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1. Full Text Reduced Exposure to Calcineurin Inhibitors in Renal Transplantation
by Ekberg, Henrik and Tedesco-Silva, Helio and Demirbas, Alper and Vítko, Štefan and Nashan, Björn and Gürkan, Alp and Margreiter, Raimund and Hugo, Christian and Grinyó, Josep M and Frei, Ulrich and Vanrenterghem, Yves and Daloze, Pierre and Halloran, Philip F and ELITE Symphony Study and ELITE-Symphony Study and Enheten för forskning kring njurfunktion och njursjukdom and Lund University and Renal Research Unit and Lunds universitet
The New England Journal of Medicine, ISSN 0028-4793, 12/2007, Volume 357, Issue 25, pp. 2562 - 2575
This study examines the toxicity of immunosuppressive regimens in renal-transplant recipients. A regimen containing mycophenolate mofetil, daclizumab, low-dose... 
MULTICENTER TRIAL | MEDICINE, GENERAL & INTERNAL | CYCLOSPORINE MICROEMULSION | EFFICACY | KIDNEY-TRANSPLANTATION | IMMUNOSUPPRESSION | ALLOGRAFT RECIPIENTS | TACROLIMUS | MYCOPHENOLATE-MOFETIL | SIROLIMUS | NEPHROTOXICITY | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Male | Adrenal Cortex Hormones - therapeutic use | Enzyme Inhibitors - administration & dosage | Antibodies, Monoclonal, Humanized | Calcineurin Inhibitors | Treatment Failure | Adult | Diabetes Mellitus - etiology | Female | Drug Therapy, Combination | Mycophenolic Acid - administration & dosage | Immunosuppressive Agents - administration & dosage | Sirolimus - adverse effects | Tacrolimus - administration & dosage | Prednisone - administration & dosage | Glomerular Filtration Rate | Graft Rejection - prevention & control | Kaplan-Meier Estimate | Kidney Transplantation | Immunoglobulin G - administration & dosage | Opportunistic Infections | Sirolimus - administration & dosage | Mycophenolic Acid - analogs & derivatives | Antibodies, Monoclonal - administration & dosage | Cyclosporine - administration & dosage | Immunosuppressive Agents - adverse effects | Aged | Adrenal Cortex Hormones - administration & dosage | Transplantation | Corticosteroids | Kidneys | Research | Health aspects | Immunosuppressive agents | Medical research | Immunology | Inhibitor drugs | Transplants & implants | Toxicity | Inhibidors enzimàtics | Posologia | Ús terapèutic | Corticosteroides | Rebuig (Biologia) | Posology | Therapeutic use | Immunosupressive agents | Graft rejection | Trasplantament renal | Enzyme inhibitors | Adrenocortical hormones | Immunosupressors | Kidney transplantation | Tacrolimus: administration & dosage | Medical and Health Sciences | Graft Rejection: prevention & control | Immunoglobulin G: administration & dosage | Medicin och hälsovetenskap | Mycophenolic Acid: administration & dosage | Antibodies | Klinisk medicin | Monoclonal: administration & dosage | Prednisone: administration & dosage | Adrenal Cortex Hormones: administration & dosage | Immunosuppressive Agents: administration & dosage | Mycophenolic Acid: analogs & derivatives | Sirolimus: administration & dosage | Cyclosporine: administration & dosage | Calcineurin: antagonists & inhibitors | Diabetes Mellitus: etiology | Urologi och njurmedicin | Sirolimus: adverse effects | Adrenal Cortex Hormones: therapeutic use | Enzyme Inhibitors: administration & dosage | Immunosuppressive Agents: adverse effects | Clinical Medicine | Immunosuppressive Agents: therapeutic use | Urology and Nephrology
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2. Full Text Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial
by Dahlöf, Björn and Sever, Peter S and Poulter, Neil R and Wedel, Hans and Beevers, D Gareth and Caulfield, Mark and Collins, Rory and Kjeldsen, Sverre E and Kristinsson, Arni and McInnes, Gordon T and Mehlsen, Jesper and Nieminen, Markku and O'Brien, Eoin and Östergren, Jan and ASCOT Investigators and Hjärt-kärlinstitutionen and Sahlgrenska akademin and Göteborgs universitet and Gothenburg University and Cardiovascular Institute and Sahlgrenska Academy
The Lancet, ISSN 0140-6736, 09/2005, Volume 366, Issue 9489, pp. 895 - 906
The apparent shortfall in prevention of coronary heart disease (CHD) noted in early hypertension trials has been attributed to disadvantages of the diuretics... 
MORTALITY | MEDICINE, GENERAL & INTERNAL | RISK-FACTORS | MANAGEMENT | MORBIDITY | DISEASE | GUIDELINES | DOUBLE-BLIND | CALCIUM-ANTAGONISTS | HYPERTENSION | INTERVENTION | Calcium Channel Blockers - adverse effects | Cardiovascular Diseases - prevention & control | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Bendroflumethiazide - administration & dosage | Hypertension - drug therapy | Male | Perindopril - administration & dosage | Sodium Chloride Symporter Inhibitors - administration & dosage | Diuretics | Adrenergic beta-Antagonists - adverse effects | Adult | Female | Blood Pressure - drug effects | Atenolol - administration & dosage | Drug Therapy, Combination | Amlodipine - administration & dosage | Adrenergic beta-Antagonists - administration & dosage | Risk Factors | Amlodipine - adverse effects | Angiotensin-Converting Enzyme Inhibitors - administration & dosage | Antihypertensive Agents - adverse effects | Coronary Disease - prevention & control | Calcium Channel Blockers - administration & dosage | Atenolol - adverse effects | Hypertension - complications | Aged | Hypertension | Antihypertensive drugs | Evaluation | Dosage and administration | Drug therapy | Prevention | Drug therapy, Combination | Health aspects | Coronary heart disease | Risk factors | Studies | Drugs | Cardiovascular disease | Medical treatment | Myocardial infarction | Heart attacks | Clinical trials | Family medical history | Blood | Randomization | Motivation | Blood pressure | Heart diseases | Antihypertensive agents | Cerebral infarction | Stroke | Fasting | Mortality | Diabetes mellitus | Health risks | Triglycerides | Metabolism | Risk analysis | Atenolol | Fatal | Patients | Coronary artery disease | Cholesterol | Heart rate | Infarction | Diabetes | Cardiovascular diseases | Health risk assessment | Potassium | Amlodipine/administration & dosage/adverse effects | Bendroflumethiazide/administration & dosage | Cardiovascular Diseases/prevention & control | Perindopril/administration & dosage | MEDICIN OCH HÄLSOVETENSKAP | Atenolol/administration & dosage/adverse effects | Combination | Antihypertensive Agents/administration & dosage/adverse effects | Angiotensin-Converting Enzyme Inhibitors/administration & dosage | MEDICAL AND HEALTH SCIENCES | Coronary Disease/prevention & control | Drug Therapy | Adrenergic beta-Antagonists/administration & dosage/adverse effects | Blood Pressure/drug effects | Hypertension/complications/drug therapy | Calcium Channel Blockers/administration & dosage/adverse effects | Sodium Chloride Symporter Inhibitors/administration & dosage
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3. Full Text Immunogenicity and safety of a mixed vaccination schedule with one dose of nonavalent and one dose of bivalent HPV vaccine versus two doses of nonavalent vaccine – A randomized clinical trial
by Gilca, Vladimir and Sauvageau, Chantal and Panicker, Gitika and De Serres, Gaston and Ouakki, Manale and Unger, Elizabeth R
Vaccine, ISSN 0264-410X, 11/2018, Volume 36, Issue 46, pp. 7017 - 7024
Limited data is available on the use of different HPV vaccines in the same subjects. We evaluated the immunogenicity and safety of a mixed vaccination schedule... 
Bivalent vaccine | Human papillomavirus (HPV) | Mixed schedule | Nonavalent vaccine | ANTIBODIES | MEDICINE, RESEARCH & EXPERIMENTAL | EFFICACY | IMMUNOLOGY | HUMAN-PAPILLOMAVIRUS VACCINATION | REDUCTION | NATIONWIDE | GENITAL WARTS | GIRLS | FEWER | QUADRIVALENT | Prospective Studies | Enzyme-Linked Immunosorbent Assay | Humans | Male | Treatment Outcome | Antibodies, Viral - blood | Drug-Related Side Effects and Adverse Reactions - epidemiology | Drug-Related Side Effects and Adverse Reactions - pathology | Papillomavirus Infections - prevention & control | Papillomavirus Vaccines - adverse effects | Female | Immunization Schedule | Papillomavirus Vaccines - immunology | Child | Papillomavirus Vaccines - administration & dosage | Clinical trials | Vaccination | Public health | Medical research | Schedules | Antigens | Aluminum | Manufacturers | Antibodies | Vaccines | Girls | Human papillomavirus | Randomization | Immunogenicity | Safety | Enzyme-linked immunosorbent assay | bivalent vaccine | nonavalent vaccine | mixed schedule
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4. Full Text Geneva Cocktail for Cytochrome P450 and P‐Glycoprotein Activity Assessment Using Dried Blood Spots
by Bosilkovska, M and Samer, C F and Déglon, J and Rebsamen, M and Staub, C and Dayer, P and Walder, B and Desmeules, J A and Daali, Y
Clinical Pharmacology & Therapeutics, ISSN 0009-9236, 09/2014, Volume 96, Issue 3, pp. 349 - 359
The suitability of the capillary dried blood spot (DBS) sampling method was assessed for simultaneous phenotyping of cytochrome P450 (CYP) enzymes and... 
P4502B6 ACTIVITY | VORICONAZOLE | LC-MS/MS | SINGLE-POINT | ORAL MIDAZOLAM | VOLUNTEERS | IN-VIVO | PHARMACOLOGY & PHARMACY | DRUG-METABOLIZING-ENZYMES | KAROLINSKA COCKTAIL | BUPROPION HYDROXYLATION | Predictive Value of Tests | Pharmaceutical Preparations - blood | Caffeine - administration & dosage | Cytochrome P-450 Enzyme Inhibitors | Dried Blood Spot Testing | Humans | Omeprazole - blood | Bupropion - blood | Midazolam - administration & dosage | Substrate Specificity | Male | Chromatography, High Pressure Liquid | ATP-Binding Cassette, Sub-Family B, Member 1 - antagonists & inhibitors | Coffee | Terfenadine - administration & dosage | Caffeine - pharmacokinetics | Feasibility Studies | Enzyme Inhibitors - administration & dosage | Young Adult | Chromatography, Reverse-Phase | Tandem Mass Spectrometry | Capsules | Spectrometry, Mass, Electrospray Ionization | Flurbiprofen - administration & dosage | Adult | Dextromethorphan - pharmacokinetics | Terfenadine - blood | ATP-Binding Cassette, Sub-Family B, Member 1 - blood | Pharmaceutical Preparations - administration & dosage | Terfenadine - pharmacokinetics | Bupropion - pharmacokinetics | Flurbiprofen - pharmacokinetics | Cytochrome P-450 Enzyme System - blood | Administration, Oral | Isoenzymes | Caffeine - blood | Omeprazole - administration & dosage | Terfenadine - analogs & derivatives | Omeprazole - pharmacokinetics | Carbonated Beverages | Midazolam - pharmacokinetics | Bupropion - administration & dosage | Dextromethorphan - blood | Flurbiprofen - blood | Phenotype | Pilot Projects | Midazolam - blood | Dextromethorphan - administration & dosage | Usage | Glycoproteins | Liquid chromatography | Research | Pharmacokinetics | Cytochrome P-450 | Index Medicus | Abridged Index Medicus
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5. Full Text Antibody avidity measurements in recipients of Cervarix® vaccine following a two-dose schedule or a three-dose schedule
by Boxus, Mathieu and Lockman, Laurence and Fochesato, Michel and Lorin, Clarisse and Thomas, Florence and Giannini, Sandra L
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 26, pp. 3232 - 3236
Highlights • Cervarix® is a licenced 3-dose HPV vaccine for preventing cervical cancer. • Avidity indices (AIs) can inform on the quality of HPV-specific... 
Allergy and Immunology | Antibodies | Avidity | Human papillomavirus | Vaccine | Cervical cancer | MEDICINE, RESEARCH & EXPERIMENTAL | L1 VLP VACCINE | CERVICAL-CANCER | IMMUNOLOGY | HPV-16/18 AS04-ADJUVANTED VACCINE | HPV | WOMEN | CONJUGATE VACCINES | IMMUNE-RESPONSES | HUMAN-PAPILLOMAVIRUS VACCINES | AGED 18-45 YEARS | MEMORY B-CELL | Enzyme-Linked Immunosorbent Assay | Humans | Middle Aged | Uterine Cervical Neoplasms - prevention & control | Antibody Affinity | Antibodies, Viral - blood | Randomized Controlled Trials as Topic | Young Adult | Papillomavirus Infections - prevention & control | Adolescent | Adult | Female | Immunization Schedule | Papillomavirus Vaccines - immunology | Vaccines, Virus-Like Particle - immunology | Child
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6. Full Text Phase II randomized, double-blinded comparison of a single high dose (5 × 108 TCID50 ) of modified vaccinia Ankara compared to a standard dose (1 × 108 TCID50 ) in healthy vaccinia-naïve individuals
by Frey, Sharon E and Winokur, Patricia L and Hill, Heather and Goll, Johannes B and Chaplin, Paul and Belshe, Robert B
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 23, pp. 2732 - 2739
Highlights • A single dose of high titer MVA vaccine was compared to 1 or 2 standard doses. • High dose MVA was safe and well-tolerated. • Median time to... 
Allergy and Immunology | IMVAMUNE | Plaque reduction neutralizing antibody | Smallpox | Variola | MVA | Vaccine | ELISA | Analysis | Enzyme-linked immunosorbent assay | vaccine | plaque reduction neutralizing antibody | smallpox
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7. Full Text Fixed‐dose vs free‐dose combinations for the management of hypertension—An analysis of 81 958 patients
by Bramlage, Peter and Schmidt, Stefanie and Sims, Helen
The Journal of Clinical Hypertension, ISSN 1524-6175, 04/2018, Volume 20, Issue 4, pp. 705 - 715
Fixed‐dose combinations (FDC) have been developed to reduce the pill burden for hypertensive patients. Data on fixed‐dose or free‐dose (freeDC)... 
fixed‐dose combination | angiotensin receptor blocker | calcium antagonist | angiotensin‐converting enzyme inhibitor | hypertension | adherence | fixed-dose combination | angiotensin-converting enzyme inhibitor | Hypertension | Dosage and administration | Enzyme inhibitors | Analysis
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8. Full Text Immunogenicity and safety of one dose of diphtheria, tetanus, acellular pertussis and poliomyelitis vaccine (Repevax® ) followed by two doses of diphtheria, tetanus and poliomyelitis vaccine (Revaxis® ) in adults aged ≥40 years not receiving a diphtheria- and tetanus-containing vaccination in the last 20 years
by Dominicus, Rolf and Galtier, Florence and Richard, Patrick and Baudin, Martine
Vaccine, ISSN 0264-410X, 2014, Volume 32, Issue 31, pp. 3942 - 3949
Highlights • Lack of boosters leaves adults susceptible to vaccine-preventable diseases. • Non up-to-date adults need three diphtheria booster doses for... 
Allergy and Immunology | Seroprotection | Safety | Immunogenicity | Boosters | Tdap-IPV | Td-IPV | MEDICINE, RESEARCH & EXPERIMENTAL | TOXIN | IMMUNOLOGY | Poliovirus Vaccine, Inactivated - administration & dosage | Humans | Middle Aged | Tetanus - prevention & control | Male | Poliomyelitis - prevention & control | Vaccines, Combined - administration & dosage | Antibodies, Viral - blood | Diphtheria-Tetanus-Pertussis Vaccine - administration & dosage | Immunization, Secondary | Vaccines, Inactivated - administration & dosage | Whooping Cough - prevention & control | Diphtheria - prevention & control | Female | Aged | France | Antibodies, Bacterial - blood | Germany | Virus diseases | Whooping-cough | Adults | Safety and security measures | Diphtheria | Vaccination | Confidence intervals | Antigens | Enzymes | Hospitals | Vaccines | Tetanus | Whooping cough | Life Sciences | Human health and pathology
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9. Full Text Clinical trial: dose‐dependent therapeutic efficacy of acotiamide hydrochloride (Z‐338) in patients with functional dyspepsia – 100 mg t.i.d. is an optimal dosage
by Matsueda, K and Hongo, M and Tack, J and Aoki, H and Saito, Y and Kato, H
Neurogastroenterology & Motility, ISSN 1350-1925, 06/2010, Volume 22, Issue 6, pp. 618 - e173
Background  Acotiamide is a selective acetylcholinesterase inhibitor and enhances the actions of cholinergic neurons localized in the stomach. Methods  The... 
clinical study | meal‐related | acotiamide | functional dyspepsia | Meal-related | Acotiamide | Functional dyspepsia | Clinical study | CONSTIPATION | meal-related | GASTRODUODENAL DISORDERS | SYMPTOMS | GASTROENTEROLOGY & HEPATOLOGY | NEUROSCIENCES | IRRITABLE-BOWEL-SYNDROME | PROKINETIC AGENT | CLINICAL NEUROLOGY | Dyspepsia - diagnosis | Dyspepsia - drug therapy | Satiety Response | Double-Blind Method | Humans | Middle Aged | Male | Thiazoles - administration & dosage | Thiazoles - therapeutic use | Thiazoles - adverse effects | Eating - physiology | Dose-Response Relationship, Drug | Young Adult | Benzamides - administration & dosage | Benzamides - therapeutic use | Gastric Emptying - drug effects | Endpoint Determination | Adult | Female | Aged | Patient Compliance | Benzamides - adverse effects | Clinical trials | Dosage and administration | Enzyme inhibitors | Dyspepsia | Health aspects
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10. Full Text Ultra-low-dose estriol and Lactobacillus acidophilus vaginal tablets (Gynoflor®) for vaginal atrophy in postmenopausal breast cancer patients on aromatase inhibitors: pharmacokinetic, safety, and efficacy phase I clinical study
by Donders, Gilbert and Neven, Patrick and Moegele, Maximilian and Lintermans, Anneleen and Bellen, Gert and Prasauskas, Valdas and Grob, Philipp and Ortmann, Olaf and Buchholz, Stefan
Breast Cancer Research and Treatment, ISSN 0167-6806, 6/2014, Volume 145, Issue 2, pp. 371 - 379
Phase I pharmacokinetic (PK) study assessed circulating estrogens in breast cancer (BC) patients on a non-steroidal aromatase inhibitor (NSAI) with vaginal... 
Medicine & Public Health | Vaginal atrophy | Lactobacilli | Oncology | Breast cancer | Vaginal estriol | Aromatase inhibitors | ESTROGEN THERAPY | INFECTIONS | 0.03 MG ESTRIOL | UROGENITAL ATROPHY | HORMONE REPLACEMENT THERAPY | WOMEN | ONCOLOGY | ESTRADIOL | RECURRENCE | ABSORPTION | SURVIVORS | Estradiol - blood | Tablets | Vagina - drug effects | Humans | Middle Aged | Administration, Intravaginal | Treatment Outcome | Lactobacillus acidophilus | Breast Neoplasms - drug therapy | Aromatase Inhibitors - adverse effects | Estriol - blood | Estriol - administration & dosage | Estriol - pharmacokinetics | Postmenopause | Female | Atrophy - chemically induced | Atrophy - drug therapy | Vagina - microbiology | Aromatase Inhibitors - therapeutic use | Vagina - pathology | Care and treatment | Cancer patients | Microbiota (Symbiotic organisms) | Oncology, Experimental | Estrogen | Clinical trials | Dosage and administration | Postmenopausal women | Research | Cancer | Clinical Trial
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