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Journal Article
Nature medicine, ISSN 1546-170X, 01/2016, Volume 22, Issue 3, pp. 312 - 318
Uncoupling protein 1 (UCP1) is highly expressed in brown adipose tissue, where it generates heat by uncoupling electron transport from ATP production. UCP1 is... 
Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Cell Biology | Research & Experimental Medicine | Enkephalins - metabolism | Humans | Middle Aged | Ion Channels - genetics | Male | RNA, Messenger - metabolism | Enkephalins - genetics | Mitochondrial Proteins - metabolism | Diet, High-Fat | Iodide Peroxidase - metabolism | Adipocytes, Brown - transplantation | Receptor, Platelet-Derived Growth Factor alpha - metabolism | Oxygen Consumption | Apoptosis Regulatory Proteins - metabolism | Protein Precursors - metabolism | Mice | Iodide Peroxidase - genetics | Blood Glucose - metabolism | Integrin beta1 - genetics | Adipocytes, White - metabolism | Glucose Intolerance - metabolism | Proprotein Convertase 1 - genetics | Adipocytes, Brown - metabolism | Homeostasis | Mitochondrial Proteins - genetics | DNA-Binding Proteins - metabolism | Polymerase Chain Reaction | Apoptosis Regulatory Proteins - genetics | Adult | Female | Capillaries | Glucose Tolerance Test | Protein Precursors - genetics | Proprotein Convertase 1 - metabolism | Cell Transplantation | Adipocytes, White - transplantation | DNA-Binding Proteins - genetics | Obesity - metabolism | Integrin beta1 - metabolism | Interleukin-33 - genetics | Animals | Ion Channels - metabolism | Receptor, Platelet-Derived Growth Factor alpha - genetics | Adipocytes - metabolism | Fluorescent Antibody Technique | Interleukin-33 - metabolism | Adipocytes - transplantation | Aged | Glucose Clamp Technique | Uncoupling Protein 1 | Neovascularization, Physiologic | Adipose tissues | Physiological aspects | Genetic aspects | Research | Index Medicus | cytokine | human adipocyte | glucose | progenitors | adipokine | capillary | adrenergic | thermogenic adipose tissue | implant
Journal Article
Drug metabolism and disposition, ISSN 1521-009X, 01/2010, Volume 38, Issue 1, pp. 168 - 176
This study investigated the role of a multispecific organic anion transporter, Oatp1a4/ Slco1a4 , in drug transport across the blood-brain barrier. In vitro... 
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Fluorobenzenes - pharmacokinetics | Gene Expression - genetics | Pyrimidines - blood | Humans | Ion Pumps - genetics | Fluorobenzenes - administration & dosage | Quinolines - administration & dosage | Pyrimidines - metabolism | Brain - metabolism | Quinolines - pharmacokinetics | Choroid Plexus - blood supply | ATP-Binding Cassette Transporters - genetics | Ochratoxins - administration & dosage | Cell Membrane - metabolism | Cerebral Cortex - drug effects | Capillaries - metabolism | Fluorobenzenes - metabolism | Tetrahydroisoquinolines - pharmacology | Organic Cation Transport Proteins - metabolism | Pravastatin - metabolism | Liver - metabolism | Rosuvastatin Calcium | Sulfonamides - pharmacokinetics | Blood-Brain Barrier - metabolism | Mice, Knockout | Brain - drug effects | Taurocholic Acid - administration & dosage | Pravastatin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - administration & dosage | Pyrimidines - pharmacokinetics | Mice | Kinetics | Organic Cation Transport Proteins - genetics | Pravastatin - pharmacokinetics | Sulfonamides - administration & dosage | Quinolines - blood | Digoxin - metabolism | Taurocholic Acid - metabolism | Choroid Plexus - metabolism | Taurocholic Acid - blood | Ochratoxins - pharmacokinetics | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Ochratoxins - metabolism | Cerebral Cortex - metabolism | Organic Anion Transporters - metabolism | Brain - blood supply | Sulfonamides - blood | Organic Anion Transporters - genetics | Transfection | Fluorobenzenes - blood | Enkephalin, D-Penicillamine (2,5)- - pharmacokinetics | Recombinant Proteins - metabolism | Cell Line | Pyrimidines - administration & dosage | Mice, Inbred C57BL | Recombinant Proteins - genetics | Blood-Brain Barrier - drug effects | Digoxin - pharmacokinetics | Quinolines - metabolism | Taurocholic Acid - pharmacokinetics | Liver - blood supply | Pharmaceutical Preparations - metabolism | Animals | Digoxin - administration & dosage | Enkephalin, D-Penicillamine (2,5)- - metabolism | Acridines - pharmacology | Sulfonamides - metabolism | Index Medicus
Journal Article
Neuropharmacology, ISSN 0028-3908, 04/2017, Volume 116, pp. 315 - 327
Joint pain is a major clinical problem mainly associated to osteoarthritis, and characterized by articular cartilage degradation resulting in a complex chronic... 
Dynorphin | Opioids | Anhedonia | Anxiety | Cognition | Osteoarthritis | KOR | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Arthralgia - pathology | Microglia - metabolism | Spinal Cord - metabolism | Enkephalins - metabolism | Epigenesis, Genetic | Hyperalgesia - psychology | Hyperalgesia - pathology | Enkephalins - genetics | Spinal Cord - pathology | Cognition - physiology | Microglia - pathology | Acetylation | Osteoarthritis - pathology | Receptors, Opioid, kappa - genetics | Arthralgia - psychology | Disease Models, Animal | Emotions - physiology | Protein Precursors - genetics | Hyperalgesia - metabolism | Mice, Inbred C57BL | Amygdala - metabolism | Receptors, Opioid, kappa - metabolism | Osteoarthritis - metabolism | Hippocampus - pathology | Chronic Pain - psychology | Chronic Pain - pathology | Amygdala - pathology | Corticotropin-Releasing Hormone - metabolism | Mice, Knockout | Protein Precursors - metabolism | Chronic Pain - metabolism | Hippocampus - metabolism | Osteoarthritis - psychology | Animals | Arthralgia - metabolism | Histones - metabolism | Corticotropin releasing hormone | Epigenetic inheritance | Analysis | Arthralgia | ACTH | Missing in action | Chronic pain | Index Medicus | Artrosi | Cognició | Angoixa | Dolor | Neuropèptids
Journal Article
Journal Article
Neuropsychopharmacology (New York, N.Y.), ISSN 1740-634X, 09/2008, Volume 34, Issue 3, pp. 775 - 785
Stress and anxiety are mainly regulated by amygdala and hypothalamic circuitries involving several neurotransmitter systems and providing physiological... 
Hypothalamic-pituitary-adrenal axis | Paraventricular | κ-opioid receptor | Amygdala | Prodynorphin knockout | Stress | Pharmacology & Pharmacy | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Psychiatry | Science & Technology | Naltrexone - analogs & derivatives | Enkephalins - metabolism | Mesencephalon - metabolism | Brain Stem - metabolism | Dynorphins - physiology | Male | Neuropeptide Y - genetics | Mice, Knockout - metabolism | Raphe Nuclei - metabolism | Morphinans | Neuropeptide Y - metabolism | Enkephalins - genetics | Naltrexone - pharmacology | Protein Precursors - physiology | Female | Enkephalins - physiology | Corticosterone - blood | Neuropeptides - genetics | Anxiety - metabolism | Neuropeptide Y - physiology | Exploratory Behavior | Receptors, Opioid, kappa - antagonists & inhibitors | Protein Precursors - genetics | Mice, Inbred C57BL | Receptors, Opioid, kappa - agonists | Amygdala - metabolism | Anxiety - physiopathology | Neuropeptides - metabolism | Guanidines | 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer - pharmacology | Corticotropin-Releasing Hormone - metabolism | Protein Precursors - metabolism | Animals | Hypothalamus - metabolism | Maze Learning | Mice | Stress, Psychological - physiopathology | Index Medicus | stress | amygdala | prodynorphin knockout | hypothalamic–pituitary–adrenal axis | paraventricular nucleus
Journal Article
Neuron (Cambridge, Mass.), ISSN 0896-6273, 06/2012, Volume 74, Issue 6, pp. 1075 - 1086
Journal Article