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Bioorganic & Medicinal Chemistry, ISSN 0968-0896, 04/2019, Volume 27, Issue 8, pp. 1704 - 1713
Synthetic derivatives of cyclic adenosine monophosphate, such as halogenated or other more hydrophobic analogs, are widely used compounds, to investigate... 
CNG and HCN channels | Protein kinase A | Epac1 and Epac2 | cAMP derivatives | CHEMISTRY, MEDICINAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | GATED CHANNELS | BINDING DOMAIN | CHEMISTRY, ORGANIC | DEPENDENT PROTEIN-KINASE | GLYCOSYLATION | CYCLIC-NUCLEOTIDE ANALOGS | OVEREXPRESSION | HCN CHANNELS | EPAC1 | PHARMACOLOGY | CAMP
Journal Article
Chinese Journal of Cancer Prevention and Treatment, ISSN 1673-5269, 04/2018, Volume 25, Issue 7, pp. 485 - 489
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 3/2016, Volume 113, Issue 11, pp. 3036 - 3041
cAMP signaling plays a key role in regulating pain sensitivity. Here, we uncover a previously unidentified molecular mechanism in which direct phosphorylation... 
Piezo2 | GRK2 | Epac1 | Epac1 translocation | Chronic pain | MECHANICAL ALLODYNIA | chronic pain | ACTIVATION | MULTIDISCIPLINARY SCIENCES | DEPENDENT PROTEIN-KINASE | CYCLIC-AMP | PHOSPHATIDIC-ACID | SENSOR EPAC | CHANNELS | CAMP | Inflammation - chemically induced | Pain Threshold - physiology | Guanine Nucleotide Exchange Factors - physiology | Phosphorylation | Freund's Adjuvant - toxicity | Mechanoreceptors - physiology | Nociception - physiology | Molecular Sequence Data | Ganglia, Spinal - physiopathology | Ion Channels - physiology | Inflammation - complications | Pain - etiology | Guanine Nucleotide Exchange Factors - deficiency | Protein Structure, Tertiary | Amino Acid Sequence | Guanine Nucleotide Exchange Factors - genetics | Nerve Tissue Proteins - physiology | Signal Transduction | G-Protein-Coupled Receptor Kinase 2 - physiology | Phosphoserine - metabolism | Hyperalgesia - physiopathology | Mice, Knockout | Protein Interaction Mapping | Animals | rap1 GTP-Binding Proteins - physiology | Pain - physiopathology | Hyperalgesia - etiology | Mice | Protein Processing, Post-Translational | Chronic Disease | Physiological aspects | Cyclic adenylic acid | Cellular signal transduction | Translocation (Genetics) | Observations | Signal transduction | Inflammation | Pain | Kinases | Rodents | Index Medicus | Biological Sciences
Journal Article
Acta Theriologica Sinica, ISSN 1000-1050, 11/2018, Volume 38, Issue 6, pp. 535 - 542
Journal Article
BBA - Molecular Cell Research, ISSN 0167-4889, 02/2019, Volume 1866, Issue 2, pp. 264 - 276
Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to... 
Cyclic AMP | Vascular endothelial cells | Inflammation | EPAC1 | Transcriptome | Cell adhesion molecules | Index Medicus
Journal Article
International journal of molecular sciences, ISSN 1422-0067, 03/2019, Volume 20, Issue 6, p. 1396
Cardiac β₂-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in cardiac fibroblasts and myocytes. The β₂AR is a Gs... 
cardiac myocytes | CRISPR | Epac1 | signal transduction | β2-adrenergic receptor | osteopontin | fibrosis | cAMP | Index Medicus
Journal Article
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY, ISSN 1871-5206, 2019, Volume 19, Issue 5, pp. 667 - 676
Background: It was recently demonstrated that the phthalimide N-(4-methyl-phenyl)-4-methylphthalimide (MPMPH-1) has important effects against acute and chronic... 
toxicity | mutagenicity | pain | CHEMISTRY, MEDICINAL | Phthalimide | ACID | breast cancer | in silico | 4T1 | CYCLIC IMIDES | METABOLISM | MODELS | ONCOLOGY | EPAC1 | DISEASE
Journal Article
European Review for Medical and Pharmacological Sciences, ISSN 1128-3602, 2019, Volume 23, Issue 5, pp. 2200 - 2207
OBJECTIVE: Both atrial fibrillation (AF) and heart failure (HF) are increasingly prevalent and related to high hospitalization rate and mortality. AF is a... 
Heart failure | L-type calcium | EPAC1 | Atrial fibrillation | PHARMACOLOGY & PHARMACY
Journal Article
Hormones and Behavior, ISSN 0018-506X, 02/2018, Volume 98, pp. 121 - 129
Alterations in circulating thyroid hormone concentrations are associated with several psychological and behavioral disorders. In humans, behavioral disorders... 
Epac1 | Aggression | Hyperthyroidism | Prkar1a | Behavioral phenotyping | PROTEIN-KINASE-A | ANTIDEPRESSANT | ALTERNATION | DISORDERS | CANCER | CYCLIC-AMP | HORMONE | RAP1 | ENDOCRINOLOGY & METABOLISM | BEHAVIORAL SCIENCES | EXPERIMENTAL HYPERTHYROIDISM | RECEPTORS | Index Medicus
Journal Article
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, ISSN 1661-6596, 03/2019, Volume 20, Issue 6
Cardiac (2)-adrenergic receptors (ARs) are known to inhibit collagen production and fibrosis in cardiac fibroblasts and myocytes. The (2)AR is a Gs... 
CRISPR | ACTIVATION | Epac1 | signal transduction | INFARCTION HEART-FAILURE | osteopontin | BIOCHEMISTRY & MOLECULAR BIOLOGY | adrenergic receptor | ANGIOTENSIN-II | cAMP | EPAC | CHEMISTRY, MULTIDISCIPLINARY | MICE LACKING | MINERALOCORTICOID RECEPTOR | CROSS-TALK | cardiac myocytes | INFLAMMATION | fibrosis | SMOOTH-MUSCLE-CELLS | ALDOSTERONE
Journal Article
Journal Article
American Journal of Physiology - Regulatory Integrative and Comparative Physiology, ISSN 0363-6119, 05/2019, Volume 316, Issue 5, pp. R417 - R426
Journal Article
by Li, Q and Teng, YF and Wang, J and Yu, M and Li, YQ and Zheng, H
PATHOLOGY RESEARCH AND PRACTICE, ISSN 0344-0338, 07/2018, Volume 214, Issue 7, pp. 1045 - 1050
Background: Rap1 is involved in a multitude of cellular signal transduction pathways, which has extensively been linked to cell proliferation and migration. It... 
APOPTOSIS | ACTIVATION | Migration | DOWN-REGULATION | Proliferation | PATHOLOGY | CANCER | RAP1GAP | INVASION | MAPK/ERK | EPAC1 | Rap1 | ENDOTHELIAL-CELLS | Vascular smooth muscle cell | Rap1-GAP | DIFFERENTIATION
Journal Article
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, ISSN 0167-4889, 02/2019, Volume 1866, Issue 2, pp. 264 - 276
Exchange protein activated by cyclic AMP (EPAC1) suppresses multiple inflammatory actions in vascular endothelial cells (VECs), partly due to its ability to... 
Vascular endothelial cells | BIOCHEMISTRY & MOLECULAR BIOLOGY | Transcriptome | KINASE | Cyclic AMP | Inflammation | NEOINTIMA FORMATION | BINDING PROTEIN | Cell adhesion molecules | CELL BIOLOGY | CYTOKINE SIGNALING 3 | ADHESION MOLECULE-1 | EPAC1-DEPENDENT INDUCTION | EPAC1 | SOCS PROTEINS | C-JUN | NF-KAPPA-B | JANUS KINASE/SIGNAL TRANSDUCERS
Journal Article
Cellular Signalling, ISSN 0898-6568, 04/2018, Volume 44, pp. 10 - 19
Journal Article
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, ISSN 0815-9319, 11/2014, Volume 29, pp. 47 - 47
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