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Proceedings of the National Academy of Sciences - PNAS, ISSN 1091-6490, 2018, Volume 115, Issue 15, pp. E3509 - E3518
Journal Article
PloS one, ISSN 1932-6203, 2016, Volume 11, Issue 12, p. e0167744
Journal Article
Nature medicine, ISSN 1546-170X, 2015, Volume 21, Issue 11, pp. 1344 - 1349
Journal Article
PloS one, ISSN 1932-6203, 10/2012, Volume 7, Issue 10, p. e47663
Enhancer of zeste homolog 2 (EZH2) is the catalytic subunit of the Polycomb-repressive complex 2 (PRC2... 
BREAST-CANCER | PROLONGS SURVIVAL | ACUTE-LEUKEMIA CELLS | TYROSINE KINASE | MULTIDISCIPLINARY SCIENCES | METHYLTRANSFERASE GENE EZH2 | THERAPEUTIC TARGET | GROUP PROTEIN EZH2 | TRANSCRIPTIONAL REPRESSION | COORDINATED REGULATION | POLYCOMB-REPRESSIVE COMPLEX-2 | Polycomb Repressive Complex 2 - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Polycomb Repressive Complex 2 - genetics | Neoplasm Invasiveness | Humans | Gene Expression Regulation, Neoplastic | Gene Silencing | Proto-Oncogene Proteins - genetics | Receptor Protein-Tyrosine Kinases - metabolism | Cell Movement - genetics | Enhancer of Zeste Homolog 2 Protein | Glioma - genetics | DNA Methylation | Glioblastoma - genetics | Receptor Protein-Tyrosine Kinases - genetics | Cell Transformation, Neoplastic | Cell Line, Tumor | Glioblastoma - metabolism | Polycomb Repressive Complex 2 - metabolism | Motility | Gliomas | Histones | Research | Methylation | Glioblastoma multiforme | Phosphotransferases | Health aspects | Cells | Cell proliferation | Transcription factors | Transcription | Laboratories | Neuropathology | Brain tumors | Leukemia | Genes | Glioblastoma | Homology | Malignancy | Metastasis | Kinases | Axl protein | Cooperation | Glioma cells | Cell cycle | DNA methylation | Catalysis | Growth factors | Deoxyribonucleic acid--DNA | Medical research | Hematology | Invasiveness | Pharmacology | Breast cancer | Studies | Polycomb group proteins | Gene silencing | DNA microarrays | Lysine | MicroRNAs | Stem cells | Epigenetics | Tumor suppressor genes | Histone H3 | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Journal Article
Nature medicine, ISSN 1546-170X, 2016, Volume 23, Issue 1, pp. 69 - 78
...) and cytotoxic drugs in AML. Low EZH2 protein levels correlated with poor prognosis in AML patients... 
TRANSFORMATION | MEDICINE, RESEARCH & EXPERIMENTAL | CELLS | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CANCER | SOMATIC MUTATIONS | CELL BIOLOGY | THERAPY | GENE EZH2 | DIFFERENTIATION | INHIBITOR | EXPRESSION | Immunohistochemistry | CDC2 Protein Kinase | Enhancer of Zeste Homolog 2 Protein - antagonists & inhibitors | Neoplasm Transplantation | Cyclin-Dependent Kinases - metabolism | Cytarabine - pharmacology | Immunoprecipitation | Humans | Middle Aged | Gene Expression Regulation, Neoplastic | Male | Bortezomib - pharmacology | Gene Knockdown Techniques | Young Adult | Flow Cytometry | Mass Spectrometry | Aged, 80 and over | Leukemia, Myeloid, Acute - drug therapy | Adult | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Blotting, Western | Homeodomain Proteins - genetics | Drug Resistance, Neoplasm - genetics | Protein Kinase Inhibitors | Animals | Proteomics | Cell Line, Tumor | HSP90 Heat-Shock Proteins - metabolism | Aged | Mice | Protein Processing, Post-Translational | Histones - metabolism | Proteasome Endopeptidase Complex - metabolism | Pyridones - pharmacology | Leukemia, Myeloid, Acute - genetics | Genetic aspects | Methyltransferases | Drug resistance | Health aspects | Drugs | Therapy | Hsp90 protein | Phosphorylation | Leukemia | Chemoresistance | Cytotoxicity | Kinases | Degradation | Proteins | Cytarabine | Restoration | Histone methyltransferase | HOX gene | Protein-tyrosine kinase | Tyrosine | Bortezomib | Myeloid leukemia | Heat shock proteins | Gene expression | Patients | Sensitivity | Inhibitors | Derepression | Proteasomes | Blast resistance | Methylation | Acute myeloid leukemia | Heat shock
Journal Article
Cell death and differentiation, ISSN 1476-5403, 2017, Volume 24, Issue 5, pp. 889 - 902
... of several cancer-related genes. Among these genes, we showed that FAK silencing decreased transcription and nuclear localization of enhancer of zeste homolog 2 (EZH2... 
OVEREXPRESSION | METHYLATION | PROTEIN | INHIBITION | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | NUCLEAR FAK | MECHANISMS | HISTONE METHYLTRANSFERASE EZH2 | CANCER | EXPRESSION | CELL BIOLOGY | Focal Adhesion Kinase 1 - genetics | Neoplasm Transplantation | RNA, Small Interfering - genetics | E2F2 Transcription Factor - genetics | Apoptosis - drug effects | Humans | Gene Expression Regulation, Neoplastic | Apoptosis - genetics | Male | Receptor, Notch2 - genetics | E2F2 Transcription Factor - metabolism | Tumor Suppressor Protein p53 - genetics | Carcinoma, Hepatocellular - genetics | Liver Neoplasms - pathology | Focal Adhesion Kinase 1 - metabolism | Promoter Regions, Genetic | Enhancer of Zeste Homolog 2 Protein - genetics | Enhancer of Zeste Homolog 2 Protein - metabolism | Liver Neoplasms - genetics | Signal Transduction | Receptor, Notch2 - metabolism | Tumor Suppressor Protein p53 - metabolism | E2F3 Transcription Factor - genetics | G2 Phase Cell Cycle Checkpoints | Hep G2 Cells | Animals | Histones - genetics | Mice, Nude | Aminopyridines - pharmacology | Carcinoma, Hepatocellular - pathology | E2F3 Transcription Factor - metabolism | Liver Neoplasms - metabolism | Cell Line, Tumor | Cell Proliferation - drug effects | Mice | Histones - metabolism | Focal Adhesion Kinase 1 - antagonists & inhibitors | Carcinoma, Hepatocellular - metabolism | RNA, Small Interfering - metabolism | Original Paper
Journal Article
Journal Article
The Journal of biological chemistry, ISSN 0021-9258, 11/2016, Volume 291, Issue 47, pp. 24594 - 24606
Journal Article