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Diabetes, ISSN 0012-1797, 01/2016, Volume 65, Issue 1, pp. 285 - 296
The rapid rise in the incidence of type 1 diabetes (T1D) suggests the involvement of environmental factors including viral infections. We evaluated the... 
UNITED-STATES | BETA-CELLS | IN-VIVO | ENDOCRINOLOGY & METABOLISM | ISLET AUTOIMMUNITY | POLYMERASE CHAIN-REACTION | COXSACKIE-B | CYTOMEGALOVIRUS-INFECTION | BARR-VIRUS INFECTION | ENTEROVIRUS INFECTIONS | IGM RESPONSES | Zinc Transporter 8 | Humans | Mumps virus - immunology | Rotavirus - immunology | Viral Proteins - immunology | Child, Preschool | Male | Cytomegalovirus Infections - immunology | Case-Control Studies | Young Adult | Adult | Female | Rubella virus - immunology | Diabetes Mellitus, Type 1 - immunology | Epstein-Barr Virus Infections | Glutamate Decarboxylase - immunology | Child | Mumps - immunology | Rubella - immunology | Diabetes Mellitus, Type 1 - virology | Herpesvirus 4, Human - immunology | Rotavirus Infections - immunology | Cytomegalovirus - immunology | Autoantibodies - immunology | High-Throughput Screening Assays | Adolescent | Proteomics | Enterovirus B, Human - immunology | Protein Array Analysis | Antibodies, Viral - immunology | Endogenous Retroviruses - immunology | Cation Transport Proteins - immunology | Coxsackievirus Infections - immunology | Viral antibodies | Virus diseases | Antiviral agents | Care and treatment | Type 1 diabetes | Antibodies | Dosage and administration | Viruses | Immunoglobulins | Diabetes | Viral infections | Index Medicus | Abridged Index Medicus | Metabolomics | Genetics | Genomes
Journal Article
Lancet, The, ISSN 0140-6736, 2013, Volume 381, Issue 9882, pp. 2024 - 2032
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57591 - e57591
Enterovirus 71 (EV71) and coxsackievirus (CVA) are the most common causative factors for hand, foot, and mouth disease (HFMD) and neurological disorders in... 
VACCINE DEVELOPMENT | SELECTIN GLYCOPROTEIN LIGAND-1 | NEUROLOGICAL DISEASE | MOUTH-DISEASE | MULTIDISCIPLINARY SCIENCES | P-SELECTIN | CENTRAL-NERVOUS-SYSTEM | BRAIN-STEM ENCEPHALITIS | CYNOMOLGUS MONKEYS | CELL-CULTURE | CEREBROSPINAL-FLUID | Enterovirus A, Human - genetics | Humans | Cercopithecus aethiops | Hand, Foot and Mouth Disease - genetics | Lysosome-Associated Membrane Glycoproteins - immunology | Enterovirus - genetics | Enterovirus Infections - genetics | Enterovirus Infections - immunology | Vero Cells | Disease Models, Animal | Cells, Cultured | Enterovirus A, Human - immunology | Hand, Foot and Mouth Disease - immunology | Genotype | Mice, Transgenic | Up-Regulation - genetics | Inflammation - immunology | Receptors, Scavenger - immunology | Coxsackievirus Infections - genetics | Animals | Receptors, Scavenger - genetics | Up-Regulation - immunology | Enterovirus - immunology | Lysosome-Associated Membrane Glycoproteins - genetics | T-Lymphocytes - immunology | Mice | Coxsackievirus Infections - immunology | Medical research | Nervous system diseases | Analysis | Medicine, Experimental | Genetic engineering | Paralysis | Coxsackievirus infections | Cell culture | Neuropathology | Pathogenesis | Central nervous system | Clinical isolates | Nervous system | Lymphocytes T | Hand-foot-and-mouth disease | Infections | Vaccines | Recruitment | Interleukin 6 | Proteins | Hepatitis | Immunology | Lymphocytes | Transgenic animals | Rodents | Animal tissues | Children | Edema | Encephalitis | Immunization | Cytokines | Neutrophils | Transgenic mice | CCL3 protein | Glycoproteins | Inflammation | Tumor necrosis factor-α | Feet | Neurological diseases | Enteroviruses | Infectious diseases | CXCL10 protein | Ligands | Chemokines | Viral infections | Index Medicus
Journal Article
Journal Article
BMC Infectious Diseases, ISSN 1471-2334, 08/2015, Volume 15, Issue 1, pp. 345 - 345
Background: Meningoencephalitis is one of the most common disorders of the central nervous system (CNS) worldwide. Viral meningoencephalitis differs from... 
DIAGNOSIS | INFECTIOUS DISEASES | VIRUS | INTERFERON-GAMMA | FREQUENCY | NESTED-PCR | MUMPS MENINGITIS | ASEPTIC-MENINGITIS | ECHOVIRUS 30 | INTERLEUKIN-10 | CHILDREN | Lentivirus Infections - cerebrospinal fluid | Meningoencephalitis - cerebrospinal fluid | Meningoencephalitis - diagnosis | Central Nervous System Viral Diseases - diagnosis | Humans | Interleukin-17 - immunology | Interleukin-12 - cerebrospinal fluid | Central Nervous System Viral Diseases - cerebrospinal fluid | Meningoencephalitis - immunology | HIV Infections - immunology | Enterovirus Infections - immunology | HIV Infections - diagnosis | Tumor Necrosis Factor-alpha - immunology | Interleukin-6 - cerebrospinal fluid | Arbovirus Infections - diagnosis | Cytokines - immunology | HIV Infections - cerebrospinal fluid | Herpesviridae Infections - cerebrospinal fluid | Enterovirus Infections - diagnosis | Cross-Sectional Studies | Interferon-gamma - cerebrospinal fluid | Coinfection - immunology | Tumor Necrosis Factor-alpha - cerebrospinal fluid | Inflammation | Herpesviridae Infections - diagnosis | Interleukin-10 - cerebrospinal fluid | Arbovirus Infections - cerebrospinal fluid | Cytokines - cerebrospinal fluid | Interleukin-17 - cerebrospinal fluid | DNA, Viral - cerebrospinal fluid | Coinfection - cerebrospinal fluid | Interferon-gamma - immunology | Lentivirus Infections - immunology | Enterovirus Infections - cerebrospinal fluid | Interleukin-12 - immunology | Interleukin-6 - immunology | RNA, Viral - cerebrospinal fluid | Arbovirus Infections - immunology | Central Nervous System Viral Diseases - immunology | Interleukin-10 - immunology | Herpesviridae Infections - immunology | Complications and side effects | Chemotherapy | Care and treatment | Patient outcomes | Developing countries | Meningitis | Development and progression | Research | Cerebrospinal fluid | Health aspects | Cancer | Medical equipment and supplies industry | HIV (Viruses) | Medical test kit industry | Index Medicus
Journal Article
Clinical & Experimental Immunology, ISSN 0009-9104, 03/2010, Volume 159, Issue 3, pp. 338 - 343
Summary Type 1 diabetes results from a T cell-mediated destruction of insulin-producing pancreatic β cells. Little is known on local factors contributing to... 
CXCL10 | type 1 diabetes | IP-10 | CXCR3 | autoreactive T cells | Autoreactive T cells | Type 1 diabetes | IMMUNE-RESPONSE | NOD MICE | AUTOANTIGENS | ALLOGRAFT | BETA-CELLS | RISK | MELLITUS | IMMUNOLOGY | INFILTRATION | T-CELL RESPONSES | INSULIN EPITOPE | Lymph Nodes - pathology | Humans | Child, Preschool | Male | Diabetes Mellitus, Type 1 - therapy | Enterovirus Infections - immunology | Chemokine CXCL10 - immunology | Adult | Enterovirus Infections - therapy | Female | Retrospective Studies | Diabetes Mellitus, Type 1 - immunology | T-Lymphocytes - pathology | Diabetes Mellitus, Type 1 - virology | Gene Expression Regulation - immunology | Diabetes Mellitus, Type 1 - pathology | Inflammation - virology | Inflammation - immunology | Lymph Nodes - immunology | Insulin-Secreting Cells - immunology | Inflammation - therapy | Insulin-Secreting Cells - virology | Interferon-gamma - immunology | Adolescent | Receptors, CXCR3 - immunology | Enterovirus - immunology | T-Lymphocytes - immunology | Enterovirus Infections - pathology | Insulin-Secreting Cells - pathology | Immunity, Cellular | Interleukin-10 - immunology | Autoimmunity | Diabetics | Pancreatic beta cells | Autoantigens | Inflammation | Biological response modifiers | T cells | Infections | Diabetes | Patients | Viral infections | Chemokines | Immune system | Index Medicus | Insulitis | Leukocyte migration | Diabetes mellitus | Data processing | Lymphocytes T | CXCR3 protein | a-Interferon | Chemokine receptors | Lymph nodes | Beta cells | Infection | Interleukins | CXCL10 protein | Remission | Islets of Langerhans | Pancreas | Translational Studies
Journal Article
Laboratory Investigation, ISSN 0023-6837, 08/2018, Volume 98, Issue 8, pp. 1039 - 1051
Enterovirus (EV) 71 infection has been widely acknowledged as the leading cause of severe hand, foot and mouth disease (HFMD), which may rapidly lead to fatal... 
MEDICINE, RESEARCH & EXPERIMENTAL | IMMUNITY | LUNG | INFLAMMATION | DISEASE | PATHOLOGY | STRAIN | EOTAXIN | Enterovirus Infections - metabolism | Humans | Mast Cells - virology | Brain - virology | Muscle, Skeletal - metabolism | Vascular Endothelial Growth Factor A - metabolism | Histamine - immunology | Brain - metabolism | Histamine - metabolism | Lung - virology | Enterovirus Infections - virology | Muscle, Skeletal - immunology | Enterovirus Infections - immunology | Mast Cells - metabolism | Lung - metabolism | Muscle, Skeletal - virology | Pulmonary Edema - metabolism | Cytokines - immunology | Disease Models, Animal | Animals, Newborn | Mast Cells - immunology | Pulmonary Edema - virology | Cytokines - metabolism | Enterovirus A, Human - immunology | Enterovirus A, Human - physiology | Vascular Endothelial Growth Factor A - immunology | Animals | Pulmonary Edema - immunology | Mice, Inbred BALB C | Brain - immunology | Lung - immunology | Neonates | Platelet-activating factor | Lung | Interleukin | Infections | Lymphocytes T | Hand-foot-and-mouth disease | Interleukin 5 | Lymphocytes | Tumor necrosis factor-TNF | Vascular endothelial growth factor | Noradrenaline | Growth factors | Edema | Foot and mouth disease | Dendritic cells | Leukocytes (eosinophilic) | Hypersensitivity | Organs | Muscles | Interleukin 13 | Inflammation | Tumor necrosis factor-α | Skeletal muscle | Histamine | Monocytes | Lungs | Nitric oxide | Tryptase | Endocrine glands | Mice | Norepinephrine | Foot-and-mouth disease | Mast cells | Eosinophils | Index Medicus
Journal Article
Diabetologia, ISSN 0012-186X, 10/2017, Volume 60, Issue 10, pp. 1931 - 1940
Journal Article
PLoS ONE, ISSN 1932-6203, 02/2013, Volume 8, Issue 2, pp. e57601 - e57601
Background: Enterovirus 71 (EV71) is a major causative agent of hand, foot and mouth disease, which has been prevalent in Asia-Pacific regions, causing... 
IMMUNIZATION | CHALLENGE | MOUTH-DISEASE | MULTIDISCIPLINARY SCIENCES | VACCINE | MICE | LETHAL | VP1 PROTEIN | IDENTIFICATION | OUTBREAK | HAND | Virion - immunology | Insecta - immunology | Enterovirus A, Human - immunology | Genotype | Baculoviridae - immunology | Epitopes - immunology | Antibodies, Neutralizing - immunology | Sf9 Cells | Animals | Vaccination - methods | Enterovirus Infections - immunology | Antibody Formation | Antibodies, Viral - immunology | Female | Mice | Mice, Inbred BALB C | Cercopithecus aethiops - immunology | Neutralization Tests - methods | Vero Cells | Viral Vaccines - immunology | Virus diseases | Infection | Viral antibodies | Medical research | Wildlife conservation | Analysis | Medicine, Experimental | Antibodies | Genetic aspects | Vaccines | Health aspects | Antigenic determinants | VP1 protein | Animal models | Process engineering | Laboratories | Viruses | Attachment | Antisera | Genomes | Hand-foot-and-mouth disease | Infections | Baculovirus | Virus-like particles | Antibody response | Proteins | Genotype & phenotype | Immunology | E coli | Children | Polyclonal antibodies | Recombinant | Foot and mouth disease | Immunization | Particulates | Vectors | Morbidity | Virology | Feet | Insects | Insect cells | Neutralizing | Foot-and-mouth disease | Growth hormone | In vitro methods and tests | Methods | Neutralization | Index Medicus
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 03/2013, Volume 123, Issue 3, pp. 1310 - 1322
Coagulation is a host defense system that limits the spread of pathogens. Coagulation proteases, such as thrombin, also activate cells by cleaving PARs. In... 
TOLL-LIKE RECEPTOR-3 | MEDICINE, RESEARCH & EXPERIMENTAL | NATURAL-KILLER-CELLS | ISCHEMIA/REPERFUSION INJURY | PROTEASE-ACTIVATED RECEPTORS | VIRUS-INFECTION | IN-VIVO | ENDOTHELIAL-CELLS | FACTOR MESSENGER-RNA | INTERFERON-BETA | TISSUE FACTOR EXPRESSION | Receptor, PAR-1 - metabolism | Humans | Male | Troponin I - blood | STAT1 Transcription Factor - metabolism | Myocardium - metabolism | HEK293 Cells | Interferon-beta - genetics | Influenza A virus - immunology | Myocarditis - immunology | Influenza A virus - physiology | Orthomyxoviridae Infections - metabolism | Coxsackievirus Infections - metabolism | Liver - metabolism | Mice, Inbred C57BL | Enterovirus - physiology | Myocarditis - blood | Immunity, Innate | STAT1 Transcription Factor - genetics | Toll-Like Receptor 3 - metabolism | Receptor, PAR-1 - genetics | Mice, Knockout | Myocarditis - virology | Animals | Interferon-beta - metabolism | Thromboplastin - genetics | Enterovirus - immunology | Mice | HeLa Cells | Thrombin - metabolism | Thromboplastin - metabolism | Fibrin - metabolism | Chemokine CXCL10 - metabolism | Coxsackievirus Infections - immunology | Orthomyxoviridae Infections - immunology | Receptor, PAR-1 - physiology | Virus diseases | Cell receptors | Immune response | Physiological aspects | Development and progression | Genetic aspects | Research | Index Medicus | Abridged Index Medicus
Journal Article