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Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2014, Volume 135, Issue 6, pp. 1625 - 1635.e5
.... Methods Wild-type and various Pparb/d mutant mice were used to monitor dermal acute vascular hyperpermeability (AVH... 
Allergy and Immunology | Peroxisome proliferator-activated receptor β/δ | smooth muscle cells | endothelium | anaphylaxis | vascular permeability | SIGNALING PATHWAYS | NITRIC-OXIDE SYNTHASE | DELTA | MAST-CELLS | DIABETIC-RATS | IMMUNOLOGY | ALLERGY | INFLAMMATION | IN-VIVO | VE-CADHERIN | Peroxisome proliferator-activated receptor beta/delta | ADHERENS JUNCTIONS | PPAR-BETA/DELTA | Edema - genetics | Myocytes, Smooth Muscle - pathology | Capillary Permeability - drug effects | Capillary Permeability - immunology | Hypothermia - immunology | Intercellular Junctions - immunology | Hypothermia - pathology | Proto-Oncogene Proteins c-akt - genetics | Thrombin - pharmacology | Intercellular Junctions - pathology | Anaphylaxis - immunology | PPAR delta - immunology | Female | Mitogen-Activated Protein Kinases - immunology | Myocytes, Smooth Muscle - drug effects | Vascular Endothelial Growth Factor A - pharmacology | PPAR delta - genetics | Skin - pathology | Skin - immunology | PPAR delta - deficiency | Edema - immunology | Histamine - pharmacology | Signal Transduction | Anaphylaxis - pathology | Gene Expression Regulation | Mice, Transgenic | PPAR-beta - immunology | PPAR-beta - genetics | PPAR-beta - deficiency | Anaphylaxis - genetics | Endothelial Cells - immunology | Skin - blood supply | Animals | Proto-Oncogene Proteins c-akt - immunology | Intercellular Junctions - drug effects | Myocytes, Smooth Muscle - immunology | Mitogen-Activated Protein Kinases - genetics | Mice | Endothelial Cells - pathology | Edema - pathology | Hypothermia - genetics | Skin - drug effects | Endothelial Cells - drug effects | Mitogen-Activated Protein Kinases/genetics | Skin/blood supply | Endothelial Cells/drug effects | Endothelial Cells/immunology | Intercellular Junctions/immunology | PPAR delta/immunology | Skin/pathology | Intercellular Junctions/drug effects | Hypothermia/genetics | Capillary Permeability/drug effects | Life Sciences | PPAR delta/genetics | PPAR delta/deficiency | Hypothermia/immunology | Immunology | Anaphylaxis/genetics | Histamine/pharmacology | PPAR-beta/immunology | Myocytes, Smooth Muscle/pathology | Anaphylaxis/pathology | Myocytes, Smooth Muscle/immunology | Endothelial Cells/pathology | Hypothermia/pathology | Vascular Endothelial Growth Factor A/pharmacology | Mitogen-Activated Protein Kinases/immunology | Myocytes, Smooth Muscle/drug effects | Edema/immunology | Proto-Oncogene Proteins c-akt/genetics | Edema/pathology | Skin/immunology | Intercellular Junctions/pathology | Proto-Oncogene Proteins c-akt/immunology | Edema/genetics | PPAR-beta/genetics | Skin/drug effects | PPAR-beta/deficiency | Thrombin/pharmacology
Journal Article
Journal Article
British journal of pharmacology, ISSN 0007-1188, 02/2014, Volume 171, Issue 3, pp. 595 - 617
Perivascular adipose tissue (PVAT) is an active endocrine and paracrine organ that modulates vascular function, with implications for the pathophysiology of cardiovascular disease (CVD... 
AMP‐activated protein kinase | atherosclerosis | adiponectin | perivascular fat | vascular reactivity | metformin | adipocytes | diabetes | leptin | hypertension | AMP-activated protein kinase | STIMULATES GLUCOSE-UTILIZATION | NITRIC-OXIDE SYNTHASE | ENDOTHELIUM-DEPENDENT RELAXATION | ENDOPLASMIC-RETICULUM STRESS | BROWN ADIPOSE-TISSUE | LOWERS BLOOD-PRESSURE | TUMOR-NECROSIS-FACTOR | AORTIC SMOOTH-MUSCLE | PHARMACOLOGY & PHARMACY | INDUCED CARDIAC-HYPERTROPHY | NF-KAPPA-B | Enzyme Activators - pharmacology | AMP-Activated Protein Kinases - metabolism | Vascular Diseases - pathology | Adipose Tissue, White - immunology | Muscle, Smooth, Vascular - metabolism | Enzyme Activators - therapeutic use | Humans | Adipose Tissue, White - metabolism | Muscle, Smooth, Vascular - immunology | Endothelium, Vascular - drug effects | Male | Autocrine Communication - drug effects | Adiposity | Female | Vascular Diseases - drug therapy | Adipose Tissue, Brown - immunology | Endothelium, Vascular - immunology | Muscle, Smooth, Vascular - drug effects | Adipose Tissue, White - pathology | Vascular Diseases - immunology | Enzyme Activation - drug effects | Adipose Tissue, Brown - pathology | Cardiovascular Agents - pharmacology | Cardiovascular Agents - therapeutic use | Muscle, Smooth, Vascular - pathology | Animals | Signal Transduction - drug effects | Endothelium, Vascular - metabolism | Models, Biological | Paracrine Communication - drug effects | Endothelium, Vascular - pathology | Adipose Tissue, Brown - drug effects | Adipose Tissue, Brown - metabolism | Vascular Diseases - metabolism | Adipose Tissue, White - drug effects | Blood circulation disorders | Protein kinases | Leptin | Atherosclerosis | Kinases | Metabolic disorders | Muscular system | Reactive oxygen species | Adipose tissue | Paracrine signalling | Smooth muscle | Adipocytes | Contraction | Protein turnover | Vascular diseases | Diabetes mellitus (non-insulin dependent) | Obesity | AMP | Cytokines | Therapeutic applications | Blood vessels | Vascular system | Muscle contraction | Protein kinase | Arteriosclerosis | Stromal cells | Metformin | Cardiovascular diseases | Thiazolidinediones | Cell migration | Review
Journal Article
PloS one, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e44668
.... Biomarkers of endothelial cell activation (intercellular adhesion molecule-1 (sICAM-1), vascular cell adhesion molecule-1 (sVCAM-1), thrombomodulin (TM... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | CAROTID ATHEROSCLEROSIS | MYOCARDIAL-INFARCTION | ARTERIAL STIFFNESS | MULTIDISCIPLINARY SCIENCES | E-SELECTIN | ADHESION MOLECULES ICAM-1 | FLOW-MEDIATED DILATION | CORONARY-HEART-DISEASE | RHEUMATOID-ARTHRITIS PATIENTS | ENDOTHELIAL FUNCTION | Lupus Erythematosus, Systemic - complications | Thrombomodulin - immunology | Arthritis, Rheumatoid - blood | Humans | Middle Aged | Lupus Erythematosus, Systemic - blood | Arthritis, Rheumatoid - complications | Atherosclerosis - etiology | Lupus Erythematosus, Systemic - immunology | Adult | Female | Intercellular Adhesion Molecule-1 - blood | Vascular Stiffness | Thromboplastin - immunology | Endothelium, Vascular - immunology | Thrombomodulin - blood | Manometry | Vascular Cell Adhesion Molecule-1 - immunology | Atherosclerosis - immunology | Intercellular Adhesion Molecule-1 - immunology | Risk Factors | Thromboplastin - analysis | Biomarkers - blood | Vascular Cell Adhesion Molecule-1 - blood | Atherosclerosis - blood | Endothelium, Vascular - metabolism | Arthritis, Rheumatoid - immunology | Rheumatoid factor | Systemic lupus erythematosus | Cardiovascular diseases | Risk factors | Atherosclerosis | Endothelium | Heart | Vascular cell adhesion molecule 1 | Cardiovascular disease | Vasodilation | Cell activation | Alterations | Cell adhesion | Stiffness | Bioindicators | Lupus | Cytokines | Intercellular adhesion molecule 1 | Rheumatology | Metabolism | Risk analysis | Patients | Augmentation | Serum levels | Rheumatoid arthritis | Arteriosclerosis | Biomarkers | Hyperemia | Health risk assessment | Risk management | Drugs | Atherogenesis | Tissue factor | Adhesion tests | Activation | Arthritis | Bone diseases | Cell adhesion molecules | Tumor necrosis factor-TNF | Thrombomodulin | Hypertension | Damage assessment | Fasting | Health risks | Inflammation | Permeability | Adhesion | Cholesterol | Endothelial cells | Chronic conditions | Womens health | Microvasculature | Autoimmune diseases
Journal Article
Journal Article
Blood, ISSN 1528-0020, 2012, Volume 121, Issue 6, pp. 1008 - 1015
The majority of peripheral serotonin is stored in platelets, which secrete it on activation. Serotonin releases Weibel-Palade bodies (WPBs) and we asked... 
PULMONARY-HYPERTENSION | PERMEABILITY | 5-HYDROXYTRYPTAMINE | ENDOTHELIAL-CELLS | MAST-CELLS | P-SELECTIN | RECEPTOR | SMOOTH-MUSCLE-CELLS | HEMATOLOGY | VON-WILLEBRAND-FACTOR | SELECTIN-DEFICIENT MICE | Blood Platelets - immunology | Endothelium, Vascular - drug effects | Male | Shock, Septic - immunology | Lipopolysaccharides | Serotonin - blood | Inflammation - metabolism | L-Selectin - immunology | Leukocytosis - metabolism | Weibel-Palade Bodies - metabolism | Chemotaxis - immunology | Neutrophils - metabolism | Serotonin - immunology | Serotonin Uptake Inhibitors - immunology | Endothelium, Vascular - immunology | Neutrophil Infiltration - immunology | Fluoxetine - pharmacology | Acute Disease | Neutrophils - drug effects | Leukocytosis - immunology | Chemotaxis - drug effects | Mice, Knockout | Blood Platelets - metabolism | Endothelium, Vascular - metabolism | Mice | Serotonin Uptake Inhibitors - pharmacology | Leukocyte Rolling - drug effects | Weibel-Palade Bodies - immunology | Histamine - immunology | L-Selectin - metabolism | Flow Cytometry | Tryptophan Hydroxylase - deficiency | Blood Platelets - drug effects | Fluoxetine - immunology | Shock, Septic - genetics | Leukocyte Rolling - genetics | Histamine - pharmacology | Shock, Septic - chemically induced | Mice, Inbred C57BL | Kaplan-Meier Estimate | Neutrophils - immunology | Inflammation - immunology | Leukocyte Rolling - immunology | Tryptophan Hydroxylase - genetics | Weibel-Palade Bodies - drug effects | Animals | Serotonin - metabolism | Inflammation - genetics | Leukocytosis - genetics | Phagocytes, Granulocytes, and Myelopoiesis | Platelets and Thrombopoiesis
Journal Article
Journal of diabetes and its complications, ISSN 1056-8727, 2016, Volume 30, Issue 4, pp. 738 - 745
Abstract Background Vascular complications are the leading cause of morbidity and mortality among patients with type 1 and type 2 diabetes mellitus... 
Endocrinology & Metabolism | vascular complications | hypercoagulability | inflammation | endothelial dysfunction | Diabetes mellitus | FACTOR-VIII | MARKERS | MICROVASCULAR COMPLICATIONS | VON-WILLEBRAND-FACTOR | URINARY ALBUMIN EXCRETION | VONWILLEBRAND-FACTOR | ENDOCRINOLOGY & METABOLISM | CARDIOVASCULAR-DISEASE | ASSOCIATION | D-DIMER | Vasculitis - metabolism | Oxidative Stress | Vasculitis - physiopathology | Humans | Diabetes Mellitus, Type 1 - metabolism | Diabetes Mellitus, Type 1 - complications | Diabetes Mellitus, Type 2 - metabolism | Thrombophilia - complications | Vasculitis - complications | Vasculitis - immunology | Thrombophilia - immunology | Diabetic Angiopathies - physiopathology | Diabetes Mellitus, Type 2 - immunology | Diabetic Angiopathies - complications | Diabetes Mellitus, Type 1 - immunology | Diabetes Mellitus, Type 2 - complications | Endothelium, Vascular - immunology | Diabetic Angiopathies - metabolism | Thrombophilia - physiopathology | Diabetes Mellitus, Type 1 - physiopathology | Endothelium, Vascular - physiopathology | Biomarkers - blood | Animals | Diabetes Mellitus, Type 2 - physiopathology | Endothelium, Vascular - metabolism | Models, Biological | Diabetic Angiopathies - immunology | Thrombophilia - metabolism | Type 2 diabetes | Oxidative stress | Complications and side effects | Inflammation | Index Medicus
Journal Article