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Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7387, pp. 100 - 104
Inhibition of the BRAF(V600E) oncoprotein by the small-molecule drug PLX4032 (vemurafenib) is highly effective in the treatment of melanoma(1). However, colon... 
PANITUMUMAB | TARGET | CETUXIMAB | MELANOMA | BRAF MUTATIONS | MULTIDISCIPLINARY SCIENCES | PAPILLARY THYROID-CARCINOMA | KRAS | METASTATIC COLORECTAL-CANCER | Erlotinib Hydrochloride | Receptor, Epidermal Growth Factor - agonists | Apoptosis - drug effects | Colorectal Neoplasms - genetics | Humans | Antineoplastic Agents - therapeutic use | Antibodies, Monoclonal, Humanized | Receptor, Epidermal Growth Factor - metabolism | RNA Interference | Colorectal Neoplasms - drug therapy | HEK293 Cells | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cetuximab | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Melanoma - metabolism | Colorectal Neoplasms - enzymology | Antibodies, Monoclonal - pharmacology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Drug Synergism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Xenograft Model Antitumor Assays | Animals | Sulfonamides - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Quinazolines - therapeutic use | Melanoma - drug therapy | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Feedback, Physiological - drug effects | Indoles - therapeutic use | Cell Proliferation - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Colorectal Neoplasms - pathology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Proteins | Library collections | Studies | Phosphorylation | Kinases | Tumors | Index Medicus
Journal Article
Nature Medicine, ISSN 1078-8956, 07/2012, Volume 18, Issue 7, pp. 1095 - 1101
Insulin-like growth factor 1 (IGF-1), the most abundant growth factor in the bone matrix, maintains bone mass in adulthood. We now report that IGF-1 released... 
MEDICINE, RESEARCH & EXPERIMENTAL | LIFE-SPAN | PHYSIOLOGY | RESORPTION | BIOCHEMISTRY & MOLECULAR BIOLOGY | OSTEOPOROSIS | CELL BIOLOGY | INSULIN-RECEPTOR | OSTEOBLAST PROGENITORS | RELEVANCE | FRACTURES | POSTMENOPAUSAL WOMEN | GROWTH-FACTOR-I | Bone Matrix - metabolism | Immunohistochemistry | Mesenchymal Stromal Cells - enzymology | Bone and Bones - pathology | Receptor, IGF Type 1 - metabolism | Insulin-Like Growth Factor I - pharmacology | Femur - pathology | TOR Serine-Threonine Kinases - metabolism | Cell Count | Humans | Aging - drug effects | Insulin-Like Growth Factor Binding Protein 3 - pharmacology | Phosphatidylinositol 3-Kinases - metabolism | Femur - diagnostic imaging | Insulin Receptor Substrate Proteins - metabolism | X-Ray Microtomography | Bone and Bones - drug effects | Insulin-Like Growth Factor Binding Protein 3 - metabolism | Bone Matrix - drug effects | Bone and Bones - metabolism | Insulin-Like Growth Factor I - administration & dosage | Bone Resorption - metabolism | Insulin-Like Growth Factor Binding Protein 3 - administration & dosage | Receptor, IGF Type 1 - deficiency | Proto-Oncogene Proteins c-akt - metabolism | Femur - growth & development | Mesenchymal Stromal Cells - drug effects | Bone Resorption - blood | Osteoblasts - enzymology | Osteoblasts - drug effects | Osteogenesis - drug effects | Rats | Enzyme Activation - drug effects | Mice, Knockout | Bone Resorption - diagnostic imaging | Osteoblasts - pathology | Organ Size - drug effects | Animals | Cell Differentiation - drug effects | Bone Resorption - pathology | Mice | Mesenchymal Stromal Cells - pathology | Insulin-Like Growth Factor I - metabolism | Aging - metabolism | Physiological aspects | Research | Insulin-like growth factor 1 | Protein kinases | Stem cells | Bone marrow | Insulin-like growth factors | Index Medicus
Journal Article
Journal Article
CELL DEATH & DISEASE, ISSN 2041-4889, 10/2013, Volume 4, Issue 10, pp. e875 - e875
Radioresistance is a major challenge in prostate cancer (CaP) radiotherapy (RT). In this study, we investigated the role and association of... 
BEZ235 | RADIATION SENSITIVITY | IDENTIFICATION | EMT | PI3K/Akt/mTOR | CELL BIOLOGY | CSC | IN-VITRO | radiation therapy | PROTEASOME | RESISTANCE | INHIBITOR | Prostate cancer | radioresistance | Prostatic Neoplasms - radiotherapy | Epithelial-Mesenchymal Transition - radiation effects | TOR Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Apoptosis - radiation effects | Neoplastic Stem Cells - drug effects | Humans | Spheroids, Cellular - pathology | Epithelial-Mesenchymal Transition - drug effects | Male | Phosphatidylinositol 3-Kinases - metabolism | Spheroids, Cellular - radiation effects | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Quinolines - pharmacology | Radiation Tolerance - radiation effects | TOR Serine-Threonine Kinases - antagonists & inhibitors | Neoplastic Stem Cells - pathology | Spheroids, Cellular - drug effects | Imidazoles - therapeutic use | Signal Transduction - radiation effects | Proto-Oncogene Proteins c-akt - metabolism | Prostatic Neoplasms - drug therapy | Prostatic Neoplasms - pathology | Reproducibility of Results | Neoplasm Invasiveness | Imidazoles - pharmacology | Enzyme Activation - drug effects | Enzyme Activation - radiation effects | Radiation Tolerance - drug effects | Phenotype | Animals | Cell Cycle Checkpoints - radiation effects | Signal Transduction - drug effects | Cell Cycle Checkpoints - drug effects | Models, Biological | Cell Line, Tumor | Prostatic Neoplasms - enzymology | Quinolines - therapeutic use | Neoplastic Stem Cells - enzymology | Index Medicus | PI3K | mTOR | Akt | Original
Journal Article
Journal Article
Nature, ISSN 0028-0836, 03/2012, Volume 483, Issue 7390, pp. 484 - 488
Journal Article
Journal Article