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Molecular and Cellular Endocrinology, ISSN 0303-7207, 07/2019, Volume 492, p. 110438
Gonadotropins, luteinizing hormone (LH) and follicle-stimulating hormone (FSH), are heterodimers of a common α subunit and unique β subunits. Regulation of... 
FSH | Gonadotropin | PACAP | GnRH | EPAC
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 11/2009, Volume 108, Issue 4, pp. 998 - 1011
Journal Article
Acta Biomaterialia, ISSN 1742-7061, 10/2019
Journal Article
Journal Article
Neurobiology of Learning and Memory, ISSN 1074-7427, 04/2019, Volume 160, pp. 91 - 97
Sleep deprivation is known to affect memory formation, but how it interacts with different memory systems is not completely understood. Adenosine, a... 
Learning | Adenosine | Sleep | EPAC | Memory | Hippocampus
Journal Article
Circulation Journal, ISSN 1346-9843, 2018
Background: It has been suggested that protein directly activated by cAMP (Epac), one of the downstream signaling molecules of β-adrenergic receptor (β-AR),... 
Arrhythmia | Atrial fibrillation | Epac | Sympathetic nervous system
Journal Article
by Ye, N and Zhu, YM and Liu, ZQ and Mei, FC and Chen, HY and Wang, PY and Cheng, XD and Zhou, J
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0223-5234, 07/2017, Volume 134, pp. 62 - 71
Two series of novel EPAC antagonists are designed, synthesized and evaluated in an effort to develop diversified analogues based on the scaffold of the... 
CHEMISTRY, MEDICINAL | SMALL MOLECULES | Exchange proteins directly activated by cAMP | ESI-09 | EPAC | Molecular docking | CAMP EPAC | CYCLIC-AMP | INVASION | RAP1 | TARGETS | Antagonist | INHIBITORS | PROTEINS | molecular docking | antagonist
Journal Article
British Journal of Pharmacology, ISSN 0007-1188, 05/2012, Volume 166, Issue 2, pp. 676 - 688
Journal Article
Circulation Journal, ISSN 1346-9843, 2019, Volume 83, Issue 2, pp. 295 - 303
Background: It has been suggested that protein directly activated by cAMP (Epac), one of the downstream signaling molecules of β-adrenergic receptor (β-AR),... 
Arrhythmia | Epac | Sympathetic nervous system | Atrial fibrillation | FIBRILLATION | CHRONIC HEART-FAILURE | RYANODINE RECEPTOR PHOSPHORYLATION | CARDIAC & CARDIOVASCULAR SYSTEMS | EPAC ACTIVATION | EUROPEAN-SOCIETY | RETICULUM CA2+ LEAK | INHIBITION | DISRUPTION | TASK-FORCE | ASSOCIATION
Journal Article
Journal Article
Molecular and Cellular Endocrinology, ISSN 0303-7207, 09/2018, Volume 473, pp. 114 - 123
Min6 cells, a mouse β cell line derived from transgenic mouse expressing the large T-antigen of SV40 in pancreatic beta cells, are commonly utilized as an... 
Min6 | EPAC2 | CRISPR-Cas9 | Sulfonylurea | β cells | Diabetes | Insulin secretion | ACTIVATION | INSULIN-SECRETION | SENSITIVITY | EXCHANGE FACTOR EPAC | SULFONYLUREA RECEPTOR | CELL BIOLOGY | GLUCOSE | ENDOCRINOLOGY & METABOLISM | PANCREATIC BETA-CELL | SENSOR EPAC | PROTEINS | EXPRESSION | beta cells | Pancreatic beta cells | RNA | Analysis | Cyclic adenylic acid | Genetic engineering | Glucose | Insulin | Dextrose
Journal Article
Cellular and Molecular Life Sciences, ISSN 1420-682X, 2/2017, Volume 74, Issue 4, pp. 591 - 606
As one of the most important second messengers, 3′,5′-cyclic adenosine monophosphate (cAMP) mediates various extracellular signals including hormones and... 
Life Sciences | Biomedicine, general | Biochemistry, general | Heart | Life Sciences, general | Heart disease | Epac | cAMP | Catecholamine | Cell Biology | CARDIOMYOCYTE HYPERTROPHY | BINDING-PROTEIN EPAC | BIOCHEMISTRY & MOLECULAR BIOLOGY | CARDIAC ADENYLYL-CYCLASE | PHOSPHOLIPASE-C | RESONANCE ENERGY-TRANSFER | VENTRICULAR MYOCYTES | CELL BIOLOGY | CYCLIC-AMP | SIGNALING PATHWAY | PHOSPHATIDIC-ACID | EXCHANGE FACTOR EPAC2 | Heart - physiology | Humans | Heart Failure - physiopathology | Cardiomegaly - pathology | Guanine Nucleotide Exchange Factors - analysis | Arrhythmias, Cardiac - pathology | Guanine Nucleotide Exchange Factors - metabolism | Myocardium - metabolism | Cyclic AMP - metabolism | Arrhythmias, Cardiac - genetics | Arrhythmias, Cardiac - metabolism | Heart - physiopathology | Myocardial Contraction | Gene Expression | Guanine Nucleotide Exchange Factors - genetics | Myocytes, Cardiac - cytology | Cardiomegaly - physiopathology | Heart Failure - genetics | Myocardium - pathology | Heart Failure - metabolism | Heart Failure - pathology | Myocytes, Cardiac - pathology | Animals | Myocytes, Cardiac - metabolism | Cardiomegaly - genetics | Apoptosis | Cardiomegaly - metabolism | Proteins | Medical colleges | Analysis | Physiological aspects | Cyclic adenylic acid | Adenylic acid | Heart diseases | Protein kinases | Studies | Adenosine | Cardiovascular disease | Pharmaceutical sciences
Journal Article