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Journal of the American College of Cardiology, ISSN 0735-1097, 05/2010, Volume 55, Issue 18, pp. 1915 - 1922
Journal Article
Annals of Internal Medicine, ISSN 0003-4819, 10/2008, Volume 149, Issue 8, pp. 521 - 530
Background: Oral sildenafil and intravenous epoprostenol have independently been shown to be effective in patients with pulmonary arterial hypertension.... 
INHALED ILOPROST | SURVIVAL | MEDICINE, GENERAL & INTERNAL | ORAL SILDENAFIL | EFFICACY | TREPROSTINIL | SAFETY | COMBINATION THERAPY | PROSTACYCLIN | BOSENTAN | Piperazines - administration & dosage | Injections, Intravenous | Humans | Middle Aged | Sulfones - adverse effects | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Dyspepsia - chemically induced | Purines - administration & dosage | Hemodynamics - physiology | Walking - physiology | Sildenafil Citrate | Time Factors | Epoprostenol - adverse effects | Adult | Female | Hypertension, Pulmonary - drug therapy | Purines - adverse effects | Drug Therapy, Combination | Headache - chemically induced | Double-Blind Method | Administration, Oral | Piperazines - adverse effects | Antihypertensive Agents - adverse effects | Adolescent | Quality of Life | Aged | Vasodilator Agents - adverse effects | Hypertension, Pulmonary - etiology | Vasodilator Agents - administration & dosage | Epoprostenol - administration & dosage | Sulfones - administration & dosage | Complications and side effects | Epoprostenol | Dosage and administration | Sildenafil | Drug therapy, Combination | Research | Drug therapy | Pulmonary hypertension | Hypertension | Inhibitor drugs | Patients | Quality of life | Index Medicus | Abridged Index Medicus
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
This article describes the preclinical pharmacology and pharmacokinetics (PK) of hexadecyl-treprostinil (C16TR), a prodrug of treprostinil (TRE), formulated in... 
PROSTACYCLIN RECEPTOR | EP4 RECEPTOR | ANALOGS | ARTERIAL-HYPERTENSION | PHARMACOLOGY & PHARMACY | BINDING | ILOPROST | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
Journal Article
Chest, ISSN 0012-3692, 2013, Volume 144, Issue 3, pp. 952 - 958
Journal Article
Chest, ISSN 0012-3692, 06/2009, Volume 135, Issue 6, pp. 1455 - 1461
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 01/2015, Volume 197, pp. 97 - 104
Prostaglandin I (PGI ) and its analogues (such as beraprost sodium, BPS) are beneficial for the treatment of pulmonary arterial hypertension (PAH). The... 
Encapsulation | Biodegradable nanoparticle | Pulmonary arterial hypertension | Prostaglandin I2 | Beraprost sodium | Prostaglandin I | SURVIVAL | RATS | VASCULAR-PERMEABILITY | CONTINUOUS INTRAVENOUS EPOPROSTENOL | BIODEGRADABLE NANOPARTICLES | COMBINATION | CHEMISTRY, MULTIDISCIPLINARY | THERAPY | Prostaglandin I-2 | PROSTACYCLIN ANALOG | NANOSPHERES | PHARMACOLOGY & PHARMACY | REGISTRY | Polymers - administration & dosage | Rhodamines - administration & dosage | Nanoparticles - chemistry | Rats, Wistar | Monocrotaline | Capillary Permeability - drug effects | Drug Carriers - administration & dosage | Delayed-Action Preparations - chemistry | Male | Polyethylene Glycols - chemistry | Drug Carriers - chemistry | Delayed-Action Preparations - administration & dosage | Pulmonary Artery - metabolism | Delayed-Action Preparations - pharmacokinetics | Polyesters | Hypertension, Pulmonary - drug therapy | Rhodamines - chemistry | Lactic Acid - administration & dosage | Disease Models, Animal | Epoprostenol - pharmacokinetics | Lactic Acid - chemistry | Mice, Inbred C57BL | Hypertension, Pulmonary - metabolism | Pulmonary Artery - drug effects | Polyethylene Glycols - administration & dosage | Epoprostenol - analogs & derivatives | Animals | Epoprostenol - chemistry | Polymers - chemistry | Drug Carriers - pharmacokinetics | Nanoparticles - administration & dosage | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Epoprostenol - administration & dosage | Nanoparticles | Fluorescence | Models | Analysis | Pulmonary hypertension | Drugs | Drug delivery systems | Drug discovery | Vehicles | Index Medicus
Journal Article
Journal of Cardiovascular Pharmacology, ISSN 0160-2446, 04/2016, Volume 67, Issue 4, pp. 290 - 298
Journal Article
European Respiratory Journal, ISSN 0903-1936, 06/2016, Volume 47, Issue 6, pp. 1727 - 1736
Journal Article
Circulation, ISSN 0009-7322, 02/2013, Volume 127, Issue 5, pp. 624 - 633
Journal Article
Chest, ISSN 0012-3692, 2012, Volume 142, Issue 6, pp. 1383 - 1390
Journal Article
Journal Article
The Journal of Physiology, ISSN 0022-3751, 11/2016, Volume 594, Issue 21, pp. 6419 - 6429
Journal Article