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Drug Metabolism and Disposition, ISSN 0090-9556, 03/2010, Volume 38, Issue 3, pp. 516 - 525
HepaRG cells possess the unique property to differentiate in vitro and to express various functions of mature hepatocytes, including the major cytochromes P450... 
COCKTAIL | TRANSPORTER | IN-VITRO MODEL | LIVER | LINE | CULTURED HUMAN HEPATOCYTES | PHARMACOLOGY & PHARMACY | INDUCTION | MICROSOMAL-ENZYME INDUCERS | TANDEM MASS-SPECTROMETRY | DRUG-METABOLISM | Phenobarbital - pharmacology | Humans | Cytochrome P-450 Enzyme System - metabolism | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear - biosynthesis | RNA, Messenger - metabolism | Glucuronosyltransferase - genetics | Hepatocytes - cytology | Glutathione Transferase - genetics | Time Factors | Isoenzymes - metabolism | Membrane Transport Proteins - genetics | Enzyme Induction - drug effects | Membrane Transport Proteins - metabolism | Omeprazole - pharmacology | Cell Differentiation | Xenobiotics - metabolism | Cell Culture Techniques | Hepatocytes - drug effects | Drug Evaluation, Preclinical - methods | Reproducibility of Results | Isoenzymes - genetics | Cells, Cultured | Glutathione Transferase - metabolism | Receptors, Cytoplasmic and Nuclear - genetics | Gene Expression Regulation - drug effects | Glutathione Transferase - biosynthesis | Membrane Transport Proteins - biosynthesis | Glucuronosyltransferase - metabolism | Cytochrome P-450 Enzyme System - biosynthesis | Cytochrome P-450 Enzyme System - genetics | Rifampin - pharmacology | Isoenzymes - biosynthesis | Glucuronosyltransferase - biosynthesis | Cell Line, Transformed | Receptors, Cytoplasmic and Nuclear - metabolism | Index Medicus | Receptors, Cytoplasmic and Nuclear | Life Sciences | Glutathione Transferase | Xenobiotics | Drug Evaluation, Preclinical | Glucuronosyltransferase | Hépatology and Gastroenterology | Isoenzymes | Gene Expression Regulation | Enzyme Induction | Cytochrome P-450 Enzyme System | Omeprazole | Human health and pathology | Phenobarbital | Hepatocytes | Membrane Transport Proteins | RNA, Messenger | Rifampin
Journal Article
Molecular Carcinogenesis, ISSN 0899-1987, 10/2014, Volume 53, Issue 10, pp. 793 - 806
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 10/2017, Volume 118, Issue 10, pp. 3290 - 3298
ABSTRACT The aim of the present study is to investigate the effect of a natural compound crocin, one of the active components of saffron, on human multiple... 
APOPTOSIS | SHP‐1 | CROCIN | STAT3 | SHP-1 | MULTIPLE-MYELOMA | TARGET | BIOCHEMISTRY & MOLECULAR BIOLOGY | PROLIFERATION | CANCER | CELL BIOLOGY | INFLAMMATION | ACTIVATION PATHWAY | EXPRESSION | CARCINOMA | SIGNAL TRANSDUCER | Apoptosis - drug effects | Humans | Apoptosis - genetics | G1 Phase - drug effects | Multiple Myeloma - metabolism | Neoplasm Proteins - metabolism | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Carotenoids - pharmacology | Enzyme Induction - genetics | Multiple Myeloma - drug therapy | Multiple Myeloma - pathology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Enzyme Induction - drug effects | G1 Phase - genetics | HeLa Cells | Neoplasm Proteins - genetics | Multiple Myeloma - genetics | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Tyrosine | Phenols | Phosphatases | Gene expression | Vascular endothelial growth factor | Multiple myeloma | Cell proliferation | Bax protein | Bcl-2 protein | SHP-1 protein | Activation | Cyclin D1 | Kinases | Phosphatase | Nuclei | Prevention | Proteins | Angiogenesis | Signal transduction | Janus kinase 2 | Cell cycle | Janus kinase | Saffron | Inhibition | G1 phase | Translocation | Pervanadate | Stat3 protein | Src protein | CXCR4 protein | Inhibitors | Protein phosphatase | Protein-tyrosine-phosphatase | Apoptosis
Journal Article
Journal Article
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 2010, Volume 246, Issue 1, pp. 8 - 17
Acetaminophen (APAP) overdose, which causes liver injury in animals and humans, activates c-jun N-terminal kinase (JNK). Although it was shown that the JNK... 
Mitochondria | Acetaminophen | JNK | Bax | Hepatotoxicity | Oxidant stress | SP600125 | BAX TRANSLOCATION | CELL INJURY | INDUCED LIVER-INJURY | TUMOR-NECROSIS-FACTOR | MITOCHONDRIAL PERMEABILITY TRANSITION | CULTURED MOUSE HEPATOCYTES | ONCOTIC NECROSIS | PROTECTIVE ROLE | IN-VIVO | PHARMACOLOGY & PHARMACY | TOXICOLOGY | NH2-TERMINAL KINASE | Liver - pathology | Phosphorylation | Liver - enzymology | Apoptosis - drug effects | Analgesics, Non-Narcotic - pharmacology | Nitric Oxide Synthase - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Male | Alanine Transaminase - blood | Analgesics, Non-Narcotic - toxicity | Liver - drug effects | Acetaminophen - pharmacology | Enzyme Induction - drug effects | Nitric Oxide Synthase - biosynthesis | JNK Mitogen-Activated Protein Kinases - drug effects | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | Subcellular Fractions - drug effects | Acetaminophen - toxicity | Mice, Inbred C57BL | bcl-2-Associated X Protein - metabolism | Enzyme Activation - drug effects | Reverse Transcriptase Polymerase Chain Reaction | Anthracenes - pharmacology | Blotting, Western | Mitochondria, Liver - drug effects | Peroxynitrous Acid - biosynthesis | Animals | JNK Mitogen-Activated Protein Kinases - physiology | Mice | Oxidative Stress - drug effects | Translocation, Genetic - genetics | Messenger RNA | Glutathione transferase | Nitric oxide | Mitochondrial DNA | Superoxide | Permeability | Index Medicus | OXYGEN COMPOUNDS | NITRIC OXIDE | DIGESTIVE SYSTEM | MITOCHONDRIA | 60 APPLIED LIFE SCIENCES | STRESSES | PHOSPHORUS-GROUP TRANSFERASES | GLANDS | OXIDIZERS | NITROGEN OXIDES | ENZYMES | DRUGS | VERTEBRATES | MICE | NITROGEN COMPOUNDS | RADIOPROTECTIVE SUBSTANCES | MAMMALS | ANIMALS | INJURIES | RODENTS | RESPONSE MODIFYING FACTORS | ORGANIC COMPOUNDS | TRANSFERASES | NITRITES | POLYPEPTIDES | CHALCOGENIDES | ORGANS | DISEASES | PEPTIDES | GLUTATHIONE | LIVER | PHOSPHOTRANSFERASES | OXIDES | PROTEINS | BODY | CELL CONSTITUENTS | Oxidant Stress
Journal Article
Journal Article
Journal Article