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Nature, ISSN 0028-0836, 11/2008, Volume 456, Issue 7219, pp. 269 - 273
Journal Article
Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5954, pp. 853 - 858
Virtually all of the 560 human proteases are stored as inactive proenyzmes and are strictly regulated. We report the identification and characterization of the... 
Executioners | T lymphocytes | Molecules | HEK293 cells | B lymphocytes | Cell lines | Cytochromes | Reports | Kidney cells | Viability | Apoptosis | APOPTOSIS | IN-VITRO | CYSTEINE PROTEASE | DOMAIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DEATH | INDUCTION | CASPASE ACTIVATION | ALLOSTERIC SITE | Enzyme Activators - pharmacology | Caspase 6 - metabolism | Pyridines - chemistry | Caspase 3 - chemistry | Granzymes - metabolism | Humans | Caspase 3 - metabolism | Enzyme Precursors - genetics | Imidazoles - chemistry | Benzopyrans - metabolism | Enzyme Activators - metabolism | Small Molecule Libraries - metabolism | Benzopyrans - chemistry | Enzyme Activators - chemistry | Caspase 3 - genetics | Enzyme Precursors - antagonists & inhibitors | Molecular Structure | Benzopyrans - pharmacology | Imidazoles - metabolism | Catalytic Domain | Biocatalysis | Enzyme Inhibitors - metabolism | Enzyme Precursors - chemistry | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Caspase Inhibitors | Small Molecule Libraries - chemistry | Enzyme Precursors - metabolism | Animals | Pyridines - metabolism | Mutagenesis | Caspase 6 - genetics | Cell Line, Tumor | Mice | Pyridines - pharmacology | Enzyme Activation | Kinetics | Caspase 6 - chemistry | Cell Line, Transformed | Chemical properties | Research | Zymogens | Proteases | Identification and classification | Enzymes | Biochemistry | Molecular biology | Index Medicus
Journal Article
Journal Article
Journal Article
Nature, ISSN 0028-0836, 02/2011, Volume 470, Issue 7334, pp. 404 - 408
Activating AMPK or inactivating calcineurin slows ageing in Caenorhabditis elegans(1,2) and both have been implicated as therapeutic targets for age-related... 
COACTIVATOR CRTC2 | TORC2 | UNFOLDED PROTEIN RESPONSE | CAENORHABDITIS-ELEGANS | PATHWAY | INSULIN-RESISTANCE | ER STRESS | MULTIDISCIPLINARY SCIENCES | KINASE | GENE-REGULATION | C-ELEGANS | AMP-Activated Protein Kinases - metabolism | Phosphorylation | Caenorhabditis elegans Proteins - chemistry | Humans | Caenorhabditis elegans Proteins - metabolism | Trans-Activators - chemistry | Gene Knockdown Techniques | Caenorhabditis elegans - physiology | Calcineurin Inhibitors | HEK293 Cells | Trans-Activators - genetics | Transcription, Genetic | Protein-Serine-Threonine Kinases - metabolism | Cyclic AMP Response Element-Binding Protein - biosynthesis | Caenorhabditis elegans - metabolism | Caenorhabditis elegans - genetics | Down-Regulation | Transcription Factors - biosynthesis | Longevity - genetics | Transcription Factors - metabolism | Animals | Trans-Activators - deficiency | Aging - physiology | Energy Metabolism | Cyclic AMP Response Element-Binding Protein - metabolism | Trans-Activators - metabolism | Enzyme Activation | Caenorhabditis elegans Proteins - genetics | Longevity - physiology | Caenorhabditis elegans - enzymology | Calcineurin - metabolism | Aging - metabolism | Caenorhabditis elegans Proteins - biosynthesis | Physiological aspects | Chemical properties | Protein kinases | Calcineurin | Proteins | Homeostasis | Mutation | Kinases | DNA repair | Metabolic disorders | Binding sites
Journal Article
The Plant Journal, ISSN 0960-7412, 11/2008, Volume 56, Issue 4, pp. 613 - 626
Journal Article
Journal Article