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Nature cell biology, ISSN 1476-4679, 2010, Volume 12, Issue 3, pp. 299 - 305
For most types of cancers, the cell at the origin of tumour initiation is still unknown. Here, we used mouse genetics to identify cells at the origin of basal... 
POPULATION | STEM-CELLS | SONIC HEDGEHOG | EPIDERMIS | HAIR FOLLICLE BULGE | KERATINOCYTES | CANCER | EXPRESSION | HUMAN HOMOLOG | MOUSE SKIN | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Receptors, G-Protein-Coupled - metabolism | Skin - metabolism | Cell Count | Ear, External - pathology | Integrin beta4 - metabolism | Tail - pathology | Hair Follicle - pathology | Hedgehog Proteins - genetics | Neoplastic Stem Cells - metabolism | Kruppel-Like Transcription Factors - metabolism | Smoothened Receptor | Neoplastic Stem Cells - pathology | Cell Differentiation | Patched Receptors | Skin - pathology | Keratin-10 - metabolism | Epidermis - metabolism | Epidermis - pathology | RNA, Untranslated | Bacterial Proteins - genetics | Receptors, Cell Surface - metabolism | Epithelial Cells - pathology | Genes, Reporter - genetics | Mice, Transgenic | Carcinoma, Basal Cell - pathology | Mice, Inbred Strains | Clone Cells - metabolism | Keratin-14 - genetics | Carcinoma, Basal Cell - metabolism | Keratin-15 - metabolism | Keratin-19 - genetics | Proteins - genetics | Cell Lineage | Animals | Clone Cells - pathology | Proteins - metabolism | Models, Biological | Hair Follicle - metabolism | Bacterial Proteins - metabolism | Luminescent Proteins - genetics | Mice | Receptors, G-Protein-Coupled - genetics | Integrases - genetics | Keratin-15 - genetics | Luminescent Proteins - metabolism | Basal cell carcinoma | Stem cells | Genetic aspects | Cellular signal transduction | Research | Health aspects | Risk factors
Journal Article
PloS one, ISSN 1932-6203, 2014, Volume 9, Issue 2, p. e87893
The most deadly phase in cancer progression is metastatic conversion. Epithelial-to-mesenchymal transition (EMT) is a key process by which cancer cells acquire... 
BREAST-CANCER | TRANSITION | MSCS | METASTASIS | FUSION | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | FOCUS | IDENTIFICATION | TUMORS | PROGRESSION | Cell Proliferation | Epithelial Cells - metabolism | Humans | Gene Expression Regulation, Neoplastic | Spheroids, Cellular - pathology | Lung Neoplasms - pathology | Gene Expression Profiling | Epithelial-Mesenchymal Transition - genetics | Cell Fusion | Neoplastic Stem Cells - metabolism | Cell Shape | Biomarkers, Tumor - metabolism | Neoplastic Stem Cells - pathology | Female | Cell Differentiation | Fibroblasts - metabolism | Hybrid Cells - metabolism | Lung Neoplasms - genetics | Neoplasm Invasiveness | Spheroids, Cellular - metabolism | Bone Marrow Cells - pathology | Carcinogenesis - genetics | Mesenchymal Stromal Cells - metabolism | Epithelial Cells - pathology | Fibroblasts - pathology | Mice, SCID | Carcinogenesis - pathology | Phenotype | Animals | Hybrid Cells - pathology | Cell Line, Tumor | Mesenchymal Stromal Cells - pathology | Bone Marrow Cells - metabolism | Cell Movement | Lung cancer, Non-small cell | Development and progression | Metastasis | Vimentin | Hybrids | Transcription factors | Motility | Mesenchyme | Oct-4 protein | Brain cancer | Lung cancer | Cytology | Stem cell transplantation | Smooth muscle | Cell fusion | E-cadherin | Fibronectin | Metastases | Genotype & phenotype | Actin | Rodents | Bone marrow | Fibroblasts | Population | Subpopulations | Myeloid cells | Invasiveness | Muscles | Non-small cell lung carcinoma | Forming | Inflammation | Tumor cell lines | Gene expression | Medicine | Properties (attributes) | Bone cancer | Hospitals | Overexpression | Morphology | Stem cells | Aberration | Cancer
Journal Article
Nature communications, ISSN 2041-1723, 2014, Volume 5, Issue 1, p. 4511
Although the principles that balance stem cell self-renewal and differentiation in normal tissue homeostasis are beginning to emerge, it is still unclear... 
FOLLICLE STEM-CELLS | PROGENITOR CELLS | SURVIVAL | MAINTENANCE | HAIR FOLLICLE | REGENERATION | MULTIDISCIPLINARY SCIENCES | NICHE | SELF-RENEWAL | DIFFERENTIATION | SKIN TUMORS | Neuropilin-1 - genetics | Neoplasm Transplantation | RNA, Small Interfering - genetics | Epithelial Cells - metabolism | Neuropilin-1 - metabolism | Skin - metabolism | Stromal Cells - pathology | Carcinoma, Squamous Cell - genetics | Carcinoma, Squamous Cell - metabolism | Carcinoma, Squamous Cell - pathology | Humans | Gene Expression Regulation, Neoplastic | SOXB1 Transcription Factors - antagonists & inhibitors | Stem Cells - cytology | Vascular Endothelial Growth Factor A - metabolism | Stem Cells - metabolism | Vascular Endothelial Growth Factor A - genetics | Neuropilin-1 - antagonists & inhibitors | SOXB1 Transcription Factors - metabolism | Tumor Microenvironment - genetics | Neoplastic Stem Cells - metabolism | SOXB1 Transcription Factors - genetics | HEK293 Cells | Neoplastic Stem Cells - pathology | Female | Transcription, Genetic | Skin - pathology | Skin Neoplasms - pathology | Signal Transduction | Stromal Cells - metabolism | Epithelial Cells - pathology | Organ Specificity | Skin Neoplasms - metabolism | Animals | Mice, Nude | Skin Neoplasms - genetics | Cell Line, Tumor | Mice | Primary Cell Culture | RNA, Small Interfering - metabolism
Journal Article
PLoS pathogens, ISSN 1553-7374, 2013, Volume 9, Issue 11, p. e1003773
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to... 
CELLS | DEFENSE | VIRUS-INFECTION | DISTINCT | RIG-I | MICROBIOLOGY | IRF-7 | ANTIVIRAL RESPONSE | VIROLOGY | GENE | SIGNALING PATHWAY | ADAPTER PROTEIN | PARASITOLOGY | Epithelial Cells - metabolism | Influenza A virus - genetics | Respiratory Mucosa - virology | Interferon Regulatory Factor-7 - genetics | Interferon Type I - immunology | Interferon Regulatory Factor-3 - genetics | Interleukins - metabolism | Orthomyxoviridae Infections - genetics | Respiratory Mucosa - pathology | Interleukins - genetics | Interleukins - immunology | Respiratory Mucosa - immunology | Adaptor Proteins, Signal Transducing - immunology | Interferon Type I - metabolism | Influenza A virus - immunology | Membrane Proteins - metabolism | Interferon Regulatory Factor-3 - immunology | Nerve Tissue Proteins - immunology | Membrane Proteins - genetics | Orthomyxoviridae Infections - metabolism | Epithelial Cells - pathology | Membrane Proteins - immunology | Interferon Regulatory Factor-7 - immunology | Interferon Regulatory Factor-7 - metabolism | Nerve Tissue Proteins - genetics | Mice, Knockout | Nerve Tissue Proteins - metabolism | Animals | Influenza A virus - metabolism | Epithelial Cells - immunology | Epithelial Cells - virology | Adaptor Proteins, Signal Transducing - genetics | Interferon Regulatory Factor-3 - metabolism | Interferon Type I - genetics | Mice | Respiratory Mucosa - metabolism | Adaptor Proteins, Signal Transducing - metabolism | Orthomyxoviridae Infections - immunology | Epithelial cells | Influenza | Physiological aspects | Host-parasite relationships | Interferon | Genetic aspects | Genetic transcription | Research | Health aspects | Airway (Medicine) | Interleukins/metabolism | Nerve Tissue Proteins/immunology | Orthomyxoviridae Infections/genetics | Orthomyxoviridae Infections/metabolism | Membrane Proteins/genetics | Adaptor Proteins, Signal Transducing/genetics | Interferon Regulatory Factor-7/genetics | Interleukins/immunology | Membrane Proteins/immunology | Life Sciences | Orthomyxoviridae Infections/immunology | Influenza A virus/genetics | Nerve Tissue Proteins/metabolism | Respiratory Mucosa/immunology | Immunology | Interferon Type I/immunology | Epithelial Cells/immunology | Epithelial Cells/virology | Interferon Regulatory Factor-7/immunology | Epithelial Cells/metabolism | Interferon Regulatory Factor-3/immunology | Respiratory Mucosa/pathology | Influenza A virus/immunology | Interleukins/genetics | Interferon Regulatory Factor-3/genetics | Influenza A virus/metabolism | Adaptor Proteins, Signal Transducing/metabolism | Epithelial Cells/pathology | Adaptor Proteins, Signal Transducing/immunology | Interferon Type I/genetics | Interferon Regulatory Factor-3/metabolism | Membrane Proteins/metabolism | Nerve Tissue Proteins/genetics | Interferon Regulatory Factor-7/metabolism | Interferon Type I/metabolism | Respiratory Mucosa/metabolism | Respiratory Mucosa/virology | Cytokines | Genes | Rodents | Genomics | Genomes | Kinases | Experiments | Viral infections
Journal Article
PloS one, ISSN 1932-6203, 2015, Volume 10, Issue 5, p. e0126522
Journal Article
Science (American Association for the Advancement of Science), ISSN 1095-9203, 2018, Volume 360, Issue 6393, pp. eaan8546 - 1086
Pulmonary neuroendocrine cells (PNECs) are rare airway epithelial cells whose function is poorly understood. Here we show that -mutant mice that have no PNECs... 
MIGRATION | NEUROEPITHELIAL BODIES | EPITHELIUM | INFLAMMATION | MULTIDISCIPLINARY SCIENCES | MUCUS OVERPRODUCTION | NEURONS | INNERVATION | GABA | INNATE LYMPHOID-CELLS | DIFFERENTIATION | Lung - pathology | Basic Helix-Loop-Helix Transcription Factors - genetics | Neuroendocrine Cells - pathology | gamma-Aminobutyric Acid - metabolism | Humans | Hyperplasia | Epithelial Cells - pathology | Animals | gamma-Aminobutyric Acid - biosynthesis | Epithelial Cells - immunology | Asthma - immunology | Female | Mice | Goblet Cells - pathology | Calcitonin Gene-Related Peptide - metabolism | Asthma - pathology | Basic Helix-Loop-Helix Transcription Factors - deficiency | Cytokines - biosynthesis | Neuroendocrine Cells - immunology | Disease Models, Animal | Reptiles | ASCL1 protein | Cell culture | Peptides | Modules | Mucosa | Amphibia | Neuropeptides | Mucus | Inactivation | Mucous membrane | Sensory neurons | Dense core vesicles | Cytokines | House dust | Epithelium | Patients | Allergies | Molecular chains | Asthma | Amplification | Calcitonin gene-related peptide | Allergens | Chemical sensors | Animal models | Amines | Epithelial cells | Interleukin | Physiological responses | Respiratory tract | Interleukin 5 | Rodents | Calcitonin | Alveoli | Immune system | Immune response | Deactivation | Hypersensitivity | Clustering | Mutants | Neurotransmitters | Acids | Lungs | Effectors | In vivo methods and tests | Surface area | Chemoreceptors
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 550, Issue 7677, pp. 529 - 533
Journal Article
Cancer cell, ISSN 1535-6108, 2015, Volume 28, Issue 6, pp. 800 - 814
The regulation and stem cell origin of normal and neoplastic gastric glands are uncertain. Here, we show that Mist1 expression marks quiescent stem cells in... 
CARCINOMA-CELLS | PROGENITOR CELLS | CHIEF CELLS | MAINTENANCE | ONCOLOGY | MOUSE STOMACH | INNATE LYMPHOID-CELLS | E-CADHERIN | BONE | INTRAEPITHELIAL NEOPLASIA | CANCER | CELL BIOLOGY | Epithelial Cells - metabolism | Cadherins - metabolism | Neoplastic Stem Cells - drug effects | Epithelial Cells - drug effects | Humans | Stomach Neoplasms - metabolism | Tumor Microenvironment | Gastric Mucosa - pathology | Male | Stomach Neoplasms - pathology | Wnt-5a Protein | Gastric Mucosa - metabolism | Wnt Proteins - metabolism | Basic Helix-Loop-Helix Transcription Factors - metabolism | Neoplastic Stem Cells - metabolism | Time Factors | Cell Transformation, Neoplastic - genetics | Cellular Senescence | Bone Marrow Transplantation | Gastric Mucosa - drug effects | Neoplastic Stem Cells - pathology | Antineoplastic Agents - pharmacology | Wnt Signaling Pathway | Lymphocytes - metabolism | Stomach Neoplasms - genetics | Basic Helix-Loop-Helix Transcription Factors - genetics | Stem Cell Niche | Signal Transduction | Endothelial Cells - metabolism | Cell Communication | Epithelial Cells - pathology | Mice, Transgenic | Stomach Neoplasms - drug therapy | Cell Transformation, Neoplastic - metabolism | Receptors, CXCR4 - metabolism | Cell Lineage | Lymphocytes - pathology | Animals | Chemokine CXCL12 - metabolism | rho GTP-Binding Proteins - metabolism | Cell Line, Tumor | Anoikis | Mice | Cell Transformation, Neoplastic - pathology | Endothelial Cells - pathology | Antimitotic agents | Medical colleges | Antineoplastic agents | Liver | Stem cells | Microbiology
Journal Article