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Nature Chemical Biology, ISSN 1552-4450, 2012, Volume 8, Issue 10, pp. 839 - 847
Cancer cells engage in a metabolic program to enhance biosynthesis and support cell proliferation. The regulatory properties of pyruvate kinase M2 (PKM2)... 
ISOZYME | INHIBITION | FRUCTOSE-1,6-BISPHOSPHATE | THYROID-HORMONE | CONVERSION | BIOCHEMISTRY & MOLECULAR BIOLOGY | ISOFORM | BINDING PROTEIN | CANCER-CELL METABOLISM | TUMOR-GROWTH | NUCLEAR TRANSLOCATION | Genes | Cells | Cancer | Tumors | Index Medicus | BASIC BIOLOGICAL SCIENCES
Journal Article
Science, ISSN 0036-8075, 11/2009, Volume 326, Issue 5954, pp. 853 - 858
Virtually all of the 560 human proteases are stored as inactive proenyzmes and are strictly regulated. We report the identification and characterization of the... 
Executioners | T lymphocytes | Molecules | HEK293 cells | B lymphocytes | Cell lines | Cytochromes | Reports | Kidney cells | Viability | Apoptosis | APOPTOSIS | IN-VITRO | CYSTEINE PROTEASE | DOMAIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DEATH | INDUCTION | CASPASE ACTIVATION | ALLOSTERIC SITE | Enzyme Activators - pharmacology | Caspase 6 - metabolism | Pyridines - chemistry | Caspase 3 - chemistry | Granzymes - metabolism | Humans | Caspase 3 - metabolism | Enzyme Precursors - genetics | Imidazoles - chemistry | Benzopyrans - metabolism | Enzyme Activators - metabolism | Small Molecule Libraries - metabolism | Benzopyrans - chemistry | Enzyme Activators - chemistry | Caspase 3 - genetics | Enzyme Precursors - antagonists & inhibitors | Molecular Structure | Benzopyrans - pharmacology | Imidazoles - metabolism | Catalytic Domain | Biocatalysis | Enzyme Inhibitors - metabolism | Enzyme Precursors - chemistry | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Caspase Inhibitors | Small Molecule Libraries - chemistry | Enzyme Precursors - metabolism | Animals | Pyridines - metabolism | Mutagenesis | Caspase 6 - genetics | Cell Line, Tumor | Mice | Pyridines - pharmacology | Enzyme Activation | Kinetics | Caspase 6 - chemistry | Cell Line, Transformed | Chemical properties | Research | Zymogens | Proteases | Identification and classification | Enzymes | Biochemistry | Molecular biology | Index Medicus
Journal Article
Journal Article
European Journal of Pharmacology, ISSN 0014-2999, 2007, Volume 572, Issue 1, pp. 12 - 22
Pulmonary fibroblast to myofibroblast conversion is a pathophysiological feature of idiopathic pulmonary fibrosis and COPD. This conversion is induced by... 
TGF-β | Sildenafil | Lung fibroblast | Fibrosis | Phosphodiesterase | lung fibroblast | CELLS | CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES | PROLIFERATION | sildenafil | CARDIAC FIBROBLASTS | TGF-beta | GROWTH-FACTOR-BETA | DISEASE | NITRIC-OXIDE | PHARMACOLOGY & PHARMACY | fibrosis | phosphodiesterase | DIFFERENTIATION | IDIOPATHIC PULMONARY-FIBROSIS | EXPRESSION | Enzyme Activators - pharmacology | Immunohistochemistry | Cyclic GMP - pharmacology | Humans | Actins - metabolism | Lung - cytology | Natriuretic Peptide, Brain - pharmacology | Sulfones - pharmacology | Quinoxalines - pharmacology | Sildenafil Citrate | Nitroso Compounds - pharmacology | Isoenzymes - metabolism | Oxadiazoles - pharmacology | Benzamides - pharmacology | Nitric Oxide Donors - pharmacology | Myocytes, Smooth Muscle - drug effects | Myocytes, Smooth Muscle - cytology | Myocytes, Smooth Muscle - metabolism | Fibroblasts - metabolism | Dinoprostone - pharmacology | Purines - pharmacology | Cells, Cultured | Transforming Growth Factor beta - physiology | Phosphodiesterase Inhibitors - pharmacology | Guanylate Cyclase - metabolism | Soluble Guanylyl Cyclase | Piperazines - pharmacology | Blotting, Western | Drug Synergism | Transforming Growth Factor beta - pharmacology | Cell Differentiation - drug effects | Fibroblasts - drug effects | Benzoates - pharmacology | Fibroblasts - cytology | Pyridines - pharmacology | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus
Journal Article
Journal of Molecular and Cellular Cardiology, ISSN 0022-2828, 2011, Volume 51, Issue 1, pp. 24 - 32
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 03/2004, Volume 279, Issue 12, pp. 11320 - 11326
Recently, we demonstrated that ceramide kinase, and its product, ceramide 1-phosphate (Cer-1-P), were mediators of arachidonic acid released in cells in... 
Enzyme Activators - pharmacology | Cytosol - enzymology | RNA Interference | Base Sequence | Humans | Fluorescent Antibody Technique | Cell Line, Tumor | Phospholipases A - metabolism | Phospholipases A2 | Ceramides - pharmacology | Index Medicus
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 09/2016, Volume 59, Issue 17, pp. 8068 - 8081
Journal Article
Science, ISSN 0036-8075, 7/2003, Volume 301, Issue 5631, pp. 370 - 373
Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the phosphorylation of glucose in cells that express this enzyme, such as... 
Circles | Blood glucose | Enzymes | Hepatocytes | Homeostasis | Reports | Glucose tolerance test | Type 2 diabetes mellitus | Diabetes | Insulin | Vehicles | GLUCOSE-HOMEOSTASIS | MUTANTS | MODY-2 | MULTIDISCIPLINARY SCIENCES | LIVER | BETA-CELL | MICE | MUTATIONS | MELLITUS | Enzyme Activators - pharmacology | Islets of Langerhans - drug effects | Rats, Wistar | Stereoisomerism | Allosteric Regulation | Humans | Liver Glycogen - biosynthesis | Male | Diabetes Mellitus, Type 2 - metabolism | Insulin - blood | Keto Acids - metabolism | Dose-Response Relationship, Drug | Liver - drug effects | Islets of Langerhans - metabolism | Enzyme Activators - chemistry | Drug Evaluation, Preclinical | Insulin Secretion | Carrier Proteins | Recombinant Proteins - metabolism | Glucose Tolerance Test | Liver - metabolism | Mice, Inbred C57BL | Rats | Hypoglycemic Agents - chemistry | Glucokinase - metabolism | Hypoglycemic Agents - pharmacology | Adaptor Proteins, Signal Transducing | Insulin - metabolism | Animals | Proteins - metabolism | Glucose - metabolism | Mice, Obese | Thiazoles - chemistry | Mice | Proteins - pharmacology | Thiazoles - pharmacology | Enzyme Activation | Blood Glucose - metabolism | Diabetes Mellitus, Type 2 - drug therapy | Type 2 diabetes | Glucose metabolism | Care and treatment | Research | Glucose | Drug therapy | Metabolism | Index Medicus
Journal Article