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Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2009, Volume 326, Issue 5954, pp. 853 - 858
.... These procaspase activators bypass the normal upstream proapoptotic signaling cascades and induce rapid apoptosis in a variety of cell lines... 
Executioners | T lymphocytes | Molecules | HEK293 cells | B lymphocytes | Cell lines | Cytochromes | Reports | Kidney cells | Viability | Apoptosis | APOPTOSIS | IN-VITRO | CYSTEINE PROTEASE | DOMAIN | INHIBITION | MULTIDISCIPLINARY SCIENCES | MECHANISMS | DEATH | INDUCTION | CASPASE ACTIVATION | ALLOSTERIC SITE | Enzyme Activators - pharmacology | Caspase 6 - metabolism | Pyridines - chemistry | Caspase 3 - chemistry | Granzymes - metabolism | Humans | Caspase 3 - metabolism | Enzyme Precursors - genetics | Imidazoles - chemistry | Benzopyrans - metabolism | Enzyme Activators - metabolism | Small Molecule Libraries - metabolism | Benzopyrans - chemistry | Enzyme Activators - chemistry | Caspase 3 - genetics | Enzyme Precursors - antagonists & inhibitors | Molecular Structure | Benzopyrans - pharmacology | Imidazoles - metabolism | Catalytic Domain | Biocatalysis | Enzyme Inhibitors - metabolism | Enzyme Precursors - chemistry | Signal Transduction | Cells, Cultured | Enzyme Inhibitors - pharmacology | Imidazoles - pharmacology | Caspase Inhibitors | Small Molecule Libraries - chemistry | Enzyme Precursors - metabolism | Animals | Pyridines - metabolism | Mutagenesis | Caspase 6 - genetics | Cell Line, Tumor | Mice | Pyridines - pharmacology | Enzyme Activation | Kinetics | Caspase 6 - chemistry | Cell Line, Transformed | Chemical properties | Research | Zymogens | Proteases | Identification and classification | Enzymes | Biochemistry | Molecular biology | Index Medicus
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2010, Volume 285, Issue 11, pp. 8340 - 8351
Journal Article
Journal Article
Nature (London), ISSN 1476-4687, 2007, Volume 450, Issue 7170, pp. 712 - 716
Journal Article
Nature chemical biology, ISSN 1552-4469, 2012, Volume 8, Issue 10, pp. 839 - 847
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2013, Volume 339, Issue 6124, pp. 1216 - 1219
.... A single amino acid in SIRT1, Glu 230 , located in a structured N-terminal domain, was critical for activation by all previously reported STAC scaffolds and a new class of chemically distinct activators... 
T lymphocytes | Killing | Proteins | Dose response relationship | Antibiotics | REPORTS | Amino acids | Diabetes | Myoblasts | Cancer | Diseases | SURVIVAL | SRT1720 | RESVERATROL | DEACETYLASE ACTIVITY | ACETYLATION | MULTIDISCIPLINARY SCIENCES | MITOCHONDRIAL-FUNCTION | TRANSCRIPTION | SIRTUINS | MODULATION | SMALL-MOLECULE ACTIVATORS | Sirtuin 1 - metabolism | Allosteric Regulation | Glutamic Acid - genetics | Humans | Molecular Sequence Data | Substrate Specificity | Stilbenes - chemistry | Stilbenes - pharmacology | Sirtuin 1 - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Myoblasts - drug effects | Forkhead Transcription Factors - chemistry | Sirtuin 1 - chemistry | Protein Structure, Tertiary | Amino Acid Sequence | Cells, Cultured | Heterocyclic Compounds, 4 or More Rings - chemistry | Forkhead Transcription Factors - genetics | Amino Acid Motifs | Animals | Hydrophobic and Hydrophilic Interactions | Mice | Enzyme Activation | Forkhead Box Protein O3 | Myoblasts - enzymology | Amino Acid Substitution | Glutamic Acid - chemistry | Transcription factors | Properties | Genetic regulation | Allosteric proteins | Aging | Mitochondria | Hydrophobic surfaces | DNA repair | Apoptosis | Drugs | Enzymes | Regulators | Control | Exploration | Activation | Substrates
Journal Article
The Journal of biological chemistry, ISSN 1083-351X, 2005, Volume 280, Issue 43, pp. 36529 - 36540