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Vaccine, ISSN 0264-410X, 2013, Volume 31, Issue 20, pp. 2457 - 2464
Highlights • We developed and tested a new oral ETEC vaccine in mice, alone and with an adjuvant. • The vaccine contains E. coli overexpressing CFA/I, CS3, CS5... 
Allergy and Immunology | Vaccine | Mucosal immunity | Immune responses | ETEC | dmLT | Colonization factors | DmLT | MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | DIARRHEA | PREVENTION | IMMUNOLOGY | VIBRIO-CHOLERAE | CELL CHOLERA VACCINE | TRAVELERS | CONSTRUCTION | ENTEROTOXIGENIC ESCHERICHIA-COLI | INTRANASAL IMMUNIZATION | ANTIBODY-RESPONSES | Immunity, Mucosal - immunology | Adjuvants, Immunologic - administration & dosage | Immunoglobulin G - blood | Escherichia coli Infections - prevention & control | Antigens, Bacterial - immunology | Antigens, Bacterial - genetics | Intestines - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Immunoglobulin G - immunology | Cholera Toxin - immunology | Bacterial Toxins - genetics | Female | Escherichia coli Proteins - immunology | Immunoglobulin G - analysis | Mutant Proteins - immunology | Fimbriae Proteins - immunology | Cholera Toxin - administration & dosage | Antibody Formation - immunology | Vaccines, Inactivated - genetics | Administration, Oral | Bacterial Toxins - immunology | Escherichia coli Infections - microbiology | Enterotoxigenic Escherichia coli - immunology | Escherichia coli Vaccines - administration & dosage | Mutant Proteins - administration & dosage | Enterotoxins - administration & dosage | Vaccines, Inactivated - adverse effects | Enterotoxins - genetics | Vaccines, Inactivated - immunology | Animals | Escherichia coli Vaccines - adverse effects | Fimbriae Proteins - genetics | Vaccines, Inactivated - administration & dosage | Cholera Toxin - genetics | Immunoglobulin A - immunology | Escherichia coli Proteins - genetics | Immunoglobulin A - blood | Bacterial Toxins - administration & dosage | Escherichia coli Infections - immunology | Escherichia coli Vaccines - genetics | Mice | Mice, Inbred BALB C | Escherichia coli Vaccines - immunology | Immunoglobulin A - analysis | Antigens | Safety and security measures | Analysis | Escherichia coli | Bacteria | Vaccines | Contamination | Proteins | Studies | Immunology | E coli | Rodents | Index Medicus | Basic Medicine | Medicinska grundvetenskaper
Journal Article
Journal of Immunology, ISSN 0022-1767, 04/2015, Volume 194, Issue 8, pp. 3829 - 3839
We have examined the molecular pathways involved in the adjuvant action of cholera toxin (CT) and two novel nontoxic molecules, multiple-mutated CT (mmCT) and... 
CELLS | TRANSCRIPTIONAL ACTIVITY | ACTIVATION | IMMUNOGENICITY | HEAT-LABILE ENTEROTOXIN | IMMUNE-RESPONSES | ESCHERICHIA-COLI | ETEC VACCINE | IMMUNOLOGY | NF-KAPPA-B | MUCOSAL ADJUVANT | CARD Signaling Adaptor Proteins - immunology | Apoptosis Regulatory Proteins - immunology | Adjuvants, Immunologic - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Middle Aged | Interleukin-1beta - immunology | Male | Caspase 1 - immunology | Enzyme Activation - drug effects | Enzyme Activation - immunology | Signal Transduction - immunology | Signal Transduction - drug effects | Calcium-Binding Proteins - immunology | Cyclic AMP-Dependent Protein Kinases - immunology | Cyclic AMP - immunology | Inflammasomes - immunology | Adaptor Proteins, Signal Transducing - immunology | Th17 Cells - immunology | Adult | Female | Th17 Cells - cytology | Cholera Toxin - pharmacology | Carrier Proteins - immunology | Calcium-Binding Proteins/immunology | Signal Transducing/immunology | Apoptosis Regulatory Proteins/immunology | Cyclic AMP/ immunology | Enzyme Activation/drug effects/immunology | Adjuvants | Immunologi inom det medicinska området | Interleukin-1beta/ immunology | Adaptor Proteins | Th17 Cells/cytology/ immunology | Signal Transduction/ drug effects/immunology | Caspase 1/immunology | Carrier Proteins/immunology | Cholera Toxin/ pharmacology | Cyclic AMP-Dependent Protein Kinases/ immunology | CARD Signaling Adaptor Proteins/immunology | Immunologic/ pharmacology | Immunology in the medical area | Inflammasomes/ immunology
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2014, Volume 192, Issue 4, pp. 1630 - 1640
Journal Article
Journal of Immunology, ISSN 0022-1767, 05/2011, Volume 186, Issue 10, pp. 5896 - 5906
Escherichia coli heat-labile enterotoxin (LT) is a powerful mucosal adjuvant; however, it is associated with toxic effects when delivered intranasally, and its... 
NONTOXIC AB COMPLEX | DENDRITIC CELLS | CELLULAR-IMMUNITY | IL-17-PRODUCING T-CELLS | INFLUENZA VACCINE | IMMUNOLOGY | BORDETELLA-PERTUSSIS | SIGNAL-REGULATED KINASE | CHOLERA-TOXIN | MUCOSAL ADJUVANTS | NALP3 INFLAMMASOME | B7-2 Antigen - genetics | B7-1 Antigen - genetics | NLR Family, Pyrin Domain-Containing 3 Protein | Dendritic Cells - immunology | Interleukin-17 - immunology | Bordetella pertussis - immunology | Caspase 1 - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Interleukin-1 - biosynthesis | CD4-Positive T-Lymphocytes - immunology | Enterotoxins - immunology | Escherichia coli Proteins - administration & dosage | Interleukin-1 - immunology | Escherichia coli Proteins - immunology | Dendritic Cells - metabolism | Bacterial Toxins - immunology | Mice, Inbred C57BL | Escherichia coli - immunology | Interleukin-17 - genetics | Escherichia coli Proteins - metabolism | Interleukin-23 - immunology | Mice, Knockout | Enterotoxins - administration & dosage | Interleukin-5 - immunology | Cell Differentiation - immunology | Interleukin-4 - immunology | Bacterial Toxins - metabolism | Animals | Carrier Proteins - metabolism | Interferon-gamma - immunology | Enterotoxins - metabolism | Interleukin-23 - biosynthesis | Th17 Cells - immunology | Bacterial Toxins - administration & dosage | Mice | Mice, Inbred BALB C | Mutation | Interleukin-10 - immunology | Index Medicus | Abridged Index Medicus
Journal Article
Immunological Reviews, ISSN 0105-2896, 10/2008, Volume 225, Issue 1, pp. 226 - 243
The bacterial superantigens are protein toxins that bind to major histocompatibility complex class II and T‐cell receptor to stimulate large numbers of T... 
toxic shock | MHC | enterotoxin | TCR | superantigen | staphylococcus | Enterotoxin | Superantigen | Toxic shock | Staphylococcus | RECEPTOR BETA-CHAIN | IMMUNOLOGY | MITOGENIC EXOTOXIN-Z | MAMMARY-TUMOR VIRUS | COMPLETE GENOME SEQUENCE | STAPHYLOCOCCAL-ENTEROTOXIN-B | GROUP-A STREPTOCOCCUS | T-CELL-ACTIVATION | TOXIC-SHOCK-SYNDROME | POLYSPECIFIC IMMUNOGLOBULIN-G | MHC CLASS-II | Superantigens - toxicity | Receptors, Antigen, T-Cell - chemistry | Shock, Septic - etiology | Humans | Antigens, Bacterial - immunology | Shock, Septic - immunology | Shock, Septic - metabolism | Enterotoxins - immunology | T-Lymphocytes - metabolism | Histocompatibility Antigens Class II - metabolism | Receptors, Antigen, T-Cell - immunology | Staphylococcal Infections - microbiology | Staphylococcus aureus - metabolism | Protein Structure, Tertiary | Streptococcal Infections - microbiology | Receptors, Antigen, T-Cell - metabolism | Staphylococcal Infections - immunology | Streptococcal Infections - therapy | Gene Expression Regulation - immunology | Streptococcus pyogenes - immunology | Streptococcus pyogenes - metabolism | Superantigens - immunology | Protein Binding - immunology | Staphylococcal Infections - therapy | Sequence Alignment | Histocompatibility Antigens Class II - immunology | Superantigens - chemistry | Superantigens - genetics | Enterotoxins - metabolism | Staphylococcus aureus - immunology | T-Lymphocytes - immunology | Streptococcal Infections - immunology | Antigens, Bacterial - metabolism | Index Medicus
Journal Article
Vaccine, ISSN 0264-410X, 2012, Volume 30, Issue 34, pp. 5099 - 5109
Highlights ► Vaccination against Staphylococcus aureus is achieved with toxoids. ► Toxoids are >107 inactivated and stimulate immunity to S. aureus . ►... 
Allergy and Immunology | Superantigen | Vaccine | Rabbit Model | Cytolysin | Staphylococcus aureus | ENTEROTOXIN-F | MEDICINE, RESEARCH & EXPERIMENTAL | BETA-TOXIN | STREPTOCOCCAL PYROGENIC EXOTOXIN | ALPHA-TOXIN | IMMUNOLOGY | METHICILLIN-RESISTANT | MEDICAL PROGRESS | PANTON-VALENTINE LEUKOCIDIN | TOXIC-SHOCK-SYNDROME | INFECTIVE ENDOCARDITIS | CLASS-II | Hemolysin Proteins - immunology | Adjuvants, Immunologic - administration & dosage | Superantigens - administration & dosage | Humans | Vaccination | Cytotoxins - administration & dosage | Male | Neutralization Tests | Pneumonia, Staphylococcal - microbiology | Shock, Septic - immunology | Shock, Septic - therapy | Hemolysin Proteins - administration & dosage | Endocarditis, Bacterial - microbiology | Female | Bacterial Proteins - immunology | Staphylococcal Infections - microbiology | Staphylococcal Toxoid - immunology | Staphylococcal Vaccines - immunology | Antibodies, Bacterial - blood | Pneumonia, Staphylococcal - immunology | Cell Line | Rabbits - immunology | Staphylococcal Infections - immunology | Bacterial Toxins - immunology | Exotoxins - immunology | Pneumonia, Staphylococcal - therapy | Endocarditis, Bacterial - immunology | Superantigens - immunology | Staphylococcus aureus - pathogenicity | Shock, Septic - microbiology | Staphylococcal Infections - therapy | Animals | Staphylococcal Toxoid - administration & dosage | Antibody Formation | Antibodies, Bacterial - immunology | Bacterial Toxins - administration & dosage | Staphylococcus aureus - immunology | Rabbits - microbiology | Cytotoxins - immunology | CD40 Antigens - immunology | Endocarditis, Bacterial - therapy | Rabbits | Medical colleges | Biological products | Staphylococcus aureus infections | Antibodies | Septic shock | Sulfates | T cells | Viral antibodies | Surface active agents | Immunotherapy | Mitogens | Index Medicus
Journal Article
Journal of Allergy and Clinical Immunology, The, ISSN 0091-6749, 2016, Volume 137, Issue 5, pp. 1449 - 1456.e4
Journal Article
Journal Article
Immunological Reviews, ISSN 0105-2896, 07/2011, Volume 242, Issue 1, pp. 233 - 246
Atopic dermatitis (AD) is an important chronic or relapsing inflammatory skin disease that often precedes asthma and allergic disorders. New insights into the... 
atopic dermatitis | epidermal barrier | filaggrin | antimicrobial peptides | eczema herpeticum | Staphylococcus aureus | Epidermal barrier | Eczema herpeticum | Filaggrin | Atopic dermatitis | Antimicrobial peptides | VITAMIN-D | OF-FUNCTION MUTATIONS | IMMUNOLOGY | THYMIC STROMAL LYMPHOPOIETIN | ICHTHYOSIS VULGARIS | STAPHYLOCOCCAL-ENTEROTOXIN-B | ALLERGIC SENSITIZATION | FILAGGRIN MUTATIONS | T-CELLS | T-Lymphocyte Subsets - immunology | Dermatitis, Atopic - genetics | Humans | Dermatitis, Atopic - therapy | Epidermis - physiopathology | Staphylococcal Skin Infections - immunology | Asthma - immunology | Dermatitis, Atopic - immunology | Intermediate Filament Proteins - genetics | Anti-Inflammatory Agents - therapeutic use | Pruritus - complications | Cytokines - immunology | Disease Models, Animal | Pruritus - immunology | Adaptive Immunity | Tight Junctions - metabolism | Epidermis - metabolism | Gene Expression Regulation | Mice, Transgenic | Dermatitis, Atopic - physiopathology | Immunity, Innate | Dermatitis, Atopic - complications | Herpes Simplex - immunology | Polymorphism, Genetic | Herpes Simplex - virology | Keratinocytes - pathology | Animals | Epidermis - immunology | Asthma - complications | Keratinocytes - metabolism | Staphylococcus aureus - immunology | Vitamin D - metabolism | Mice | Simplexvirus - immunology | Dermatitis, Atopic - metabolism | Intermediate Filament Proteins - metabolism | Staphylococcal Skin Infections - microbiology | Tight Junctions - pathology | Peptides | Health aspects | Staphylococcus aureus infections | Reviews | Hypersensitivity | Epidermis | Skin diseases | Colonization | Inflammatory diseases | Asthma
Journal Article