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1. Full Text Interleukin-33 and Interferon-γ Counter-Regulate Group 2 Innate Lymphoid Cell Activation during Immune Perturbation
by Molofsky, Ari B and Van Gool, Frédéric and Liang, Hong-Erh and Van Dyken, Steven J and Nussbaum, Jesse C and Lee, Jinwoo and Bluestone, Jeffrey A and Locksley, Richard M
Immunity, ISSN 1074-7613, 07/2015, Volume 43, Issue 1, pp. 161 - 174
Group 2 innate lymphoid cells (ILC2s) and regulatory T (Treg) cells are systemically induced by helminth infection but also sustain metabolic homeostasis in... 
OBESITY | INSULIN-RESISTANCE | MACROPHAGES | ADIPOSE-TISSUE INFLAMMATION | ALLOGRAFT SURVIVAL | TYPE-2 IMMUNITY | PPAR-GAMMA | IMMUNOLOGY | BEIGE FAT | IL-33 | T-CELLS | Obesity - immunology | Intra-Abdominal Fat - cytology | Listeria monocytogenes - immunology | Nippostrongylus - immunology | Lung - cytology | Enzyme Activation - immunology | Inducible T-Cell Co-Stimulator Protein - biosynthesis | T-Lymphocytes, Regulatory - immunology | Aging - immunology | Lymphocyte Activation - immunology | Receptors, Immunologic - biosynthesis | Strongylida Infections - parasitology | Diet, High-Fat | Interleukins - immunology | Strongylida Infections - immunology | Listeriosis - immunology | Inducible T-Cell Co-Stimulator Protein - immunology | Intra-Abdominal Fat - immunology | Lung - pathology | Interleukin-33 | Mice, Transgenic | Animals | Interferon-gamma - immunology | Interleukin-2 - pharmacology | Listeriosis - microbiology | Mice | Interferon-gamma - pharmacology | Lung - immunology | Index Medicus
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2. Full Text PD-L1 is a novel direct target of HIF-1α, and its blockade under hypoxia enhanced: MDSC-mediated T cell activation
by Noman, Muhammad Zaeem and Desantis, Giacomo and Janji, Bassam and Hasmim, Meriem and Karray, Saoussen and Dessen, Philippe and Bronte, Vincenzo and Chouaib, Salem
Journal of Experimental Medicine, ISSN 0022-1007, 2014, Volume 211, Issue 5, pp. 781 - 790
Tumor-infiltrating myeloid cells such as myeloid-derived suppressor cells (MDSCs) and tumor-associated macrophages (TAMs) form an important component of the... 
MEDICINE, RESEARCH & EXPERIMENTAL | INDUCIBLE FACTOR-1-ALPHA | MICROENVIRONMENT | SAFETY | SUSCEPTIBILITY | ANTIBODY | SUPPRESSOR-CELLS | FACTOR-I | INDUCTION | IMMUNOLOGY | EXPRESSION | CANCER | Cell Hypoxia - immunology | Enzyme-Linked Immunosorbent Assay | Gene Expression Regulation - immunology | Organic Chemicals | Mice, Inbred C57BL | Tumor Microenvironment - immunology | B7-H1 Antigen - metabolism | Lymphocyte Activation - immunology | Animals | Flow Cytometry | Chromatin Immunoprecipitation | RNA Interference | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Luciferases | Myeloid Cells - immunology | Female | T-Lymphocytes - immunology | Mice | Real-Time Polymerase Chain Reaction | Index Medicus | Brief Definitive Report
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3. Full Text Neutrophil IL-1β processing induced by pneumolysin is mediated by the NLRP3/ASC inflammasome and caspase-1 activation and is dependent on K+ efflux
by Karmakar, Mausita and Katsnelson, Michael and Malak, Hesham A and Greene, Neil G and Howell, Scott J and Hise, Amy G and Camilli, Andrew and Kadioglu, Aras and Dubyak, George R and Pearlman, Eric
Journal of Immunology, ISSN 0022-1767, 02/2015, Volume 194, Issue 4, pp. 1763 - 1775
Although neutrophils are the most abundant cells in acute infection and inflammation, relatively little attention has been paid to their role in inflammasome... 
PATHWAYS | INTERLEUKIN-1-BETA | DISEASE | DEFICIENT | INNATE | MICE | DEATH | NLRC4 | IMMUNOLOGY | CONTRIBUTES | STREPTOCOCCUS-PNEUMONIAE KERATITIS | Pneumococcal Infections | Potassium - metabolism | Eye Infections, Bacterial - immunology | Keratitis - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Humans | Caspase 1 - metabolism | Caspase 1 - immunology | Enzyme Activation - immunology | Signal Transduction - immunology | Flow Cytometry | Interleukin-1beta - metabolism | Bacterial Proteins - immunology | Eye Infections, Bacterial - metabolism | Neutrophils - metabolism | Carrier Proteins - immunology | Disease Models, Animal | Apoptosis Regulatory Proteins - immunology | Enzyme-Linked Immunosorbent Assay | Mice, Inbred C57BL | Neutrophils - immunology | Interleukin-1beta - immunology | Blotting, Western | Mice, Knockout | Spectrophotometry, Atomic | Animals | CARD Signaling Adaptor Proteins | Inflammasomes - immunology | Fluorescent Antibody Technique | Keratitis - metabolism | Mice | Streptolysins - immunology | Index Medicus | Abridged Index Medicus
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4. Full Text IL-22+CD4+ T Cells Promote Colorectal Cancer Stemness via STAT3 Transcription Factor Activation and Induction of the Methyltransferase DOT1L
by Kryczek, Ilona and Lin, Yanwei and Nagarsheth, Nisha and Peng, Dongjun and Zhao, Ende and Zhao, Lili and Vatan, Linda and Szeliga, Wojciech and Dou, Yali and Owens, Scott and Zgodzinski, Witold and Majewski, Marek and Wallner, Grzegorz and Fang, Jingyuan and Huang, Emina and Zou, Weiping
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 772 - 784
Little is known about how the immune system impacts human colorectal cancer invasiveness and stemness. Here we detected interleukin-22 (IL-22) in patient... 
COLON-CANCER | IMMUNE CELLS | HISTONE H3 | INTERLEUKIN 22 | INFLAMMATION | HOST-DEFENSE | IMMUNOLOGY | NF-KAPPA-B | IL-22 | EXPRESSION | OVARIAN-CARCINOMA | Receptors, CCR6 - immunology | Neoplasm Transplantation | Chemokine CCL20 - metabolism | Cell Proliferation | Homeodomain Proteins - metabolism | Humans | Methyltransferases - metabolism | Neoplastic Stem Cells - immunology | Homeodomain Proteins - immunology | Methyltransferases - immunology | Enzyme Activation - immunology | SOXB1 Transcription Factors - metabolism | CD4-Positive T-Lymphocytes - immunology | Chemokine CCL20 - immunology | SOXB1 Transcription Factors - immunology | Interleukins - immunology | Receptors, CCR6 - metabolism | Neoplastic Stem Cells - pathology | Octamer Transcription Factor-3 - immunology | STAT3 Transcription Factor - metabolism | Colorectal Neoplasms - mortality | Nanog Homeobox Protein | HT29 Cells | Animals | Colorectal Neoplasms - immunology | Octamer Transcription Factor-3 - metabolism | Cell Line, Tumor | Mice | STAT3 Transcription Factor - immunology | Colorectal Neoplasms - pathology | Medical research | Colon | Rodents | Colorectal cancer | Stem cells | Index Medicus | Th22 | colon cancer | DOT1L | STAT3 | ILC22 | Cancer stem cell | CCR6 | H3K79 | epigenetics
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5. Full Text Human Ebola virus infection results in substantial immune activation
by Anita K. McElroy and Rama S. Akondy and Carl W. Davis and Ali H. Ellebedy and Aneesh K. Mehta and Colleen S. Kraft and G. Marshall Lyon and Bruce S. Ribner and Jay Varkey and John Sidney and Alessandro Sette and Shelley Campbell and Ute Ströher and Inger Damon and Stuart T. Nichol and Christina F. Spiropoulou and Rafi Ahmed
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 4/2015, Volume 112, Issue 15, pp. 4719 - 4724
Four Ebola patients received care at Emory University Hospital, presenting a unique opportunity to examine the cellular immune responses during acute Ebola... 
SEE COMMENTARY | Ebola infection | Human immune response | Immune activation | T cells | Plasmablasts | NONHUMAN-PRIMATES | plasmablasts | DENDRITIC CELLS | MULTIDISCIPLINARY SCIENCES | immune activation | MARBURG VIRUSES | CHALLENGE | LYMPHOCYTE APOPTOSIS | IN-VITRO | T-CELL RESPONSES | HEMORRHAGIC-FEVER | KIKWIT | human immune response | VACCINES | Tumor Necrosis Factor-alpha - metabolism | Ebolavirus - metabolism | Immunoglobulin G - blood | Immunity, Humoral - immunology | Humans | Precursor Cells, B-Lymphoid - metabolism | Viral Proteins - immunology | Precursor Cells, B-Lymphoid - immunology | Interferon-gamma - metabolism | Viral Proteins - metabolism | Ebolavirus - immunology | CD4-Positive T-Lymphocytes - immunology | Lymphocyte Activation - immunology | Flow Cytometry | Immunoglobulin G - immunology | Hemorrhagic Fever, Ebola - virology | Tumor Necrosis Factor-alpha - immunology | CD8-Positive T-Lymphocytes - metabolism | Hemorrhagic Fever, Ebola - immunology | Enzyme-Linked Immunosorbent Assay | CD4-Positive T-Lymphocytes - metabolism | Immunophenotyping | Hemorrhagic Fever, Ebola - blood | Immunity, Cellular - immunology | Interferon-gamma - immunology | CD8-Positive T-Lymphocytes - immunology | Complications and side effects | Ebola virus infections | Care and treatment | Immune response | Research | Ebola virus | Proteins | Plasma | Antigens | Immunoglobulins | T cell receptors | Vaccines | Index Medicus | Biological Sciences
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6. Full Text Inflammatory T Cell Responses Rely on Amino Acid Transporter ASCT2 Facilitation of Glutamine Uptake and mTORC1 Kinase Activation
by Nakaya, Mako and Xiao, Yichuan and Zhou, Xiaofei and Chang, Jae-Hoon and Chang, Mikyoung and Cheng, Xuhong and Blonska, Marzenna and Lin, Xin and Sun, Shao-Cong
Immunity, ISSN 1074-7613, 05/2014, Volume 40, Issue 5, pp. 692 - 705
Glutamine has been implicated as an immunomodulatory nutrient, but how glutamine uptake is mediated during T cell activation is poorly understood. We have... 
MAMMALIAN TARGET | RAPAMYCIN | EFFECTOR | METABOLISM | PATHWAY | C-MYC | DIFFERENTIATION | IMMUNOLOGY | GLUCOSE-UPTAKE | NF-KAPPA-B | TRANSLATIONAL CONTROL | TOR Serine-Threonine Kinases - metabolism | Minor Histocompatibility Antigens | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Glutamine - metabolism | Adoptive Transfer | Neoplasm Proteins - metabolism | Th1 Cells - immunology | Enzyme Activation - immunology | Mechanistic Target of Rapamycin Complex 1 | Multiprotein Complexes - metabolism | Signal Transduction - immunology | CARD Signaling Adaptor Proteins - metabolism | Lymphocyte Activation - immunology | Caspases - metabolism | Biological Transport | Receptors, Antigen, T-Cell - immunology | Amino Acid Transport System ASC - genetics | Leucine - metabolism | Encephalomyelitis, Autoimmune, Experimental - pathology | Amino Acid Transport System ASC - immunology | Jurkat Cells | Mice, Inbred C57BL | Amino Acid Transport System ASC - metabolism | CD28 Antigens - immunology | Inflammation - immunology | Mice, Knockout | Cell Differentiation - immunology | Animals | B-Cell CLL-Lymphoma 10 Protein | Mice | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 Protein | Adaptor Proteins, Signal Transducing - metabolism | Interleukin-2 - biosynthesis | Autoimmunity | T cells | Analysis | Glutamine | Cytokines | Sucrose | Colleges & universities | Homeostasis | Amino acids | T cell receptors | Glucose | Kinases | Proteins | Cell growth | Lymphocytes | Immune system | Cancer | Index Medicus | ASCT2 | CARMA1 | TCR signaling | EAE | T-cell differentiation | mTORC1 | Glutamine uptake
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7. Full Text Calcium-dependent protein kinase/NADPH oxidase activation circuit is required for rapid defense signal propagation
by Ullrich Dubiella and Heike Seybold and Guido Durian and Eileen Komander and Roman Lassig and Claus-Peter Witte and Waltraud X. Schulze and Tina Romeis
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 5/2013, Volume 110, Issue 21, pp. 8744 - 8749
In animals and plants, pathogen recognition triggers the local activation of intracellular signaling that is prerequisite for mounting systemic defenses in the... 
Proteins | Oxidases | Pathogens | Enzymes | Phosphorylation | Reactive oxygen species | Calcium | Plant propagation | Protoplasts | Biochemistry | ANION CHANNEL | ABIOTIC STRESS | PATHOGEN | MULTIDISCIPLINARY SCIENCES | ROS signaling | RECEPTOR | IMMUNE | disease resistance | plant innate immunity | CA2 | ROS | RESISTANCE | ACCUMULATION | KINASES | Arabidopsis - enzymology | Reactive Oxygen Species - metabolism | NADPH Oxidases - metabolism | Arabidopsis - immunology | NADPH Oxidases - immunology | Cell Communication - physiology | Enzyme Activation - immunology | Tobacco - immunology | Arabidopsis Proteins - metabolism | Reactive Oxygen Species - immunology | NADPH Oxidases - genetics | Calcium-Calmodulin-Dependent Protein Kinases - immunology | Arabidopsis Proteins - genetics | Calcium-Calmodulin-Dependent Protein Kinases - genetics | Plants, Genetically Modified - genetics | Plants, Genetically Modified - immunology | Plants, Genetically Modified - enzymology | Plant Immunity - physiology | Arabidopsis Proteins - immunology | Arabidopsis - genetics | Tobacco - genetics | Signal Transduction - physiology | Mutation | Plant Diseases | Enzyme Activation - genetics | Tobacco - enzymology | Calcium-Calmodulin-Dependent Protein Kinases - metabolism | Arabidopsis thaliana | Physiological aspects | Research | Protein kinases | Plant immunology | Flowers & plants | Kinases | Gene expression | Cells | Index Medicus | Biological Sciences
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8. Full Text Caspase-11 Activation in Response to Bacterial Secretion Systems that Access the Host Cytosol
by Casson, Cierra N and Copenhaver, Alan M and Zwack, Erin E and Nguyen, Hieu T and Strowig, Till and Javdan, Bahar and Bradley, William P and Fung, Thomas C and Flavell, Richard A and Brodsky, Igor E and Shin, Sunny
PLoS Pathogens, ISSN 1553-7366, 06/2013, Volume 9, Issue 6, pp. e1003400 - e1003400
Inflammasome activation is important for antimicrobial defense because it induces cell death and regulates the secretion of IL-1 family cytokines, which play a... 
LEGIONELLA-PNEUMOPHILA | FLAGELLIN | PROTEIN | DISTINCT PATHWAYS | RECOGNITION | INFLAMMASOME ACTIVATION | INTERLEUKIN-1-BETA | INNATE | LEGIONNAIRES DISEASE | MICROBIOLOGY | DIFFERENTIAL REQUIREMENT | VIROLOGY | PARASITOLOGY | Interleukin-1alpha - immunology | Caspases - immunology | NLR Family, Pyrin Domain-Containing 3 Protein | Cytosol - immunology | Enzyme Activation - immunology | Legionnaires' Disease - immunology | Calcium-Binding Proteins - immunology | Legionnaires' Disease - microbiology | Legionella pneumophila - pathogenicity | Bacterial Secretion Systems - immunology | Carrier Proteins - immunology | Macrophages - immunology | Macrophages - microbiology | Cell Line | Legionella pneumophila - immunology | Apoptosis Regulatory Proteins - immunology | Macrophages - pathology | Caspases - genetics | Interleukin-1beta - immunology | Inflammasomes - genetics | Mice, Knockout | Immunity, Innate - immunology | Animals | Inflammasomes - immunology | Legionnaires' Disease - pathology | Cytosol - microbiology | Mice | Host-parasite relationships | Physiological aspects | Research | Interleukins | Cytosol | Health aspects | Index Medicus | Bacterial infections | Microbiology | Cytokines | Infections | Experiments | Bacteriology | Recruitment | Scholarships & fellowships | E coli | Bone marrow | Bacteria | Interferon | Gram-negative bacteria | Adapter proteins | Apoptosis
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9. Full Text CaMK4-dependent activation of AKT/mTOR and CREM-α underlies autoimmunity-associated Th17 imbalance
by Koga, Tomohiro and Hedrich, Christian M and Mizui, Masayuki and Yoshida, Nobuya and Otomo, Kotaro and Lieberman, Linda A and Rauen, Thomas and Crispín, José C and Tsokos, George C
Journal of Clinical Investigation, ISSN 0021-9738, 2014, Volume 124, Issue 5, pp. 2234 - 2245
Tissue inflammation in several autoimmune diseases, including SLE and MS, has been linked to an imbalance of IL-17-producing Th (Th17) cells and Tregs;... 
EPIGENETIC MECHANISMS | CRUCIAL ROLE | MEDICINE, RESEARCH & EXPERIMENTAL | KINASE TYPE-IV | SYSTEMIC-LUPUS-ERYTHEMATOSUS | MULTIPLE-SCLEROSIS | INTERLEUKIN-17 | SUPPRESSES IL-2 PRODUCTION | HELPER-CELLS | ROR-GAMMA | REGULATORY T-CELLS | RNA, Messenger - immunology | Humans | Interleukin-17 - immunology | Male | Lupus Erythematosus, Systemic - therapy | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - genetics | Enzyme Activation - immunology | Proto-Oncogene Proteins c-akt - genetics | Cell Differentiation - genetics | TOR Serine-Threonine Kinases - genetics | Lupus Erythematosus, Systemic - immunology | Female | Th17 Cells - pathology | RNA, Messenger - genetics | Interleukin-17 - genetics | Multiple Sclerosis - genetics | Cyclic AMP Response Element Modulator - immunology | Multiple Sclerosis - therapy | Mice, Knockout | Cell Differentiation - immunology | TOR Serine-Threonine Kinases - immunology | Animals | Cyclic AMP Response Element Modulator - genetics | Proto-Oncogene Proteins c-akt - immunology | Lupus Erythematosus, Systemic - genetics | Multiple Sclerosis - immunology | Multiple Sclerosis - pathology | Th17 Cells - immunology | Mice | Enzyme Activation - genetics | Lupus Erythematosus, Systemic - pathology | Calcium-Calmodulin-Dependent Protein Kinase Type 4 - immunology | Index Medicus | Abridged Index Medicus
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10. Full Text Mincle is an ITAM-coupled activating receptor that senses damaged cells
by Ogata, Koji and Yamasaki, Sho and Saito, Takashi and Sakuma, Machie and Hara, Hiromitsu and Ishikawa, Eri
Nature Immunology, ISSN 1529-2908, 10/2008, Volume 9, Issue 10, pp. 1179 - 1188
Macrophage-inducible C-type lectin (Mincle) is expressed mainly in macrophages and is induced after exposure to various stimuli and stresses. Here we show that... 
ADAPTER PROTEIN CARD9 | C-TYPE LECTIN | INNATE IMMUNE-RESPONSES | APOPTOTIC CELLS | SMALL NUCLEAR RIBONUCLEOPROTEIN | TOLL-LIKE RECEPTORS | DEFICIENT MICE | IMMUNOLOGY | BINDING PROTEIN | MYELOID CELLS | AUTOIMMUNE-DISEASE | Epitope Mapping | Immunoprecipitation | Humans | Cell Death - immunology | Lectins, C-Type - immunology | Molecular Sequence Data | Immunoblotting | Lectins, C-Type - genetics | Flow Cytometry | Ribonucleoproteins, Small Nuclear - immunology | Conserved Sequence | Receptors, Immunologic - immunology | Macrophages - immunology | Cytokines - immunology | Neutrophil Infiltration - immunology | Amino Acid Sequence | Transduction, Genetic | Enzyme-Linked Immunosorbent Assay | Macrophage Activation - immunology | Membrane Proteins - genetics | Mice, Inbred C57BL | Models, Molecular | Membrane Proteins - immunology | Receptors, IgG - immunology | Reverse Transcriptase Polymerase Chain Reaction | Animals | Mice | Cytokines - biosynthesis | Physiological aspects | Cell receptors | Research | Cytokines | Neutrophils | Index Medicus
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