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Nature, ISSN 0028-0836, 07/2012, Volume 487, Issue 7408, pp. 505 - 509
Mutationally activated kinases define a clinically validated class of targets for cancer drug therapy(1). However, the efficacy of kinase inhibitors in... 
CELL LUNG-CANCER | SURVIVAL | HETEROGENEITY | ACTIVATION | RECEPTOR TYROSINE KINASES | THERAPY | MET AMPLIFICATION | MULTIDISCIPLINARY SCIENCES | ACQUIRED-RESISTANCE | SENSITIVITY | TUMOR-CELLS | Receptor, ErbB-2 - genetics | Humans | Receptor, ErbB-2 - metabolism | Melanoma - enzymology | Phosphatidylinositol 3-Kinases - metabolism | Hepatocyte Growth Factor - pharmacology | Breast Neoplasms - metabolism | Melanoma - genetics | Female | Indoles - pharmacology | Antineoplastic Agents - pharmacology | Cell Survival - drug effects | Melanoma - pathology | Receptor Protein-Tyrosine Kinases - metabolism | Sulfonamides - pharmacology | Breast Neoplasms - drug therapy | Hepatocyte Growth Factor - metabolism | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Breast Neoplasms - genetics | Signal Transduction - drug effects | Breast Neoplasms - pathology | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Cell Line, Tumor | Ligands | Protein Kinase Inhibitors - pharmacology | Quinazolines - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinases - metabolism | Antimitotic agents | Physiological aspects | Antineoplastic agents | Growth factors | Health aspects | Phosphotransferases | Substance abuse treatment | Epidermal growth factor | Rodents | Biomarkers | Breast cancer | Insulin-like growth factors | Kinases | Drug resistance | Tumors | Index Medicus
Journal Article
Oncogene, ISSN 0950-9232, 12/2010, Volume 29, Issue 49, pp. 6485 - 6498
Journal Article
Journal Article
Nature Cell Biology, ISSN 1465-7392, 03/2007, Volume 9, Issue 3, pp. 324 - 330
The mitogen-activated protein kinase (MAPK) network is a conserved signalling module that regulates cell fate by transducing a myriad of growth-factor signals.... 
ACTIVATION | PROTEIN | SPECIFICITY | PHOSPHORYLATION | DYNAMICS | RAF-1 | CASCADE | IDENTIFICATION | SIGNAL-REGULATED KINASE | TRANSIENT | CELL BIOLOGY | RNA, Small Interfering - genetics | MAP Kinase Signaling System - physiology | Tetradecanoylphorbol Acetate - pharmacology | Receptor, trkA - antagonists & inhibitors | Extracellular Signal-Regulated MAP Kinases - metabolism | PC12 Cells | MAP Kinase Kinase 1 - genetics | Flow Cytometry | Mitogen-Activated Protein Kinase 1 - genetics | Phosphorylation - drug effects | Cell Differentiation - physiology | Proto-Oncogene Proteins B-raf - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Proto-Oncogene Proteins c-raf - genetics | Nerve Growth Factor - pharmacology | Rats | MAP Kinase Kinase 1 - metabolism | Protein Kinase C - antagonists & inhibitors | Proto-Oncogene Proteins c-raf - metabolism | Animals | MAP Kinase Signaling System - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Cell Differentiation - drug effects | Intercellular Signaling Peptides and Proteins - pharmacology | Models, Biological | Proto-Oncogene Proteins B-raf - genetics | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Cell Cycle - drug effects | Monte Carlo Method | Mitogen-Activated Protein Kinase 1 - metabolism | Cell proliferation | Evaluation | Pheochromocytoma | Physiological aspects | Cell differentiation | Properties | Protein kinases | Growth factors | Index Medicus
Journal Article
Journal Article
Cancer Research, ISSN 0008-5472, 03/2008, Volume 68, Issue 6, pp. 1953 - 1961
Journal Article
Nature Cell Biology, ISSN 1465-7392, 01/2016, Volume 18, Issue 2, pp. 213 - 224
Although long non-coding RNAs (lncRNAs) predominately reside in the nucleus and exert their functions in many biological processes, their potential involvement... 
METASTASIS | LONG NONCODING RNAS | TYROSINE KINASE | EPIDERMAL-GROWTH-FACTOR | BINDING PROTEINS | DISEASE | EPIGENETIC REGULATION | HYPOXIA | TUMOR-GROWTH | PROMOTES | CELL BIOLOGY | Heparin-binding EGF-like Growth Factor - pharmacology | Phosphorylation | Prognosis | Membrane Glycoproteins - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Multiprotein Complexes | Serine | Gene Expression Regulation, Neoplastic | Proline | Cytoplasm - metabolism | E1A-Associated p300 Protein - metabolism | Neoplasm Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Transfection | RNA Interference | Time Factors | Hypoxia-Inducible Factor 1, alpha Subunit - metabolism | Triple Negative Breast Neoplasms - pathology | Female | Transcription, Genetic | Protein Stability | Protein-Serine-Threonine Kinases - metabolism | Tyrosine | Hydroxylation | Hypoxia-Inducible Factor 1, alpha Subunit - genetics | RNA, Long Noncoding - genetics | Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 | Animals | Triple Negative Breast Neoplasms - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Glycolysis | RNA, Long Noncoding - metabolism | Index Medicus | glycoprotein non-metastatic b (GPNMB) | Epidermal Growth Factor Receptor (EGFR) | Triple-negative Breast Cancer (TNBC) | Long Noncoding RNA | Signaling Transduction | Glycolysis Reprogramming | HIF1α
Journal Article
Nature Medicine, ISSN 1078-8956, 03/2013, Volume 19, Issue 3, pp. 295 - 304
The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth... 
PROGENITOR CELLS | MEDICINE, RESEARCH & EXPERIMENTAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | SELF-RENEWAL | FACTOR RECEPTOR | CELL BIOLOGY | STEM-CELL NUMBER | REPOPULATING CAPACITY | LETHALLY IRRADIATED MICE | EX-VIVO CULTURE | ENDOTHELIAL-CELLS | APOPTOTIC PATHWAYS | EGF RECEPTOR | Erlotinib Hydrochloride | Whole-Body Irradiation | Apoptosis - radiation effects | bcl-2 Homologous Antagonist-Killer Protein - genetics | Bone Marrow - radiation effects | Receptor, Epidermal Growth Factor - metabolism | Hematopoiesis | Radiation Injuries, Experimental - drug therapy | Hematopoietic Stem Cells - physiology | Female | Signal Transduction - radiation effects | Hematopoietic Stem Cells - radiation effects | bcl-2-Associated X Protein - genetics | Apoptosis Regulatory Proteins - biosynthesis | Mice, Inbred C57BL | Cells, Cultured | Epidermal Growth Factor - metabolism | Bone Marrow Cells - radiation effects | Mice, Knockout | Regeneration | Animals | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Mice | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Quinazolines - pharmacology | Tumor Suppressor Proteins - biosynthesis | Care and treatment | Epidermal growth factor | Radiation injuries | Transplantation | Research | Health aspects | Hematopoietic stem cells | Cytokines | Gene expression | Stem cells | Radiation | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 03/2014, Volume 9, Issue 3, pp. e92248 - e92248
Three-dimensional (3D) cell culture is gaining acceptance in response to the need for cellular models that better mimic physiologic tissues. Spheroids are one... 
CANCER-CELLS | CARCINOMA-CELLS | CROSS-TALK | GROWTH-FACTOR RECEPTOR | MULTIDISCIPLINARY SCIENCES | PROSTATE-CANCER | ERLOTINIB RESISTANCE | C-MET ANTIBODY | MULTICELLULAR SPHEROIDS | KINASE INHIBITORS | ANTICANCER DRUGS | Proto-Oncogene Proteins c-met - metabolism | Lung Neoplasms - drug therapy | Humans | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Antineoplastic Agents - therapeutic use | Hepatocyte Growth Factor - pharmacology | Cell Culture Techniques - methods | Receptor, Epidermal Growth Factor - metabolism | Antineoplastic Agents - pharmacology | Spheroids, Cellular - drug effects | Phosphorylation - drug effects | Tumor Cells, Cultured | Tumor Microenvironment - drug effects | Cell Survival - drug effects | Reproducibility of Results | Proto-Oncogene Proteins c-met - antagonists & inhibitors | Treatment Outcome | Drug Discovery | Cell Movement - drug effects | Protein Kinase Inhibitors - therapeutic use | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Ligands | Cell Proliferation - drug effects | Protein Kinase Inhibitors - pharmacology | Epidermal Growth Factor - pharmacology | Epidermal growth factor | Health aspects | Lung cancer | Tumors | Monomolecular films | Cell proliferation | Drugs | Self assembly | Cell culture | Flow cytometry | Biotechnology | Phosphorylation | Lung | Systematic review | Drug development | Kinases | Tissues | Pharmaceutical industry | Growth factors | Epidermal growth factor receptors | Hepatocyte growth factor | Research & development--R&D | Tumor cells | Cultures | Pharmacology | Tumor cell lines | Chemical compounds | Spheroids | Studies | Cytometry | Self-assembly | Inhibitors | Monolayers | Mutation | Three dimensional models | Cell migration | Index Medicus | Research & development | R&D
Journal Article
PLoS ONE, ISSN 1932-6203, 01/2012, Volume 7, Issue 1, pp. e29597 - e29597
Human embryonic stem cells (hESC) and induced pluripotent stem cells (iPSC) provide new prospects for studying human neurodevelopment and modeling neurological... 
HUMAN ES | INHIBITION | FGF | MULTIDISCIPLINARY SCIENCES | CENTRAL-NERVOUS-SYSTEM | DIFFERENTIATION CAPACITY | PRECURSORS | TRIPOTENT | Oligonucleotide Array Sequence Analysis | Humans | Fibroblast Growth Factor 2 - pharmacology | Neurons - cytology | Gene Expression Profiling | Neural Stem Cells - cytology | Neuroepithelial Cells - cytology | Neuroglia - cytology | Neurons - metabolism | Induced Pluripotent Stem Cells - cytology | Induced Pluripotent Stem Cells - metabolism | Cell Line | Pluripotent Stem Cells - cytology | Transcription Factors - genetics | Reverse Transcriptase Polymerase Chain Reaction | Pluripotent Stem Cells - metabolism | Transcription Factors - metabolism | Cell Differentiation - drug effects | Fluorescent Antibody Technique | Neuroglia - metabolism | Cell Proliferation - drug effects | Neuroepithelial Cells - metabolism | Epidermal Growth Factor - pharmacology | Neural Stem Cells - metabolism | Cluster Analysis | Medical research | Nervous system diseases | Epidermal growth factor | Neurons | Medicine, Experimental | Fibroblast growth factors | Comparative analysis | Embryonic stem cells | Neurophysiology | Neurosciences | Laboratories | Neurobiology | Embryo cells | Radial glial cells | Nervous system | Biochemistry | Neurodevelopmental disorders | Neuronal-glial interactions | Genotype & phenotype | Fibroblasts | Physiology | Growth factors | Fibroblast growth factor 2 | Fetuses | Embryos | Brain research | Stem cells | Comparative studies | Hindbrain | Bayesian analysis | Pluripotency | Index Medicus
Journal Article