X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (10111) 10111
Publication (1014) 1014
Book Review (45) 45
Conference Proceeding (17) 17
Book Chapter (14) 14
Dissertation (8) 8
Streaming Video (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
animals (6919) 6919
male (4711) 4711
humans (4382) 4382
rats (3956) 3956
endothelin-1 (3825) 3825
endothelin-1 - metabolism (3499) 3499
index medicus (2990) 2990
female (2482) 2482
endothelin (2391) 2391
endothelin-1 - pharmacology (2247) 2247
cells, cultured (1927) 1927
pharmacology & pharmacy (1618) 1618
rats, sprague-dawley (1600) 1600
expression (1503) 1503
cells (1265) 1265
cardiac & cardiovascular systems (1256) 1256
endothelin-1 - genetics (1219) 1219
mice (1168) 1168
endothelin-1 - blood (1138) 1138
physiology (1129) 1129
middle aged (1114) 1114
rats, wistar (1065) 1065
peripheral vascular disease (1044) 1044
hypertension (1011) 1011
adult (996) 996
biochemistry & molecular biology (960) 960
rna, messenger - metabolism (931) 931
dose-response relationship, drug (918) 918
endothelin receptor antagonists (898) 898
nitric-oxide (876) 876
nitric oxide (839) 839
endothelium, vascular - metabolism (822) 822
disease models, animal (818) 818
cell biology (803) 803
in vitro techniques (786) 786
receptors, endothelin - metabolism (750) 750
endothelin-1 - physiology (743) 743
time factors (738) 738
endothelium (694) 694
endocrinology & metabolism (689) 689
gene-expression (682) 682
calcium - metabolism (674) 674
receptor (668) 668
endothelin-1 - biosynthesis (660) 660
nitric oxide - metabolism (660) 660
aged (658) 658
signal transduction (635) 635
receptor, endothelin a (623) 623
activation (622) 622
enzyme inhibitors - pharmacology (619) 619
blood pressure - drug effects (597) 597
immunohistochemistry (595) 595
vasoconstriction - drug effects (591) 591
rat (589) 589
gene expression (581) 581
myocardium - metabolism (579) 579
receptor, endothelin a - metabolism (577) 577
medicine, research & experimental (573) 573
oxidative stress (567) 567
endothelins - metabolism (559) 559
endothelium, vascular - drug effects (553) 553
phosphorylation (522) 522
receptors (517) 517
muscle, smooth, vascular - drug effects (506) 506
physiological aspects (492) 492
peptides, cyclic - pharmacology (491) 491
angiotensin-ii (482) 482
neurosciences (482) 482
rna, messenger - genetics (475) 475
vasoconstriction (474) 474
disease (463) 463
receptor, endothelin b (463) 463
endothelins - pharmacology (458) 458
nitric-oxide synthase (458) 458
smooth-muscle cells (457) 457
muscle, smooth, vascular - metabolism (454) 454
reverse transcriptase polymerase chain reaction (453) 453
blood pressure (445) 445
endothelin-converting enzymes (434) 434
blood-pressure (429) 429
research (427) 427
oligopeptides - pharmacology (418) 418
inflammation (417) 417
cell line (411) 411
inhibition (410) 410
respiratory system (410) 410
atherosclerosis (408) 408
receptor, endothelin b - metabolism (407) 407
endothelin a receptor antagonists (399) 399
swine (399) 399
in-vivo (397) 397
smooth-muscle-cells (393) 393
messenger-rna (389) 389
up-regulation (389) 389
rabbits (388) 388
release (384) 384
signal transduction - drug effects (382) 382
article (379) 379
hypertrophy (367) 367
heart (364) 364
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9681) 9681
Chinese (253) 253
Russian (74) 74
Polish (37) 37
Japanese (31) 31
French (11) 11
German (10) 10
Spanish (7) 7
Hungarian (5) 5
Ukrainian (4) 4
Portuguese (2) 2
Romanian (2) 2
Arabic (1) 1
Danish (1) 1
Finnish (1) 1
Italian (1) 1
Korean (1) 1
Norwegian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Arteriosclerosis, Thrombosis, and Vascular Biology, ISSN 1079-5642, 04/2010, Volume 30, Issue 4, pp. 749 - 757
OBJECTIVE—Animal and clinical studies have suggested that polyphenols in fruits, red wine, and tea may delay the development of atherosclerosis through their... 
Endothelial dysfunction | Soluble P-selectin | Oxidative stress | Polyphenol | Inflammation | Endothelin-1 | polyphenol | endothelial dysfunction | soluble P-selectin | inflammation | NITRIC-OXIDE | PERIPHERAL VASCULAR DISEASE | BLACK TEA CONSUMPTION | SMOOTH-MUSCLE-CELLS | HEME OXYGENASE-1 | RED WINE | endothelin-1 | HEMATOLOGY | E-DEFICIENT MICE | NF-KAPPA-B | oxidative stress | CORONARY-ARTERY-DISEASE | Inflammation - pathology | Heme Oxygenase-1 - metabolism | Apolipoproteins E - deficiency | Cholesterol - blood | Endothelium, Vascular - drug effects | Male | Aorta - metabolism | F2-Isoprostanes - metabolism | Lignans - pharmacology | Aortic Diseases - metabolism | Inflammation - metabolism | Leukotriene B4 - metabolism | Aortic Diseases - prevention & control | Dioxoles - pharmacology | Polyphenols | Anti-Inflammatory Agents - administration & dosage | Disease Models, Animal | Phenols - pharmacology | Biomarkers - metabolism | Atherosclerosis - pathology | Anti-Inflammatory Agents - pharmacology | Atherosclerosis - physiopathology | Atherosclerosis - metabolism | Mice, Knockout | Aorta - pathology | Diet | Endothelium, Vascular - metabolism | Inflammation - prevention & control | Mice | Oxidative Stress - drug effects | Biflavonoids - pharmacology | Chlorogenic Acid - pharmacology | Nitrates - urine | Superoxides - metabolism | Flavonoids - administration & dosage | Flavonoids - pharmacology | Membrane Proteins - metabolism | Aorta - physiopathology | Nitric Oxide Synthase Type III - metabolism | Catechin - pharmacology | Fatty Acids - metabolism | Nitrites - urine | Aorta - drug effects | Mice, Inbred C57BL | Endothelium, Vascular - physiopathology | Aortic Diseases - physiopathology | Animals | Quercetin - pharmacology | Apolipoproteins E - genetics | Endothelin-1 - urine | P-Selectin - blood | Phenols - administration & dosage | Nitric Oxide - metabolism | Atherosclerosis - prevention & control | Inflammation - physiopathology
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 01/2018, Volume 314, Issue 1, pp. H52 - H64
Hyperglycemia-induced production of endothelin (ET)-1 is a hallmark of endothelial dysfunction in diabetes. Although the detrimental vascular effects of... 
Endothelial dysfunction | Hyperglycemia | Endothelin-1 | TRAF3 interacting protein 2 | VASCULAR-DISEASE PATHOPHYSIOLOGY | OXIDATIVE STRESS | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | ACTIVATED PROTEIN-KINASE | ETA-RECEPTOR BLOCKADE | CLINICAL CONSEQUENCES | endothelial dysfunction | DIABETES-MELLITUS | hyperglycemia | CONVERTING ENZYME-1 | RESTRICTED OVEREXPRESSION | DEPENDENT VASODILATATION | CARDIOVASCULAR-DISEASE | PERIPHERAL VASCULAR DISEASE | endothelin-1 | Inflammation - chemically induced | Coculture Techniques | Humans | Diabetes Mellitus, Experimental - genetics | Diabetes Mellitus, Type 1 - metabolism | Male | Monocytes - metabolism | Inflammation - metabolism | I-kappa B Kinase - metabolism | Inflammation Mediators - metabolism | Female | Glucose - toxicity | Diabetes Mellitus, Experimental - metabolism | Diabetic Angiopathies - genetics | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - genetics | Diabetic Angiopathies - chemically induced | Diabetic Angiopathies - metabolism | Cytokines - metabolism | Endothelial Cells - metabolism | Endothelin-1 - genetics | Endothelin-1 - metabolism | Mitogen-Activated Protein Kinase 8 - metabolism | Cells, Cultured | Diabetes Mellitus, Type 1 - genetics | Cell Adhesion | Cell Adhesion Molecules - metabolism | Endothelin-1 - toxicity | Tumor Necrosis Factor Receptor-Associated Peptides and Proteins - metabolism | Animals | Signal Transduction - drug effects | Adaptor Proteins, Signal Transducing - genetics | Inflammation - genetics | Mice, Inbred NOD | Adaptor Proteins, Signal Transducing - metabolism | Endothelial Cells - drug effects
Journal Article
Circulation Research, ISSN 0009-7330, 04/2010, Volume 106, Issue 8, pp. 1363 - 1373
RATIONALE:Although Nox5 (Nox2 homolog) has been identified in the vasculature, its regulation and functional significance remain unclear. OBJECTIVES:We sought... 
ERK1/2 | Reactive oxygen species | Vasoactive peptides | Vascular cells | ACTIVATION | SUPEROXIDE | CARDIAC & CARDIOVASCULAR SYSTEMS | SPONTANEOUSLY HYPERTENSIVE-RATS | PHOSPHORYLATION | PROTEIN-KINASE | vasoactive peptides | FAMILY NADPH OXIDASES | vascular cells | reactive oxygen species | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | HYDROGEN-PEROXIDE | HEMATOLOGY | EXPRESSION | C-SRC | Phosphorylation | Calcium - metabolism | Humans | NADPH Oxidases - metabolism | JNK Mitogen-Activated Protein Kinases - metabolism | RNA, Messenger - metabolism | Pyrones - pharmacology | Quinolines - pharmacology | Diltiazem - pharmacology | RNA Interference | Time Factors | Superoxides - metabolism | NADPH Oxidases - genetics | Membrane Proteins - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Calmodulin - metabolism | Angiotensin II - metabolism | Endothelin-1 - metabolism | Membrane Proteins - genetics | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | NADPH Oxidase 5 | Calcium Channel Blockers - pharmacology | Gene Expression Regulation, Enzymologic | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | rac1 GTP-Binding Protein - antagonists & inhibitors | Enzyme Activation | Proliferating Cell Nuclear Antigen - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Calmodulin - antagonists & inhibitors | Endothelial Cells - enzymology | Inflammation - enzymology | rac1 GTP-Binding Protein - metabolism | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | ERK1
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2014, Volume 9, Issue 1, p. e87936
The growing incidence of chronic kidney disease remains a global health problem. Obesity is a major risk factor for type-2 diabetes and renal impairment.... 
CHRONIC HEART-FAILURE | TISSUE INFLAMMATION | ATRIAL-NATRIURETIC-PEPTIDE | WAIST CIRCUMFERENCE | GLUCOSE-METABOLISM | MULTIDISCIPLINARY SCIENCES | IN-VIVO | ENHANCES INSULIN SENSITIVITY | FACTOR-KAPPA-B | CHRONIC KIDNEY-DISEASE | HYPERTENSIVE-RATS | Tumor Necrosis Factor-alpha - metabolism | Atrial Natriuretic Factor - metabolism | Endothelin-1 - metabolism | Diabetic Nephropathies - metabolism | Rats | Male | Dinoprost - metabolism | Interleukins - metabolism | Hemin - metabolism | Rats, Zucker | Inflammation - metabolism | Kidney - metabolism | Macrophages - metabolism | Animals | Diabetic Nephropathies - physiopathology | Chemokine CCL3 - metabolism | Adiposity - physiology | Dinoprost - analogs & derivatives | Blood Glucose - metabolism | Heme Oxygenase (Decyclizing) - metabolism | Extracellular Matrix Proteins - metabolism | Kidney - physiopathology | Inflammation - physiopathology | Type 2 diabetes | Adipose tissues | Fibronectins | Obesity | Endothelin | Cytokines | Diabetic nephropathies | Macrophages | Risk factors | Glucose metabolism | Chronic kidney failure | Collagen | Heme | Natriuretic peptides | Adipose tissue | Syngeneic grafts | Selectivity | Adipocytes | Fibronectin | Proteins | Genotype & phenotype | Cyclic GMP | Fibroblasts | Physiology | Carbon monoxide | Public health | Pulmonary arteries | Endothelin 1 | Tumor necrosis factor-α | Metabolism | Gene expression | Studies | Oxygenase | Hemin | Nephropathy | Fibrosis | Interleukin 10 | Infiltration | Renal function | Paracrine signalling | Adiponectin | Interleukin 6 | Rodents | Diaphragm (anatomy) | Extracellular matrix | Tumor necrosis factor-TNF | Lesions | Inducers | Creatinine | Hypertension | Excretion | Kidneys | Diabetes mellitus | Markers | Health risks | Inflammation | Morbidity | Scaffolding | Insulin resistance | Diaphragm | Diabetes | Proteinuria
Journal Article
Molecular Endocrinology, ISSN 0888-8809, 01/2012, Volume 26, Issue 1, pp. 203 - 217
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 06/2004, Volume 15, Issue 6, pp. 2707 - 2719
Journal Article
American Journal of Respiratory Cell and Molecular Biology, ISSN 1044-1549, 01/2012, Volume 46, Issue 1, pp. 14 - 22
Endothelin-1 is a potent vasoactive peptide that occurs in chronically high levels in humans with pulmonary hypertension and in animal models of the disease.... 
Pulmonary artery smooth muscle | Inflammation | Endothelin | Hyaluronic acid | Unfolded protein response | ER STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HYALURONAN SYNTHESIS | RATS | ATHEROSCLEROSIS | ENDOPLASMIC-RETICULUM STRESS | PROINFLAMMATORY CYTOKINES | HYPOXIA | hyaluronic acid | CELL BIOLOGY | unfolded protein response | endothelin | inflammation | RESPIRATORY SYSTEM | pulmonary artery smooth muscle | DISEASE | HYPERTENSION | PROGRESSION | Phosphorylation - physiology | Arteritis - pathology | Muscle, Smooth, Vascular - metabolism | Myocytes, Smooth Muscle - pathology | Arteritis - metabolism | Monocytes - metabolism | DNA-Binding Proteins - metabolism | Phosphorylation - genetics | Pulmonary Artery - metabolism | Endothelin A Receptor Antagonists | Myocytes, Smooth Muscle - metabolism | Cytokines - metabolism | Unfolded Protein Response - genetics | Endothelin-1 - genetics | Endothelin-1 - metabolism | Rats | Hypertension, Pulmonary - genetics | Hypertension, Pulmonary - metabolism | Signal Transduction - genetics | Regulatory Factor X Transcription Factors | Transcription Factors - metabolism | Activating Transcription Factor 6 - metabolism | Muscle, Smooth, Vascular - pathology | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Hyaluronic Acid - metabolism | Receptor, Endothelin A - metabolism | Signal Transduction - physiology | Receptor, Endothelin B - metabolism | Unfolded Protein Response - physiology | Mitogen-Activated Protein Kinase 1 - metabolism
Journal Article
American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 10/2014, Volume 307, Issue 8, pp. E695 - E702
Ocular ischemic microenvironment plays a critical role in the progression of diabetic retinopathy (DR). In this study, we investigated the effect of vitreous... 
Vitreous | Aqueous | Proliferative diabetic retinopathy | CD34 | Progenitor cells | STEM-CELLS | PHYSIOLOGY | ANGIOGENESIS | THROMBOSPONDIN-1 | TISSUE INHIBITORS | progenitor cells | MICROVASCULAR ENDOTHELIAL-CELLS | UP-REGULATES ANGIOPOIETIN-2 | IN-VITRO | CD34(+) | ENDOCRINOLOGY & METABOLISM | vitreous | RETINOPATHY | PROMOTES ADHESION | TNF-ALPHA | aqueous | proliferative diabetic retinopathy | Platelet Factor 4 - chemistry | Retina - metabolism | Antigens, CD34 - metabolism | Humans | Middle Aged | Platelet Factor 4 - agonists | Eye Proteins - chemistry | Nerve Growth Factors - metabolism | Retina - immunology | Diabetic Retinopathy - pathology | Eye Proteins - agonists | Serpins - chemistry | Aqueous Humor - immunology | Adult Stem Cells - immunology | Neovascularization, Pathologic - pathology | Aqueous Humor - metabolism | Peptide Mapping | Vitreous Body - metabolism | Bone Marrow Cells - immunology | Adult | Neovascularization, Pathologic - immunology | Adult Stem Cells - pathology | Endothelin-1 - chemistry | Adult Stem Cells - cytology | Diabetic Retinopathy - immunology | Serpins - agonists | Serpins - metabolism | Bone Marrow Cells - cytology | Endothelin-1 - metabolism | Vitreoretinopathy, Proliferative - pathology | Bone Marrow Cells - pathology | Cells, Cultured | Nerve Growth Factors - chemistry | Vitreoretinopathy, Proliferative - immunology | Endothelin-1 - agonists | Vitreoretinopathy, Proliferative - metabolism | Chemotaxis | Nerve Growth Factors - agonists | Diabetic Retinopathy - metabolism | Adult Stem Cells - metabolism | Eye Proteins - metabolism | Vitreous Body - immunology | Aged | Neovascularization, Pathologic - metabolism | Platelet Factor 4 - metabolism | Nitric Oxide - metabolism | Retina - pathology | Bone Marrow Cells - metabolism
Journal Article
Nature Communications, ISSN 2041-1723, 2013, Volume 4, Issue 1, p. 2516
Cancer and stromal cells actively exert physical forces (solid stress) to compress tumour blood vessels, thus reducing vascular perfusion. Tumour interstitial... 
INTERSTITIAL FLUID PRESSURE | BREAST-CANCER | GROWTH-FACTOR-BETA | PANCREATIC STELLATE CELLS | TGF-BETA | AORTIC-ANEURYSM | SOLID STRESS | MULTIDISCIPLINARY SCIENCES | MOUSE MODEL | GENE-EXPRESSION | II TYPE-2 RECEPTOR
Journal Article
Progress in Cardiovascular Diseases, ISSN 0033-0620, 2002, Volume 45, Issue 3, pp. 173 - 202
Journal Article