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1. Full Text Endothelin receptor antagonists
by Motte, Sophie and McEntee, Kathleen and Naeije, Robert
Pharmacology and Therapeutics, ISSN 0163-7258, 2006, Volume 110, Issue 3, pp. 386 - 414
Endothelin receptor antagonists (ERAs) have been developed to block the effects of endothelin-1 (ET-1) in a variety of cardiovascular conditions. ET-1 is a... 
Heart failure | Clinical trials | Endothelin receptor antagonist | Pulmonary hypertension | heart failure | PULMONARY ARTERIAL-HYPERTENSION | pulmonary hypertension | ACUTE CORONARY SYNDROMES | CLINICAL-TRIALS UPDATE | CONVERTING ENZYME-INHIBITION | RANDOMIZED INTRAVENOUS TEZOSENTAN | ACUTE MYOCARDIAL-INFARCTION | endothelin receptor antagonist | PHARMACOLOGY & PHARMACY | clinical trials | SMOOTH-MUSCLE-CELLS | VASOACTIVE INTESTINAL CONTRACTOR | CONGESTIVE-HEART-FAILURE | RIGHT-VENTRICULAR HYPERTROPHY | Animals | Humans | Heart Failure - metabolism | Hypertension, Pulmonary - drug therapy | Hypertension, Pulmonary - metabolism | Antihypertensive Agents - therapeutic use | Heart Failure - etiology | Hypertension, Pulmonary - etiology | Endothelin Receptor Antagonists | Heart Failure - drug therapy | Hypertension | Enzymes | Micropollutants | Endothelin | Cardiac patients | Atherosclerosis | Physiological aspects | Respiratory agents
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2. Full Text Endothelin receptor antagonists in pulmonary arterial hypertension
by Dupuis, J and Hoeper, M. M
European Respiratory Journal, ISSN 0903-1936, 02/2008, Volume 31, Issue 2, pp. 407 - 415
The endothelin (ET) system, especially ET-1 and the ETA and ETB receptors, has been implicated in the pathogenesis of pulmonary arterial hypertension (PAH).... 
Hypertension | Endothelin receptor antagonists | Endothelin | Pulmonary | INHALED ILOPROST | ETB-RECEPTOR | RESISTANCE ARTERIES | COMBINATION THERAPY | pulmonary | BOSENTAN THERAPY | 1ST-LINE BOSENTAN | endothelin receptor antagonists | PERIPHERAL LUNG | endothelin | MEDIATED VASODILATION | RESPIRATORY SYSTEM | NITRIC-OXIDE | hypertension | SMOOTH-MUSCLE CELLS | Severity of Illness Index | Hypertension, Pulmonary - mortality | Thiophenes - therapeutic use | Prognosis | Humans | Survival Rate | Treatment Outcome | Endothelin B Receptor Antagonists | Receptor, Endothelin B - therapeutic use | Randomized Controlled Trials as Topic | Clinical Trials, Phase III as Topic | Phenylpropionates - therapeutic use | Animals | Receptors, Endothelin - therapeutic use | Sulfonamides - therapeutic use | Endothelin A Receptor Antagonists | Hypertension, Pulmonary - drug therapy | Isoxazoles - therapeutic use | Hypertension, Pulmonary - etiology | Endothelin Receptor Antagonists | Pyridazines - therapeutic use | Receptor, Endothelin A - therapeutic use
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3. Full Text Endothelin receptor antagonists for pulmonary arterial hypertension
by Liu, Chao and Liu, Chao and Chen, Junmin and Chen, Junmin and Gao, Yanqiu and Gao, Yanqiu and Deng, Bao and Deng, Bao and Liu, Kunshen and Liu, Kunshen
Cochrane database of systematic reviews (Online), ISSN 1469-493X, 2013, Volume 2, Issue 2, p. CD004434
Background Pulmonary arterial hypertension is a devastating disease, which leads to right heart failure and premature death. Recent evidence suggests that... 
PHARMACOKINETIC INTERACTION | Humans | EISENMENGER-SYNDROME | CONNECTIVE-TISSUE DISEASE | SELECTIVE ENDOTHELIN | CONTINUOUS INTRAVENOUS EPOPROSTENOL | CALCIUM-CHANNEL BLOCKERS | Randomized Controlled Trials as Topic | Receptors, Endothelin [antagonists & inhibitors] | Antihypertensive Agents [therapeutic use] | Hypertension, Pulmonary [drug therapy] | MEDICINE, GENERAL & INTERNAL | DOUBLE-BLIND | NITRIC-OXIDE | IMPROVES EXERCISE CAPACITY | PLACEBO-CONTROLLED TRIAL | Hypertension, Pulmonary - drug therapy | Antihypertensive Agents - therapeutic use | Endothelin Receptor Antagonists
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4. Full Text Endothelin receptor antagonists for aneurysmal subarachnoid hemorrhage: A systematic review and meta-analysis update
by Vergouwen, Mervyn D.I and Algra, Ale and Rinkel, Gabriel J.E
Stroke, ISSN 0039-2499, 10/2012, Volume 43, Issue 10, pp. 2671 - 2676
Background and Purpose-Endothelin is considered to be a key mediator of vasospasm after subarachnoid hemorrhage. A meta-analysis of randomized trials on the... 
cerebral infarction | subarachnoid hemorrhage | endothelin receptor | vasospasm | delayed cerebral ischemia | systematic review | antagonist | outcome | MULTICENTER | CLAZOSENTAN | DELAYED CEREBRAL-ISCHEMIA | DAMAGE | CLINICAL NEUROLOGY | DOUBLE-BLIND | PERIPHERAL VASCULAR DISEASE | COMPLICATIONS | Vasospasm, Intracranial - epidemiology | Humans | Treatment Outcome | Receptors, Endothelin - physiology | Contraindications | Incidence | Subarachnoid Hemorrhage - physiopathology | Sulfonamides - therapeutic use | Vasospasm, Intracranial - physiopathology | Pyrimidines - therapeutic use | Dioxanes - therapeutic use | Peptides, Cyclic - therapeutic use | Tetrazoles - therapeutic use | Endothelin Receptor Antagonists | Subarachnoid Hemorrhage - drug therapy | Pyridines - therapeutic use
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5. Full Text Endothelin receptor antagonists
by Clozel, Martine and Maresta, Alessandro and Humbert, Marc
Handbook of Experimental Pharmacology, ISSN 0171-2004, 2013, Volume 218, pp. 199 - 227
Three pathways have been identified in the pathogenesis of pulmonary arterial hypertension (PAH): the endothelin (ET), nitric oxide (NO) and prostacyclin... 
Endothelin receptor antagonist | Pulmonary arterial hypertension | Endothelin | Animals | Cardiomegaly - prevention & control | Drug Interactions | Humans | Fibrosis | Familial Primary Pulmonary Hypertension | Myocardium - pathology | Hypertension, Pulmonary - drug therapy | Receptors, Endothelin - physiology | Hypertension, Pulmonary - etiology | Endothelin Receptor Antagonists
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6. Full Text Endothelin receptor antagonists in pulmonary arterial hypertension
by Channick, Richard N and Sitbon, Olivier and Barst, Robyn J and Manes, Alessandra and Rubin, Lewis J
Journal of the American College of Cardiology, ISSN 0735-1097, 06/2004, Volume 43, Issue 12, pp. S62 - S67
Endothelin receptor antagonism has emerged as an important therapeutic strategy in pulmonary arterial hypertension (PAH). Laboratory and clinical... 
chronic thromboembolic pulmonary hypertension | endothelin receptor antagonists | endothelin | endothelin receptor B | endothelin receptor A | 6-min walk test | PAH | CTEPH | IPAH | 6MWT | idiopathic pulmonary arterial hypertension | ERAs | CARDIAC & CARDIOVASCULAR SYSTEMS | SITAXSENTAN | CONGENITAL HEART-DISEASE | VASOCONSTRICTOR | NITRIC-OXIDE | PLASMA ENDOTHELIN-1 | UP-REGULATION | EXPRESSION | SMOOTH-MUSCLE CELLS | VASCULAR-TONE | BOSENTAN | Pulmonary Artery - metabolism | Endothelin-1 - metabolism | Humans | Hypertension, Pulmonary - drug therapy | Hypertension, Pulmonary - metabolism | Pulmonary Artery - drug effects | Endothelin-1 - drug effects | Forecasting | Endothelin Receptor Antagonists | Pulmonary Artery - pathology | Randomized Controlled Trials as Topic | Endothelin | Cardiology | Drug approval | Pulmonary hypertension | Enzymes | Peptides | Pulmonary arteries | Rodents | Nitric oxide | Clinical trials | Smooth muscle | Muscular system | Drug dosages
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7. Full Text Slow Receptor Dissociation Kinetics Differentiate Macitentan from Other Endothelin Receptor Antagonists in Pulmonary Arterial Smooth Muscle Cells
by Gatfield, John and Mueller Grandjean, Celia and Sasse, Thomas and Clozel, Martine and Nayler, Oliver
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47662
Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a... 
PATHWAYS | GENE | MULTIDISCIPLINARY SCIENCES | SHEAR-STRESS | IN-VIVO | CALCIUM | DEGRADATION | PROLIFERATION | MECHANISMS | HYPERTENSION | EXPRESSION | Cricetinae | Endothelin-1 - metabolism | Humans | Receptors, Endothelin - metabolism | Familial Primary Pulmonary Hypertension | Calcium - analysis | Hypertension, Pulmonary - metabolism | Pulmonary Artery - drug effects | Pyridazines - pharmacology | Pyrimidines - pharmacology | Sulfonamides - pharmacology | Pulmonary Artery - cytology | Inositol Phosphates - analysis | Phenylpropionates - pharmacology | Clinical Trials, Phase III as Topic | Pulmonary Artery - metabolism | Animals | Hypertension, Pulmonary - drug therapy | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Endothelin Receptor Antagonists | CHO Cells | Endothelin | Physiological aspects | Smooth muscle | Genetic aspects | Research | Drug therapy | Pulmonary hypertension | Membrane proteins | Cell proliferation | Phosphates | Calcium | Assaying | Contraction | Cell growth | Rodents | Hypertension | Incubation | Pulmonary arteries | Muscles | Radioactive half-life | Pharmacology | Endothelin 1 | Gene expression | Muscle contraction | Morbidity | Calcium phosphates | In vivo methods and tests | Kinetics | Receptor mechanisms | Aberration | Prolongation | Pharmaceuticals | Veins & arteries
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8. Full Text Mineralocorticoid receptor antagonists and kidney diseases: pathophysiological basis
by Barrera-Chimal, Jonatan and Girerd, Sophie and Jaisser, Frederic
Kidney International, ISSN 0085-2538, 08/2019, Volume 96, Issue 2, pp. 302 - 319
Chronic kidney disease (CKD) represents a global health concern, and its prevalence is increasing. The ultimate therapeutic option for CKD is kidney... 
clinical study | fibrosis | kidney injury | inflammation | aldosterone | ENDOTHELIN-B RECEPTOR | OXIDATIVE STRESS | ACTIVATED PROTEIN-KINASE | HEART-FAILURE | COLLAGEN GENE-EXPRESSION | ANGIOTENSIN-ALDOSTERONE SYSTEM | DIABETIC-NEPHROPATHY | GELATINASE-ASSOCIATED LIPOCALIN | SODIUM ZIRCONIUM CYCLOSILICATE | UROLOGY & NEPHROLOGY | RENAL INTERSTITIAL FIBROSIS
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9. Full Text Endothelin receptor antagonists for the treatment of pulmonary artery hypertension
by Rubin, Lewis J
Life Sciences, ISSN 0024-3205, 10/2012, Volume 91, Issue 13-14, pp. 517 - 521
The demonstration that endothelin production is upregulated in pulmonary artery hypertension (PAH) served as the rationale for developing endothelin-receptor... 
Endothelin receptor antagonists | Endothelin | Pulmonary artery hypertension | MEDICINE, RESEARCH & EXPERIMENTAL | BOSENTAN THERAPY | DIAPHRAGMATIC-HERNIA | CONGENITAL HEART-DISEASE | NITRIC-OXIDE | GENE-EXPRESSION | PHARMACOLOGY & PHARMACY | SMOOTH-MUSCLE-CELLS | PLASMA ENDOTHELIN-1 | UP-REGULATION | NEWBORN-INFANTS | IMMUNOREACTIVE ENDOTHELIN-1 | Antihypertensive Agents - pharmacology | Administration, Oral | Endothelin-1 - metabolism | Humans | Phenylpropionates - administration & dosage | Hypertension, Pulmonary - physiopathology | Familial Primary Pulmonary Hypertension | Pyridazines - pharmacology | Antihypertensive Agents - therapeutic use | Sulfonamides - pharmacology | Phenylpropionates - pharmacology | Phenylpropionates - therapeutic use | Animals | Sulfonamides - therapeutic use | Drug Design | Pyridazines - administration & dosage | Hypertension, Pulmonary - drug therapy | Drug Monitoring | Endothelin Receptor Antagonists | Pyridazines - therapeutic use | Sulfonamides - administration & dosage | Hypertension | Respiratory agents | Drug therapy
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10. Full Text Endothelin-Receptor Antagonists beyond Pulmonary Arterial Hypertension: Cancer and Fibrosis
by Aubert, John-David and Juillerat-Jeanneret, Lucienne
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 18, pp. 8168 - 8188
The endothelin axis and in particular the two endothelin receptors, ETA and ETB, are targets for therapeutic intervention in human diseases.... 
CONVERTING ENZYME | IV METASTATIC MELANOMA | CHEMISTRY, MEDICINAL | A RECEPTOR | IN-VITRO CHARACTERIZATION | PHARMACOLOGICAL CHARACTERIZATION | DOUBLE-BLIND | OVARIAN-CANCER | RESISTANT PROSTATE-CANCER | B-RECEPTOR | VASCULAR SMOOTH-MUSCLE | Neoplasms - metabolism | Cardiovascular Diseases - metabolism | Cardiovascular Diseases - drug therapy | Humans | Receptors, Endothelin - metabolism | Clinical Trials as Topic | Hypertension, Pulmonary - metabolism | Cardiovascular Diseases - pathology | Neoplasms - drug therapy | Endothelin Receptor Antagonists - pharmacology | Animals | Endothelin Receptor Antagonists - chemistry | Fibrosis | Endothelin Receptor Antagonists - adverse effects | Hypertension, Pulmonary - drug therapy | Endothelin Receptor Antagonists - therapeutic use | Neoplasms - pathology | Hypertension, Pulmonary - pathology
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