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epidithiodiketopiperazine (15) 15
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The Chemical Record, ISSN 1527-8999, 12/2018, Volume 18, Issue 12, pp. 1658 - 1658
The Cover picture shows chaetocin and S‐adenosylmethionine analogues as tools for studying protein methylation regulated by protein methyltransferases (PMTs).... 
epidithiodiketopiperazine | inhibitor | proteomics | protein methylation | detector
Journal Article
by Liu, YY and Wang, ZP and Banne, S and Guo, J and He, Y
JOURNAL OF ORGANIC CHEMISTRY, ISSN 0022-3263, 05/2019, Volume 84, Issue 9, pp. 5838 - 5845
The enantioselective synthesis of a desulfur-scabrosin skeleton was reported. The synthesis began from 3-(hydroxymethyl)phenol, and key steps include... 
CORE | BIOLOGICAL EVALUATION | CHEMISTRY | CHEMISTRY, ORGANIC | EPIDITHIODIKETOPIPERAZINE | STRATEGY
Journal Article
Natural Product Research, ISSN 1478-6419, 2019, pp. 1 - 9
A new epidithiodiketopiperazine (ETP), pretrichodermamide G ( ), along with three known (epi)dithiodiketopiparazines ( ) were isolated from cultures of and ,... 
Epicoccum nigrum | Trichoderma harzianum | endophytic fungi | apoptosis | epidithiodiketopiperazine | antimicrobial activity | cytotoxicity
Journal Article
Phosphorus, Sulfur, and Silicon and the Related Elements, ISSN 1042-6507, 07/2019, Volume 194, Issue 7, pp. 630 - 633
Novel findings during the course of the total synthesis of sulfur-containing natural products are described. These natural products include sporidesmin A,... 
epidithiodiketopiperazine | total synthesis | Natural products | dithiolanone | thiazoline | CHEMISTRY, ORGANIC | CHEMISTRY, INORGANIC & NUCLEAR
Journal Article
Journal of Experimental & Clinical Cancer Research, ISSN 1756-9966, 12/2019, Volume 38, Issue 1, pp. 1 - 15
Pancreatic cancer is one of the most lethal malignancies due to frequent late diagnosis, aggressive tumor growth and metastasis formation. Continuously raising... 
Liver cancer | Cancer patients | Care and treatment | Patient outcomes | Pancreatic cancer | Liver | Metastasis | DNA binding proteins | Vismodegib | Cancer | ETP | Hedgehog signaling | Epidithiodiketopiperazine | NT1721 | GLI
Journal Article
Synlett, ISSN 0936-5214, 12/2013, Volume 24, Issue 19, pp. 2563 - 2566
Abstract A novel base-catalysed approach to disubstituted epidithiodiketopiperazines (ETP) is described. The synthetic route involves a multicomponent reaction... 
letter | gliotoxin | multicomponent reactions | chaetocin | epidithiodiketopiperazine | chetomin | CELLS | ANTIBIOTICS GLIOTOXIN | EPIPOLYTHIODIOXOPIPERAZINES | CHEMISTRY, ORGANIC | HYPOXIA | ARANOTIN | SPORIDESMIN | INHIBITION | L-PROLINE ANHYDRIDE
Journal Article
Journal of Natural Products, ISSN 0163-3864, 03/2019, Volume 82, Issue 3, pp. 462 - 468
Rogersonins A (1) and B (2), two new indole alkaloid polyketide hybrids, have been isolated from cultures of a verG disruption mutant of the... 
CHEMISTRY, MEDICINAL | FUNGUS | EPIDITHIODIOXOPIPERAZINES | CHEMICAL-SHIFTS | ELECTRONIC CIRCULAR-DICHROISM | EPIDITHIODIKETOPIPERAZINES | PLANT SCIENCES | VERTICILLIN | ABSOLUTE-CONFIGURATION | CORDYCEPS | BIOSYNTHESIS | GLIOTOXIN | PHARMACOLOGY & PHARMACY
Journal Article
Journal Article
ChemBioChem, ISSN 1439-4227, 11/2013, Volume 14, Issue 17, pp. 2256 - 2258
Journal Article
Phytochemistry Letters, ISSN 1874-3900, 03/2015, Volume 11, pp. 168 - 172
Two new epidithiodiketopiperazines, pretrichodermamide C ( ) and N-methylpretrichodermamide B ( ) were isolated from the fungus sp., derived from the sediment... 
Penicillium sp | Cytotoxicity | Sediment | Epidithiodiketopiperazines | CHEMISTRY, MEDICINAL | CITRINUM | FUNGUS | ANALOGS | POLYKETIDES | ALKALOIDS | PLANT SCIENCES
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 03/2012, Volume 53, Issue 12, pp. 1504 - 1506
A tricyclic epidithiodiketopiperazine was prepared having structural features related to the antitumor antibiotic MPC1001. The method is based on the use of... 
Trisulfide | Sulfenylation | Sulfur deprotection | Epidithiodiketopiperazine | Protection of sulfur | EPIDITHIODIOXOPIPERAZINES | REVERSE TRANSCRIPTASE ACTIVITY | GLIOTOXIN ANALOG | CHEMISTRY, ORGANIC | C-S BOND | DEHYDROGLIOTOXIN | FUNGAL METABOLITES | AMINO-ACIDS | CHEMISTRY | GENERAL-APPROACH | DERIVATIVES | Sulfur compounds | Tetrahedrons | Formations | Oxidation | Antibiotics | Sulfur | Disulfides
Journal Article
Angewandte Chemie, ISSN 0044-8249, 01/2012, Volume 124, Issue 3, pp. 752 - 756
Schwefel in Aktion: Eine praktische und einfache Methode zur Einführung von Schwefelatomen in 2,5‐Diketopiperazine (I) unter milden Bedingungen wurde... 
Bismethylthiodiketopiperazine | Epidithiodiketopiperazine | Naturstoffsynthesen | Sulfenylierungen
Journal Article
Cell Chemical Biology, ISSN 2451-9456, 11/2018, Volume 25, Issue 11, pp. 1350 - 1358.e9
The 26S proteasome is the major proteolytic machine for breaking down cytosolic and nuclear proteins in eukaryotes. Due to the lack of a suitable assay, it is... 
gliotoxin | JAMM protease | proteasome | Capzimin | PSMD14 | Rpn11 | epidithiodiketopiperazine | POH1 | protein degradation | ubiquitin | SYSTEM | CELLS | PATHWAY | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | GLIOTOXIN | LIGAND | MODEL | 26S PROTEASOME | NF-KAPPA-B | HUNTINGTONS-DISEASE
Journal Article
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