Articles

Search Articles

Advanced search
Help

Catalogue

Articles

Databases

X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (267778) 267778
Patent (62795) 62795
Publication (35369) 35369
Newsletter (28710) 28710
Newspaper Article (18073) 18073
Book Chapter (3551) 3551
Book Review (1924) 1924
Book / eBook (1423) 1423
Magazine Article (815) 815
Conference Proceeding (782) 782
Dissertation (560) 560
Trade Publication Article (412) 412
Web Resource (306) 306
Reference (205) 205
Government Document (177) 177
Transcript (61) 61
Data Set (60) 60
Paper (43) 43
Streaming Video (13) 13
Report (11) 11
Journal / eJournal (8) 8
Presentation (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
enzymes (164911) 164911
index medicus (107577) 107577
biochemistry (88428) 88428
microbiology (79554) 79554
humans (78913) 78913
animals (78807) 78807
chemistry (75353) 75353
biochemistry & molecular biology (67962) 67962
enzymology (66996) 66996
wine (62957) 62957
beer (62874) 62874
metallurgy (62813) 62813
vinegar (62807) 62807
spirits (62796) 62796
mutation or genetic engineering (62795) 62795
research (56347) 56347
proteins (52319) 52319
culture media (47575) 47575
compositions thereof (46923) 46923
microorganisms or enzymes (46923) 46923
propagating, preserving or maintaining microorganisms (46923) 46923
analysis (35806) 35806
human necessities (34650) 34650
hygiene (31450) 31450
medical or veterinary science (31388) 31388
amino acid sequence (31038) 31038
molecular sequence data (31008) 31008
models, molecular (29806) 29806
organic chemistry (29201) 29201
research article (28080) 28080
physiological aspects (27798) 27798
peptides (27143) 27143
multidisciplinary sciences (26420) 26420
kinetics (26032) 26032
preparations for medical, dental, or toilet purposes (24897) 24897
mice (24848) 24848
structure-activity relationship (24528) 24528
enzyme inhibitors - pharmacology (24181) 24181
binding sites (23522) 23522
cell biology (22508) 22508
male (22135) 22135
crystal-structure (21864) 21864
medicine (21173) 21173
gene expression (20547) 20547
physics (19663) 19663
protein binding (19413) 19413
compositions or test papers therefor (19293) 19293
condition-responsive control in microbiological orenzymological processes (19293) 19293
measuring or testing processes involving enzymes, nucleicacids or microorganisms (19293) 19293
processes of preparing such compositions (19293) 19293
catalysis (19184) 19184
molecular structure (19000) 19000
mutation (18806) 18806
enzyme-linked immunosorbent assay (18483) 18483
science (18377) 18377
female (18093) 18093
rats (18023) 18023
expression (17953) 17953
protein conformation (17753) 17753
biology (17388) 17388
article (17194) 17194
escherichia-coli (16725) 16725
genetic aspects (16469) 16469
testing (16342) 16342
genes (16282) 16282
biotechnology & applied microbiology (16090) 16090
measuring (15968) 15968
metabolism (15957) 15957
biophysics (15829) 15829
investigating or analysing materials by determining theirchemical or physical properties (15766) 15766
protein structure, tertiary (15491) 15491
substrate specificity (15424) 15424
enzyme activation (15302) 15302
enzyme (15143) 15143
amino acids (14860) 14860
protein (14698) 14698
identification (14350) 14350
dna (14324) 14324
bacteria (13952) 13952
crystallography, x-ray (13942) 13942
cancer (13910) 13910
chemistry, medicinal (13864) 13864
base sequence (13846) 13846
enzyme inhibitors - chemistry (13688) 13688
binding (13217) 13217
fermentation or enzyme-using processes to synthesise a desiredchemical compound or composition or to separate optical isomersfrom a racemic mixture (13152) 13152
phosphorylation (12904) 12904
biosynthesis (12639) 12639
life sciences (12427) 12427
prostheses (12120) 12120
studies (12066) 12066
bandages, dressings or absorbent pads (12022) 12022
devices providing patency to, or preventing collapsing of,tubular structures of the body, e.g. stents (12022) 12022
filters implantable into blood vessels (12022) 12022
first-aid kits (12022) 12022
fomentation (12022) 12022
orthopaedic, nursing or contraceptive devices (12022) 12022
treatment or protection of eyes or ears (12022) 12022
specific therapeutic activity of chemical compounds ormedicinal preparations (11833) 11833
reports (11410) 11410
more...
Library Location Library Location
Library Location Library Location
X
Sort by Item Count (A-Z)
Filter by Count
Gerstein Science - Stacks (647) 647
Online Resources - Online (126) 126
UofT at Mississauga - Stacks (126) 126
Chemistry (A D Allen) - Stacks (89) 89
Engineering & Comp. Sci. - Stacks (83) 83
Collection Dvlpm't (Acquisitions) - Vendor file (70) 70
UTL at Downsview - May be requested (64) 64
UofT at Scarborough - Stacks (47) 47
Collection Dvlpm't (Acquisitions) - Closed Orders (33) 33
Earth Sciences (Noranda) - Stacks (20) 20
Gerstein Science - Reference (6) 6
Chemistry (A D Allen) - May be requested in 6-10 wks (5) 5
Gerstein Science - Missing (4) 4
Robarts - Stacks (4) 4
Royal Ontario Museum - Stacks (4) 4
St. Michael's College (John M. Kelly) - 2nd Floor (3) 3
Trinity College (John W Graham) - Stacks (3) 3
UofT at Scarborough - Withdrawn (3) 3
Collection Dvlpm't (Acquisitions) - Cancelled Order (2) 2
Gerstein Science - Periodical Stacks (2) 2
Gerstein Science - Theses (2) 2
UofT at Mississauga - Reference (2) 2
UofT at Scarborough - May be requested in 6-10 wks (2) 2
Chemistry (A D Allen) - Reference (1) 1
Collection Dvlpm't (Acquisitions) - Stacks (1) 1
Criminology - Stacks (1) 1
Engineering & Comp. Sci. - May be requested in 6-10 wks (1) 1
Engineering & Comp. Sci. - Missing (1) 1
Engineering & Comp. Sci. - Not Returned (1) 1
Engineering & Comp. Sci. - Reference (1) 1
Gerstein Science - Circulation Desk (1) 1
Gerstein Science - Not Returned (1) 1
Mt Sinai Hospital - Pathology (1) 1
Online (1) 1
Online Resources - Pharmacy (1) 1
Physics - Stacks (1) 1
St Josephs Health Centre - Stacks (1) 1
St. Michael's Hospital - Stacks (1) 1
Thomas Fisher Rare Book - Rare Book (1) 1
University Archives - Archives (1) 1
UofT at Scarborough - Storage (1) 1
Victoria University E.J. Pratt - Stacks (1) 1
more...
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (376475) 376475
French (20544) 20544
German (8544) 8544
Chinese (7784) 7784
Japanese (3005) 3005
Russian (2108) 2108
Korean (2016) 2016
Spanish (1243) 1243
Portuguese (517) 517
Norwegian (312) 312
Danish (264) 264
Polish (164) 164
Czech (128) 128
Finnish (118) 118
Swedish (102) 102
Ukrainian (75) 75
Hungarian (66) 66
Italian (59) 59
Hebrew (55) 55
Slovenian (47) 47
Turkish (42) 42
Bulgarian (38) 38
Greek (34) 34
Slovak (27) 27
Dutch (25) 25
Croatian (23) 23
Serbian (21) 21
Romanian (20) 20
Lithuanian (18) 18
Arabic (14) 14
Estonian (14) 14
Icelandic (14) 14
Indonesian (10) 10
Latvian (9) 9
Persian (6) 6
Catalan (1) 1
Malay (1) 1
Ndonga (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


1. Full Text Highly Selective and Potent Human β‐Secretase 2 (BACE2) Inhibitors against Type 2 Diabetes: Design, Synthesis, X‐ray Structure and Structure–Activity Relationship Studies
by Ghosh, Arun K and Brindisi, Margherita and Yen, Yu‐Chen and Lendy, Emma K and Kovela, Satish and Cárdenas, Emilio Leal and Reddy, Bhavanam Sekhara and Rao, Kalapala Venketeswara and Downs, Deborah and Huang, Xiangping and Tang, Jordan and Mesecar, Andrew D
ChemMedChem, ISSN 1860-7179, 03/2019, Volume 14, Issue 5, pp. 545 - 560
Herein we present the design, synthesis, and biological evaluation of potent and highly selective β‐secretase 2 (memapsin 1, beta‐site amyloid precursor... 
Tmem27 | type 2 diabetes | BACE2 inhibitors | β-secretase 2 | structure-based design | type 2 diabetes | β-secretase 2 | TARGET | SITE | CHEMISTRY, MEDICINAL | MANAGEMENT | SPECIFICITY | MODEL | DEFICIENCY | ASPARTIC PROTEASE | IMPACT | beta-secretase 2 | BIOLOGICAL EVALUATION | PHARMACOLOGY & PHARMACY | CATHEPSIN-D | Enzymes | b-Site APP cleaving enzyme 1 | b-Site APP cleaving enzyme 2 | Diabetes mellitus | Hydrocarbons | Event-related potentials | Selectivity | Amyloid precursor protein | Proteins | Inhibitors | Synthesis | Benzene | Computer applications | Docking | Diabetes | b-Site APP cleaving enzyme | Diabetes mellitus (non-insulin dependent) | Alzheimer's disease | Secretase
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
2. Full Text Structure of the ATP synthase catalytic complex (F 1 ) from Escherichia coli in an autoinhibited conformation
by Cingolani, Gino and Duncan, Thomas M and BROOKHAVEN NATIONAL LABORATORY (BNL)
Nature Structural & Molecular Biology, ISSN 1545-9993, 06/2011, Volume 18, Issue 6, pp. 701 - 707
ATP synthase is a membrane-bound rotary motor enzyme that is critical for cellular energy metabolism in all kingdoms of life. Despite conservation of its basic... 
PROTEIN | C-TERMINUS | MECHANISM | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | F-1-ATPASE | RESOLUTION | BETA-SUBUNITS | ELASTIC POWER TRANSMISSION | EPSILON-SUBUNIT | CELL BIOLOGY | BIOPHYSICS | GAMMA-SUBUNIT | Escherichia coli - enzymology | Protein Structure, Quaternary | Models, Molecular | Crystallography, X-Ray | Protein Conformation | Escherichia coli Proteins - chemistry | ATP Synthetase Complexes - chemistry | Enzymes | Biochemistry | E coli | Molecular biology | Crystal structure | ROTATION | BACTERIA | ESCHERICHIA COLI | BASIC BIOLOGICAL SCIENCES | MITOCHONDRIA | CHLOROPLASTS | CRYSTAL STRUCTURE | STATORS | 60 APPLIED LIFE SCIENCES | METABOLISM | ENZYMES | ROTORS | MOTORS | FUNCTIONALS
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
3. Full Text Metallo‐β‐lactamase structure and function
by Palzkill, Timothy
Annals of the New York Academy of Sciences, ISSN 0077-8923, 01/2013, Volume 1277, Issue 1, pp. 91 - 104
β‐Lactam antibiotics are the most commonly used antibacterial agents and growing resistance to these drugs is a concern. Metallo‐β‐lactamases are a diverse set... 
carbapenem | antibiotic resistance | β‐lactamase | zinc metallo‐enzyme | Carbapenem | Zinc metallo-enzyme | β-lactamase | Antibiotic resistance | ACTIVE-SITE | zinc metallo-enzyme | CRYSTAL-STRUCTURE | ANTIBIOTIC-RESISTANCE | SITE-DIRECTED MUTAGENESIS | BACTEROIDES-FRAGILIS | PSEUDOMONAS-AERUGINOSA | PENICILLIN-BINDING PROTEINS | PHARMACOLOGY & PHARMACY | beta-lactamase | BACILLUS-CEREUS | STANDARD NUMBERING SCHEME | BACTERIAL-CELL WALL | beta-Lactamases - chemistry | Catalytic Domain | beta-Lactamases - classification | Mutagenesis | Metalloendopeptidases - chemistry | Protein Binding | Substrate Specificity | Metalloendopeptidases - metabolism | Catalysis | Metalloendopeptidases - classification | beta-Lactamases - metabolism | Drugs | Enzymes | Inhibitors | Genes | Blocking | Bacteria | Antiinfectives and antibacterials | Zinc
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
4. Full Text Crystal Structure of a Complex between the Catalytic and Regulatory (RIα) Subunits of PKA
by Choel Kim and Nguyen-Huu Xuong and Susan S. Taylor
Science, ISSN 0036-8075, 2/2005, Volume 307, Issue 5710, pp. 690 - 696
The 2.0-angstrom structure of the cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) catalytic subunit bound to a deletion mutant of a... 
Phosphates | Proteins | Solvents | Docks | Phosphorylation | Active sites | Drug regulation | Biochemistry | Research Articles | Binding sites | Crystal structure | PHOSPHORYLASE-KINASE | AMIDE H/H-2 EXCHANGE | MECHANISM | CAMP-BINDING DOMAINS | MULTIDISCIPLINARY SCIENCES | RESOLUTION | SITES | DEPENDENT PROTEIN-KINASE | MONOPHOSPHATE | CLASSIFICATION | MOLECULAR-BASIS | Cyclic AMP-Dependent Protein Kinases - metabolism | Protein Structure, Tertiary | Catalytic Domain | Protein Structure, Secondary | Crystallization | Cyclic AMP-Dependent Protein Kinases - chemistry | Models, Molecular | Tryptophan - chemistry | Crystallography, X-Ray | Hydrogen Bonding | Cyclic AMP-Dependent Protein Kinase RIalpha Subunit | Protein Structure, Quaternary | Hydrophobic and Hydrophilic Interactions | Protein Binding | Protein Conformation | Cyclic AMP-Dependent Protein Kinases - antagonists & inhibitors | Enzyme Activation | Binding Sites | Cyclic AMP - metabolism | Tyrosine - chemistry | Research | Structure | Cells | Crystals | Enzymes | Mutation | Catalysts
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
5. Full Text Crystal structures of murine angiogenin‐2 and ‐3 – probing ‘structure – function’ relationships amongst angiogenin homologues
by Iyer, Shalini and Holloway, Daniel E and Acharya, K. Ravi
FEBS Journal, ISSN 1742-464X, 01/2013, Volume 280, Issue 1, pp. 302 - 318
The crystal structure of murine Angiogenin with a zinc ion bound at the active site, the first visual confirmation of the binding of angiogenin to a divalent... 
crystal structure | angiogenin | enzyme mechanism | metal‐ion binding | ribonuclease A | metal-ion binding | PROTEIN | VARIANTS | RECOGNITION | ACTIVE-SITE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TUMOR | IDENTIFICATION | REFINEMENT | TARGETING SIGNAL | PLACENTAL RIBONUCLEASE INHIBITOR | BINDING | Amino Acid Sequence | Catalytic Domain | Protein Structure, Secondary | Ribonucleases - chemistry | Humans | Models, Molecular | Molecular Sequence Data | Crystallography, X-Ray | RNA Cleavage | Nuclear Localization Signals | Ribonuclease, Pancreatic - chemistry | Zinc - chemistry | Hydrogen Bonding | Sulfates - chemistry | Protein Binding | Protein Interaction Domains and Motifs | Structural Homology, Protein | RNA, Transfer - chemistry | Nervous system diseases | Parkinson's disease | Crystals | Development and progression | Ribonuclease | Sulfates | Structure | Investigations | Mutagenesis | Neurodegeneration | Crystal structure | Cancer | Original
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
6. Enzyme structure
by Hirs, C. H. W and Timasheff, Serge N
1967, ISBN 9780121819491, Volume 11, 25-27, 47-49, 61, 91, 117, 130, 131., v.
Analyse | Enzymes | Analysis
Book
Details down arrow
7. Biochimica et biophysica acta
: Protein structure and molecular enzymology
Biochimica et biophysica acta, ISSN 0167-4838, 1982
Proteins | Enzymes | Periodicals | Structure | Protéines
Journal
Details down arrow
8. Full Text A novel β‐xylosidase structure from Geobacillus thermoglucosidasius: the first crystal structure of a glycoside hydrolase family GH52 enzyme reveals unpredicted similarity to other glycoside hydrolase folds
by Espina, Giannina and Eley, Kirstin and Pompidor, Guillaume and Schneider, Thomas R and Crennell, Susan J and Danson, Michael J
Acta Crystallographica Section D, ISSN 1399-0047, 05/2014, Volume 70, Issue 5, pp. 1366 - 1374
Geobacillus thermoglucosidasius is a thermophilic bacterium that is able to ferment both C6 and C5 sugars to produce ethanol. During growth on hemicellulose... 
β‐xylosidase | GH family 52 | Geobacillus thermoglucosidasius | fold conservation | retaining mechanism | thermophile | β-xylosidase | CRYSTALLOGRAPHY | BIOPHYSICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | Catalytic Domain | Disaccharides - metabolism | Escherichia coli - genetics | Xylosidases - metabolism | Cloning, Molecular | Xylosidases - chemistry | Xylosidases - genetics | Models, Molecular | Crystallography, X-Ray | Protein Conformation | Geobacillus - enzymology | Disaccharides - chemistry | Enzymes | Addition polymerization | Similarity | Glycosides | Ethyl alcohol | Biomass | Crystal structure | Recombinant
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
9. How enzymes work
: from structure to function
by Suzuki, Haruo, 1941- author
2015, ISBN 9789814463928, xii, 222 pages
For a long time, enzymes have been studied by measuring their activity, which has led to the advancement of "enzyme kinetics." In recent years, the mechanism... 
Enzymes | Protein Conformation | Kinetics | Enzyme Activation | Enzymology | Biology, life sciences | Biochemistry | Biophysics | Cell Biology | Enzyme kinetics
Book
Details down arrow
10. Full Text Structure and function of the 5′3′ exoribonuclease Rat1 and its activating partner Rai1
by Xiang, Song and Cooper-Morgan, Amalene and Jiao, Xinfu and Kiledjian, Megerditch and Manley, James L and Tong, Liang
Nature, ISSN 0028-0836, 04/2009, Volume 458, Issue 7239, pp. 784 - 788
The 5'-> 3' exoribonucleases (XRNs) comprise a large family of conserved enzymes in eukaryotes with crucial functions in RNA metabolism and RNA... 
RNA-POLYMERASE-II | MACROMOLECULAR STRUCTURES | PROTEIN | TURNOVER | NUCLEAR | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | EXONUCLEASE | TRANSCRIPTION TERMINATION | SACCHAROMYCES-CEREVISIAE | PIN DOMAINS | Protein Structure, Tertiary | Recombinant Proteins - metabolism | Schizosaccharomyces pombe Proteins - chemistry | Exoribonucleases - genetics | Schizosaccharomyces pombe Proteins - genetics | Schizosaccharomyces - chemistry | Exoribonucleases - chemistry | Models, Molecular | Recombinant Proteins - chemistry | Nuclear Proteins - metabolism | Nuclear Proteins - chemistry | Schizosaccharomyces - genetics | Animals | Schizosaccharomyces pombe Proteins - metabolism | Protein Binding | Schizosaccharomyces - enzymology | Mice | Mutation | Exoribonucleases - metabolism | Physiological aspects | Ribonuclease | Research | Structure | Crystals | Proteins | Enzymes | Bacteria | E coli | Crystal structure | Index Medicus | pol II termination | RNAi | RNA pyrophosphohydrolase | mRNA processing | torpedo model | nonsense mediated decay | protein complex | RNA metabolism
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights
11. Enzyme structure
by Hirs, C.H and Timasheff, S.N
1967, Methods in enzymology, Volume 11, 25-27, 47-49, 61, 91., v.
Enzymes | Analysis
Book
Details down arrow
12. Full Text Telomeres—structure, function, and regulation
by Lu, Weisi and Zhang, Yi and Liu, Dan and Songyang, Zhou and Wan, Ma
Experimental Cell Research, ISSN 0014-4827, 01/2013, Volume 319, Issue 2, pp. 133 - 141
In mammals, maintenance of the linear chromosome ends (or telomeres) involves faithful replication of genetic materials and protection against DNA damage... 
Telomere dysfunction | Telomere maintenance | Extra-telomeric | End protection | Telomere | Telomerase | Telosome | FISSION YEAST | DNA-DAMAGE | DOWN-REGULATION | DOUBLE-STRAND BREAKS | RIBOSOMAL-RNA GENES | PROTEIN COMPLEX | CELL BIOLOGY | HUMAN RAP1 | ONCOLOGY | REVERSE-TRANSCRIPTASE HTERT | G-QUADRUPLEX | HUMAN CANCER | Telomere - chemistry | DNA - chemistry | Humans | Tumor Suppressor Protein p53 - metabolism | Cyclin-Dependent Kinase Inhibitor p16 - metabolism | Protein Binding | G-Quadruplexes | Telomere - metabolism | DNA - metabolism | Telomere - genetics | Enzymes | DNA replication | Biological control | DNA | Pests | Chromosomes | Protein binding | Proteins | Homeostasis | Deoxyribonucleic acid--DNA | Binding sites | telomerase | telosome | end protection | extra-telomeric | telomere dysfunction | telomere | telomere maintenance
Journal Article
Details down arrow
Digital rights down arrow
loading Loading Rights