosis | CpG Islands | Myocytes, Cardiac - metabolism | Mice | GTPase-Activating Proteins - genetics | Endothelial Cells - pathology | Bone Morphogenetic Protein 7 - pharmacology
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 01/2015, Volume 290, Issue 5, pp. 2547 - 2559
Journal Article
Atherosclerosis, ISSN 0021-9150, 2015, Volume 242, Issue 1, pp. 251 - 260
Abstract Background Calcific aortic valve disease (CAVD) is the most common heart valve disease in the Western world. We previously proposed that valvular... 
Cardiovascular | Calcification | Endothelial-to-mesenchymal transformation | Calcific aortic valve disease | Valvular interstitial cells | Valvular endothelial cells | Research Support, Non-U.S. Gov't | Journal Article | Research Support, N.I.H., Extramural | PROGENITOR CELLS | CARDIAC-VALVE | MITRAL REGURGITATION | HEART | GROWTH-FACTOR-BETA | WORKING GROUP | IN-VITRO | ADAPTATION | PERIPHERAL VASCULAR DISEASE | EXTRACELLULAR-MATRIX | AORTIC-VALVE DISEASE | Calcinosis - genetics | Aortic Valve Stenosis - genetics | Apolipoproteins E - deficiency | Coculture Techniques | Humans | Aortic Valve - drug effects | Male | RNA, Messenger - metabolism | Culture Media - metabolism | Aortic Valve - pathology | Cell Differentiation - genetics | Time Factors | Epithelial-Mesenchymal Transition | Calcinosis - metabolism | Osteogenesis - genetics | Transforming Growth Factor beta1 - pharmacology | Disease Models, Animal | Biomarkers - metabolism | Endothelial Cells - metabolism | Osteogenesis - drug effects | Cells, Cultured | Gene Expression Regulation | Aortic Valve - metabolism | Mice, Knockout | Animals | Aortic Valve Stenosis - pathology | Cell Differentiation - drug effects | Apolipoproteins E - genetics | Cell Communication - drug effects | Aortic Valve Stenosis - metabolism | Sheep | Calcinosis - pathology | Endothelial Cells - pathology | Cell Movement | Endothelial Cells - drug effects | Stem cells | Endothelium
Journal Article