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Nature, ISSN 0028-0836, 10/2015, Volume 526, Issue 7575, pp. 715 - 718
Journal Article
The Journal of Cell Biology, ISSN 0021-9525, 3/2004, Volume 164, Issue 5, pp. 769 - 779
All ligands of the epidermal growth factor receptor (EGFR), which has important roles in development and disease, are released from the membrane by proteases.... 
EGF receptor | Growth factor signaling | EGF receptor ligands | ADAMs | Ectodomain shedding | ectodomain shedding | HB-EGF | MEMBRANE | TACE | ALPHA-CONVERTING-ENZYME | growth factor signaling | FACTOR RECEPTOR | MICE LACKING | FAMILY | CELL BIOLOGY | EPIDERMAL-GROWTH-FACTOR | TGF-ALPHA | METALLOPROTEASE-DISINTEGRIN | ADAM17 Protein | Metalloendopeptidases - genetics | Phenylalanine - analogs & derivatives | Glycoproteins - metabolism | Metalloendopeptidases - metabolism | Thiophenes - metabolism | Epiregulin | Amphiregulin | Disintegrins - genetics | ADAM12 Protein | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | EGF Family of Proteins | Embryo, Mammalian - anatomy & histology | Aspartic Acid Endopeptidases | Amyloid Precursor Protein Secretases | Muscle Proteins - metabolism | Membrane Proteins - metabolism | Transforming Growth Factor alpha - metabolism | Fibroblasts - metabolism | Tetradecanoylphorbol Acetate - metabolism | Protein Structure, Tertiary | Endopeptidases - metabolism | Phenylalanine - metabolism | Disintegrins - metabolism | Membrane Proteins - genetics | Cells, Cultured | Epidermal Growth Factor - metabolism | Genotype | Protease Inhibitors - metabolism | ADAM Proteins | Mice, Knockout | Muscle Proteins - genetics | Heparin-binding EGF-like Growth Factor | Animals | Endopeptidases - genetics | Betacellulin | Ligands | Fibroblasts - cytology | Mice | Cytology | Research | EGF receptor; EGF receptor ligands; ADAMs; ectodomain shedding; growth factor signaling
Journal Article
American Journal of Physiology - Heart and Circulatory Physiology, ISSN 0363-6135, 07/2015, Volume 309, Issue 1, pp. H103 - H113
Fibulin-4 is an extracellular matrix protein that is essential for proper assembly of arterial elastic fibers. Mutations in fibulin-4 cause cutis laxa with... 
Mechanics | Gene array | Fibulin-4 | Elastin | Aneurysm | aneurysm | MATRIX | NEUTROPHIL COLLAGENASE | CARDIAC & CARDIOVASCULAR SYSTEMS | PHYSIOLOGY | EPIREGULIN | gene array | mechanics | ANGIOTENSIN-II | EXPRESSION PROFILES | elastin | fibulin-4 | MARFAN-SYNDROME | PERIPHERAL VASCULAR DISEASE | SMOOTH-MUSCLE-CELLS | GROWTH-FACTOR | MUTATIONS | Heparin-binding EGF-like Growth Factor - genetics | Up-Regulation | Aorta - ultrastructure | Aortic Aneurysm, Thoracic - genetics | Muscle, Smooth, Vascular - metabolism | Elastic Modulus | Gene Expression Profiling | Acute-Phase Proteins - genetics | Aorta - metabolism | RNA, Messenger - metabolism | Cyclooxygenase 2 - genetics | Matrix Metalloproteinase 8 - metabolism | Muscle Proteins - metabolism | Aorta - physiopathology | Nuclear Proteins - genetics | Myocytes, Smooth Muscle - metabolism | Epiregulin - metabolism | Repressor Proteins - metabolism | Animals, Newborn | Matrix Metalloproteinase 8 - genetics | Serpins - genetics | Serpins - metabolism | Acute-Phase Proteins - metabolism | Extracellular Matrix Proteins - genetics | Aorta, Thoracic - metabolism | Receptors, Cell Surface - metabolism | Repressor Proteins - genetics | Nuclear Proteins - metabolism | Aorta, Thoracic - physiopathology | Epiregulin - genetics | Microscopy, Electron | Muscle, Smooth, Vascular - cytology | Reverse Transcriptase Polymerase Chain Reaction | Aorta, Thoracic - ultrastructure | Mice, Knockout | Heparin-binding EGF-like Growth Factor - metabolism | Muscle Proteins - genetics | Animals | Cyclooxygenase 2 - metabolism | Collagen Type VIII - metabolism | Mice | Myocytes, Smooth Muscle - ultrastructure | Collagen Type VIII - genetics | Receptors, Cell Surface - genetics | Cellular proteins | Aortic aneurysms | Development and progression | Cellular signal transduction | Genetic aspects | Properties | Genetic regulation | Health aspects | Aneurysms | Gene expression | Analysis | Vascular Biology and Microcirculation
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2014, Volume 348, Issue 2, pp. 236 - 245
Rheumatoid arthritis (RA) is a chronic autoimmune disease with high morbidity and mortality. Within the inflammatory milieu, resident fibroblast-like... 
OVEREXPRESSION | CIGARETTE-SMOKING | MMP EXPRESSION | VEGF | DIOXIN RECEPTOR | PHARMACOLOGY & PHARMACY | LIGAND | METALLOPROTEINASES | INHIBITORY FACTOR | T-CELLS | 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN | Receptors, Aryl Hydrocarbon - antagonists & inhibitors | Humans | Synovial Membrane - pathology | Vascular Endothelial Growth Factor A - metabolism | Epiregulin | Interleukin-1beta - genetics | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Promoter Regions, Genetic - drug effects | Vascular Endothelial Growth Factor A - genetics | Vascular Endothelial Growth Factor A - secretion | Arthritis, Rheumatoid - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Arthritis, Rheumatoid - drug therapy | Interleukin-1beta - metabolism | Gelatinases - metabolism | Interleukin-1beta - antagonists & inhibitors | Glycoproteins - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Gelatinases - antagonists & inhibitors | Receptors, Aryl Hydrocarbon - genetics | Recombinant Proteins - chemistry | Cell Movement - drug effects | Fibroblast Growth Factor 2 - antagonists & inhibitors | Fibroblast Growth Factor 2 - genetics | Epidermal Growth Factor - secretion | Glycoproteins - metabolism | Synovial Membrane - immunology | Synovial Membrane - drug effects | Amphiregulin | Molecular Targeted Therapy | Intercellular Signaling Peptides and Proteins - metabolism | EGF Family of Proteins | Fibroblast Growth Factor 2 - metabolism | Receptors, Aryl Hydrocarbon - metabolism | Indoles - pharmacology | Antirheumatic Agents - pharmacology | Recombinant Proteins - metabolism | Cytokines - metabolism | Epidermal Growth Factor - genetics | Purines - pharmacology | Cells, Cultured | Gene Silencing | Glycoproteins - antagonists & inhibitors | Intercellular Signaling Peptides and Proteins - genetics | Epidermal Growth Factor - metabolism | Basic Helix-Loop-Helix Transcription Factors - antagonists & inhibitors | Down-Regulation - drug effects | Arthritis, Rheumatoid - pathology | Response Elements - drug effects | Synovial Membrane - secretion | Gelatinases - genetics | Epidermal Growth Factor - antagonists & inhibitors | Cell Proliferation - drug effects | Cytokines - antagonists & inhibitors | Arthritis, Rheumatoid - immunology
Journal Article
Journal Article
Laboratory Investigation, ISSN 0023-6837, 03/2011, Volume 91, Issue 3, pp. 379 - 391
Journal Article
Journal Article
Journal Article
Journal Article
Journal of Immunology, ISSN 0022-1767, 02/2015, Volume 194, Issue 3, pp. 1039 - 1046
Journal Article
Journal Article
Molecular Biology of the Cell, ISSN 1059-1524, 01/2007, Volume 18, Issue 1, pp. 176 - 188
Journal Article
Traffic, ISSN 1398-9219, 08/2009, Volume 10, Issue 8, pp. 1115 - 1127
Endocytic downregulation is a pivotal mechanism turning off signalling from the EGF receptor (EGFR). It is well established that whereas EGF binding leads to... 
amphiregulin | betacellulin | epiregulin | transforming growth factor‐α | epidermal growth factor receptor | heparin‐binding EGF‐like growth factor | endocytic trafficking | epidermal growth factor | Epidermal growth factor | Betacellulin | Heparin-binding EGF-like growth factor | Transforming growth factor-α | Endocytic trafficking | Epiregulin | Amphiregulin | Epidermal growth factor receptor | heparin-binding EGF-like growth factor | transforming growth factor-alpha | CBL | FACTOR-ALPHA | CELL BIOLOGY | UBIQUITINATION | CETUXIMAB | INTERNALIZATION | COLORECTAL-CANCER | EPIDERMAL-GROWTH-FACTOR | ERBB RECEPTORS | Cell Line | Receptor, Epidermal Growth Factor - genetics | Phosphorylation | Proto-Oncogene Proteins c-cbl - metabolism | Vesicular Transport Proteins - metabolism | Humans | Glycoproteins - metabolism | Epidermal Growth Factor - metabolism | Protein Transport - physiology | Endocytosis - physiology | Heparin-binding EGF-like Growth Factor | Intercellular Signaling Peptides and Proteins - metabolism | Receptor, Epidermal Growth Factor - metabolism | Ubiquitination | Animals | EGF Family of Proteins | Ligands | Lysosomal-Associated Membrane Protein 1 - metabolism | Signal Transduction - physiology | Transforming Growth Factor alpha - metabolism | Hydrogen-Ion Concentration | Ubiquitin | Universities and colleges | Transforming growth factors | Ligases | transforming growth factor-α | Original
Journal Article