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1. Full Text Engineering microRNA responsiveness to decrease virus pathogenicity
by Kelly, Elizabeth J and Greiner, Suzanne and Hadac, Elizabeth M and Russell, Stephen J
Nature Medicine, ISSN 1078-8956, 11/2008, Volume 14, Issue 11, pp. 1278 - 1283
The cellular tropisms of eukaryotic viruses are shaped by their need for entry receptors and intracellular transcription factors. Here we show that viral... 
MEDICINE, RESEARCH & EXPERIMENTAL | EFFICACY | BIOCHEMISTRY & MOLECULAR BIOLOGY | ONCOLYTIC VIROTHERAPY | TISSUE | COMBINATION | TUMORS | ADENOVIRUS | CELL BIOLOGY | THERAPY | TRANSGENE EXPRESSION | COXSACKIEVIRUS A21 | ENDOGENOUS MICRORNA | Genetic Engineering - methods | Cell Line | Myositis - metabolism | Down-Regulation | Humans | Molecular Sequence Data | Myositis - genetics | Mice, SCID | Enterovirus - pathogenicity | Animals | Enterovirus - genetics | Base Sequence | Mice | MicroRNAs - genetics | Myositis - pathology | Genetic Therapy - methods | RNA | Physiological aspects | Genetic aspects | Research | Gene expression | Health aspects | Oncogenic viruses | Viruses | Cellular biology | Ribonucleic acid--RNA | Virology | Index Medicus
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2. Full Text Viruses with masked pathogenicity and genetically susceptible hosts—How to discover potentially pathogenic viruses
by Nagafuchi, Seiho and Mine, Keiichiro and Takahashi, Hirokazu and Anzai, Keizo and Yoshikai, Yasunobu
Journal of Medical Virology, ISSN 0146-6615, 08/2019, Volume 91, Issue 8, pp. 1365 - 1367
mutation | pathogenicity | vaccine | enterovirus | host susceptibility | Koch's postulate | VIROLOGY | Pathogenicity | Pathogens | Viruses
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3. Full Text Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: A potential role of recombination in emergence and pathogenicity
by Gaunt, Eleanor and Harvala, Heli and Österback, Riikka and Sreenu, Vattipally B and Thomson, Emma and Waris, Matti and Simmonds, Peter
Journal of General Virology, ISSN 0022-1317, 05/2015, Volume 96, Issue 5, pp. 1067 - 1079
Human coxsackievirus A6 (CVA6) is an enterically transmitted enterovirus. Until recently, CVA6 infections were considered as being of minor clinical... 
NUCLEOTIDE | HUMAN-ENTEROVIRUS-B | VIROLOGY | CIRCULATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | POPULATIONS | EVOLUTIONARY DYNAMICS | OUTBREAK | SELECTION | Enterovirus - classification | Humans | Molecular Sequence Data | Genotype | United Kingdom | Enterovirus - isolation & purification | Phylogeny | Sequence Analysis, DNA | Sequence Homology | Enterovirus - pathogenicity | Enterovirus - genetics | RNA, Viral - genetics | Recombination, Genetic | Hand, Foot and Mouth Disease - pathology | Kaposi Varicelliform Eruption - complications | Adult | Hand, Foot and Mouth Disease - virology | Cluster Analysis | Index Medicus | Animal | Standard
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4. Full Text A neonatal murine model for evaluation of enterovirus E HY12 virus infection and pathogenicity
by Gai, Xiaochun and Zhang, Qun and Lu, Haibing and Yang, Zhanqing and Zhu, Lisai and Li, Xin and Wang, Xinping
PLoS ONE, ISSN 1932-6203, 02/2018, Volume 13, Issue 2, pp. e0193155 - e0193155
Backgrounds HY12 viruses are enteroviruses recently isolated from cattle characterized by severe respiratory and digestive disease with high morbidity and... 
BOVINE | MULTIDISCIPLINARY SCIENCES | Development and progression | Models | Research | Enterovirus diseases | Immunohistochemistry | Tropism | Neonates | Brain | Veterinary colleges | Animal models | Disease | Pathogenesis | Liver | Lung | Viruses | Infections | Veterinary medicine | Immunity | Recovery | Suckling behavior | Histopathology | Cattle | Intestine | Rodents | Animal tissues | Lesions | Antigens | Pathogens | Mortality | Oral administration | Intranasal administration | Inflammation | Injection | Morbidity | Zoonoses | Pathogenicity | Polymerase chain reaction | Respiratory diseases | Mice | Laboratory animals | Index Medicus
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5. Full Text The untranslated regions of EV-A71 contribute to its pathogenicity and virulence
by Dong, Zhen and Liu, Zi-Wei and Chen, Rui and Wen, Hong-Ling and Wen, Xiao-Jing and Ji, Jing and Zheng, Xue-Xing and Zhao, Li and Wang, Zhi-Yu
Virus Research, ISSN 0168-1702, 04/2019, Volume 263, pp. 55 - 63
Enterovirus A71 (EV-A71) is known for its manifestation as hand foot and mouth disease (HFMD), which has caused countless large-scale epidemic outbreaks... 
Untranslated regions | Pathogenicity | Replication capacity | Enterovirus A71 | ENTEROVIRUS 71 INFECTION | REPLICATION | VIROLOGY | NEURONAL CELLS | OUTBREAK | Epidemics | Medical research | Analysis | Communicable diseases | Medicine, Experimental | Brain damage | Virulence (Microbiology) | Coxsackievirus infections | Health aspects | Index Medicus
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6. Full Text UGGT1 enhances enterovirus 71 pathogenicity by promoting viral RNA synthesis and viral replication
by Huang, Peng-Nien and Jheng, Jia-Rong and Arnold, Jamie J and Wang, Jen-Ren and Cameron, Craig E and Shih, Shin-Ru
PLoS Pathogens, ISSN 1553-7366, 05/2017, Volume 13, Issue 5, pp. e1006375 - e1006375
Positive-strand RNA virus infections can induce the stress-related unfolded protein response (UPR) in host cells. This study found that enterovirus A71 (EVA71)... 
PICORNAVIRUS GENOME REPLICATION | PROTEIN | POLYMERASE | MICROBIOLOGY | VPG URIDYLYLATION | POLIOVIRUS INFECTION | VIROLOGY | HEPATITIS-C VIRUS | MOUTH-DISEASE | POLIOMYELITIS-LIKE DISEASE | ENDOPLASMIC-RETICULUM | NUCLEAR FACTOR | PARASITOLOGY | Endoplasmic Reticulum - enzymology | Enterovirus A, Human - genetics | Amino Acid Sequence | Cell Proliferation | Cell Survival | Virus Replication - genetics | Enterovirus A, Human - physiology | RNA, Viral - analysis | Viral Proteins - genetics | Unfolded Protein Response | Viral Proteins - metabolism | Mice, Knockout | Host-Pathogen Interactions | Glucosyltransferases - metabolism | Animals | RNA, Viral - genetics | Virulence - genetics | Cell Line, Tumor | Mice | Enterovirus A, Human - pathogenicity | Glucosyltransferases - genetics | Epidemics | Biotechnology | Membranes | Growth rate | Transcription | Laboratories | Virulence | Science | Viruses | Infections | Biochemistry | Defense mechanisms | Glucose | Proteins | Hepatitis | Protein folding | Research centers | Glucosyltransferase | Pathogens | RNA viruses | Dengue fever | Glycoprotein | Glycoproteins | RNA polymerase | Ribonucleic acid--RNA | Virology | Pathogenicity | Medicine | Polymerase | Enteroviruses | West Nile virus | Replication | Molecular biology | Endoplasmic reticulum | Viral infections | Index Medicus | RNA | Ribonucleic acid
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7. Full Text A laboratory study of survival of selected microorganisms after heat treatment of biowaste used in biogas plants
by Sahlström, Leena and Bagge, Elisabeth and Emmoth, Eva and Holmqvist, Annika and Danielsson-Tham, Marie-Louise and Albihn, Ann and Sveriges lantbruksuniversitet
Bioresource Technology, ISSN 0960-8524, 11/2008, Volume 99, Issue 16, pp. 7859 - 7865
The aim of the study was to assess the effect of pasteurisation, as set by the European regulation EC 1774/2002, on selected pathogens and indicator organisms.... 
E. coli O157 | Enterococci | Fertiliser | Anaerobic digestion | Campylobacter | BACTERIOPHAGES | PIG SLURRY | ENERGY & FUELS | SEWAGE | fertiliser | INACTIVATION | MANURE | AGRICULTURAL ENGINEERING | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | anaerobic digestion | VIRUSES | SLUDGE | enterococci | Anaerobiosis | Guidelines as Topic - standards | Viruses - pathogenicity | Humans | Ascaris suum - physiology | Colony Count, Microbial | Clostridium - isolation & purification | Clostridium - classification | Feces - microbiology | Escherichia coli O157 - pathogenicity | Feces - virology | Parasites - isolation & purification | Time Factors | Feces - parasitology | Swine | Parasites - pathogenicity | Clostridium - pathogenicity | Parvovirus, Porcine - pathogenicity | Biodegradation, Environmental | Viruses - isolation & purification | Escherichia coli O157 - isolation & purification | Listeria monocytogenes - isolation & purification | Virulence Factors - isolation & purification | ADP Ribose Transferases - isolation & purification | Hot Temperature | Survival | Bacteria - isolation & purification | Listeria monocytogenes - pathogenicity | Animals | Bioreactors | Ovum - physiology | Refuse Disposal - methods | Bacteria - pathogenicity | Enterovirus B, Human - pathogenicity | Biogas | Biomass energy | Escherichia coli | Index Medicus | Agricultural Science | Jordbruksvetenskap
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8. Full Text Genome analysis of enterovirus 71 strains differing in mouse pathogenicity
by Li, Peng and Yue, Yingying and Song, Nannan and Li, Bingqing and Meng, Hong and Yang, Guiwen and Li, Zhihui and An, Liguo and Qin, Lizeng
Virus Genes, ISSN 0920-8569, 4/2016, Volume 52, Issue 2, pp. 161 - 171
Enterovirus 71 (EV71) is a major causative agent of hand, foot, and mouth disease (HFMD) and is occasionally associated with severe neurological diseases. The... 
Medical Microbiology | Biomedicine | Enterovirus 71 (EV71) | Virulence | Mutation | Genome | Plant Sciences | 3C proteinase (3C pro ) | Virology | 3C proteinase (3C | PROTEIN | CRYSTAL-STRUCTURE | CHINA | HAND | FOOT | VIROLOGY | MOUTH-DISEASE | VP1 | 3C proteinase (3C(pro)) | GENETICS & HEREDITY | INFECTION | MUTATIONS | OUTBREAK | Enterovirus A, Human - genetics | Cell Line | Genome, Viral | Viral Proteins - chemistry | Genomics | Humans | Models, Molecular | Viral Proteins - genetics | Untranslated Regions | Phylogeny | Sequence Analysis, DNA | Animals | RNA, Viral - chemistry | RNA, Viral - genetics | Virus Replication | Enterovirus A, Human - classification | Protein Conformation | Mice | Nucleic Acid Conformation | Hand, Foot and Mouth Disease - virology | Disease Models, Animal | Nervous system diseases | Catalytic RNA | Analysis | Genetic research | Amino acids | Virulence (Microbiology) | Coxsackievirus infections | Index Medicus
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9. Full Text Enterovirus 71 pathogenicity in monkeys and cotton rats
by Koroleva, Galina A and Karmysheva, Valentina Ya and Lukashev, Alexander N
Archives of Virology, ISSN 0304-8608, 5/2014, Volume 159, Issue 5, pp. 1133 - 1138
Enterovirus 71 (EV71) is a neurovirulent non-polio enterovirus that can cause severe central nervous system (CNS) infection in infants. Vervet monkeys infected... 
Medical Microbiology | Infectious Diseases | Biomedicine | Virology | ENCEPHALOMYELITIS | BULGARIA | VIROLOGY | MOUTH-DISEASE | POLIOMYELITIS-LIKE DISEASE | CYNOMOLGUS MONKEYS | INFECTION | EPIDEMIC | OUTBREAK | TYPE-71 | CHILDREN | Encephalomyelitis - virology | Enterovirus Infections - veterinary | Humans | Brain - virology | Cercopithecus aethiops | Infant | Male | Macaca mulatta | Sigmodontinae | Animals | Enterovirus Infections - virology | Poliomyelitis - virology | Enterovirus A, Human - pathogenicity | Enterovirus Infections - pathology | Spinal Cord - virology | Health aspects | Monkeys | Index Medicus
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10. Full Text A novel enterovirus 71 (EV71) virulence determinant: The 69th residue of 3C protease modulates pathogenicity
by Li, Bingqing and Yue, Yingying and Zhang, Yajie and Yuan, Zenglin and Li, Peng and Song, Nannan and Lin, Wei and Liu, Yan and Gu, Lichuan and Meng, Hong
Frontiers in Cellular and Infection Microbiology, ISSN 2235-2988, 02/2017, Volume 7, pp. 26 - 26
Human enterovirus type 71 (EV71), the major causative agent of hand-foot-and-mouth disease, has been known to cause fatal neurological complications.... 
3C protease | Human enterovirus type 71 | N69D substitution | Virulence determinantion | Crystal structure | human enterovirus type 71 | DESIGN | virulence determinantion | POLY(A)-BINDING PROTEIN | MICROBIOLOGY | IMMUNOLOGY | CLEAVAGE | TRANSLATION | TOLL-LIKE RECEPTOR-3 | RESPONSES | POLIOVIRUS | STRUCTURAL BASIS | crystal structure | RUPINTRIVIR | BINDING | Cysteine Endopeptidases - chemistry | Cell Line | Virulence Factors - genetics | Viral Proteins - chemistry | Humans | Virulence | Mutant Proteins - genetics | Models, Molecular | Viral Proteins - genetics | Crystallography, X-Ray | Mutant Proteins - metabolism | Virulence Factors - chemistry | Enterovirus A, Human - growth & development | Viral Proteins - metabolism | Point Mutation | Cysteine Endopeptidases - metabolism | Virus Replication | Cysteine Endopeptidases - genetics | Protein Conformation | Virulence Factors - metabolism | Enterovirus A, Human - pathogenicity | Amino Acid Substitution | Complications and side effects | Nervous system diseases | Research | Protease inhibitors | Enterovirus diseases | Risk factors | Index Medicus
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11. Full Text Motor coordination and balance measurements reveal differential pathogenicity of currently spreading enterovirus 71 strains in human SCARB2 transgenic mice
by Chen, Mei-Feng and Shih, Shin-Ru
Journal of General Virology, ISSN 0022-1317, 12/2016, Volume 97, Issue 12, pp. 3243 - 3247
Enterovirus 71 (EV71) has caused large-scale epidemics with neurological complications in the Asia-Pacific region. The C4a and B5 strains are the two major... 
Enterovirus 71 | Monocyte chemoattractant protein-1 | Motor coordination | Human SCARB2 transgenic mice | VIROLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | ENCEPHALITIS | DISEASE | INJURY | INFECTION | MODEL | EPIDEMIC | Enterovirus Infections - metabolism | Lysosome-Associated Membrane Glycoproteins - metabolism | Humans | Virulence | Enterovirus A, Human - physiology | Genotype | Mice, Transgenic | Enterovirus Infections - physiopathology | Motor Activity | Mice, Inbred ICR | Animals | Enterovirus Infections - virology | Receptors, Scavenger - genetics | Enterovirus Infections - genetics | Lysosome-Associated Membrane Glycoproteins - genetics | Chemokine CCL2 - metabolism | Mice | Enterovirus A, Human - pathogenicity | Receptors, Scavenger - metabolism | Index Medicus
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12. Full Text Pretreatment with a heat-killed probiotic modulates monocyte chemoattractant protein-1 and reduces the pathogenicity of influenza and enterovirus 71 infections
by Chen, M.-F and Weng, K.-F and Huang, S.-Y and Liu, Y.-C and Tseng, S.-N and Ojcius, D.M and Shih, S.-R
Mucosal Immunology, ISSN 1933-0219, 01/2017, Volume 10, Issue 1, pp. 215 - 227
It has been proposed that inactivated probiotics may modulate the host immune system and contribute to mitigation of viral infections. This study demonstrated... 
A VIRUS | MCP-1 | VIRUS-INFECTION | LIPOTEICHOIC ACID | IMMUNE-RESPONSES | NEURONAL DEATH | LACTOBACILLUS-PARACASEI | MICE | IMMUNOLOGY | ENTEROCOCCUS-FAECALIS FK-23 | HOUSE-DUST MITE | Enterococcus faecalis - immunology | Probiotics - administration & dosage | Receptors, CCR2 - genetics | Immunomodulation | Humans | Mice, Inbred C57BL | Cells, Cultured | Enterovirus A, Human - immunology | Male | Hot Temperature | Mice, Knockout | Orthomyxoviridae - immunology | Animals | Enterovirus Infections - immunology | Chemokine CCL2 - metabolism | Mice | Enterovirus A, Human - pathogenicity | Orthomyxoviridae - pathogenicity | Orthomyxoviridae Infections - immunology | Index Medicus
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13. Full Text Clinically isolated enterovirus A71 subgenogroup C4 strain with lethal pathogenicity in 14-day-old mice and the application as an EV-A71 mouse infection model
by Xu, Yi and Xu, Yuhua and Ma, Shuzhi and Zhu, Limeng and Huang, Zhiqiu and Chen, Liyun and Yin, Haibin and Peng, Tao and Wang, Yi
Antiviral Research, ISSN 0166-3542, 01/2017, Volume 137, pp. 67 - 75
The Enterovirus A71 (EV-A71) subgenogroup C4 is prevalent in China. EV-A71 causes hand, foot and mouth disease (HFMD) in children and may lead to severe... 
Vaccine | Mouse infection model | Enterovirus A71 (EV-A71) | Primary isolate | VIROLOGY | PROTECTION | VP1 | ENHANCEMENT | ADAPTATION | DISEASE | PHARMACOLOGY & PHARMACY | CYNOMOLGUS MONKEYS | Enterovirus A, Human - genetics | Age Factors | Humans | Virulence | Enterovirus A, Human - isolation & purification | Hand, Foot and Mouth Disease - prevention & control | Enterovirus Infections - virology | Enterovirus Infections - immunology | China | Enterovirus A, Human - classification | Enterovirus Infections - therapy | Enterovirus A, Human - pathogenicity | Child | Hand, Foot and Mouth Disease - virology | Disease Models, Animal | Enterovirus Infections - prevention & control | Hand, Foot and Mouth Disease - immunology | Hand, Foot and Mouth Disease - therapy | Viral Vaccines - administration & dosage | Vaccines, Inactivated - immunology | Animals | Vaccines, Inactivated - administration & dosage | Virus Replication | Immunization, Passive | Mice | Mutation | Viral Vaccines - immunology | Medical colleges | Antiviral agents | Nervous system diseases | Genomics | Therapeutics | Virulence (Microbiology) | Coxsackievirus infections | Homeopathy | Materia medica and therapeutics | Index Medicus
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14. Full Text Association of viral replication capacity with the pathogenicity of enterovirus 71
by Sun, Le-le and Wang, Jia-Kun and Wang, Zhi-Yu and Cui, Xiao-qing and Hao, Shu-Bin and Li, Jing and Zhao, Li and Yuan, Xiao-jing and Wen, Hong-ling and Yu, Xue-jie
Virus Research, ISSN 0168-1702, 08/2014, Volume 189, pp. 1 - 7
Enterovirus 71 (EV71) is a major cause of hand-foot-and-mouth disease, which is associated with fatal neurological disease. The mechanism of EV71 pathogenesis... 
Pathogenicity | Replication | EV71 | STRAINS | TAIWAN | CHINA | HAND | CHILDREN | FOOT | VIROLOGY | MOUTH-DISEASE | INFECTION | OUTBREAK | Immunohistochemistry | Cell Line | Humans | Virulence | Enterovirus A, Human - physiology | Enterovirus A, Human - growth & development | Mice, Inbred ICR | Animals | Enterovirus Infections - virology | Animal Structures - virology | Virus Replication | Female | Enterovirus A, Human - pathogenicity | Enterovirus Infections - pathology | Disease Models, Animal | Virus diseases | Quality control equipment | Index Medicus
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15. Full Text Human and Bovine Viruses and Bacteria at Three Great Lakes Beaches: Environmental Variable Associations and Health Risk
by Corsi, Steven R and Borchardt, Mark A and Carvin, Rebecca B and Burch, Tucker R and Spencer, Susan K and Lutz, Michelle A and McDermott, Colleen M and Busse, Kimberly M and Kleinheinz, Gregory T and Feng, Xiaoping and Zhu, Jun
Environmental Science and Technology, ISSN 0013-936X, 01/2016, Volume 50, Issue 2, pp. 987 - 995
Waterborne pathogens were measured at three beaches in Lake Michigan, environmental factors for predicting pathogen concentrations were identified, and the... 
ENTERIC VIRUSES | RECREATIONAL BEACHES | ENTEROVIRUSES | ENVIRONMENTAL SCIENCES | MICHIGAN | TRANSPORT | ENGINEERING, ENVIRONMENTAL | ESCHERICHIA-COLI | SEPTIC SYSTEM | WATER-QUALITY | FECAL CONTAMINATION | PATHOGENS | Risk Assessment - methods | Viruses - isolation & purification | Environmental Monitoring | Viruses - pathogenicity | Campylobacter jejuni - pathogenicity | Humans | Bathing Beaches | Enterovirus - isolation & purification | Salmonella - pathogenicity | Enterovirus - pathogenicity | Bacteria - isolation & purification | Animals | Campylobacter jejuni - isolation & purification | Lakes - microbiology | Lakes - virology | Cattle | Salmonella - isolation & purification | Bacteria - pathogenicity | Seasons | Great Lakes Region | Water Microbiology | Pathogens | Salmonella | Beaches | Regression analysis | Health risk assessment | Contamination | Index Medicus
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