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1. Addition of inhaled treprostinil to oral therapy for pulmonary arterial hypertension: A randomized controlled clinical trial
by McLaughlin, Vallerie V and Benza, Raymond L and Rubin, Lewis J and Channick, Richard N and Voswinckel, Robert and Tapson, Victor F and Robbins, Ivan M and Olschewski, Horst and Rubenfire, Melvyn and Seeger, Werner
Journal of the American College of Cardiology, ISSN 0735-1097, 05/2010, Volume 55, Issue 18, pp. 1915 - 1922
Treprostinil sodium | Inhalation therapy | Aerosol | Pulmonary heart disease | Pulmonary vascular disease | Prostacyclin | Pulmonary arterial hypertension | Cardiac & Cardiovascular Systems | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Piperazines - administration & dosage | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Purines - administration & dosage | Exercise Tolerance - drug effects | Sildenafil Citrate | Young Adult | Peptide Fragments - blood | Adult | Female | Hypertension, Pulmonary - drug therapy | Drug Therapy, Combination | Natriuretic Peptide, Brain - blood | Administration, Oral | Administration, Inhalation | Treatment Outcome | Epoprostenol - analogs & derivatives | Quality of Life | Aged | Vasodilator Agents - administration & dosage | Sulfonamides - administration & dosage | Epoprostenol - administration & dosage | Sulfones - administration & dosage | Hypertension | Studies | Pulmonary arteries | Collagen | Family medical history | Drug therapy | Drug dosages
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2. Full Text Addition of sildenafil to long-term intravenous epoprostenol therapy in patients with pulmonary arterial hypertension: A randomized trial
by Simonneau, Gérald and Rubin, Lewis J and Galiè, Nazzareno and Barst, Robyn J and Fleming, Thomas R and Frost, Adaani E and Engel, Peter J and Kramer, Mordechai R and Burgess, Gary and Collings, Lorraine and Cossons, Nandini and Sitbon, Olivier and Badesch, David B and PACES Study Grp and PACES Study Group
Annals of internal medicine, ISSN 0003-4819, 10/2008, Volume 149, Issue 8, pp. 521 - 530
Medicine, General & Internal | Life Sciences & Biomedicine | General & Internal Medicine | Science & Technology | Biological and medical sciences | General aspects | Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases | Medical sciences | Pneumology | Piperazines - administration & dosage | Injections, Intravenous | Humans | Middle Aged | Sulfones - adverse effects | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Dyspepsia - chemically induced | Purines - administration & dosage | Hemodynamics - physiology | Walking - physiology | Sildenafil Citrate | Time Factors | Epoprostenol - adverse effects | Adult | Female | Hypertension, Pulmonary - drug therapy | Purines - adverse effects | Drug Therapy, Combination | Headache - chemically induced | Double-Blind Method | Administration, Oral | Piperazines - adverse effects | Antihypertensive Agents - adverse effects | Adolescent | Quality of Life | Aged | Vasodilator Agents - adverse effects | Hypertension, Pulmonary - etiology | Vasodilator Agents - administration & dosage | Epoprostenol - administration & dosage | Sulfones - administration & dosage | Complications and side effects | Epoprostenol | Dosage and administration | Sildenafil | Drug therapy, Combination | Research | Drug therapy | Pulmonary hypertension | Hypertension | Inhibitor drugs | Patients | Quality of life | Index Medicus | Abridged Index Medicus
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3. Full Text Preclinical pharmacology and pharmacokinetics of inhaled hexadecyl-treprostinil (C16TR), a pulmonary vasodilator prodrug
by Corboz, Michel R and Li, Zhili and Malinin, Vladimir and Plaunt, Adam J and Konicek, Donna M and Leifer, Franziska G and Chen, Kuan-Ju and Laurent, Charles E and Yin, Han and Biernat, Marzena C and Salvail, Dany and Zhuang, Jianguo and Xu, Fadi and Curran, Aidan and Perkins, Walter R and Chapman, Richard W
The Journal of pharmacology and experimental therapeutics, ISSN 0022-3565, 12/2017, Volume 363, Issue 3, pp. 348 - 357
Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Antihypertensive Agents - pharmacology | Nanoparticles - chemistry | Vasodilator Agents - pharmacokinetics | Phosphatidylethanolamines - adverse effects | Humans | Excipients - adverse effects | Male | Polyethylene Glycols - chemistry | Squalene - analogs & derivatives | Drug Compounding | Hypertension, Pulmonary - drug therapy | Epoprostenol - pharmacokinetics | Guinea Pigs | Squalene - adverse effects | Antihypertensive Agents - therapeutic use | Excipients - administration & dosage | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Lung - drug effects | Vasodilation - drug effects | Phosphatidylethanolamines - chemistry | Drug Delivery Systems - adverse effects | Epoprostenol - administration & dosage | Prodrugs - administration & dosage | Epoprostenol - metabolism | Vasodilator Agents - therapeutic use | Antihypertensive Agents - administration & dosage | Polyethylene Glycols - adverse effects | Hypertension, Pulmonary - blood | Nanoparticles - adverse effects | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Excipients - chemistry | Epoprostenol - pharmacology | Female | Lung - metabolism | Platelet Aggregation - drug effects | Drug Evaluation, Preclinical | Squalene - chemistry | Vasodilator Agents - pharmacology | Administration, Inhalation | Phosphatidylethanolamines - administration & dosage | Squalene - administration & dosage | Antihypertensive Agents - pharmacokinetics | Polyethylene Glycols - administration & dosage | Animals | Prodrugs - pharmacokinetics | Dogs | Nanoparticles - administration & dosage | Prodrugs - therapeutic use | Lung - blood supply | Prodrugs - pharmacology | Vasodilator Agents - administration & dosage | Index Medicus
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4. Full Text Oral treprostinil for the treatment of pulmonary arterial hypertension in patients receiving background endothelin receptor antagonist and phosphodiesterase type 5 inhibitor therapy (The FREEDOM-C2 Study): A randomized controlled trial
by Tapson, Victor F and Jing, Zhi-Cheng and Xu, Kai-Feng and Pan, Lei and Feldman, Jeremy and Kiely, David G and Kotlyar, Eugene and McSwain, C. Shane and Laliberte, Kevin and Arneson, Carl and Rubin, Lewis J and FREEDOM-C2 Study Team
Chest, ISSN 0012-3692, 2013, Volume 144, Issue 3, pp. 952 - 958
Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Prospective Studies | Follow-Up Studies | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Male | Exercise Tolerance - drug effects | Dose-Response Relationship, Drug | Young Adult | Time Factors | Adult | Female | Blood Pressure - drug effects | Hypertension, Pulmonary - drug therapy | Drug Therapy, Combination | Endothelin Receptor Antagonists | Double-Blind Method | Administration, Oral | Phosphodiesterase 5 Inhibitors - administration & dosage | Familial Primary Pulmonary Hypertension | Treatment Outcome | Epoprostenol - analogs & derivatives | Adolescent | Aged | Vasodilator Agents - administration & dosage | Epoprostenol - administration & dosage | Complications and side effects | Care and treatment | Patient outcomes | Treprostinil | Clinical trials | Dosage and administration | Research | Drug therapy | Pulmonary hypertension | Index Medicus | Abridged Index Medicus
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5. Full Text BLOODSTREAM INFECTIONS RELATED WITH PROSTAGLANDIN ANALOGUE INTRAVENOUS ADMINISTRATION IN SEVERE PULMONARY HYPERTENSION
by Camara, R and Coelho, F and Marques-Alves, P and Baptista, R and Castro, G and Loureiro, M.J
Chest, ISSN 0012-3692, 06/2020, Volume 157, Issue 6, pp. A41 - A41
Complications and side effects | Epoprostenol | Care and treatment | Iloprost | Causes of | Sepsis | Dosage and administration | Diagnosis | Pulmonary hypertension
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6. Full Text Gender-related differences in pulmonary arterial hypertension targeted drugs administration
by Marra, Alberto M and Benjamin, Nicola and Eichstaedt, Christina and Salzano, Andrea and Arcopinto, Michele and Gargani, Luna and D́Alto, Michele and Argiento, Paola and Falsetti, Lorenzo and Di Giosia, Paolo and Isidori, Andrea M and Ferrara, Francesco and Bossone, Eduardo and Cittadini, Antonio and Grünig, Ekkehard
Pharmacological research, ISSN 1043-6618, 12/2016, Volume 114, pp. 103 - 109
Female | Male | Pulmonary arterial hypertension | Treatment | Gender | Risk stratification | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Endothelin Receptor Antagonists - administration & dosage | Humans | Phosphodiesterase 5 Inhibitors - administration & dosage | Antihypertensive Agents - administration & dosage | Hypertension, Pulmonary - physiopathology | Treatment Outcome | Hypertension, Pulmonary - epidemiology | Antihypertensive Agents - therapeutic use | Epoprostenol - therapeutic use | Epoprostenol - analogs & derivatives | Sex Factors | Hypertension, Pulmonary - drug therapy | Phosphodiesterase 5 Inhibitors - therapeutic use | Endothelin Receptor Antagonists - therapeutic use | Epoprostenol - administration & dosage | Drug therapy | Cardiology | Pulmonary hypertension | Index Medicus
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7. Upfront triple combination therapy in pulmonary arterial hypertension: A pilot study
by Sitbon, Olivier and Sitbon, Olivier and Jaïs, Xavier and Savale, Laurent and Cottin, Vincent and Bergot, Emmanuel and Bergot, Emmanuel and Macari, Elise Artaud and Bouvaist, Hél̀ene and Bouvaist, Hél̀ene and Dauphin, Claire and Dauphin, Claire and Picard, François and Bulifon, Sophie and Montani, David and Humbert, Marc and Simonneau, Gérald and Simonneau, Gérald
The European respiratory journal, ISSN 0903-1936, 1791, Volume 43, Issue 6, pp. 1691 - 1697
Life Sciences & Biomedicine | Respiratory System | Science & Technology | Piperazines - administration & dosage | Prognosis | Follow-Up Studies | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Treatment Outcome | Purines - administration & dosage | Sildenafil Citrate | Young Adult | Drug Therapy, Combination - methods | Pilot Projects | Adolescent | Adult | Female | Registries | Aged | Hypertension, Pulmonary - drug therapy | Retrospective Studies | Sulfonamides - administration & dosage | Epoprostenol - administration & dosage | Sulfones - administration & dosage
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8. Full Text Treatment of sarcoidosis-associated pulmonary hypertension: A two-center experience
by Barnett, Christopher F and Bonura, Eric J and Nathan, Steven D and Ahmad, Shahzad and Shlobin, Oksana A and Osei, Kwabena and Zaiman, Ari L and Hassoun, Paul M and Moller, David R and Barnett, Scott D and Girgis, Reda E
Chest, ISSN 0012-3692, 06/2009, Volume 135, Issue 6, pp. 1455 - 1461
Prostacyclin | Bosentan | Sildenafil | Sarcoidosis | Pulmonary hypertension | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Cardiology. Vascular system | Biological and medical sciences | Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Pneumology | Piperazines - administration & dosage | Sarcoidosis - mortality | Follow-Up Studies | Humans | Middle Aged | Antihypertensive Agents - administration & dosage | Male | Purines - administration & dosage | Hemodynamics - physiology | Sildenafil Citrate | Statistics, Nonparametric | Female | Hypertension, Pulmonary - drug therapy | Retrospective Studies | Drug Therapy, Combination | Severity of Illness Index | Hypertension, Pulmonary - mortality | Sarcoidosis - diagnosis | Iloprost - administration & dosage | Risk Assessment | Administration, Oral | Kaplan-Meier Estimate | Administration, Inhalation | Probability | Linear Models | Survival Rate | Treatment Outcome | Sarcoidosis - complications | Aged | Hemodynamics - drug effects | Respiratory Function Tests | Hypertension, Pulmonary - etiology | Sulfonamides - administration & dosage | Cohort Studies | Epoprostenol - administration & dosage | Sulfones - administration & dosage | Index Medicus | Abridged Index Medicus | sarcoidosis | Original Research | bosentan | prostacyclin | sildenafil | pulmonary hypertension
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9. Full Text A Comprehensive Review of Treprostinil Pharmacokinetics via Four Routes of Administration
by Kumar, Parag and Thudium, Emily and Laliberte, Kevin and Zaccardelli, David and Nelsen, Andrew
Clinical pharmacokinetics, ISSN 0312-5963, 12/2016, Volume 55, Issue 12, pp. 1495 - 1505
Pharmacotherapy | Internal Medicine | Medicine & Public Health | Pharmacology/Toxicology | Life Sciences & Biomedicine | Pharmacology & Pharmacy | Science & Technology | Drug Administration Routes | Epoprostenol - pharmacokinetics | Area Under Curve | Antihypertensive Agents - administration & dosage | Metabolic Clearance Rate | Antihypertensive Agents - pharmacokinetics | Antihypertensive Agents - therapeutic use | Circadian Rhythm | Dose-Response Relationship, Drug | Epoprostenol - therapeutic use | Epoprostenol - analogs & derivatives | Maximum Tolerated Dose | Drug Interactions | Hypertension, Pulmonary - drug therapy | Delayed-Action Preparations | Epoprostenol - administration & dosage
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10. Full Text Inhaled therapies for pulmonary hypertension
by Hill, Nicholas S and Preston, Ioana R and Roberts, Kari E
Respiratory care, ISSN 0020-1324, 06/2015, Volume 60, Issue 6, pp. 794 - 802
Aerosol therapies | Pulmonary arterial hypertension | Inhaled nitric oxide | Inhaled route | Pulmonary hypertension | Respiratory System | Life Sciences & Biomedicine | Critical Care Medicine | General & Internal Medicine | Science & Technology | Off-Label Use | Iloprost - administration & dosage | Bronchodilator Agents - administration & dosage | Humans | Administration, Inhalation | Antihypertensive Agents - administration & dosage | Nitric Oxide - administration & dosage | Prostaglandins I - administration & dosage | Epoprostenol - analogs & derivatives | Adult | Hypertension, Pulmonary - drug therapy | Vasodilator Agents - administration & dosage | Infant, Newborn | Epoprostenol - administration & dosage | Cell proliferation | Usage | Care and treatment | Nitric oxide | Analysis | Diagnosis | Health aspects | Pressure | Index Medicus
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11. Full Text Encapsulation of beraprost sodium in nanoparticles: Analysis of sustained release properties, targeting abilities and pharmacological activities in animal models of pulmonary arterial hypertension
by Ishihara, Tomoaki and Ishihara, Tomoaki and Hayashi, Erika and Hayashi, Erika and Yamamoto, Shuhei and Yamamoto, Shuhei and Kobayashi, Chisa and Kobayashi, Chisa and Tamura, Yuichi and Tamura, Yuichi and Tamura, Yuichi and Sawazaki, Ryoichi and Sawazaki, Ryoichi and Tamura, Fumiya and Tamura, Fumiya and Tahara, Kayoko and Tahara, Kayoko and Kasahara, Tadashi and Kasahara, Tadashi and Ishihara, Tsutomu and Ishihara, Tsutomu and Takenaga, Mitsuko and Takenaga, Mitsuko and Fukuda, Keiichi and Fukuda, Keiichi and Fukuda, Keiichi and Mizushima, Tohru and Mizushima, Tohru
Journal of controlled release, ISSN 0168-3659, 01/2015, Volume 197, pp. 97 - 104
Encapsulation | Biodegradable nanoparticle | Pulmonary arterial hypertension | Beraprost sodium | Prostaglandin I | Pharmacology & Pharmacy | Physical Sciences | Chemistry | Life Sciences & Biomedicine | Chemistry, Multidisciplinary | Science & Technology | Polymers - administration & dosage | Rhodamines - administration & dosage | Nanoparticles - chemistry | Rats, Wistar | Monocrotaline | Capillary Permeability - drug effects | Drug Carriers - administration & dosage | Delayed-Action Preparations - chemistry | Male | Polyethylene Glycols - chemistry | Drug Carriers - chemistry | Delayed-Action Preparations - administration & dosage | Pulmonary Artery - metabolism | Delayed-Action Preparations - pharmacokinetics | Polyesters | Hypertension, Pulmonary - drug therapy | Rhodamines - chemistry | Lactic Acid - administration & dosage | Disease Models, Animal | Epoprostenol - pharmacokinetics | Lactic Acid - chemistry | Mice, Inbred C57BL | Hypertension, Pulmonary - metabolism | Pulmonary Artery - drug effects | Polyethylene Glycols - administration & dosage | Epoprostenol - analogs & derivatives | Animals | Epoprostenol - chemistry | Polymers - chemistry | Drug Carriers - pharmacokinetics | Nanoparticles - administration & dosage | Hypertension, Pulmonary - pathology | Pulmonary Artery - pathology | Epoprostenol - administration & dosage | Nanoparticles | Fluorescence | Models | Analysis | Pulmonary hypertension | Drugs | Drug delivery systems | Drug discovery | Vehicles | Index Medicus
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12. Full Text Intratracheal Administration of Prostacyclin Analogue–incorporated Nanoparticles Ameliorates the Development of Monocrotaline and Sugen-Hypoxia-induced Pulmonary Arterial Hypertension
by Akagi, Satoshi and Nakamura, Kazufumi and Matsubara, Hiromi and Kondo, Megumi and Miura, Daiji and Matoba, Tetsuya and Egashira, Kensuke and Ito, Hiroshi
Journal of cardiovascular pharmacology, ISSN 0160-2446, 04/2016, Volume 67, Issue 4, pp. 290 - 298
Prostacyclin | Pulmonary arterial smooth muscle cells | Drug delivery system | Nanomedicine | Pulmonary hypertension | Intratracheal administration | Cardiac & Cardiovascular Systems | Pharmacology & Pharmacy | Life Sciences & Biomedicine | Cardiovascular System & Cardiology | Science & Technology | Humans | Male | Hypertension, Pulmonary - prevention & control | Drug Delivery Systems | Hypertrophy, Right Ventricular - drug therapy | Cell Hypoxia | Nanoparticles | Young Adult | Pulmonary Artery - metabolism | Time Factors | Adult | Epoprostenol - pharmacology | Female | Hypertrophy, Right Ventricular - pathology | Myocytes, Smooth Muscle - drug effects | Child | Myocytes, Smooth Muscle - metabolism | Disease Models, Animal | Rats | Monocrotaline - toxicity | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | Epoprostenol - analogs & derivatives | Animals | Adolescent | Cell Proliferation - drug effects | Epoprostenol - administration & dosage | Index Medicus | intratracheal administration | prostacyclin | pulmonary hypertension | pulmonary arterial smooth muscle cells | nanomedicine | drug delivery system | Original
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