X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (47731) 47731
Publication (4514) 4514
Newsletter (1640) 1640
Newspaper Article (1119) 1119
Patent (981) 981
Book Chapter (719) 719
Book / eBook (704) 704
Book Review (408) 408
Dissertation (66) 66
Magazine Article (66) 66
Conference Proceeding (60) 60
Data Set (15) 15
Reference (13) 13
Trade Publication Article (11) 11
Paper (10) 10
Government Document (8) 8
Web Resource (6) 6
Transcript (2) 2
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
index medicus (23980) 23980
enzymes (21760) 21760
animals (18119) 18119
humans (18107) 18107
enzyme inhibitors - pharmacology (12599) 12599
proteins (9452) 9452
research (8833) 8833
biochemistry & molecular biology (8608) 8608
chemistry, medicinal (8507) 8507
enzyme inhibitors - chemical synthesis (8141) 8141
structure-activity relationship (7631) 7631
research article (7270) 7270
enzyme inhibitors - chemistry (7162) 7162
biochemistry (6538) 6538
mice (6458) 6458
multidisciplinary sciences (6457) 6457
medicine (6192) 6192
rats (5941) 5941
male (5702) 5702
chemistry, organic (5661) 5661
physiological aspects (5495) 5495
science (5319) 5319
analysis (5085) 5085
gene expression (5056) 5056
molecular structure (4986) 4986
metabolism (4832) 4832
cancer (4512) 4512
models, molecular (4494) 4494
chemistry (4386) 4386
biology (4239) 4239
kinetics (4121) 4121
cell biology (3928) 3928
inhibitors (3774) 3774
expression (3765) 3765
apoptosis (3695) 3695
kinases (3655) 3655
female (3576) 3576
rodents (3480) 3480
drug design (3471) 3471
physiology (3357) 3357
binding sites (3343) 3343
article (3332) 3332
inhibition (3312) 3312
microbiology (3299) 3299
biosynthesis (3272) 3272
pharmacology & pharmacy (3219) 3219
phosphorylation (3139) 3139
oxidative stress (3102) 3102
health aspects (3100) 3100
dose-response relationship, drug (3088) 3088
genetic aspects (2997) 2997
signal transduction (2968) 2968
cell line, tumor (2928) 2928
enzyme inhibitors (2878) 2878
studies (2695) 2695
amino acid sequence (2650) 2650
molecular sequence data (2639) 2639
chemistry, multidisciplinary (2552) 2552
activation (2551) 2551
cell line (2493) 2493
protein binding (2491) 2491
cells, cultured (2449) 2449
cells (2447) 2447
inflammation (2444) 2444
peptides (2417) 2417
amino acids (2414) 2414
organic chemistry (2399) 2399
derivatives (2333) 2333
biology and life sciences (2311) 2311
oncology (2281) 2281
genes (2278) 2278
enzyme-linked immunosorbent assay (2265) 2265
catalysis (2262) 2262
mutation (2248) 2248
biotechnology & applied microbiology (2213) 2213
identification (2154) 2154
biotechnology (2146) 2146
in-vitro (2143) 2143
enzyme activation - drug effects (2130) 2130
binding (2085) 2085
substrate specificity (2077) 2077
enzymology (2067) 2067
escherichia-coli (2018) 2018
crystallography, x-ray (1988) 1988
mechanism (1982) 1982
ligands (1979) 1979
antineoplastic agents - pharmacology (1962) 1962
dna (1942) 1942
lipids (1942) 1942
enzyme activation (1941) 1941
deoxyribonucleic acid--dna (1938) 1938
chemical properties (1865) 1865
protein (1827) 1827
antioxidants (1820) 1820
inhibitory concentration 50 (1811) 1811
bacteria (1798) 1798
synthesis (1796) 1796
molecular biology (1789) 1789
metabolites (1777) 1777
enzyme (1766) 1766
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (415) 415
UofT at Mississauga - Stacks (63) 63
Engineering & Comp. Sci. - Stacks (48) 48
UTL at Downsview - May be requested (48) 48
Chemistry (A D Allen) - Stacks (41) 41
Collection Dvlpm't (Acquisitions) - Vendor file (26) 26
UofT at Scarborough - Stacks (23) 23
Earth Sciences (Noranda) - Stacks (16) 16
Online Resources - Online (15) 15
Collection Dvlpm't (Acquisitions) - Closed Orders (11) 11
Gerstein Science - Reference (5) 5
Chemistry (A D Allen) - May be requested in 6-10 wks (3) 3
UofT at Scarborough - Withdrawn (3) 3
UofT at Scarborough - May be requested in 6-10 wks (2) 2
Chemistry (A D Allen) - Reference (1) 1
Collection Dvlpm't (Acquisitions) - Cancelled Order (1) 1
Engineering & Comp. Sci. - May be requested in 6-10 wks (1) 1
Engineering & Comp. Sci. - Missing (1) 1
Engineering & Comp. Sci. - Not Returned (1) 1
Engineering & Comp. Sci. - Reference (1) 1
Gerstein Science - Missing (1) 1
Gerstein Science - Not Returned (1) 1
Mt Sinai Hospital - Pathology (1) 1
Online (1) 1
Online Resources - Pharmacy (1) 1
Physics - Stacks (1) 1
Robarts - Stacks (1) 1
Royal Ontario Museum - Stacks (1) 1
St. Michael's College (John M. Kelly) - 2nd Floor (1) 1
St. Michael's Hospital - Stacks (1) 1
Sunnybrook Health Sciences Centre - Sunnybrook Stacks (1) 1
Trinity College (John W Graham) - Stacks (1) 1
UofT at Mississauga - Reference (1) 1
UofT at Scarborough - Storage (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (52654) 52654
French (328) 328
German (246) 246
Spanish (105) 105
Chinese (75) 75
Danish (68) 68
Russian (64) 64
Japanese (62) 62
Norwegian (38) 38
Portuguese (17) 17
Korean (16) 16
Turkish (10) 10
Czech (9) 9
Ukrainian (8) 8
Polish (7) 7
Dutch (6) 6
Arabic (4) 4
Icelandic (4) 4
Italian (4) 4
Slovak (3) 3
Finnish (2) 2
Slovenian (2) 2
Swedish (2) 2
Hungarian (1) 1
Ndonga (1) 1
Romanian (1) 1
Serbian (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Journal of the American Chemical Society, ISSN 0002-7863, 10/2017, Volume 139, Issue 40, pp. 14077 - 14089
Journal Article
European Journal of Medicinal Chemistry, ISSN 0223-5234, 11/2016, Volume 123, pp. 803 - 813
Two new series of -substituted indole derivatives and were synthesized. Their chemical structures were confirmed using spectroscopic tools including IR, H NMR,... 
Molecular docking study | Anti-inflammatory activity | Antiproliferative activity | Indole derivatives | Cyclooxygenase enzymes | DESIGN | CHEMISTRY, MEDICINAL | INDOMETHACIN | CELECOXIB | SELECTIVE COX-2 INHIBITORS | LIPOXYGENASES | NONSTEROIDAL ANTIINFLAMMATORY DRUGS | INFLAMMATION | ESTERS | AGENTS | DERIVATIVES | Antineoplastic Agents - chemical synthesis | Humans | Indoles - chemical synthesis | Cyclooxygenase 2 Inhibitors - chemistry | Anti-Inflammatory Agents - metabolism | Antineoplastic Agents - metabolism | Indoles - metabolism | Lipoxygenase Inhibitors - chemical synthesis | Lipoxygenase Inhibitors - chemistry | Arachidonate 5-Lipoxygenase - chemistry | Drug Design | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cyclooxygenase 2 Inhibitors - metabolism | Cyclooxygenase 2 Inhibitors - chemical synthesis | Catalytic Domain | Chemistry Techniques, Synthetic | Arachidonate 5-Lipoxygenase - metabolism | Cyclooxygenase 2 Inhibitors - pharmacology | Anti-Inflammatory Agents - pharmacology | Antineoplastic Agents - chemistry | Anti-Inflammatory Agents - chemistry | Schiff Bases - chemistry | Cyclooxygenase 2 - metabolism | Cell Line, Tumor | Anti-Inflammatory Agents - chemical synthesis | Lipoxygenase Inhibitors - metabolism | Molecular Docking Simulation | Cyclooxygenase 1 - metabolism | Indoles - chemistry | Lipoxygenase Inhibitors - pharmacology | Schiff bases | COX-2 inhibitors | Analysis | Phytochemistry | Pharmacy | Drugstores | Nuclear magnetic resonance spectroscopy | Mass spectrometry | Cells
Journal Article
Bioorganic and Medicinal Chemistry, ISSN 0968-0896, 2016, Volume 24, Issue 18, pp. 4324 - 4338
A novel series of compounds obtained by fusing the acetylcholinesterase (AChE) inhibitor donepezil and the antioxidant melatonin were designed as... 
Melatonin | Biometal chelators | Alzheimer's disease | Antioxidant activity | Donepezil | Cholinesterase | AMYLOID-BETA AGGREGATION | OXIDATIVE STRESS | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHEMISTRY, ORGANIC | NEUROPROTECTIVE PROPERTIES | CHOLINESTERASE-INHIBITORS | BUTYRYLCHOLINESTERASE INHIBITORS | NEURODEGENERATIVE DISEASES | TACRINE-TROLOX HYBRIDS | MULTIFUNCTIONAL AGENTS | BIOLOGICAL EVALUATION | PHARMACOLOGICAL EVALUATION | Cholinesterase Inhibitors - toxicity | Humans | Protein Multimerization | Indoles - chemical synthesis | Cholinesterase Inhibitors - chemical synthesis | Zinc - chemistry | Piperidines - pharmacology | Butyrylcholinesterase - metabolism | Indoles - pharmacology | Piperidines - toxicity | Catalytic Domain | Iron - chemistry | Alzheimer Disease - drug therapy | Rats | Electrophorus | Indoles - toxicity | Antioxidants - chemical synthesis | Antioxidants - pharmacology | Chelating Agents - pharmacology | Piperidines - chemical synthesis | Blood-Brain Barrier - metabolism | Antioxidants - toxicity | Melatonin - toxicity | Amyloid beta-Peptides - antagonists & inhibitors | Melatonin - analogs & derivatives | Animals | Chelating Agents - toxicity | Cholinesterase Inhibitors - pharmacology | Peptide Fragments - antagonists & inhibitors | Cell Line, Tumor | Horses | Indans - toxicity | Indans - chemical synthesis | Melatonin - chemical synthesis | Molecular Docking Simulation | Kinetics | Chelating Agents - chemical synthesis | Melatonin - pharmacology | Acetylcholinesterase - metabolism | Indans - pharmacology | Drug therapy | Analysis | Oligomers | Enzyme inhibitors | Surface active agents | Cell death
Journal Article
Journal Article