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PloS one, ISSN 1932-6203, 06/2009, Volume 4, Issue 6, pp. e6093 - e6093
... T-cell clones, we here demonstrated a strong synergistic activation of HIV-1 production by clinically used histone deacetylase inhibitors (HDACIs... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Anti-HIV Agents - pharmacology | HIV-1 - metabolism | NF-KappaB Inhibitor alpha | NF-kappa B - antagonists & inhibitors | Humans | Middle Aged | Enzyme Inhibitors - pharmacology | Nucleosomes - metabolism | Cytoplasm - metabolism | I-kappa B Proteins - metabolism | Virus Latency - drug effects | Drug Synergism | Monocytes - virology | Cell Nucleus - metabolism | CD8-Positive T-Lymphocytes - metabolism | Phorbol Esters - pharmacology | Adult | HIV Infections - drug therapy | HIV-1 - enzymology | Aged | Highly active antiretroviral therapy | Antiviral agents | Control | Physiological aspects | Genetic research | Genetic transcription | T cells | HIV (Viruses) | Health aspects | Therapy | Oxidative stress | Histone deacetylase | Transcription | Laboratories | CD8 antigen | Leukocytes (mononuclear) | Viruses | Lymphocytes T | Infections | Activation | Remodeling | DNA-directed RNA polymerase | Synergism | Recruitment | Long terminal repeat | Cell growth | Transfection | Acquired immune deficiency syndrome--AIDS | Lymphocytes | Human immunodeficiency virus--HIV | Peripheral blood mononuclear cells | Elongation | Deoxyribonucleic acid--DNA | NF-κB protein | Latent infection | Gene expression | Ribonucleic acid--RNA | Patients | Virology | CD4 antigen | Monocytes | Inhibitors | Replication | Reservoirs | Combined treatment | RNA polymerase II | Index Medicus | HIV Infections | HIV-1 | Enzyme Inhibitors | Virus Latency | I-kappa B Proteins | Anti-HIV Agents | CD8-Positive T-Lymphocytes | Life Sciences | Microbiology and Parasitology | NF-kappa B | Nucleosomes | Phorbol Esters | Cell Nucleus | Cytoplasm | RNA | Acquired immune deficiency syndrome | Deoxyribonucleic acid | Ribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Nature (London), ISSN 1476-4687, 02/2010, Volume 464, Issue 7287, pp. 427 - 430
.... We found that ATP-competitive RAF inhibitors inhibit ERK signalling in cells with mutant BRAF, but unexpectedly enhance signalling in cells with wild-type BRAF... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Neoplasms - metabolism | ras Proteins - genetics | Phosphorylation | raf Kinases - antagonists & inhibitors | Humans | Protein Multimerization | Transcriptional Activation - drug effects | ras Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | raf Kinases - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Neoplasms - genetics | Adenosine Triphosphate - metabolism | Indoles - pharmacology | raf Kinases - genetics | Proto-Oncogene Proteins B-raf - metabolism | Proto-Oncogene Proteins B-raf - chemistry | Cell Line | raf Kinases - chemistry | Catalytic Domain | Neoplasms - enzymology | Enzyme Activation - drug effects | Sulfonamides - pharmacology | Neoplasms - drug therapy | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Animals | MAP Kinase Signaling System - drug effects | Models, Biological | Protein Kinase Inhibitors - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Cell Line, Tumor | Protein Binding | Mice | Protein Kinase Inhibitors - pharmacology | Protein Kinase Inhibitors - metabolism | Care and treatment | Enzyme inhibitors | Gene mutations | Cellular signal transduction | Genetic aspects | Research | Health aspects | Cancer | Proteins | Competition | Drugs | Mutation | Kinases | Tumors | Index Medicus
Journal Article
Expert review of anticancer therapy, ISSN 1473-7140, 02/2004, Volume 4, Issue 1, pp. 105 - 128
.... The mammalian target of rapamycin (mTOR) is an important regulator of cell growth and metabolism and is often... 
PI3K | signal transduction | angiogenesis | neuro-oncology | mTOR | PTEN | brain tumor | molecular | Akt | SHH/PTCH | Brain tumor | Angiogenesis | Signal transduction | Neuro-oncology | Molecular | Protein Kinases - metabolism | Molecular Biology | Tumor Suppressor Proteins - antagonists & inhibitors | Humans | Receptors, Cell Surface | Brain Neoplasms - blood supply | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Drug Delivery Systems | Hedgehog Proteins | PTEN Phosphohydrolase | Drug Design | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Angiogenesis Inhibitors - therapeutic use | Membrane Proteins - metabolism | Patched Receptors | Protein-Serine-Threonine Kinases - metabolism | Phosphoric Monoester Hydrolases - antagonists & inhibitors | Proto-Oncogene Proteins - metabolism | Proto-Oncogene Proteins - antagonists & inhibitors | Tumor Suppressor Proteins - metabolism | Signal Transduction | Enzyme Inhibitors - pharmacology | Angiogenesis Inhibitors - pharmacology | Brain Neoplasms - drug therapy | Enzyme Inhibitors - therapeutic use | Proto-Oncogene Proteins c-akt | Medical Oncology | Protein Kinase Inhibitors | Membrane Proteins - antagonists & inhibitors | Neovascularization, Pathologic - drug therapy | Trans-Activators - metabolism | TOR Serine-Threonine Kinases | Trans-Activators - antagonists & inhibitors | Phosphoric Monoester Hydrolases - metabolism | Patched-1 Receptor | Care and treatment | Brain tumors | Patient outcomes | Development and progression | Genetic aspects | Cellular signal transduction | Research | Gene therapy | Health aspects | Index Medicus
Journal Article
Angewandte Chemie (International ed.), ISSN 1433-7851, 01/2015, Volume 54, Issue 5, pp. 1578 - 1582
... precursor protein (APP). A key enzyme has been identified as being responsible for Aβ formation, namely, the aspartyl protease β‐secretase (BACE‐1). 3 BACE‐1 inhibitors... 
enzymes | neurochemistry | drug discovery | drug design | heterocycles | Neurochemistry | Enzymes | Heterocycles | Drug design | Drug discovery | Index Medicus | Drugs | Brain | Inhibitors | Pathways | Strategy | Assessments | Alzheimer's disease
Journal Article
Journal Article
Metabolism, clinical and experimental, ISSN 0026-0495, 06/2014, Volume 63, Issue 6, pp. 735 - 745
..., also known as 3-hydroxy-3-methyl-glutaryl coenzyme-A (HMG-CoA) reductase inhibitors, in primary and secondary CVD prevention [3] . Statins mainly act to decrease... 
Endocrinology & Metabolism | Ca2 + channels | HMG-CoA inhibitors | Diabetes mellitus | Adipocytes | GLUT4 | Lipophilicity | Cholesterol | Adiponectin | Isoprenoids | Life Sciences & Biomedicine | Science & Technology | Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage | Calcium Channels - metabolism | Glucose Transporter Type 4 - metabolism | Humans | Leptin - metabolism | MicroRNAs - metabolism | Caveolins - metabolism | Adipocytes - drug effects | Insulin-Secreting Cells - metabolism | Hyperglycemia - chemically induced | Terpenes - antagonists & inhibitors | Mitochondrial Proteins - metabolism | Adiponectin - metabolism | Insulin Secretion | Calcium Channels - drug effects | Hyperinsulinism - metabolism | Ubiquinone - analogs & derivatives | Insulin Resistance | Diabetes Mellitus - metabolism | Ubiquinone - antagonists & inhibitors | Hyperglycemia - metabolism | Hyperinsulinism - chemically induced | Insulin - metabolism | Animals | Dolichol - antagonists & inhibitors | Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects | Insulin-Secreting Cells - drug effects | Ion Channels - metabolism | Cell Differentiation - drug effects | Diabetes Mellitus - chemically induced | Uncoupling Protein 3 | Phosphates | Enzymes | Pancreatic beta cells | Development and progression | Glucose | Dextrose | Cardiovascular agents | Glucose metabolism | Analysis | Leptin | Cellular signal transduction | Diabetes | Statins | Protein binding | Diabetes therapy | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 10/2001, Volume 413, Issue 6857, pp. 739 - 743
Proteins with expanded polyglutamine repeats cause Huntington's disease and other neurodegenerative diseases. Transcriptional dysregulation and loss of... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Acetyltransferases - metabolism | Histone Acetyltransferases | Glutamine - metabolism | E1A-Associated p300 Protein | Drosophila Proteins - metabolism | Neurodegenerative Diseases - drug therapy | PC12 Cells | Nerve Tissue Proteins - chemistry | Repetitive Sequences, Amino Acid | Peptides - metabolism | Acetylation | Huntington Disease - enzymology | Repressor Proteins - metabolism | Disease Models, Animal | Drosophila - genetics | Protein Structure, Tertiary | Huntington Disease - prevention & control | Enzyme Inhibitors - metabolism | Animals, Genetically Modified | CREB-Binding Protein | Gene Expression Regulation | Glutathione Transferase - metabolism | Rats | Repressor Proteins - genetics | Histone Deacetylases - metabolism | Nuclear Proteins - metabolism | Neurodegenerative Diseases - metabolism | Nuclear Proteins - chemistry | Huntington Disease - metabolism | Nerve Tissue Proteins - metabolism | Huntingtin Protein | Animals | Saccharomyces cerevisiae Proteins | Trans-Activators - metabolism | Histone Deacetylase Inhibitors | Drosophila - metabolism | Drosophila Proteins - genetics | Histones - metabolism | Nerve Degeneration | Neurodegenerative Diseases - enzymology | Proteins | Amino acids | Insects | Disease | Htt exon 1 protein | polyglutamine | Animal models | Index Medicus
Journal Article
Nature (London), ISSN 0028-0836, 07/2018, Volume 560, Issue 7719, pp. 499 - 503
Journal Article