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Nature immunology, ISSN 1529-2908, 2016, Volume 17, Issue 4, pp. 406 - 413
The acute phase of sepsis is characterized by a strong inflammatory reaction. At later stages in some patients, immunoparalysis may be encountered, which is... 
SYSTEMIC INFLAMMATION | MESSENGER-RNA TRANSLATION | ACTIVATION | INTERFERON-GAMMA | IFN-GAMMA | MACROPHAGES | SIRTUIN 1 | DYSFUNCTION | IMMUNOLOGY | EXPRESSION | CELLULAR-METABOLISM | Prospective Studies | Humans | Middle Aged | Transcriptome | Immunoblotting | Male | Monocytes - metabolism | Monocytes - immunology | Lipopolysaccharides - immunology | Antifungal Agents - therapeutic use | Leukocytes - immunology | Young Adult | Sepsis - drug therapy | Immune Tolerance - immunology | Sepsis - metabolism | Adenosine Triphosphate - metabolism | Candidiasis, Invasive - drug therapy | Endotoxemia - immunology | Adult | Aspergillosis - metabolism | Female | Macrophages - immunology | NAD - metabolism | Aspergillosis - drug therapy | Cytokines - immunology | Sepsis - immunology | Interferon-gamma - therapeutic use | Lactic Acid - metabolism | Oxidative Phosphorylation | Oxygen Consumption | Energy Metabolism - immunology | Escherichia coli Infections - metabolism | Candidiasis, Invasive - metabolism | Immunity, Innate - immunology | Macrophages - metabolism | Animals | Candidiasis, Invasive - immunology | Glycolysis | Escherichia coli Infections - immunology | Mice | Endotoxemia - metabolism | Leukocytes - metabolism | Aspergillosis - immunology | Complications and side effects | Energy metabolism | Immune response | Bioenergetics | Abnormalities | Sepsis | Regulation | Leukocytes | Properties | Health aspects | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 03/2015, Volume 519, Issue 7542, pp. 242 - 246
Journal Article
Journal Article
FASEB Journal, ISSN 0892-6638, 06/2015, Volume 29, Issue 6, pp. 2315 - 2326
Conventional T (Tcon) cells and Foxp3(+) T-regulatory (Treg) cells are thought to have differing metabolic requirements, but little is known of mitochondrial... 
Transplant survival | Histone deacetylase | Immunometabo-lism | Immunoregulation | Immunity | MEMORY DEVELOPMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | EFFECTOR FUNCTION | immunity | transplant survival | histone deacetylase | ENHANCER FACTOR-2 MEF2 | CELL BIOLOGY | immunometabolism | INFLAMMATION | CARDIAC-HYPERTROPHY | BIOLOGY | immunoregulation | DIFFERENTIATION | EXPRESSION | MOLECULAR-MECHANISMS | LYMPHOCYTES | Forkhead Transcription Factors - immunology | T-Lymphocytes, Regulatory - metabolism | Graft Survival - immunology | Reactive Oxygen Species - metabolism | Sirtuin 3 - metabolism | Gene Expression Profiling | Mitochondria - immunology | Histone Deacetylases - immunology | Mice, 129 Strain | T-Lymphocytes, Regulatory - immunology | Mitochondria - genetics | T-Lymphocytes - metabolism | Forkhead Transcription Factors - metabolism | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha | Energy Metabolism - genetics | Transcription Factors - immunology | MEF2 Transcription Factors - immunology | Repressor Proteins - metabolism | Sirtuin 3 - genetics | Histone Deacetylases - genetics | Mice, Inbred C57BL | Oxidative Phosphorylation | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Energy Metabolism - immunology | Mitochondria - metabolism | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Mice, Knockout | Transcription Factors - metabolism | Sirtuin 3 - immunology | Animals | Graft Survival - genetics | Repressor Proteins - immunology | MEF2 Transcription Factors - metabolism | T-Lymphocytes - immunology | Mice, Inbred BALB C | Index Medicus | Research Communication
Journal Article
Nature, ISSN 0028-0836, 01/2010, Volume 463, Issue 7279, pp. 369 - 373
Journal Article
The Journal of Immunology, ISSN 0022-1767, 11/2009, Volume 183, Issue 10, pp. 6095 - 6101
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2017, Volume 114, Issue 47, pp. 12542 - 12547
The metabolic programs of functionally distinct T cell subsets are tailored to their immunologic activities. While quiescent T cells use oxidative... 
Autoimmune disease | Lkb1 | Cellular metabolism | Foxp3 | Treg | ACTIVATION | ENTEROPATHY | MULTIDISCIPLINARY SCIENCES | KINASE | MOUSE | IMMUNOMETABOLISM | autoimmune disease | RESPONSES | GLUCOSE-HOMEOSTASIS | cellular metabolism | HEMATOPOIETIC STEM-CELLS | IN-VIVO | AMPK | Protein-Serine-Threonine Kinases - deficiency | T-Lymphocytes, Regulatory - metabolism | Cell Proliferation | Lymph Nodes - pathology | Spleen - immunology | Male | Mitochondria - immunology | Protein-Tyrosine Kinases - immunology | T-Lymphocytes, Regulatory - pathology | T-Lymphocytes, Cytotoxic - pathology | T-Lymphocytes, Regulatory - immunology | Autoimmune Diseases - genetics | Protein-Tyrosine Kinases - genetics | AMP-Activated Protein Kinases - immunology | Energy Metabolism - genetics | Spleen - pathology | Autoimmune Diseases - metabolism | Autoimmune Diseases - pathology | T-Lymphocytes, Cytotoxic - immunology | Signal Transduction | Cell Survival | Gene Expression Regulation - immunology | Mice, Inbred C57BL | Autoimmune Diseases - immunology | Protein-Serine-Threonine Kinases - genetics | Homeostasis - immunology | Immune Tolerance | Lymph Nodes - metabolism | CD4 Lymphocyte Count | Energy Metabolism - immunology | Lymph Nodes - immunology | Mitochondria - pathology | Mice, Knockout | Animals | Spleen - metabolism | T-Lymphocytes, Cytotoxic - metabolism | Protein-Serine-Threonine Kinases - immunology | Mice | AMP-Activated Protein Kinases - genetics | Immune response | Research | Cell differentiation | T cells | Cell proliferation | Phosphorylation | Energy metabolism | Salts | Homeostasis | Effector cells | Lymphocytes T | Kinases | AMP-activated protein kinase | Defects | LKB1 protein | Mitochondria | Clonal deletion | Energy | Lymphocytes | Deletion | Age | Cell survival | AMP | Immunoregulation | Metabolism | Survival | Immunological tolerance | Energy balance | Oxidative phosphorylation | Glycolysis | Autoimmune diseases | Index Medicus | Biological Sciences
Journal Article
Journal of Immunology, ISSN 0022-1767, 12/2010, Volume 185, Issue 12, pp. 7474 - 7479
Chronic inflammation can associate with autoreactive immune responses, including CD4(+) T cell responses to self-Ags. In this paper, we show that the... 
IMMUNE-RESPONSE | NEUROTROPHIC FACTOR | INSULIN-RESISTANCE | INFLAMMATION | RECEPTOR | MICE | CYTOKINE | RESTRICTION | IMMUNOLOGY | TYPE-1 | AUTOIMMUNE ENCEPHALOMYELITIS | Th1 Cells - pathology | Cell Proliferation | Proto-Oncogene Proteins c-bcl-2 - immunology | TOR Serine-Threonine Kinases - metabolism | Humans | Leptin - metabolism | Encephalomyelitis, Autoimmune, Experimental - immunology | Apoptosis - genetics | Th1 Cells - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - metabolism | Inflammation - metabolism | Phosphorylation - genetics | TOR Serine-Threonine Kinases - genetics | Th17 Cells - metabolism | Peptide Fragments - immunology | Phosphorylation - immunology | Encephalomyelitis, Autoimmune, Experimental - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Myelin-Oligodendrocyte Glycoprotein | Mice, Transgenic | Energy Metabolism - immunology | Glycoproteins - immunology | Mitogen-Activated Protein Kinase 3 - metabolism | Th17 Cells - immunology | Mice, Obese | Mice | Chronic Disease | Encephalomyelitis, Autoimmune, Experimental - metabolism | Species Specificity | Glycoproteins - metabolism | Th1 Cells - immunology | Proto-Oncogene Proteins c-bcl-2 - metabolism | Female | Leptin - immunology | Energy Metabolism - genetics | Multiple Sclerosis - metabolism | Th17 Cells - pathology | Mitogen-Activated Protein Kinase 3 - immunology | Peptide Fragments - metabolism | Cyclin-Dependent Kinase Inhibitor p27 - immunology | Multiple Sclerosis - genetics | Inflammation - immunology | Leptin - genetics | TOR Serine-Threonine Kinases - immunology | Animals | Apoptosis - immunology | Inflammation - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Proto-Oncogene Proteins c-bcl-2 - genetics | Cyclin-Dependent Kinase Inhibitor p27 - genetics | Index Medicus | Abridged Index Medicus
Journal Article
NATURE COMMUNICATIONS, ISSN 2041-1723, 04/2019, Volume 10, Issue 1, pp. 1685 - 11
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2017, Volume 18, Issue 6, pp. 665 - 674
Journal Article
Journal of Immunology, ISSN 0022-1767, 09/2015, Volume 195, Issue 5, pp. 2442 - 2451
Macrophages integrate information from the tissue microenvironment and adjust their effector functions according to the prevalent extracellular stimuli.... 
RHEUMATOID-ARTHRITIS | ACTIVIN-A | METABOLISM | GM-CSF | TOLL-LIKE RECEPTOR | PYRUVATE-KINASE M2 | NITRIC-OXIDE | ACTIVATED MACROPHAGES | IMMUNOLOGY | TYPE-2 MACROPHAGES | INNATE IMMUNITY | Oligonucleotide Array Sequence Analysis | Humans | Transcriptome - immunology | Cell Hypoxia | Signal Transduction - immunology | Basic Helix-Loop-Helix Transcription Factors - metabolism | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Macrophage Colony-Stimulating Factor - pharmacology | Energy Metabolism - genetics | Cytokines - genetics | Macrophages - immunology | Cytokines - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - immunology | Basic Helix-Loop-Helix Transcription Factors - genetics | Cytokines - metabolism | Glucose - immunology | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | Macrophage Activation - immunology | Cells, Cultured | Granulocyte-Macrophage Colony-Stimulating Factor - pharmacology | Energy Metabolism - immunology | Signal Transduction - genetics | Transcriptome - genetics | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Macrophage Colony-Stimulating Factor - immunology | Macrophages - metabolism | Granulocyte-Macrophage Colony-Stimulating Factor - immunology | Glucose - metabolism | Basic Helix-Loop-Helix Transcription Factors - immunology | Macrophage Activation - drug effects | Index Medicus | Abridged Index Medicus
Journal Article