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1. Full Text Acute Epididymitis Revisited: Impact of Molecular Diagnostics on Etiology and Contemporary Guideline Recommendations
by Pilatz, Adrian and Hossain, Hamid and Kaiser, Rolf and Mankertz, Annette and Schüttler, Christian G and Domann, Eugen and Schuppe, Hans-Christian and Chakraborty, Trinad and Weidner, Wolfgang and Wagenlehner, Florian
European Urology, ISSN 0302-2838, 2014, Volume 68, Issue 3, pp. 428 - 435
Abstract Background Acute epididymitis is a common infectious disease of unknown etiology in about 30% of cases with guidelines based on studies published >15... 
Urology | Epididymitis | Guideline recommendations | Antimicrobial therapy | Sexually transmitted infections | MULTICENTER | MANAGEMENT | PREVALENCE | SEMEN | MEN | UROLOGY & NEPHROLOGY | INFECTION | COMPLICATIONS | EPIDIDIMOORCHITIS | DNA, Ribosomal | Humans | Middle Aged | Male | Anti-Bacterial Agents - therapeutic use | Enterovirus Infections - epidemiology | Enterovirus - genetics | Enterovirus Infections - virology | Epididymitis - drug therapy | Polymerase Chain Reaction | Chlamydia Infections - drug therapy | Adult | Escherichia coli Infections - drug therapy | Chlamydia trachomatis - genetics | Mycoplasma Infections - microbiology | Epididymitis - epidemiology | Mycoplasma - genetics | Escherichia coli Infections - microbiology | Chlamydia Infections - epidemiology | Mycoplasma Infections - drug therapy | Epididymitis - microbiology | Germany - epidemiology | Escherichia coli Infections - epidemiology | Chlamydia Infections - microbiology | DNA, Bacterial - genetics | Molecular Epidemiology | Escherichia coli - genetics | Aged | Mycoplasma Infections - epidemiology | Enterococcus - genetics | Practice Guidelines as Topic | Causes and theories of causation | Diseases
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2. Full Text Evaluation of antiviral therapies in respiratory and neurological disease models of Enterovirus D68 infection in mice
by Hurst, Brett L and Evans, W. Joseph and Smee, Donald F and Van Wettere, Arnaud J and Tarbet, E. Bart
Virology, ISSN 0042-6822, 01/2019, Volume 526, pp. 146 - 154
Enterovirus D68 (EV-D68) is unique among enteroviruses because of the ability to cause severe respiratory disease as well as neurological disease. We developed... 
Enterovirus D68 | Animal model | Respiratory disease | Guanidine | Antiviral | Neurological disease | Acute flaccid myelitis | 3C PROTEASE | ILLNESS | PENH | TRACT | ACUTE FLACCID PARALYSIS | VIROLOGY | ANIMAL-MODELS | VIRUS-INFECTIONS | MYELITIS | OUTBREAK | Humans | Male | Enterovirus Infections - physiopathology | Lung - virology | Enterovirus Infections - virology | Enterovirus D, Human | Guanidine - therapeutic use | Female | Lung - metabolism | Nervous System Diseases - physiopathology | Respiratory Tract Infections - virology | Respiratory Tract Infections - physiopathology | Disease Models, Animal | Nervous System Diseases - pathology | Respiratory Tract Infections - pathology | Enterovirus Infections - drug therapy | Lung - pathology | Cytokines - metabolism | Antiviral Agents - therapeutic use | Nervous System Diseases - drug therapy | Respiratory Tract Infections - drug therapy | Treatment Outcome | Lung - physiopathology | Animals | Viremia - prevention & control | Nervous System Diseases - virology | Mice | Enterovirus Infections - pathology | Viral Load - drug effects | Virus diseases | Antiviral agents | Nervous system diseases | Analysis | Models | Paralysis | Health aspects | Neurological Disease | Animal Model | Respiratory Disease | Acute Flaccid Myelitis
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3. Full Text In vitro efficacy of antiviral compounds against enterovirus D68
by Rhoden, Eric and Zhang, Mingyu and Nix, W. Allan and Oberste, M. Steven
Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, 12/2015, Volume 59, Issue 12, pp. 7779 - 7781
In 2014, the United States experienced a large outbreak of severe respiratory illness associated with enterovirus D68 (EV-D68). We used a homogeneous,... 
VIRUS | REPLICATION | PROTEIN | DAS181 | MICROBIOLOGY | PHARMACOLOGY & PHARMACY | INFECTION | ITRACONAZOLE | CHILDREN | Enterovirus Infections - drug therapy | Microbial Sensitivity Tests | Protease Inhibitors - pharmacology | Antiviral Agents - pharmacology | Capsid - drug effects | Enterovirus Infections - virology | Disease Outbreaks | Humans | Respiratory Tract Infections - drug therapy | Enterovirus D, Human - drug effects | Respiratory Tract Infections - virology | Antiviral Agents
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4. Full Text Structure and inhibition of EV-D68, a virus that causes respiratory illness in children
by Liu, Y and Sheng, J and Fokine, A and Meng, G and Shin, WH and Long, F and Kuhn, RJ and Kihara, D and Rossmann, MG and Purdue Univ., West Lafayette, IN (United States)
SCIENCE, ISSN 0036-8075, 01/2015, Volume 347, Issue 6217, pp. 71 - 74
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We... 
PLECONARIL | ATTACHMENT | SEROTYPES | POLIOVIRUS | HUMAN RHINOVIRUS-14 | MULTIDISCIPLINARY SCIENCES | ENTEROVIRUS 71 | RESOLUTION | SUSCEPTIBILITY | PICORNAVIRUS | FEATURES | United States - epidemiology | Capsid - ultrastructure | Capsid - chemistry | Humans | Crystallography, X-Ray | Enterovirus D, Human - drug effects | Respiratory Tract Diseases - drug therapy | Enterovirus Infections - epidemiology | Capsid - drug effects | Enterovirus Infections - virology | Antiviral Agents - chemistry | Oxadiazoles - pharmacology | Oxadiazoles - chemistry | Child | Enterovirus Infections - drug therapy | Antiviral Agents - pharmacology | Antiviral Agents - therapeutic use | Viral Proteins - chemistry | Enterovirus D, Human - ultrastructure | Viral Proteins - ultrastructure | Oxadiazoles - therapeutic use | Respiratory Tract Diseases - epidemiology | Hydrophobic and Hydrophilic Interactions | Respiratory Tract Diseases - virology | Enterovirus D, Human - chemistry | Pediatrics | Pharmacology | Antiviral drugs | Fatty acids | Respiratory diseases | Virology | Drugs | Illnesses | Pocket | Viruses | Outbreaks | Children | Displacement | 60 APPLIED LIFE SCIENCES
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5. Full Text Developments towards antiviral therapies against enterovirus 71
by Wu, Kan X and Ng, Mary M.-L and Chu, Justin J.H
Drug Discovery Today, ISSN 1359-6446, 2010, Volume 15, Issue 23, pp. 1041 - 1051
Enterovirus 71 (EV71) has emerged as a clinically important neurotropic virus that can cause acute flaccid paralysis and encephalitis, leading to... 
RNA INTERFERENCE | BROAD-SPECTRUM | CAPSID-BINDING | SELECTIN GLYCOPROTEIN LIGAND-1 | PROTEIN | POLIOVIRUS | PYRIDYL IMIDAZOLIDINONES | PHARMACOLOGY & PHARMACY | INFECTION | INHIBITORS | IN-VITRO ACTIVITY | Enterovirus Infections - drug therapy | Central Nervous System Viral Diseases - virology | Antiviral Agents - pharmacology | Enterovirus Infections - virology | Enterovirus A, Human - drug effects | Humans | Antiviral Agents - metabolism | Central Nervous System Viral Diseases - drug therapy | Enterovirus C, Human - drug effects | Development
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6. Full Text Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes as an In Vitro Model for Coxsackievirus B3–Induced Myocarditis and Antiviral Drug Screening Platform
by Sharma, Arun and Marceau, Caleb and Hamaguchi, Ryoko and Burridge, Paul W and Rajarajan, Kuppusamy and Churko, Jared M and Wu, Haodi and Sallam, Karim I and Matsa, Elena and Sturzu, Anthony C and Che, Yonglu and Ebert, Antje and Diecke, Sebastian and Liang, Ping and Red-Horse, Kristy and Carette, Jan E and Wu, Sean M and Wu, Joseph C
Circulation Research, ISSN 0009-7330, 08/2014, Volume 115, Issue 6, pp. 556 - 566
RATIONALE:Viral myocarditis is a life-threatening illness that may lead to heart failure or cardiac arrhythmias. A major causative agent for viral myocarditis... 
stem cells | myocarditis | myocytes | cardiac | myocytes, cardiac | CARDIAC & CARDIOVASCULAR SYSTEMS | MECHANISMS | INTERFERON-BETA | MATURATION | FLUOXETINE | INHIBITION | REPLICATION | PERIPHERAL VASCULAR DISEASE | INFECTION | ADENOVIRUS-RECEPTOR | DIFFERENTIATION | HEMATOLOGY | EXPRESSION | Enterovirus Infections - drug therapy | Antiviral Agents - pharmacology | Cell Proliferation | Enterovirus Infections - metabolism | Antiviral Agents - therapeutic use | Calcium - metabolism | Models, Cardiovascular | Humans | Myocarditis - drug therapy | Cells, Cultured | Treatment Outcome | Pluripotent Stem Cells - virology | Pluripotent Stem Cells - pathology | Myocarditis - virology | Myocytes, Cardiac - pathology | Myocytes, Cardiac - virology | Myocytes, Cardiac - drug effects | Pluripotent Stem Cells - drug effects | Myocarditis - metabolism | RNA, Viral - metabolism | Enterovirus B, Human - isolation & purification | Drug Evaluation, Preclinical | In Vitro Techniques | Coxsackie type B | drug screening | Stem cell | cardiomyocyte
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7. Full Text Curcumin inhibits Zika and chikungunya virus infection by inhibiting cell binding
by Mounce, Bryan C and Cesaro, Teresa and Carrau, Lucia and Vallet, Thomas and Vignuzzi, Marco
Antiviral Research, ISSN 0166-3542, 06/2017, Volume 142, pp. 148 - 157
Several compounds extracted from spices and herbs exhibit antiviral effects , suggesting potential pharmacological uses. Curcumin, a component of turmeric, has... 
Enveloped virus | Viral binding | Curcumin | APOPTOSIS | REPLICATION | VIROLOGY | PHARMACOLOGY & PHARMACY | ACETYLTRANSFERASE | Zika Virus Infection - drug therapy | Zika Virus - genetics | Chikungunya virus - genetics | Enterovirus - drug effects | Curcumin - chemistry | Humans | Vesicular stomatitis Indiana virus - drug effects | Cercopithecus aethiops | Curcumin - administration & dosage | Virus Internalization - drug effects | Dose-Response Relationship, Drug | Inhibitory Concentration 50 | Vero Cells | Cell Line | Cell Survival - drug effects | Virus Replication - drug effects | Antiviral Agents - pharmacology | Chikungunya Fever - drug therapy | Curcumin - pharmacology | Zika Virus - drug effects | Coxsackievirus Infections - drug therapy | Virus Attachment - drug effects | Chikungunya virus - drug effects | Animals | HeLa Cells | RNA, Viral - drug effects | Virus diseases | Antiviral agents | Medicine, Botanic | Dengue viruses | Food additives | Dietary supplements | Medicine, Herbal | Hepatitis C virus | Coxsackievirus infections | Health aspects | Cells | Mosquitoes | Monoglycerides
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8. Full Text Betaferon in chronic viral cardiomyopathy (BICC) trial: Effects of interferon-β treatment in patients with chronic viral cardiomyopathy
by Schultheiss, Heinz-Peter and Piper, Cornelia and Sowade, Olaf and Waagstein, Finn and Kapp, Joachim-Friedrich and Wegscheider, Karl and Groetzbach, Georg and Pauschinger, Matthias and Escher, Felicitas and Arbustini, Eloisa and Siedentop, Harald and Kuehl, Uwe
Clinical Research in Cardiology, ISSN 1861-0684, 9/2016, Volume 105, Issue 9, pp. 763 - 773
Chronic viral infections of the heart are considered one antecedent event leading to progressive dysfunction of the myocardium, often with an impaired... 
Chronic viral cardiomyopathy | Medicine & Public Health | Antiviral therapy, myocardial biopsies | Cardiology | Interferon beta | CARDIAC & CARDIOVASCULAR SYSTEMS | ENTEROVIRAL RNA | PERSISTENCE | VENTRICULAR ENDOMYOCARDIAL BIOPSY | MYOCARDITIS | B19 | DILATED CARDIOMYOPATHY | PREVALENCE | PATHOGENESIS | INFECTION | DYSFUNCTION | Adenoviridae Infections - drug therapy | Adenoviridae Infections - virology | Humans | Middle Aged | Male | Enterovirus Infections - physiopathology | Recovery of Function | Viral Load | Cardiomyopathies - physiopathology | Adenoviridae Infections - physiopathology | Enterovirus Infections - virology | Erythema Infectiosum - physiopathology | Time Factors | Cardiomyopathies - diagnosis | Erythema Infectiosum - diagnosis | Adult | Female | Erythema Infectiosum - virology | Cardiomyopathies - drug therapy | Enterovirus Infections - drug therapy | Enterovirus Infections - diagnosis | Double-Blind Method | Antiviral Agents - therapeutic use | Europe | Treatment Outcome | Erythema Infectiosum - drug therapy | Adenoviridae Infections - diagnosis | Interferon beta-1b - adverse effects | Cardiomyopathies - virology | Biopsy | Antiviral Agents - adverse effects | Interferon beta-1b - therapeutic use | Quality of Life | Aged | Chronic Disease
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9. Full Text Interferon-Beta Improves Survival in Enterovirus-Associated Cardiomyopathy
by Kühl, Uwe, MD, PhD and Lassner, D., PhD and von Schlippenbach, Jessica, MD and Poller, Wolfgang, MD and Schultheiss, Heinz-Peter, MD
JACC (Journal of the American College of Cardiology), ISSN 0735-1097, 2012, Volume 60, Issue 14, pp. 1295 - 1296
  All patients received heart failure medication including angiotensin-converting enzyme inhibitors or angiotensin-receptor blockers (67%), beta-blockers... 
Cardiovascular | Internal Medicine | CARDIAC & CARDIOVASCULAR SYSTEMS | MYOCARDITIS | DYSFUNCTION | PERSISTENCE | Enterovirus Infections - drug therapy | Interferon-beta - administration & dosage | Follow-Up Studies | Antiviral Agents - blood | Humans | Middle Aged | Male | Treatment Outcome | Enterovirus - isolation & purification | Antiviral Agents - administration & dosage | Cardiomyopathy, Dilated - virology | Enterovirus Infections - mortality | Enterovirus Infections - virology | Cardiomyopathy, Dilated - drug therapy | Biopsy | Interferon-beta - blood | Adult | Female | Cardiomyopathy, Dilated - mortality | Cohort Studies | Interferon | Biological response modifiers | Cardiomyopathy | Heart diseases | Heart failure | Enzymes | Survival analysis | Mortality | Medical prognosis | Infections | Drug therapy | Viral infections
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10. Full Text Understanding physician antibiotic prescribing behavior for children with enterovirus infection
by Kuo, Kuang-Che and Yeh, Yi-Chun and Huang, Ying-Hsien and Ling Chen, I and Lee, Chen-Hsiang
PLoS ONE, ISSN 1932-6203, 09/2018, Volume 13, Issue 9, p. e0202316
Background Our previous study demonstrated that pediatricians prescribe antibiotics without proper clinical justification to patients with enterovirus... 
C-REACTIVE PROTEIN | VIRAL-INFECTIONS | TAIWAN | MULTIDISCIPLINARY SCIENCES | ASTHMA | CLINICAL-FEATURES | EXPOSURE | HOSPITALIZATION | Enterovirus Infections - drug therapy | Enterovirus - drug effects | Humans | Enterovirus - physiology | Child, Preschool | Infant | Male | Hand, Foot and Mouth Disease - blood | Hand, Foot and Mouth Disease - drug therapy | Practice Patterns, Physicians | Herpangina - blood | Herpangina - virology | Anti-Bacterial Agents - therapeutic use | C-Reactive Protein - metabolism | Enterovirus Infections - virology | Adolescent | Female | Retrospective Studies | Herpangina - drug therapy | Child | Enterovirus Infections - blood | Leukocytosis - blood | Hand, Foot and Mouth Disease - virology | Antibiotics | Physicians | Practice | Dosage and administration | Children | Behavior | Health aspects | Enterovirus diseases | Health care | Pediatrics | C-reactive protein | Laboratories | Medical records | Viruses | Nervous system | Infections | Proteins | Demographics | Immunology | Drug dosages | Bacterial infections | Decision making | Data processing | Patients | Allergies | Asthma | Medicine | Studies | Enteroviruses | Infectious diseases | Leukocytosis | Hospitals | Viral infections
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11. Full Text Towards the design of combination therapy for the treatment of enterovirus infections
by Thibaut, Hendrik Jan and Leyssen, Pieter and Puerstinger, Gerhard and Muigg, Alexandra and Neyts, Johan and De Palma, Armando Mirko
Antiviral Research, ISSN 0166-3542, 2011, Volume 90, Issue 3, pp. 213 - 217
We report here on a comparative study of the activity of 10 enterovirus inhibitors against poliovirus 1, enterovirus 71 and human rhinovirus 14. Three of the... 
Virus | Antiviral | Enterovirus | Poliovirus | Combination therapy | Rhinovirus | ANTIVIRAL AGENTS | BROAD-SPECTRUM | COMMON COLD | COMPOUND | RIBAVIRIN | POTENT | REPLICATION | VIROLOGY | HEPATITIS | PHARMACOLOGY & PHARMACY | POLIO | Enterovirus Infections - drug therapy | Microbial Sensitivity Tests | Cell Line | Antiviral Agents - pharmacology | Drug Interactions | Enterovirus Infections - virology | Enterovirus - drug effects | Humans | Enterovirus - physiology | Drug Therapy, Combination
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12. Full Text Viral myocarditis
by Rose, Noel R
Current Opinion in Rheumatology, ISSN 1040-8711, 07/2016, Volume 28, Issue 4, pp. 383 - 389
PURPOSE OF REVIEWThe article traces the pathways leading from viral infection of the heart by coxsackievirus B3 to autoimmune myocarditis in its various... 
cardiac myosin | coxsackievirus B3 | myocarditis | dilated cardiomyopathy | DIAGNOSIS | ETIOLOGY | EXPERIMENTAL AUTOIMMUNE MYOCARDITIS | MANAGEMENT | RHEUMATOLOGY | IMMUNOSUPPRESSIVE THERAPY | MICE | UPDATE | CARDIAC INFLAMMATION | Antiviral Agents - therapeutic use | Coxsackievirus Infections - diagnosis | Humans | Enterovirus B, Human | Coxsackievirus Infections - drug therapy | Autoimmune Diseases - virology | Virus Diseases - complications | Biopsy - adverse effects | Cardiomyopathy, Dilated - virology | Myocarditis - diagnosis | Coxsackievirus Infections - complications | Myocarditis - virology | Animals | Virus Diseases - drug therapy | Virus Diseases - diagnosis | Cardiomyopathy, Dilated - immunology | Cardiomyopathy, Dilated - diagnosis | Myocarditis - immunology | Coxsackievirus Infections - immunology | Disease Models, Animal | Myocarditis
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13. Full Text The enteroviruses: Problems in need of treatments
by Abzug, Mark J
Journal of Infection, ISSN 0163-4453, 2013, Volume 68, Issue 1, pp. S108 - S114
Summary Specific antiviral therapy is currently not available for enterovirus (EV) infections. Poliomyelitis, EV 71 neurologic disease, and neonatal EV disease... 
Infectious Disease | Enterovirus 71 | Neonatal | Antiviral therapy | Enterovirus | Poliovirus | Poliomyelitis | INFECTIOUS DISEASES | SAFETY | CHILDREN | POLIO ERADICATION | IMMUNOGENICITY | 71 VACCINE | PROGRESS | INFANTS | DISEASE | DOUBLE-BLIND | INFECTION | Enterovirus Infections - drug therapy | Oxadiazoles - isolation & purification | Antiviral Agents - pharmacology | Enterovirus Infections - epidemiology | Global Health | Antiviral Agents - therapeutic use | Oxadiazoles - pharmacology | Humans | Drug Discovery - trends | Antiviral Agents - isolation & purification | Oxadiazoles - therapeutic use | Antiviral agents | Development and progression | Paralysis | Coxsackievirus infections | Health aspects
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14. Full Text Norovirus: Targets and tools in antiviral drug discovery
by Rocha-Pereira, Joana and Neyts, Johan and Jochmans, Dirk
Biochemical Pharmacology, ISSN 0006-2952, 09/2014, Volume 91, Issue 1, pp. 1 - 11
The development of antiviral strategies to treat or prevent norovirus infections is a pressing matter. Noroviruses are the number 1 cause of acute... 
Cell culture models | Norovirus | Antiviral drugs | Small animal models | Antiviral targets | GNOTOBIOTIC PIGS | UNITED-STATES | SYSTEMATIC ANALYSIS | DEPENDENT RNA-POLYMERASE | MURINE NOROVIRUS | NORWALK-LIKE VIRUS | INTESTINAL EPITHELIAL-CELLS | SECRETORY PATHWAY | NONSTRUCTURAL PROTEIN | PHARMACOLOGY & PHARMACY | ENTEROVIRUS REPLICATION | Gastroenteritis - epidemiology | Virus Replication - drug effects | Antiviral Agents - pharmacology | Caliciviridae Infections - virology | Norovirus - pathogenicity | Humans | Gastroenteritis - virology | Gastroenteritis - prevention & control | Molecular Targeted Therapy | Caliciviridae Infections - drug therapy | Genetic Variation | Caliciviridae Infections - transmission | Animals | Swine | Mice | Cells, Cultured - virology | Norovirus - drug effects | Viral Vaccines - immunology | Caliciviridae Infections - epidemiology | Norovirus - genetics
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