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Diabetes, ISSN 0012-1797, 01/2016, Volume 65, Issue 1, pp. 285 - 296
The rapid rise in the incidence of type 1 diabetes (T1D) suggests the involvement of environmental factors including viral infections. We evaluated the... 
UNITED-STATES | BETA-CELLS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | ISLET AUTOIMMUNITY | POLYMERASE CHAIN-REACTION | COXSACKIE-B | CYTOMEGALOVIRUS-INFECTION | BARR-VIRUS INFECTION | ENTEROVIRUS INFECTIONS | IGM RESPONSES | Zinc Transporter 8 | Humans | Mumps virus - immunology | Rotavirus - immunology | Viral Proteins - immunology | Child, Preschool | Male | Cytomegalovirus Infections - immunology | Case-Control Studies | Young Adult | Adult | Female | Rubella virus - immunology | Diabetes Mellitus, Type 1 - immunology | Epstein-Barr Virus Infections | Glutamate Decarboxylase - immunology | Child | Mumps - immunology | Rubella - immunology | Diabetes Mellitus, Type 1 - virology | Herpesvirus 4, Human - immunology | Rotavirus Infections - immunology | Cytomegalovirus - immunology | Autoantibodies - immunology | High-Throughput Screening Assays | Adolescent | Proteomics | Enterovirus B, Human - immunology | Protein Array Analysis | Antibodies, Viral - immunology | Endogenous Retroviruses - immunology | Cation Transport Proteins - immunology | Coxsackievirus Infections - immunology | Viral antibodies | Virus diseases | Antiviral agents | Care and treatment | Type 1 diabetes | Antibodies | Dosage and administration | Viruses | Immunoglobulins | Diabetes | Viral infections | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Genomes
Journal Article
Scientific Reports, ISSN 2045-2322, 02/2016, Volume 6, Issue 1, pp. 22002 - 22002
When retinoic acid-inducible gene 1 protein (RIG-I)-like receptors sense viral dsRNA in the cytosol, RIG-I and melanoma differentiation-associated gene 5... 
RNA | PATHWAY | MULTIDISCIPLINARY SCIENCES | TOLL-LIKE RECEPTORS | INNATE | MECHANISMS | INDUCTION | NF-KAPPA-B | ADAPTER PROTEIN | VIRAL REPLICATION | MDA5 | Enterovirus A, Human - genetics | RNA, Small Interfering - genetics | Interferon-Induced Helicase, IFIH1 - genetics | Humans | NF-kappa B - immunology | Vesiculovirus - immunology | eIF-2 Kinase - immunology | NF-KappaB Inhibitor alpha - genetics | Influenza A Virus, H3N2 Subtype - genetics | Interferon Type I - immunology | Luciferases - genetics | RNA, Viral - genetics | RNA, Small Interfering - immunology | DEAD Box Protein 58 - genetics | Luciferases - immunology | HEK293 Cells | Pyruvate Carboxylase - immunology | Adaptor Proteins, Signal Transducing - immunology | Vesiculovirus - genetics | Cytokines - genetics | Genes, Reporter | Cytokines - immunology | eIF-2 Kinase - genetics | Signal Transduction | Enterovirus A, Human - immunology | Gene Expression Regulation | Pyruvate Carboxylase - genetics | NF-KappaB Inhibitor alpha - immunology | Hepatocytes - immunology | Immunity, Innate | Influenza A Virus, H3N2 Subtype - immunology | Pyruvate Carboxylase - antagonists & inhibitors | Interferon-Induced Helicase, IFIH1 - immunology | DEAD Box Protein 58 - immunology | Animals | NF-kappa B - genetics | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Hepatocytes - virology | Interferon Type I - genetics | RNA, Viral - immunology | RNA viruses | eIF-2 kinase | Phosphorylation | Immune response | Cytokines | Myxovirus resistance proteins | Double-stranded RNA | Melanoma | Pyruvic acid | Viruses | Biotin | Inflammation | Kinases | Cytosol | Pyruvate carboxylase | Nuclear transport | Proteins | Stomatitis | Mitochondria | Protein kinase | Transcription activation | Antiviral activity | Interferon | Retinoic acid | Index Medicus
Journal Article
Journal of Immunology, ISSN 0022-1767, 03/2007, Volume 178, Issue 6, pp. 3466 - 3473
The serine/threonine kinase, protein kinase C-theta (PKC-theta), plays a central role in the activation and differentiation of Th2 cells while being redundant... 
EFFECTOR | RESPONSES | ACTIVATION | DISEASE | TH1 CELLS | COXSACKIEVIRUS B3-INDUCED MYOCARDITIS | DEFICIENT MICE | IMMUNOLOGY | PKC-THETA | BALB/C MICE | LYMPHOCYTES | Myocarditis - chemically induced | CD8-Positive T-Lymphocytes - pathology | Cell Proliferation | Myocardium - immunology | Dendritic Cells - immunology | Protein Kinase C-theta | Dendritic Cells - pathology | Myocarditis - enzymology | Th2 Cells - immunology | Autoimmune Diseases - virology | Protein Kinase C - deficiency | Coxsackievirus Infections - enzymology | Isoenzymes - immunology | Toll-Like Receptor 9 - immunology | Cell Differentiation - genetics | Signal Transduction - immunology | Peptides - toxicity | Autoimmune Diseases - pathology | Myocarditis - immunology | Th2 Cells - pathology | Cytokines - immunology | CpG Islands - immunology | Autoimmune Diseases - enzymology | Peptides - immunology | Autoimmune Diseases - immunology | Myocardium - pathology | Protein Kinase C - immunology | Signal Transduction - genetics | Isoenzymes - deficiency | CD8-Positive T-Lymphocytes - enzymology | Mice, Knockout | Coxsackievirus Infections - pathology | Cell Differentiation - immunology | Myocarditis - virology | Myocardium - enzymology | Animals | Dendritic Cells - enzymology | Enterovirus B, Human - immunology | Mice | Mice, Inbred BALB C | Myocarditis - pathology | Autoimmune Diseases - chemically induced | CD8-Positive T-Lymphocytes - immunology | Toll-Like Receptor 9 - metabolism | Th2 Cells - enzymology | Coxsackievirus Infections - immunology | Cytokines - biosynthesis | Index Medicus | Abridged Index Medicus
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 03/2010, Volume 159, Issue 3, pp. 338 - 343
Summary Type 1 diabetes results from a T cell-mediated destruction of insulin-producing pancreatic β cells. Little is known on local factors contributing to... 
CXCL10 | type 1 diabetes | IP-10 | CXCR3 | autoreactive T cells | Autoreactive T cells | Type 1 diabetes | IMMUNE-RESPONSE | NOD MICE | AUTOANTIGENS | ALLOGRAFT | BETA-CELLS | RISK | MELLITUS | IMMUNOLOGY | INFILTRATION | T-CELL RESPONSES | INSULIN EPITOPE | Lymph Nodes - pathology | Humans | Child, Preschool | Male | Diabetes Mellitus, Type 1 - therapy | Enterovirus Infections - immunology | Chemokine CXCL10 - immunology | Adult | Enterovirus Infections - therapy | Female | Retrospective Studies | Diabetes Mellitus, Type 1 - immunology | T-Lymphocytes - pathology | Diabetes Mellitus, Type 1 - virology | Gene Expression Regulation - immunology | Diabetes Mellitus, Type 1 - pathology | Inflammation - virology | Inflammation - immunology | Lymph Nodes - immunology | Insulin-Secreting Cells - immunology | Inflammation - therapy | Insulin-Secreting Cells - virology | Interferon-gamma - immunology | Adolescent | Receptors, CXCR3 - immunology | Enterovirus - immunology | T-Lymphocytes - immunology | Enterovirus Infections - pathology | Insulin-Secreting Cells - pathology | Immunity, Cellular | Interleukin-10 - immunology | Autoimmunity | Diabetics | Pancreatic beta cells | Autoantigens | Inflammation | Biological response modifiers | T cells | Infections | Diabetes | Patients | Viral infections | Chemokines | Immune system | Index Medicus | Insulitis | Leukocyte migration | Diabetes mellitus | Data processing | Lymphocytes T | CXCR3 protein | a-Interferon | Chemokine receptors | Lymph nodes | Beta cells | Infection | Interleukins | CXCL10 protein | Remission | Islets of Langerhans | Pancreas | Translational Studies
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57591 - e57591
Enterovirus 71 (EV71) and coxsackievirus (CVA) are the most common causative factors for hand, foot, and mouth disease (HFMD) and neurological disorders in... 
VACCINE DEVELOPMENT | SELECTIN GLYCOPROTEIN LIGAND-1 | NEUROLOGICAL DISEASE | MOUTH-DISEASE | MULTIDISCIPLINARY SCIENCES | P-SELECTIN | CENTRAL-NERVOUS-SYSTEM | BRAIN-STEM ENCEPHALITIS | CYNOMOLGUS MONKEYS | CELL-CULTURE | CEREBROSPINAL-FLUID | Enterovirus A, Human - genetics | Humans | Cercopithecus aethiops | Hand, Foot and Mouth Disease - genetics | Lysosome-Associated Membrane Glycoproteins - immunology | Enterovirus - genetics | Enterovirus Infections - genetics | Enterovirus Infections - immunology | Vero Cells | Disease Models, Animal | Cells, Cultured | Enterovirus A, Human - immunology | Hand, Foot and Mouth Disease - immunology | Genotype | Mice, Transgenic | Up-Regulation - genetics | Inflammation - immunology | Receptors, Scavenger - immunology | Coxsackievirus Infections - genetics | Animals | Receptors, Scavenger - genetics | Up-Regulation - immunology | Enterovirus - immunology | Lysosome-Associated Membrane Glycoproteins - genetics | T-Lymphocytes - immunology | Mice | Coxsackievirus Infections - immunology | Medical research | Nervous system diseases | Analysis | Medicine, Experimental | Genetic engineering | Paralysis | Coxsackievirus infections | Cell culture | Neuropathology | Pathogenesis | Central nervous system | Clinical isolates | Nervous system | Lymphocytes T | Hand-foot-and-mouth disease | Infections | Vaccines | Recruitment | Interleukin 6 | Proteins | Hepatitis | Immunology | Lymphocytes | Transgenic animals | Rodents | Animal tissues | Children | Edema | Encephalitis | Immunization | Cytokines | Neutrophils | Transgenic mice | CCL3 protein | Glycoproteins | Inflammation | Tumor necrosis factor-α | Feet | Neurological diseases | Enteroviruses | Infectious diseases | CXCL10 protein | Ligands | Chemokines | Viral infections | Index Medicus
Journal Article
Journal Article
Circulation, ISSN 0009-7322, 09/2014, Volume 130, Issue 18, pp. 1589 - 1600
Background-Common causative agents in the development of inflammatory cardiomyopathy include cardiotropic viruses such as coxsackievirus B3 (CVB3). Here, we... 
Human | infection | models, animal | viruses | ISG15 protein, human | Cardiomyopathy | myocarditis | Dilated | ISG15 protein | cardiomyopathy, dilated | inflammation | Animal | interferon type I | Models | immunology | CARDIAC & CARDIOVASCULAR SYSTEMS | COXSACKIEVIRUS | ENTEROVIRUS MYOCARDITIS | VIRAL MYOCARDITIS | BETA | E3 LIGASE | CONJUGATION | REPLICATION | LEFT-VENTRICULAR DYSFUNCTION | POLIOVIRUS | PERIPHERAL VASCULAR DISEASE | Ubiquitins - genetics | Humans | Middle Aged | Viral Proteins - immunology | Male | T-Lymphocytes - virology | Heart Failure - virology | Heart Failure - immunology | Killer Cells, Natural - immunology | Adult | Female | Cytokines - genetics | Ubiquitins - metabolism | Cytokines - immunology | Disease Models, Animal | Cardiomyopathy, Dilated - genetics | Ubiquitins - immunology | Cytokines - metabolism | Killer Cells, Natural - virology | Mice, Inbred C57BL | Heart Failure - genetics | Cardiomyopathy, Dilated - virology | Coxsackievirus Infections - complications | Immunity, Innate - immunology | Coxsackievirus Infections - genetics | Myocytes, Cardiac - virology | Animals | Virus Replication | Biopsy | Myocytes, Cardiac - physiology | Cardiomyopathy, Dilated - immunology | Enterovirus B, Human - immunology | T-Lymphocytes - immunology | Cysteine Endopeptidases - immunology | Coxsackievirus Infections - immunology | Heart failure | Ubiquitin | Care and treatment | Usage | Mortality | Heart diseases | Risk factors | Index Medicus | Abridged Index Medicus
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57601 - e57601
Background: Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease, which has been prevalent in Asia-Pacific regions, causing... 
IMMUNIZATION | CHALLENGE | MOUTH-DISEASE | MULTIDISCIPLINARY SCIENCES | VACCINE | MICE | LETHAL | VP1 PROTEIN | IDENTIFICATION | OUTBREAK | HAND | Virion - immunology | Insecta - immunology | Enterovirus A, Human - immunology | Genotype | Baculoviridae - immunology | Epitopes - immunology | Antibodies, Neutralizing - immunology | Sf9 Cells | Animals | Vaccination - methods | Enterovirus Infections - immunology | Antibody Formation | Antibodies, Viral - immunology | Female | Mice | Mice, Inbred BALB C | Cercopithecus aethiops - immunology | Neutralization Tests - methods | Vero Cells | Viral Vaccines - immunology | Virus diseases | Infection | Viral antibodies | Medical research | Wildlife conservation | Analysis | Medicine, Experimental | Antibodies | Genetic aspects | Vaccines | Health aspects | Antigenic determinants | VP1 protein | Animal models | Process engineering | Laboratories | Viruses | Attachment | Antisera | Genomes | Hand-foot-and-mouth disease | Infections | Baculovirus | Virus-like particles | Antibody response | Proteins | Genotype & phenotype | Immunology | E coli | Children | Polyclonal antibodies | Recombinant | Foot and mouth disease | Immunization | Particulates | Vectors | Morbidity | Virology | Feet | Insects | Insect cells | Neutralizing | Foot-and-mouth disease | Growth hormone | In vitro methods and tests | Methods | Neutralization | Index Medicus
Journal Article
BMC Infectious Diseases, ISSN 1471-2334, 08/2015, Volume 15, Issue 1, pp. 345 - 345
Background: Meningoencephalitis is one of the most common disorders of the central nervous system (CNS) worldwide. Viral meningoencephalitis differs from... 
DIAGNOSIS | INFECTIOUS DISEASES | VIRUS | INTERFERON-GAMMA | FREQUENCY | NESTED-PCR | MUMPS MENINGITIS | ASEPTIC-MENINGITIS | ECHOVIRUS 30 | INTERLEUKIN-10 | CHILDREN | Lentivirus Infections - cerebrospinal fluid | Meningoencephalitis - cerebrospinal fluid | Meningoencephalitis - diagnosis | Central Nervous System Viral Diseases - diagnosis | Humans | Interleukin-17 - immunology | Interleukin-12 - cerebrospinal fluid | Central Nervous System Viral Diseases - cerebrospinal fluid | Meningoencephalitis - immunology | HIV Infections - immunology | Enterovirus Infections - immunology | HIV Infections - diagnosis | Tumor Necrosis Factor-alpha - immunology | Interleukin-6 - cerebrospinal fluid | Arbovirus Infections - diagnosis | Cytokines - immunology | HIV Infections - cerebrospinal fluid | Herpesviridae Infections - cerebrospinal fluid | Enterovirus Infections - diagnosis | Cross-Sectional Studies | Interferon-gamma - cerebrospinal fluid | Coinfection - immunology | Tumor Necrosis Factor-alpha - cerebrospinal fluid | Inflammation | Herpesviridae Infections - diagnosis | Interleukin-10 - cerebrospinal fluid | Arbovirus Infections - cerebrospinal fluid | Cytokines - cerebrospinal fluid | Interleukin-17 - cerebrospinal fluid | DNA, Viral - cerebrospinal fluid | Coinfection - cerebrospinal fluid | Interferon-gamma - immunology | Lentivirus Infections - immunology | Enterovirus Infections - cerebrospinal fluid | Interleukin-12 - immunology | Interleukin-6 - immunology | RNA, Viral - cerebrospinal fluid | Arbovirus Infections - immunology | Central Nervous System Viral Diseases - immunology | Interleukin-10 - immunology | Herpesviridae Infections - immunology | Complications and side effects | Chemotherapy | Care and treatment | Patient outcomes | Developing countries | Meningitis | Development and progression | Research | Cerebrospinal fluid | Health aspects | Cancer | Medical equipment and supplies industry | HIV (Viruses) | Medical test kit industry | Index Medicus
Journal Article
The Journal of Immunology, ISSN 0022-1767, 06/2006, Volume 176, Issue 11, pp. 6411 - 6415
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2012, Volume 7, Issue 12, pp. e51957 - e51957
Journal Article