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PloS one, ISSN 1932-6203, 12/2010, Volume 5, Issue 12, pp. e14222 - e14222
.... Here the potential of this plant is explored for rapid production of precursors of artemisinin, a sesquiterpenoid compound that is used for malaria treatment... 
acid | reductase | expression system | plants | biosynthesis | annua | yield | tobacco | molecular-cloning | antimalarial-drug artemisinin | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Oligonucleotides - chemistry | Antimalarials - metabolism | Chemistry, Pharmaceutical - methods | Gas Chromatography-Mass Spectrometry | Models, Chemical | Plant Extracts - pharmacology | Tobacco - metabolism | Open Reading Frames | Cytochrome P-450 Enzyme System - metabolism | Mitochondria - metabolism | Oxygen - metabolism | Antimalarials - pharmacology | Artemisinins - pharmacology | Plant Extracts - metabolism | Agrobacterium tumefaciens - metabolism | Plant Leaves - metabolism | Tobacco - genetics | Drug Design | Artemisinins - metabolism | Plant Proteins - metabolism | Oxidases | Malaria | Transferases | Genetic aspects | Fermentation | Chemical synthesis | Health aspects | Drugs | Biotechnology | Metabolomics | Dehydrogenases | Laboratories | Genes | Artemisinin | Alcohol | Biosynthesis | Drug resistance | Proteins | Engineering | Leaves | Parasitic diseases | Precursors | Physiology | Oxidation | Trends | Vector-borne diseases | Plants (botany) | Metabolism | Chromatography | Tobacco | Acids | Headspace | Growth hormones | Scientific imaging | Infiltration | Mass spectrometry | Pharmaceuticals | Reductase | Index Medicus
Journal Article
Journal of neurochemistry, ISSN 1471-4159, 07/2008, Volume 106, Issue 1, pp. 475 - 485
.... In this study, we evaluated the cognitive performance in rodent models of hypercholesterolemia in relation to neuroinflammatory changes and amyloid precursor protein (APP... 
cholesterol | low density lipoprotein receptor | beta‐site APP cleaving enzyme 1 | amyloid precursor protein processing | neuroinflammation | working memory | Neuroinflammation | Low density lipoprotein receptor | Working memory | Beta-site APP cleaving enzyme 1 | Amyloid precursor protein processing | Cholesterol | Biochemistry & Molecular Biology | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Alzheimer Disease - etiology | Dietary Fats - metabolism | Memory Disorders - physiopathology | Neurons - pathology | Memory Disorders - metabolism | Brain - metabolism | Encephalitis - physiopathology | Encephalitis - metabolism | Up-Regulation - physiology | Amyloid beta-Protein Precursor - metabolism | Neurons - metabolism | Disease Models, Animal | Receptors, LDL - genetics | Alzheimer Disease - physiopathology | Dietary Fats - adverse effects | Cytokines - metabolism | Amyloid beta-Peptides - biosynthesis | Brain - physiopathology | Mice, Inbred C57BL | Cholesterol - metabolism | Peptide Fragments - biosynthesis | Mice, Knockout | Amyloid Precursor Protein Secretases - metabolism | Animals | Maze Learning | Memory Disorders - etiology | Aspartic Acid Endopeptidases - metabolism | Alzheimer Disease - metabolism | Hypercholesterolemia - complications | Hypercholesterolemia - physiopathology | Mice | Memory, Short-Term | Hypercholesterolemia - metabolism | Encephalitis - etiology | Hypercholesterolemia | Tumor necrosis factor | Amyloid beta-protein | Short-term memory | Alzheimer's disease | Neurology | Biochemistry | Alzheimers disease | Rodents | Memory | Index Medicus | BACE1 | APP processing | LDLR
Journal Article
Plant physiology (Bethesda), ISSN 0032-0889, 3/2014, Volume 164, Issue 3, pp. 1222 - 1236
Journal Article
Journal of Alzheimer's disease, ISSN 1387-2877, 2017, Volume 55, Issue 4, pp. 1549 - 1570
...). We studied herein the subcellular distribution, the processing, and the protein interactome of the amyloid-beta protein precursor (A beta PP... 
proteomic | lipids | amyloid-β protein precursor | mitochondria associated membranes | Alzheimer disease | Neurosciences | Neurosciences & Neurology | Life Sciences & Biomedicine | Science & Technology | Immunoprecipitation | Cricetulus | Humans | Ryanodine Receptor Calcium Release Channel - metabolism | Mitochondria - ultrastructure | Quinolines - pharmacology | Electron Transport Complex IV - metabolism | Transfection | Amyloid beta-Peptides - genetics | Amyloid beta-Peptides - metabolism | Amyloid beta-Protein Precursor - metabolism | Cell Membrane - metabolism | Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | Cell Membrane - drug effects | Neuroblastoma - pathology | CHO Cells | Pyrazoles - pharmacology | Enzyme Inhibitors - pharmacology | Voltage-Dependent Anion Channel 1 - metabolism | Gene Expression Regulation - physiology | Presenilin-1 - genetics | Mice, Transgenic | Cell Membrane - ultrastructure | Mitochondria - metabolism | Mitochondria - drug effects | Microscopy, Electron | Mutation - genetics | Gene Expression Regulation - drug effects | Amyloid Precursor Protein Secretases - metabolism | Amyloid beta-Protein Precursor - genetics | Animals | Presenilin-1 - metabolism | Cell Line, Tumor | Mice | Membranes | Deregulation | Animal models | Neurodegenerative diseases | Pathogenesis | Transgenic mice | Proteins | Mitochondria | Proteolysis | Rodents | Amyloid | Mutation | Localization | Alzheimer's disease | Catabolites | Index Medicus | Life Sciences
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 09/2010, Volume 330, Issue 6000, pp. 70 - 74
Taxol (paclitaxel) is a potent anticancer drug first isolated from the Taxus brevifolia Pacific yew tree. Currently, cost-efficient production of Taxol and its... 
Enzymes | Cellular metabolism | Terpenoids | Chemical engineering | Bioreactors | Plasmids | REPORTS | Operons | Biosynthesis | Indoles | Streams | Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Metabolomics | NADPH-Ferrihemoprotein Reductase - genetics | Erythritol - analogs & derivatives | Cytochrome P-450 Enzyme System - metabolism | Taxoids - metabolism | Organophosphorus Compounds - metabolism | Recombinant Fusion Proteins - metabolism | Farnesyltranstransferase - metabolism | Escherichia coli K12 - metabolism | Hemiterpenes - metabolism | Indoles - metabolism | Terpenes - metabolism | Erythritol - metabolism | Isomerases - genetics | Diterpenes - metabolism | NADPH-Ferrihemoprotein Reductase - metabolism | Paclitaxel - biosynthesis | Oxidation-Reduction | Fermentation | Taxus - enzymology | Metabolic Networks and Pathways - genetics | Genetic Engineering | Sugar Phosphates - metabolism | Farnesyltranstransferase - genetics | Cytochrome P-450 Enzyme System - genetics | Isomerases - metabolism | Escherichia coli K12 - genetics | Alkenes - metabolism | Escherichia coli K12 - enzymology | Physiological aspects | Research | Health aspects | Escherichia coli | Biological transport | Biochemistry | Pharmacology | E coli | Drugs | Pathways | Searching | Taxol | Modules | Modular | Pacific yew | Optimization | Index Medicus
Journal Article