X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (5212) 5212
Publication (515) 515
Book Review (417) 417
Book Chapter (23) 23
Conference Proceeding (16) 16
Dissertation (9) 9
Magazine Article (1) 1
Presentation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (4862) 4862
animals (3830) 3830
male (2877) 2877
endotoxemia (2484) 2484
humans (1797) 1797
mice (1735) 1735
rats (1646) 1646
inflammation (1416) 1416
sepsis (1344) 1344
female (1205) 1205
endotoxemia - metabolism (1203) 1203
septic shock (872) 872
lipopolysaccharide (850) 850
disease models, animal (797) 797
lipopolysaccharides (790) 790
immunology (716) 716
abridged index medicus (698) 698
lipopolysaccharides - pharmacology (680) 680
rats, sprague-dawley (667) 667
tumor-necrosis-factor (652) 652
mice, inbred c57bl (648) 648
expression (646) 646
cytokines (631) 631
endotoxemia - physiopathology (604) 604
rats, wistar (588) 588
surgery (587) 587
adult (560) 560
endotoxemia - drug therapy (542) 542
tumor necrosis factor-alpha - metabolism (537) 537
critical care medicine (534) 534
lipopolysaccharides - toxicity (520) 520
endotoxemia - chemically induced (518) 518
rodents (477) 477
endotoxin (475) 475
hematology (466) 466
activation (465) 465
biochemistry & molecular biology (460) 460
liver - metabolism (452) 452
middle aged (439) 439
nitric oxide (438) 438
endotoxemia - immunology (436) 436
cell biology (434) 434
metabolism (431) 431
endotoxemia - pathology (427) 427
liver (425) 425
peripheral vascular disease (424) 424
analysis (415) 415
endotoxemia - blood (412) 412
obesity (411) 411
pharmacology & pharmacy (410) 410
physiology (406) 406
time factors (396) 396
mitogens (372) 372
oxidative stress (362) 362
physiological aspects (362) 362
research (361) 361
nitric-oxide synthase (352) 352
cells (348) 348
macrophages (345) 345
cells, cultured (343) 343
endocrinology & metabolism (334) 334
permeability (334) 334
endotoxemia - complications (319) 319
shock (316) 316
in-vivo (309) 309
cytokines - metabolism (308) 308
mice, knockout (306) 306
gastroenterology & hepatology (301) 301
medicine, research & experimental (299) 299
health aspects (292) 292
aged (291) 291
microbiota (288) 288
proteins (287) 287
nitric-oxide (281) 281
gene expression (276) 276
nitric oxide - metabolism (274) 274
injury (271) 271
article (270) 270
inhibition (269) 269
insulin-resistance (269) 269
mice, inbred balb c (265) 265
nf-kappa-b (254) 254
gut microbiota (253) 253
tnf-alpha (248) 248
mortality (246) 246
disease (242) 242
endotoxins (241) 241
liver - pathology (241) 241
rna, messenger - metabolism (241) 241
dose-response relationship, drug (240) 240
research article (240) 240
inflammation - metabolism (238) 238
liver - drug effects (238) 238
signal transduction (237) 237
gene-expression (236) 236
medicine (234) 234
multidisciplinary sciences (233) 233
insulin resistance (231) 231
nutrition & dietetics (231) 231
apoptosis (230) 230
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (5087) 5087
Chinese (72) 72
Russian (37) 37
French (11) 11
Japanese (8) 8
German (5) 5
Ukrainian (5) 5
Spanish (4) 4
Hungarian (3) 3
Polish (2) 2
Bulgarian (1) 1
Portuguese (1) 1
Swedish (1) 1
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature immunology, ISSN 1529-2908, 2016, Volume 17, Issue 4, pp. 406 - 413
The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is... 
SYSTEMIC INFLAMMATION | MESSENGER-RNA TRANSLATION | ACTIVATION | INTERFERON-GAMMA | IFN-GAMMA | MACROPHAGES | SIRTUIN 1 | DYSFUNCTION | IMMUNOLOGY | EXPRESSION | CELLULAR-METABOLISM | Prospective Studies | Humans | Middle Aged | Transcriptome | Immunoblotting | Male | Monocytes - metabolism | Monocytes - immunology | Lipopolysaccharides - immunology | Antifungal Agents - therapeutic use | Leukocytes - immunology | Young Adult | Sepsis - drug therapy | Immune Tolerance - immunology | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Candidiasis, Invasive - drug therapy | Endotoxemia - immunology | Adult | Aspergillosis - metabolism | Female | Macrophages - immunology | NAD - metabolism | Aspergillosis - drug therapy | Cytokines - immunology | Sepsis - immunology | Interferon-gamma - therapeutic use | Lactic Acid - metabolism | Oxidative Phosphorylation | Oxygen Consumption | Energy Metabolism - immunology | Escherichia coli Infections - metabolism | Candidiasis, Invasive - metabolism | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Candidiasis, Invasive - immunology | Glycolysis | Escherichia coli Infections - immunology | Mice | Endotoxemia - metabolism | Leukocytes - metabolism | Aspergillosis - immunology | Complications and side effects | Energy metabolism | Immune response | Bioenergetics | Abnormalities | Sepsis | Regulation | Leukocytes | Properties | Health aspects | Index Medicus
Journal Article
Journal Article
Cell Metabolism, ISSN 1550-4131, 06/2012, Volume 15, Issue 6, pp. 813 - 826
Immune cells are somewhat unique in that activation responses can alter quantitative phenotypes upwards of 100,000-fold. To date little is known about the... 
PROTEIN | GENE | CELL ACTIVATION | GLUTATHIONE | MURINE MACROPHAGES | TRANSCRIPTION | ENDOCRINOLOGY & METABOLISM | RECEPTOR | BINDING-ACTIVITY | DIFFERENTIATION | INFLAMMATORY RESPONSE | CELL BIOLOGY | Tumor Necrosis Factor-alpha - metabolism | Cell Polarity | Transcription Factors - chemistry | Endotoxemia - enzymology | Phosphotransferases (Alcohol Group Acceptor) - chemistry | Humans | Tumor Necrosis Factor-alpha - genetics | Male | Endotoxemia - immunology | Interleukin-6 - metabolism | Macrophages - immunology | Macrophages - physiology | Protein Structure, Tertiary | Amino Acid Sequence | Cell Line | Double-Blind Method | Interleukin-6 - genetics | Down-Regulation | Mice, Inbred C57BL | Tumor Necrosis Factor-alpha - secretion | Carbohydrate Metabolism | Models, Molecular | Phosphotransferases (Alcohol Group Acceptor) - genetics | Transcription Factors - genetics | Interleukin-6 - secretion | Macrophages - enzymology | Phosphotransferases (Alcohol Group Acceptor) - metabolism | Gene Expression Regulation, Enzymologic | Transcription Factors - metabolism | Macrophages - metabolism | Phenotype | Animals | Energy Metabolism | Lipopolysaccharides - pharmacology | Glucose - metabolism | Mice | Receptors, Immunologic - genetics | Receptors, Immunologic - metabolism | Phosphates | Glucose metabolism | Medical colleges | Orphans | Physiological aspects | Glucose | Macrophages | Phosphotransferases | Dextrose | Sugars | Monosaccharides | Index Medicus | Adaptations | Carbohydrates | Polarization | Cell activation | Immunomodulation | Pentose phosphate pathway | Lipopolysaccharides
Journal Article
Diabetes, ISSN 0012-1797, 2011, Volume 60, Issue 11, pp. 2775 - 2786
OBJECTIVE To investigate deep and comprehensive analysis of gut microbial communities and biological parameters after prebiotic administration in obese and... 
GLUCAGON-LIKE PEPTIDE-1 | PERMEABILITY | MECHANISM | INULIN-TYPE FRUCTANS | PHYLOGENETIC MICROARRAY | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | ENDOTOXEMIA | RATS | ADIPOGENESIS | Obesity - diet therapy | Leptin - metabolism | Diabetes Mellitus, Type 2 - diet therapy | Glucagon-Like Peptide 1 - blood | Cecum - microbiology | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Gram-Negative Bacteria - isolation & purification | Obesity - blood | Molecular Typing | Glucose Intolerance - prevention & control | Enteroendocrine Cells - metabolism | Proglucagon - metabolism | Enteroendocrine Cells - pathology | Hyperglycemia - prevention & control | Dietary Fats - adverse effects | Colon - pathology | Mice, Inbred C57BL | Gene Expression Regulation | Hyperlipidemias - prevention & control | Colon - metabolism | Obesity - metabolism | Obesity - pathology | Prebiotics | Diabetes Mellitus, Type 2 - blood | Animals | Gram-Positive Bacteria - classification | Gram-Positive Bacteria - isolation & purification | Mice, Obese | Mice | Proglucagon - genetics | Diabetes Mellitus, Type 2 - pathology | Gram-Negative Bacteria - classification | Glucose metabolism | Obesity | Microbiota (Symbiotic organisms) | Physiological aspects | Development and progression | Research | Gene expression | Oxidative stress | Animal models | rRNA 16S | Diabetes mellitus | Homeostasis | Abundance | Feeding | Diets | Glucose tolerance | Polymerase chain reaction | DNA microarrays | Leptin | Lipid metabolism | Catalogs | Digestive tract | Glucagon-like peptide 1 | Index Medicus | Abridged Index Medicus | Metabolism | insulin-resistance | adipogenesis | inflammation | glucagon-like peptide-1 | permeability | endotoxemia | inulin-type fructans | rats | phylogenetic microarray | mechanism
Journal Article
Gastroenterology, ISSN 0016-5085, 2009, Volume 137, Issue 1, pp. 350 - 360.e5
Background & Aims Acute pancreatitis constitutes a life-threatening condition in which pancreatic acinar cells undergo massive cell death. We investigated the... 
Gastroenterology and Hepatology | ACTIVATED PROTEIN-KINASE | INHIBITION | RAT PANCREAS | TRYPSINOGEN ACTIVATION | IN-VIVO | ENDOTOXIN | LIPOPOLYSACCHARIDE | CHRONIC ALCOHOL EXPOSURE | ACINAR-CELLS | GASTROENTEROLOGY & HEPATOLOGY | CELL-DEATH | Caspase 9 - metabolism | Pancreatitis - etiology | Humans | Caspase 3 - metabolism | Endotoxemia - chemically induced | Lysosomes - enzymology | Male | Endotoxemia - pathology | Autophagy | Lipopolysaccharides | Necrosis | Lysosomes - metabolism | Transfection | RNA Interference | Time Factors | Adenosine Triphosphate - metabolism | HMGB1 Protein - metabolism | Pancreatitis, Alcoholic - metabolism | Disease Models, Animal | Pancreas - enzymology | Pancreatitis, Alcoholic - etiology | Cell Line | Acute Disease | Lysosome-Associated Membrane Glycoproteins - metabolism | Ethanol | Down-Regulation | Lysosomal-Associated Membrane Protein 2 - genetics | Pancreas - pathology | Rats | Cathepsin B - metabolism | Pancreas - metabolism | Trypsin - metabolism | Rats, Sprague-Dawley | Animals | Endotoxemia - complications | Pancreatitis, Alcoholic - pathology | Pancreatitis - pathology | Pancreatitis - metabolism | Endotoxemia - metabolism | Lysosomal-Associated Membrane Protein 2 - metabolism | Apoptosis | Chromosomal proteins | Mitogens | Pancreatitis | Index Medicus | Abridged Index Medicus
Journal Article
Nutrition, ISSN 0899-9007, 2014, Volume 30, Issue 5, pp. 602 - 611
Abstract Objective The aim of the present study was to determine the effects of oral supplementation with l -glutamine plus l -alanine (GLN+ALA), both in the... 
Gastroenterology and Hepatology | Antioxidants | l-alanine | Sepsis | Amino acids | Cytokines | Nuclear factor-κB | L-alanine | Nuclear factor-kappa B | INJURY | RATS | PERITONEAL-MACROPHAGES | NUTRITION & DIETETICS | PLASMA | METABOLISM | GLUTATHIONE | AMINO-ACIDS | GENE-EXPRESSION | HEALTH | Inflammation - chemically induced | Interleukin-1 Receptor-Associated Kinases - metabolism | Interleukin-1 Receptor-Associated Kinases - genetics | Glutathione - metabolism | Antioxidants - metabolism | Glutamine - metabolism | Male | Muscle, Skeletal - metabolism | NF-kappa B - metabolism | RNA, Messenger - metabolism | Lipopolysaccharides | Inflammation - metabolism | Inflammation - drug therapy | Inflammation Mediators - metabolism | Anti-Inflammatory Agents - therapeutic use | Glutamine - pharmacology | Endotoxemia - microbiology | Escherichia coli Infections - drug therapy | Lymphocytes - metabolism | Dipeptides - therapeutic use | Anti-Inflammatory Agents - pharmacology | Dipeptides - pharmacology | Endotoxemia - drug therapy | Liver - metabolism | Myeloid Differentiation Factor 88 - genetics | Escherichia coli Infections - microbiology | Antioxidants - pharmacology | Mice, Inbred Strains | Antioxidants - therapeutic use | Animals | Endotoxemia - complications | Thiobarbituric Acid Reactive Substances | Glutamine - therapeutic use | Mice | Oxidative Stress - drug effects | Dietary Supplements | Myeloid Differentiation Factor 88 - metabolism | Escherichia coli Infections - complications | Glutamine | Proteins | Oxidative stress | Musculoskeletal system | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 06/2012, Volume 122, Issue 6, pp. 1973 - 1990
EC activation and dysfunction have been linked to a variety of vascular inflammatory disease states. The function of microRNAs (miRNAs) in vascular EC... 
CELL-ADHESION MOLECULE-1 | TRANSCRIPTION FACTORS | MEDICINE, RESEARCH & EXPERIMENTAL | TUMOR-NECROSIS-FACTOR | DEPENDENT INDUCTION | LEUKOCYTE RECRUITMENT | HUMAN-ENDOTHELIAL-CELLS | ACUTE MYELOID-LEUKEMIA | PROGNOSTIC-SIGNIFICANCE | EXPRESSION PROFILES | SIGNAL-TRANSDUCTION PATHWAY | alpha Karyopherins - metabolism | Endotoxemia - therapy | Leukocytes - pathology | Vasculitis - metabolism | Acute Lung Injury - therapy | Endotoxemia - genetics | Humans | NF-kappa B - immunology | Critical Illness | Acute Lung Injury - genetics | MicroRNAs - metabolism | NF-kappa B - metabolism | Endotoxemia - pathology | Vasculitis - immunology | Leukocytes - immunology | Vasculitis - genetics | alpha Karyopherins - immunology | E-Selectin - genetics | Endotoxemia - immunology | Vascular Cell Adhesion Molecule-1 - genetics | Acute Lung Injury - metabolism | Vascular Cell Adhesion Molecule-1 - immunology | Vasculitis - therapy | Lipopolysaccharides - toxicity | Endothelial Cells - metabolism | E-Selectin - metabolism | E-Selectin - immunology | MicroRNAs - immunology | Acute Lung Injury - pathology | Endothelial Cells - immunology | Animals | NF-kappa B - genetics | alpha Karyopherins - genetics | Acute Lung Injury - immunology | Mice | MicroRNAs - genetics | Endothelial Cells - pathology | Endotoxemia - metabolism | Vascular Cell Adhesion Molecule-1 - metabolism | Leukocytes - metabolism | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 04/2015, Volume 125, Issue 4, pp. 1579 - 1590
Metabolic reprogramming is implicated in macrophage activation, but the underlying mechanisms are poorly understood. Here, we demonstrate that the NOTCH1... 
MEDICINE, RESEARCH & EXPERIMENTAL | GENE | CELL ACTIVATION | NITRIC-OXIDE SYNTHASE | INFLAMMATION | ALCOHOLIC LIVER-DISEASE | TRANSCRIPTION | ROS | DIFFERENTIATION | HYPOXIA | PYRUVATE-DEHYDROGENASE COMPLEX | Up-Regulation | Macrophage Activation - genetics | Reactive Oxygen Species - metabolism | Electron Transport - genetics | Liver Failure, Acute - etiology | Male | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - antagonists & inhibitors | Fatty Liver, Alcoholic - metabolism | Inflammation - metabolism | Receptor, Notch1 - deficiency | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism | Transcription, Genetic | Fatty Liver, Alcoholic - pathology | Macrophage Activation - physiology | Protein Structure, Tertiary | Pyruvate Dehydrogenase Complex - metabolism | Cell Line | Mice, Inbred C57BL | Gene Expression Regulation | Oxidative Phosphorylation | Fatty Liver, Alcoholic - immunology | Inflammation - immunology | Liver Failure, Acute - metabolism | Mitochondria - metabolism | Mice, Knockout | Feedback, Physiological | Animals | Endotoxemia - complications | Liver Failure, Acute - immunology | Liver Failure, Acute - pathology | Glucose - metabolism | Myeloid Cells - metabolism | Signal Transduction - physiology | Mice | Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - genetics | Myeloid Cells - pathology | Nitric Oxide - metabolism | Receptor, Notch1 - physiology | Cell metabolism | Genetic research | Genetic aspects | Genetic transcription | Research | Macrophages | Properties | Liver diseases | Cytokines | Microscopy | Pilot projects | Rodents | Mitochondrial DNA | Metabolism | Gene expression | Index Medicus | Abridged Index Medicus | Hepatology | Inflammation | Immunology
Journal Article
Scientific Reports, ISSN 2045-2322, 05/2014, Volume 4, Issue 1, pp. 4828 - 4828
Periodontitis has been implicated as a risk factor for metabolic disorders such as type 2 diabetes, atherosclerotic vascular diseases, and non-alcoholic fatty... 
C-REACTIVE PROTEIN | RHEUMATOID-ARTHRITIS | POLYMERASE-CHAIN-REACTION | PORPHYROMONAS-GINGIVALIS | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | CARDIOVASCULAR-DISEASE | CORONARY-HEART-DISEASE | DIET-INDUCED OBESITY | PERIODONTAL-DISEASE | ADIPOSE-TISSUE | Glucose Intolerance - metabolism | Inflammation - pathology | Ileum - pathology | Metabolic Diseases - pathology | Diabetes Mellitus, Type 2 - microbiology | Periodontitis - microbiology | Glucose Intolerance - microbiology | Ileum - metabolism | Male | Glucose Intolerance - pathology | Diabetes Mellitus, Type 2 - metabolism | Endotoxemia - pathology | Periodontitis - metabolism | Dental Plaque - microbiology | Gingiva - metabolism | Inflammation - metabolism | Microbiota | Gingiva - pathology | Insulin Resistance - physiology | Tight Junction Proteins - metabolism | Disease Models, Animal | Endotoxemia - microbiology | Porphyromonas gingivalis | Inflammation - microbiology | Cytokines - metabolism | Mice, Inbred C57BL | Periodontitis - pathology | Insulin - metabolism | Animals | Metabolic Diseases - metabolism | Mice | Diabetes Mellitus, Type 2 - pathology | Endotoxemia - metabolism | Gingiva - microbiology | Ileum - microbiology | Metabolic Diseases - microbiology | Liver diseases | Diabetes mellitus | Oral administration | Dental plaque | Inflammation | Gene expression | Insulin | Ileum | Glucose tolerance | Intolerance | Fatty liver | Vascular diseases | Periodontitis | Arteriosclerosis | Rodents | Gingiva | Endotoxemia | Metabolic disorders | Index Medicus
Journal Article
Journal of Cellular and Molecular Medicine, ISSN 1582-1838, 12/2017, Volume 21, Issue 12, pp. 3178 - 3189
The purpose of the present study was to investigate the effect of salidroside (Sal) on myocardial injury in lipopolysaccharide ( LPS )‐induced endotoxemic in... 
H9C2 | myocardial injury | ROS | mTOR | salidroside | 3K/Akt | LPS | PI3K/Akt/mTOR | MEDICINE, RESEARCH & EXPERIMENTAL | OXIDATIVE STRESS | PHOSPHATIDYLINOSITOL 3-KINASE | RATS | ACUTE LUNG INJURY | ISCHEMIA REPERFUSION INJURY | NLRP3 INFLAMMASOME | CELL BIOLOGY | MITOCHONDRIAL ROS | SIGNALING PATHWAY | TANSHINONE IIA SULFONATE | KAPPA-B PATHWAY | Superoxide Dismutase - genetics | Reactive Oxygen Species - metabolism | TOR Serine-Threonine Kinases - metabolism | Tumor Necrosis Factor-alpha - genetics | Endotoxemia - chemically induced | Endotoxemia - pathology | Interleukin-1beta - genetics | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Lipopolysaccharides | Myocardial Reperfusion Injury - pathology | Dexamethasone - pharmacology | TOR Serine-Threonine Kinases - genetics | Interleukin-1beta - metabolism | Myocardium - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Interleukin-6 - metabolism | Myocardial Reperfusion Injury - genetics | Phenols - pharmacology | Glutathione Peroxidase - metabolism | Interleukin-6 - genetics | Signal Transduction | Catalase - genetics | Endotoxemia - drug therapy | Rats | Cardiotonic Agents - pharmacology | Rats, Sprague-Dawley | Glutathione Peroxidase - genetics | Myocytes, Cardiac - pathology | Reactive Oxygen Species - antagonists & inhibitors | Myocytes, Cardiac - drug effects | Myocytes, Cardiac - metabolism | Hemodynamics - drug effects | Nitric Oxide Synthase Type II - metabolism | Tumor Necrosis Factor-alpha - metabolism | Endotoxemia - genetics | Glutathione - metabolism | Myocardial Reperfusion Injury - chemically induced | Phosphatidylinositol 3-Kinases - metabolism | Proto-Oncogene Proteins c-akt - genetics | TOR Serine-Threonine Kinases - antagonists & inhibitors | Myocardial Reperfusion Injury - drug therapy | Superoxide Dismutase - metabolism | Cell Line | Glucosides - pharmacology | Gene Expression Regulation | Myocardium - pathology | Catalase - metabolism | Phosphatidylinositol 3-Kinases - genetics | Animals | Nitric Oxide Synthase Type II - genetics | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Mitogens | Cysteine | Index Medicus | PI3K | Akt | Original
Journal Article