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Journal of Biological Chemistry, ISSN 0021-9258, 07/2012, Volume 287, Issue 31, pp. 25758 - 25769
The early initiation phase of acute inflammation is anabolic and primarily requires glycolysis with reduced mitochondrial glucose oxidation for energy, whereas... 
MACROPHAGE-MEDIATED INFLAMMATION | HOMEOSTASIS | T-CELL MEMORY | METABOLISM | ADIPONECTIN | INSULIN-RESISTANCE | IMMUNOSUPPRESSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENDOTOXIN TOLERANCE | SEPSIS | DIFFERENTIATION | Sirtuin 1 - metabolism | Humans | Monocyte-Macrophage Precursor Cells - immunology | Glucose Transporter Type 1 - metabolism | Monocyte-Macrophage Precursor Cells - metabolism | Leukocytes - immunology | Heat-Shock Proteins - genetics | Monocyte-Macrophage Precursor Cells - physiology | Nicotinamide Phosphoribosyltransferase - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Sepsis - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | NAD - biosynthesis | Fatty Acids - metabolism | Cell Line | Sepsis - immunology | Cytokines - metabolism | Oxidation-Reduction | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Heat-Shock Proteins - metabolism | Mice, Inbred C57BL | Transcription Factors - genetics | Toll-Like Receptor 4 - metabolism | Transcription Factors - metabolism | Carrier Proteins - genetics | Adaptation, Physiological - immunology | Animals | Carrier Proteins - metabolism | Energy Metabolism | Lipopolysaccharides - pharmacology | Glucose - metabolism | Glycolysis | Mice | Leukocytes - metabolism | Sirtuins - metabolism | Index Medicus | NAD | Sirtuins | Immunology | Acute Inflammation | Bioenergetics | PGC-1 | Sepsis | HIF-1α | Biosensors | Macrophages | Metabolism
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2005, Volume 6, Issue 8, pp. 777 - 784
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2005, Volume 280, Issue 48, pp. 39914 - 39924
The CATERPILLER (CLR, also NOD and NLR) proteins share structural similarities with the nucleotide binding domain ( NBD)leucine- rich repeat (LRR) superfamily... 
ENDOTOXIN-TOLERANT CELLS | CROHNS-DISEASE | AUTOINFLAMMATORY DISORDERS | HOST RECOGNITION | NEGATIVE REGULATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BACTERIAL PEPTIDOGLYCAN | NF-KAPPA-B | CIAS1 MUTATIONS | CUTTING EDGE | FAMILY | Protein Kinases - metabolism | Tumor Necrosis Factor-alpha - metabolism | Phosphorylation | Immunoprecipitation | Luciferases - metabolism | Humans | Transcriptional Activation | Interleukin-1 Receptor-Associated Kinases | Monocytes - metabolism | NF-kappa B - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Transfection | Retroviridae - genetics | Antigens, Differentiation - metabolism | Toll-Like Receptors - metabolism | Caspases - chemistry | Mycobacterium tuberculosis - metabolism | Genes, Reporter | RNA - metabolism | Protein Structure, Tertiary | Cell Line | Promoter Regions, Genetic | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Signal Transduction | Nuclear Pore Complex Proteins - metabolism | TNF Receptor-Associated Factor 2 - metabolism | Inflammation | Cytoskeletal Proteins - chemistry | Myeloid Differentiation Factor 88 | Reverse Transcriptase Polymerase Chain Reaction | Plasmids - metabolism | Pyrin | Amino Acid Motifs | Transcription Factor RelA - metabolism | TNF Receptor-Associated Factor 6 - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Intracellular Signaling Peptides and Proteins - physiology | RNA-Binding Proteins - metabolism | Receptors, Immunologic - metabolism | RNA, Small Interfering - metabolism | Index Medicus
Journal Article
Journal Article
by Peng, JH and Cui, T and Huang, F and Chen, L and Zhao, Y and Xu, L and Xu, LL and Feng, Q and Hu, YY
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 03/2013, Volume 344, Issue 3, pp. 646 - 654
Puerarin, an isoflavone component extracted from Kudzu (Pueraria lobata), has been demonstrated to alleviate alcohol-related disorders. Our study examined... 
HEPATITIS | LIPOPOLYSACCHARIDE-BINDING PROTEIN | DISEASE | BARRIER | FATTY LIVER | RATS | ETHANOL | PHARMACOLOGY & PHARMACY | MICE | KAPPA-B | INTESTINAL PERMEABILITY | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Tight Junctions - genetics | Isoflavones - pharmacology | Male | Alanine Transaminase - blood | Alcohol-Related Disorders - genetics | Antigens, CD - genetics | Receptors, Immunologic - antagonists & inhibitors | Antigens, CD - metabolism | Liver Diseases, Alcoholic - drug therapy | Zonula Occludens-1 Protein - metabolism | Neutrophil Infiltration - drug effects | Disease Models, Animal | Tight Junctions - drug effects | Tight Junctions - metabolism | Zonula Occludens-1 Protein - genetics | Fatty Liver - metabolism | Portal Vein - metabolism | Liver - metabolism | Rats | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 2 - metabolism | Neutrophil Infiltration - genetics | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Fatty Liver - drug therapy | Triglycerides - metabolism | Microvilli - genetics | Aspartate Aminotransferases - blood | Diet | Microvilli - metabolism | Receptors, Immunologic - genetics | Intestines - drug effects | Tumor Necrosis Factor-alpha - metabolism | Liver - enzymology | Intestines - metabolism | Acute-Phase Proteins - genetics | Alcohol-Related Disorders - drug therapy | Lipopolysaccharide Receptors - metabolism | Alcohol-Related Disorders - metabolism | Liver Diseases, Alcoholic - genetics | Receptors, Immunologic - biosynthesis | Kupffer Cells - metabolism | Endotoxins - metabolism | Fatty Liver - genetics | Portal Vein - drug effects | Acute-Phase Proteins - metabolism | Endotoxins - genetics | gamma-Glutamyltransferase - metabolism | Antigens, Differentiation, Myelomonocytic - genetics | Liver Diseases, Alcoholic - metabolism | Kupffer Cells - drug effects | Membrane Glycoproteins - genetics | Carrier Proteins - genetics | Microvilli - drug effects | Endotoxins - antagonists & inhibitors | Animals | Carrier Proteins - metabolism | Antigens, Differentiation, Myelomonocytic - metabolism | Lipopolysaccharide Receptors - genetics | Receptors, Immunologic - metabolism | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, pp. e49023 - e49023
Intrauterine infection and inflammation are major reasons for preterm birth. The switch from placenta-mediated to lung-mediated oxygen supply during birth is... 
INDUCED CELL-DEATH | ISCHEMIC TOLERANCE | MICROGLIAL TOXICITY | NITRIC-OXIDE SYNTHASE | MULTIDISCIPLINARY SCIENCES | PERIVENTRICULAR LEUKOMALACIA | DEVELOPING OLIGODENDROCYTES | NECROSIS-FACTOR-ALPHA | EXCITOTOXIC INJURY | INDUCED BRAIN-INJURY | BACTERIAL-ENDOTOXIN SENSITIZES | Inflammation - chemically induced | Inflammation - pathology | Microglia - metabolism | Oligodendroglia - metabolism | Rats, Wistar | Apoptosis - drug effects | Caspase 3 - metabolism | Brain - metabolism | Inflammation - metabolism | Oligodendroglia - drug effects | Nerve Fibers, Myelinated - pathology | Hyperoxia - metabolism | Microglia - pathology | Animals, Newborn | Nerve Fibers, Myelinated - metabolism | Leukoencephalopathies - pathology | Microglia - drug effects | Nerve Fibers, Myelinated - drug effects | Cells, Cultured | Rats | Leukoencephalopathies - metabolism | Rats, Sprague-Dawley | Brain - drug effects | Hyperoxia - pathology | Oligodendroglia - pathology | Animals | Lipopolysaccharides - pharmacology | Brain - pathology | Apoptosis - physiology | Immunohistochemistry | Brain | Cell death | Infants (Premature) | Inflammation | Research | Mitogens | Health aspects | Injuries | Neuroimaging | Neonates | Cell culture | Pediatrics | Transcription factors | Traumatic brain injury | Lung | Premature birth | Interleukin | Superoxide dismutase | Infants | Infections | Birth | Western blotting | Lipopolysaccharides | Head injuries | Newborn babies | Ischemia | Rodents | Oligodendrocytes | Oxygen | Pain perception | Cytokines | Maturation | Incubation | Mortality | Superoxide | Gene expression | Substantia alba | Microglia | Hospitals | Placenta | Magnetic resonance imaging | Magnetic permeability | Hyperoxia | Interleukin 10 | Brain damage | Hypoxia | Oxygen tension | Brain injury | Apoptosis | Index Medicus | pathology | Leukoencephalopathies | Sprague-Dawley | pharmacology | Caspase 3 | Cultured | Basic Medicine | chemically induced | Myelinated | physiology | drug effects | Cells | Newborn | Wistar | Medicinska grundvetenskaper | Oligodendroglia | metabolism | Nerve Fibers
Journal Article
Journal of Neuroscience, ISSN 0270-6474, 06/2010, Volume 30, Issue 23, pp. 7975 - 7983
A single postnatal exposure to the bacterial endotoxin, lipopolysaccharide (LPS), reduces the neuroimmune response to a subsequent LPS exposure in the adult... 
VAGUS NERVE | MATERNAL-CARE | INDIVIDUAL-DIFFERENCES | ENDOTOXIN EXPOSURE | MESSENGER-RNA | IMMUNE CHALLENGE | NEUROIMMUNE RESPONSES | PITUITARY-ADRENAL AXIS | CYTOKINE GENE-EXPRESSION | NEUROSCIENCES | LONG-TERM ALTERATIONS | Inflammation - chemically induced | Adrenal Glands - immunology | Up-Regulation | Spleen - immunology | Pituitary Gland - metabolism | Receptors, Glucocorticoid - metabolism | RNA, Messenger - metabolism | Lipopolysaccharides | Brain - metabolism | Inflammation - metabolism | Liver - immunology | Time Factors | Cyclooxygenase 2 - genetics | Corticotropin-Releasing Hormone - genetics | Pro-Opiomelanocortin - genetics | Neural Pathways - immunology | Adrenocorticotropic Hormone - blood | Hypothalamo-Hypophyseal System - immunology | Pituitary-Adrenal System - metabolism | Prostaglandins E - metabolism | Liver - metabolism | Injections, Intraperitoneal | Rats | Toll-Like Receptor 4 - genetics | Reverse Transcriptase Polymerase Chain Reaction | Rats, Sprague-Dawley | Toll-Like Receptor 4 - metabolism | Blotting, Western | Corticotropin-Releasing Hormone - metabolism | Hypothalamo-Hypophyseal System - metabolism | Pituitary-Adrenal System - immunology | Pro-Opiomelanocortin - metabolism | Hippocampus - metabolism | Animals | Hypothalamus - metabolism | Adrenal Glands - metabolism | Spleen - metabolism | Cyclooxygenase 2 - metabolism | Receptors, Glucocorticoid - genetics | Brain - immunology | Index Medicus
Journal Article
The Journal of Nutritional Biochemistry, ISSN 0955-2863, 09/2013, Volume 24, Issue 9, pp. 1609 - 1615
The therapeutic effects of probiotic treatment in alcoholic liver disease (ALD) have been studied in both patients and experimental animal models. Although the... 
Probiotics | Alcohol | Inflammation | TNF | Liver | TRANSCRIPTION FACTORS | OXIDATIVE STRESS | CYTOKINE RESPONSES | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHRONIC ETHANOL | NECROSIS-FACTOR-ALPHA | BLOOD MONONUCLEAR-CELLS | CHROMOGENIC ASSAY | NUTRITION & DIETETICS | MESSENGER-RNA | TOLL-LIKE RECEPTORS | Probiotics - administration & dosage | Tumor Necrosis Factor-alpha - metabolism | Inflammation - pathology | Leukocytes, Mononuclear - metabolism | Intestinal Mucosa - metabolism | Liver - pathology | Phosphorylation | Toll-Like Receptor 5 - genetics | Humans | Lipopolysaccharides - metabolism | Male | Cytochrome P-450 CYP2E1 - genetics | Cytochrome P-450 CYP2E1 - metabolism | Gram-Negative Bacteria - metabolism | RNA, Messenger - metabolism | Lipopolysaccharides - adverse effects | Liver Diseases, Alcoholic - therapy | Flagellin - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Flagellin - adverse effects | Lactobacillus rhamnosus | Endotoxins - metabolism | Liver Diseases, Alcoholic - pathology | Toll-Like Receptor 5 - metabolism | Ethanol - metabolism | Mice, Inbred C57BL | RNA, Messenger - genetics | Toll-Like Receptor 4 - genetics | Toll-Like Receptor 4 - metabolism | Inflammation - therapy | Macrophages - metabolism | Animals | Intestines - microbiology | Probiotics - therapeutic use | Mice | Endotoxins - adverse effects | Index Medicus
Journal Article
Journal of Experimental Medicine, ISSN 0022-1007, 01/2003, Volume 197, Issue 2, pp. 263 - 268
Journal Article
Diabetes, Obesity and Metabolism, ISSN 1462-8902, 03/2017, Volume 19, Issue 3, pp. 457 - 462
We aimed to investigate the effects of gemigliptin, a dipeptidyl peptidase‐4 inhibitor, on postprandial lipoprotein levels and endotoxemia in a randomized,... 
antidiabetic drug | DPP | dyslipidaemia | randomized trial | 4 inhibitor | DPP-4 inhibitor | OBESITY | STATES | SITAGLIPTIN THERAPY | INSULIN-RESISTANCE | INFLAMMATION | ENDOCRINOLOGY & METABOLISM | Endotoxins - blood | Dipeptidyl-Peptidase IV Inhibitors - therapeutic use | Humans | Middle Aged | Transcriptome | Apolipoprotein B-48 - metabolism | Male | Piperidones - therapeutic use | Diabetes Mellitus, Type 2 - metabolism | RNA, Messenger - metabolism | Apolipoprotein B-100 - metabolism | Diabetes Mellitus, Type 2 - immunology | Diet, High-Fat | Postprandial Period | Subcutaneous Fat, Abdominal - immunology | Tumor Necrosis Factor-alpha - immunology | Adiponectin - metabolism | Adult | Female | Cytokines - genetics | Endotoxemia | Cytokines - immunology | Double-Blind Method | Glucagon-Like Peptide 1 - metabolism | Cholesterol, HDL - metabolism | Insulin Resistance | Lipid Metabolism | Cholesterol - metabolism | Triglycerides - metabolism | Cross-Over Studies | Insulin - metabolism | Pyrimidines - therapeutic use | Interleukin-6 - immunology | Cholesterol, LDL - metabolism | Glucagon - metabolism | Aged | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Subcutaneous Fat, Abdominal - metabolism | C-Reactive Protein - immunology | Type 2 diabetes | Care and treatment | Analysis | Physiological aspects | Hypoglycemic agents | Apolipoproteins | Gene expression | Diabetes | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, pp. e47713 - e47713
Background & Aims: While it is widely accepted that obesity is associated with low-grade systemic inflammation, the molecular origin of the inflammation... 
SYSTEM | ACTIVATION | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | DISEASE | ECOLOGY | MODEL | NF-KAPPA-B | ADIPOSE-TISSUE | INFILTRATION | Endotoxins - blood | Diet, High-Fat - adverse effects | Male | Adipose Tissue - metabolism | Inflammation - metabolism | Forkhead Transcription Factors - metabolism | Inflammation Mediators - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Cytokines - blood | Endotoxins - metabolism | Cytokines - metabolism | Macrophages - pathology | Signal Transduction | Adipose Tissue - pathology | Inflammation Mediators - blood | Gastrointestinal Tract - microbiology | Toll-Like Receptor 4 - genetics | Adiposity - genetics | Toll-Like Receptor 4 - metabolism | Gastrointestinal Tract - metabolism | Mice, Knockout | Obesity - metabolism | Colitis - etiology | Animals | Mice | Forkhead Box Protein O3 | Metagenome | Obesity | Microbiota (Symbiotic organisms) | Causes of | Physiological aspects | Toll-like receptors | Development and progression | Inflammation | Genetic aspects | Research | Ketogenic diet | Phosphorylation | Adipose tissue | Body weight | AKT protein | Kinases | Macrophages | High fat diet | Proteins | Signal transduction | Microbiota | Intestine | Rodents | Colon | Digestive tract | FOXO3 protein | NF-κB protein | Cytokines | Digestive system | Permeability | TLR4 protein | Nitric-oxide synthase | Immune systems | Signaling | Insulin resistance | Infiltration | Cyclooxygenase-2 | Index Medicus
Journal Article
Glia, ISSN 0894-1491, 10/2013, Volume 61, Issue 10, pp. 1698 - 1711
Increasing evidence indicates that “functional plasticity” is not solely a neuronal attribute but a hallmark of microglial cells, the main brain resident... 
M2 inflammation | brain macrophages | microglia | endotoxin tolerance | Endotoxin tolerance | Brain macrophages | M1 | Microglia | CELLS | ACTIVATION | BRAIN-INJURY | TOLERANCE | ENDOTOXIN | NEUROSCIENCES | PROSTANOID PRODUCTION | IN-VIVO | MACROPHAGE POLARIZATION | EXPRESSION | Membrane Glycoproteins - metabolism | Arginase - metabolism | Insulin-Like Growth Factor I - genetics | RNA, Messenger - metabolism | Antigens, CD - metabolism | Microglia - physiology | Time Factors | Cyclooxygenase 2 - genetics | Cell Polarity - drug effects | Membrane Proteins - metabolism | Cytokines - genetics | Organ Culture Techniques | Animals, Newborn | Cyclooxygenase 1 - genetics | Phagocytosis - drug effects | Cytokines - metabolism | Enzyme-Linked Immunosorbent Assay | Microglia - drug effects | Membrane Proteins - genetics | Rats | Receptors, Cell Surface - metabolism | Arginase - genetics | Hippocampus - cytology | Membrane Glycoproteins - genetics | Dinoprostone - metabolism | Cell Movement - drug effects | Animals | Nitric Oxide Synthase Type II - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Cyclooxygenase 2 - metabolism | Lipopolysaccharides - pharmacology | Cell Polarity - physiology | Cyclooxygenase 1 - metabolism | Insulin-Like Growth Factor I - metabolism | Nitric Oxide Synthase Type II - metabolism | Receptors, Cell Surface - genetics | Index Medicus
Journal Article